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| 1 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 2 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 3 | Tanshinone IIA-Induced Attenuation of Lung Injury in Endotoxemic Mice Is Associated with Reduction of Hypoxia-Inducible Factor 1[alpha] Expression显示文摘 | Xu Min Cao Fale Liu Lili Zhang Bo Wang Yanxia Dong Haiying Cui Yan Dong Mingqing Xu Dunquan Liu Yi Zhao Pengtao Niu Wen Li Zhichao | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，5： | 1 |
| 4 | Hot deformation behavior and processing map of Mg-2Zn-1Al-0.2RE alloy显示文摘In this study,uniaxial hot compression tests were carried out between 200 and 400℃ over strain rates of0.001-1 s-1 to investigate the hot deformation behavior of Mg-2 Zn-1 Al-0.2 RE alloy with coarse grains.The average activation energy was measured to be 174.51 kJ/mol.In addition,a constitutive relation based on the Arrhenius equation was established.Dynamic recrystallization(DRX) kinetics were studied by Avrami equation to characterize the evolution of DRX volume fraction.DRX was favored at high temperatures of 300-400℃ and low strain rates of 0.001-0.01 s-1.According to dynamic material model and Prasad’s instability criterion,a maximum power dissipation of 38% and 32% occurs at 400℃/0.001 s-1 and 400℃/0.01 s-1,respectively.According to the proce ssing map,330-400℃/0.001-0.01 s-1was determined as the optimum deformation parameter range. | Yanxia Niu Jian Hou Fangkun Ning Xingrui Chen Yonghui Jia Qichi Le | 2020 | Journal of Rare Earths2020，38，6： | 1 |
| 5 | Application of dynamic recrystallization model in AZ12 magnesium alloy rolling process显示文摘To deeply understand the dynamic recrystallization behavior of as-cast AZ12 magnesium alloy in deformation process,the uniaxial hot compression experiments were implemented through systematic isothermal compression experiments.The true strain of thermal compression experiments was set to 50%with temperatures of 200,250,300,350,400℃and the strain rates of 0.001,0.01,0.1,1 s^(-1).The Dynamic Recrystallization(DRX)kinetic model of AZ12 magnesium alloy was established and the accuracy of this model was verified.The model is used to predict the volume fraction of the sheet obtained by rolling through different rolling passes under the condition of consistent total reduction(50%).And the predicted results are in good agreement with the experimental results. | Yanxia NIU Yan SHI Xuelin ZHAO Qichi LE Yixuan WANG Shuai REN Na WANG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 0 |
| 6 | New technology for pipeline defect detection显示文摘Rupture and leakage of urban sewer pipes will seriously affect the daily life of urban residents.Defect detection is one of the most important segments in the assessment of pipeline health status.With the continuous extension of pipeline service time,pipeline leakage accidents caused by corrosion。 | NIU YanXia SUN LongXiang WANG YiXuan SHEN GuoLang SHI Yan | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 7 | Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension显示文摘Increased mitochondrial reactive oxygen species(mROS)and glycolysis have been established in pulmonary hypertension(PH).However,the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle cell(PASMC)proliferation and vascular remodeling remain elusive.Here,we reported that hypoxia-induced mROS inhibit HIF-1αhydroxylation and further trigger PASMC glycolytic switch through the upregulated HIF-1α/PDK1&PDK2/p-PDH-E1αaxis,which facilitates lactate accumulation and histone lactylation.Through H3K18la and HIF-1αChIP–seq analysis,we found that the enhanced histone lactylation of HIF-1αtargets,such as Bmp5,Trpc5,and Kit,promotes PASMC proliferation.Knockdown of Pdk1&2 blunts lactate production,histone lactylation marks,and PASMC proliferation.Moreover,pharmacological intervention with lactate dehydrogenase inhibitor diminishes histone lactylation and ameliorates PASMC proliferation and vascular remodeling in hypoxic PH rats.Taken together,this study provides proof of concept for anti-remodeling therapy through lactate manipulation. | Jian Chen Meiling Zhang Yanjie Liu Shihong Zhao Yanxia Wang Meng Wang Wen Niu Faguang Jin Zhichao Li | 2022 | Journal of Molecular Cell Biology2022，14，12： | 0 |
| 8 | Insight into the experiment and extraction mechanism for separating carbazole from anthracene oil with quaternary ammonium-based deep eutectic solvents显示文摘Carbazole is an irreplaceable basic organic chemical raw material and intermediate in industry.The separation of carbazole from anthracene oil by environmental benign solvents is important but still a challenge in chemical engineering.Deep eutectic solvents (DESs) as a sustainable green separation solvent have been proposed for the separation of carbazole from model anthracene oil.In this research,three quaternary ammonium-based DESs were prepared using ethylene glycol (EG) as hydrogen bond donor and tetrabutylammonium chloride (TBAC),tetrabutylammonium bromide or choline chloride as hydrogen bond acceptors.To explore their extraction performance of carbazole,the conductor-like screening model for real solvents (COSMO-RS) model was used to predict the activity coefficient at infinite dilution (γ^(∞)) of carbazole in DESs,and the result indicated TBAC:EG (1:2) had the stronger extraction ability for carbazole due to the higher capacity at infinite dilution (C^(∞)) value.Then,the separation performance of these three DESs was evaluated by experiments,and the experimental results were in good agreement with the COSMO-RS prediction results.The TBAC:EG (1:2) was determined as the most promising solvent.Additionally,the extraction conditions of TBAC:EG (1:2) were optimized,and the extraction efficiency,distribution coefficient and selectivity of carbazole could reach up to 85.74%,30.18 and 66.10%,respectively.Moreover,the TBAC:EG (1:2) could be recycled by using environmentally friendly water as antisolvent.In addition,the separation performance of TBAC:EG (1:2) was also evaluated by real crude anthracene,the carbazole was obtained with purity and yield of 85.32%,60.27%,respectively.Lastly,the extraction mechanism was elucidated byσ-profiles and interaction energy analysis.Theoretical calculation results showed that the main driving force for the extraction process was the hydrogen bonding ((N–H...Cl) and van der Waals interactions (C–H...O and C–H...π),which corresponding to the blue and green isosurfaces in IGMH analysis.This work presented a novel method for separating carbazole from crude anthracene oil,and will provide an important reference for the separation of other high value-added products from coal tar. | Xudong Zhang Yanhua Liu Jun Shen Yugao Wang Gang Liu Yanxia Niu Qingtao Sheng | 2024 | Chinese Journal of Chemical Engineering2024，65，1： | 0 |
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