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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 3 | Optical Perfect Shuffle Interconnection Using Computer-Generated Blazed Grating Array显示文摘 | Ping Xu Xiang Zhou Xiaochun Zhang Yongkang Guo Lurong Guo Hong Tang Shida Wu Lixing Yang Ying Chen | 1995 | Optical Review1995，，5： | 1 |
| 4 | A Hybrid Algorithm for Optimizing Multi-Modal Functions显示文摘A new genetic algorithm is presented based on the musical performance.The novelty of this algorithm is that a new genetic algorithm, mimicking the musical process of searching for a perfect state of harmony, which increases the robustness of it greatly and gives a new meaning of it in the meantime, has been developed. Combining the advantages of the new genetic algorithm, simplex algorithm and tabu search, a hybrid algorithm is proposed. In order to verify the effectiveness of the hybrid algorithm, it is applied to solving some typical numerical function optimization problems which are poorly solved by traditional genetic algorithms. The experimental results show that the hybrid algorithm is fast and reliable. | Li Qinghua Yang Shida Ruan Youlin | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 1 |
| 5 | India and the Indo-Pacific Strategy Vision: Orientation, Involvement and Limits显示文摘In 2017, the Trump administration formally articulated its vision for the Indo-Pacific strategy, replacing 'Asia-Pacific' with'Indo-Pacific'in policy papers and taking measures to promote the realization of an 'Indo-Pacific dream'. This represents a significant adjustment in US regional policies. An important power in the Indian Ocean region, India is perceived as key to the successful implementation of this Indo-Pacific strategy. Generally speaking, the current Indian government and strategy circle actively support the upgrading of the'Indo-Pacific'concept from a geographical and academic term to a US vision for foreign strategies, anticipating that India could garner significant strategic benefits from it. Given this, New Delhi will continually adapt its foreign policies to the US Indo-Pacific strategy and may even direct the development of the strategy to counter the Belt and Road Initiative, work with other nations to balance China's influence and finally make the rise of India as a great power a reality. Nonetheless, the Indo-pacific strategy is in its early stages, and the content is not completely pro-India currently. On top of this India is still skeptical of the US and will proceed cautiously, leaving room for maneuver in the future,fully tapping into the benefits of the Indo-Pacific strategy and avoiding direct confrontation with China. | Yang Rui Wang Shida | 2018 | Contemporary International Relations2018，28，3： | 1 |
| 6 | Active-layer evolution and (CH3NH3)3Bi2l9-based solar substrate efficiency improvement of cell on TiO2-deposited ITO显示文摘 | Xinqian Zhang Gang Wu Zhuowei Gu Bing Guo Wenqing Liu Shida Yang Tao Ye Chen Chen Weiwei Tu Hongzheng Chen | 2016 | Nano Research2016，9，10： | 1 |
| 7 | Recurrent ovarian carcinoma of low malignant potential:the role of secondary surgical cytoreduction and the prognosis in chinese patients显示文摘 | Zang RY Yang WT Shida R | 2005 | J Surg Oncol2005，91，1： | 1 |
| 8 | Gbest-guided Artificial Chemical Reaction Algorithm for Global Numerical Optimization 显示文摘 | Yang Shida Yi Yalin Shan Zhiyong | 2011 | Procedia Engineering2011，24，： | 1 |
| 9 | Coil-to-Stretch Transition of Binder Chains Enabled by“Nano-Combs”to Facilitate Highly Stable SiO_(x) Anode显示文摘The commercialized binder carboxymethyl cellulose sodium(CMC-Na)is considered unsuitable for micro-sized SiO_(x) anode as it cannot endure the large volume change to retain the conductive network during repeated charge/discharge cycles.Herein,a small amount of silicon nanoparticles(SiNPs)is added during slurry preparation process as“nano-combs”to unfold the convoluted CMC-Na polymer chains so that they undergo a coilto-stretch transition by interaction between polar groups(e.g.,-OH,-COONa)of polymer and SiNPs’large surface.Through maximizing the utilization of binders,a uniform conductive network is constructed with increased interfacial contact with micro-sized SiO_(x).As a result,the SiO_(x) electrode with optimized(10 wt%)SiNPs addition shows significantly improved initial capacity and cycling performance.Through revisiting CMCNa,a currently deemed unqualified binder in SiO_(x) anode,this work gives a brand-new perspective on the failing mechanism of Si-based anode materials and an improving strategy for electrode preparation. | Shida Xue Yanda Fu Zhibo Song Shiming Chen Yuchen Ji Yan Zhao Huizhi Wang Guoyu Qian Luyi Yang Feng Pan | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 10 | Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma显示文摘5-Methylcytosine(m5C)methylation contributes to the development and progression of various malignant tumors.This study aimed to explore the potential role of m5C methylation regulators(m5CMRs)in head and neck squamous cell carcinoma(HNSCC).Methods:The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas(TCGA)and the Gene Expression Omnibus(GEO)databases.Subsequently,the m5C patterns in HNSCC were evaluated based on 14 m5CMRs.Then,the m5Cscore was developed to quantify m5C patterns by using principal component analysis(PCA)algorithms.Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value and sensitivity to immunotherapy.Finally,key prognostic m5CMRs were identified using univariate COX regression analysis,and their clinical significance was validated based on the Human Protein Atlas(HPA)database and by using immunohistochemistry.Results:Two distinct m5C clusters were identified.m5C cluster A is characterized by an immune-activated microenvironment and is associated with a favorable prognosis.Notable differences were observed in prognosis,immune infiltration,and immunotherapy response between the high-and low-m5Cscore groups.Patients in the high-m5Cscore group exhibited high TMB,which is correlated with poor prognosis.The m5Cscore of epithelial cells in HNSCC was higher than that in other cells.Key prognostic m5CMRs,including NSUN2,DNMT3B,ALKBH1,and Y-Box Binding Protein 1(YBX1),were associated with poor prognosis.Conclusion:Our research indicates that in head and neck squamous cell carcinoma,the m5C modification profoundly affects the TME’s diversity and complexity,influencing prognosis and the success of immunotherapy.Targeting m5C regulatory elements may be a new method for enhancing the efficacy of immunotherapy in HNSCC. | SHIDA HOU TIANJUN LAN YAOCHENG YANG PEISHENG LIANG XIN LIU JUNJIE WANG ZHIFENG CHEN RONGSHENG ZENG ZIJING HUANG | 2023 | BIOCELL2023，47，12： | 0 |
| 11 | Can Ursodeoxycholic Acid Prevent SARS-CoV-2 Infection or Reduce the COVID-19 Severity? Current Knowledge and Unresolved Issues显示文摘A recent study revealed that the inhibition of the farnesoid X receptor using ursodeoxycholic acid(UDCA)significantly reduces angiotensin-converting enzyme 2(ACE2)expression.Therefore,considerable attention has been paid to the use of UDCA to prevent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and reduce the severity of the disease.This review compre-hensively summarizes the role of ACE2 in SARS-CoV-2 infection and the potential role and mechanisms of UDCA in the prevention of SARS-CoV-2 infection or reinfection.It also discusses unresolved issues and the potential use of UDCA in the treatment of patients with coronavirus disease. | Shida Pan Yang Zhang Fanping Meng Fu-Sheng Wang | 2023 | Infectious Diseases & Immunity2023，3，3： | 0 |
| 12 | A Novel Algorithm for DOA Estimation in Asynchronous DS-CDMA Systems显示文摘A novel algorithm for DOA estimation using linear antenna array in the asynchronous DS-CDMA systems is pre-sented in the presence of channel mismatches or signal fading between the sensors. Code-matched filters and parallel MUSIC algorithms are proposed to overcome the restriction that the num-ber of array elements must exceeds the number of the sources for subspace-based direction of arrival. It can be shown that multiple access interference throughout the code-matched filter is asymp-totically Gaussian in the asynchronous DS-CDMA systems. A relevant performance analysis is derived. Computer simulation proved the efficiency of the proposed algorithm. | SHAN Zhiyong YANG Shida ZHOU Xiyang SHEN Wenhui | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 0 |
| 13 | Recent Political Developments in India and Their Effects显示文摘In March 2017, Narendra Modi led his Bharatiya Janata Party(BJP) to victory in state elections, among which he gained parliamentary election of Uttar Pradesh(state in northern India), known as the weather vane of Indian elections. Back in 2014, the BJP had already won a simple majority in Lok Sabha(the lower house of parliament), bringing an end to more than 30 years of coalition government. Now, the BJP is exhibiting stronger presence as a one-party-rule at both federal and local levels, with no counter-balance from the Indian National Congress, local parties, or left wing parties now or in the foreseeable future. This increases the likelihood of Modi's re-election as prime minister in 2019. Obviously,Indian political development is characterized by complexity, accidental factors and intrinsic logic, which will definitely exert great influence on the future of India. | Wang Shida Yang Rui | 2017 | Contemporary International Relations2017，27，4： | 0 |
| 14 | Polymeric Wetting Matrix for a Stable Interface between Solid-state Electrolytes and Li Metal Anode显示文摘Succinonitrile(SN)based solid-state electrolytes(SSEs)have potential applications in lithium(Li)batteries due to their ease of preparation and high ionic conductivity at room temperature.Here,a novel SSE consisting of poly(vinylidene fluoride-hexafluoropropy-lene)(PVDF-HFP),poly(methyl methacrylate)(PMMA)and Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) with SN is fabricated,where PMMA is added to serve as a polymer matrix for better wettability of SN.Due to the addition of PMMA,improved room-temperature ionic conductivity of the SSE is resulted.More importantly,better interfacial contact as well as more stable solid-state electrolyte(SEI)layer between SSE and Li anode can be also obtained.As a result,homogeneous and dendrite-free Li plating can be achieved for over 1000 h in Li symmetric cells.When coupled with LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2) cathode and Li anode,the proposed SSE delivers excellent cycling stability and rate capability in full-cells.By implementing SSEs with a polymeric wetting agent,this work provides fresh perspectives on stabilizing the interface between SSEs and Li metal anodes. | Haoran Song Shida Xue Shiming Chen Zijian Wang Yongli Song Jiawen Li Zhibo Song Luyi Yang Feng Pan | 2022 | Chinese Journal of Structural Chemistry2022，41，5： | 0 |
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