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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Relationship between electrochemical characteristics and SCC of X70 pipeline steel in an acidic soil simulated solution显示文摘Stress corrosion cracking (SCC) of X70 pipeline steel in simulated solution of the acidic soil in Yingtan in China was investigated using slow strain rate test (SSRT), SEM and potentiodynamic polarization technique. Experiment results indicate that X70 steel is highly susceptible to SCC as applied potential reduces, which is manifested in loss of toughness and brittle fracture. Constant polarization current can detect the occurrence of SCC. The lower the polarization current is the sooner stress corrosion cracking occurs. The SCC mechanisms are different at varying potentials. When potential is higher than open circuit potential, anodic process controls SCC, whereas when potential is far lower than open circuit potential, cathodic process controls SCC, and between these two potential regions, a combined electrochemical process controls the SCC. Stress or strain has a synergistic effect with electrochemical reactions to accelerate the cathodic hydrogen evolution process, which makes the X70 pipeline steel to be more susceptible to SCC. | Zhiyong LIU Xiaogang LI Yingrui ZHANG Cuiwei DU Guoli ZHA | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 13 |
| 3 | Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing显示文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment. | Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li Mingbang Wang Tao Wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping Wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi Wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun | 2018 | Journal of Genetics and Genomics2018，45，10： | 3 |
| 4 | Double Peak Derived from Piezoelectric Coefficient Nonlinearity and Proposal for Self-Powered Systems显示文摘With the development of wireless sensor network(WSN)applications in intelligent monitoring,additional support for the low power consumption wireless nodes can be provided by piezoceramics that harvest vibrational energy.First,we describe the effects of stimulation variations on piezoceramics and the energy harvesting circuit set-up.Two types of piezoceramics were stimulated at different frequencies and amplitudes to obtain the power output characteristics.Then,the energy harvesting circuit was studied and coupled with the piezoceramics.A double peak phenomenon was found in energy harvesting using a hard piezoceramic which gave a direct proof that the nonlinearity of the piezo constant should be considered in application.Finally,energy storage and output were studied and analyzed.Electronic components for the WSN were recommended according to the output power and the application.The results will give an instruction for piezoceramic energy harvesting under various stress amplitudes on its implementation. | Zhang Bin Li Dezhi Li Yingrui Ducharne Benjamin Gao Jun | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 3 |
| 5 | Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function显示文摘Peripheral nerve regeneration and functional recovery remain a major clinical challenge.Nerve guidance conduit(NGC)that can regulate biological behavior of Schwann cells(SCs)and facilitate axonal regeneration through microenvironmental remodeling is beneficial for nerve regeneration and functional recovery.Gastrodin,a main constituent of a Chinese traditional herbal medicine,has been known to display several biological and pharmacological properties,especially antioxidative,anti-inflammatory and nerve regeneration.Herein,polyurethane(PU)NGCs modified by different weight ratio of Gastrodin(0,1 and 5 wt%)were designed for sequential and sustainable drug release,that created a favorable microenvironment for nerve regeneration.The scaffold showed suitable pore structure and biocompatibility in vitro,and evidently promoted morphological and functional recovery of regenerated sciatic nerves in vivo.Compared to the PU and 1% Gastrodin/PU scaffolds,the 5% Gastrodin/PU significantly enhanced the proliferation,migration and myelination of SCs and up-regulated expression of neurotrophic factors,as well as induction of the differentiation of PC12 cells.Interestingly,the obvious anti-inflammatory response was observed in 5% Gastrodin/PU by reduced expression of TNF-α and iNOS,which also evidenced by the few fibrous capsule formation in the subcutaneous implantation.Such a construct presented a similarity to autograft in vivo repairing a 10 mm sciatic nerve defects.It was able to not only boost the regenerated area of nerve and microvascular network,but also facilitate functional axons growth and remyelination,leading to highly improved functional restoration.These findings demonstrate that the 5% Gastrodin/PU NGC efficiently promotes nerve regeneration,indicating their potential for use in peripheral nerve regeneration applications. | Hongcai Yang Qing Li Limei Li Shaochun Chen Yu Zhao Yingrui Hu Lu wang Xiaoqian Lan Lianmei Zhong Di Lu | 2022 | Bioactive Materials2022，7，2： | 1 |
| 6 | Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis显示文摘Wound healing is a highly orchestrated process involving a variety of cells,including immune cells.Developing immunomodulatory biomaterials for regenerative engineering applications,such as bone regeneration,is an appealing strategy.Herein,inspired by the immunomodulatory effects of gastrodin(a bioactive component in traditional Chinese herbal medicine),a series of new immunomodulatory gastrodin-comprising biodegradable polyurethane(gastrodin-PU)and nano-hydroxyapatite(n-HA)(gastrodin-PU/n-HA)composites were developed.RAW 264.7 macrophages,rat bone marrow mesenchymal stem cells(rBMSCs),and human umbilical vein endothelial cells(HUVECs)were cultured with gastrodin-PU/n-HA containing different concentrations of gastrodin(0.5%,1%,and 2%)to decipher their immunomodulatory effects on osteogenesis and angiogenesis in vitro.Results demonstrated that,compared with PU/n-HA,gastrodin-PU/n-HA induced macrophage polarization toward the M2 phenotype,as evidenced by the higher expression level of pro-regenerative cytokines(CD206,Arg-1)and the lower expression of pro-inflammatory cytokines(iNOS).The expression levels of osteogenesis-related factors(BMP-2 and ALP)in the rBMSCs and angiogenesis-related factors(VEGF and BFGF)in the HUVECs were significantly up-regulated in gastrodin-PU/n-HA/macrophage-conditioned medium.The immunomodulatory effects of gastrodin-PU/n-HA to reprogram macrophages from a pro-inflammatory(M1)phenotype to an anti-inflammatory and pro-healing(M2)phenotype were validated in a rat subcutaneous implantation model.And the 2%gastrodin-PU/n-HA significantly decreased fibrous capsule formation and enhanced angiogenesis.Additionally,2%gastrodin-PU/n-HA scaffolds implanted in the rat femoral condyle defect model showed accelerated osteogenesis and angiogenesis.Thus,the novel gastrodin-PU/n-HA scaffold may represent a new and promising immunomodulatory biomaterial for bone repair and regeneration. | Limei Li Qing Li Li Gui Yi Deng Lu Wang Jianlin Jiao Yingrui Hu Xiaoqian Lan Jianhong Hou Yao Li Di Lu | 2023 | Bioactive Materials2023，，1： | 1 |
| 7 | Moisture-preventing MAPbI_(3) solar cells with high photovoltaic performance via multiple ligand engineering显示文摘Perovskite solar cells present one of the most prominent photovoltaic technologies,yet their stability,and engineering at the molecular level remain challenging.We have demonstrated multifunctional molecules to improve the operating stability of perovskite solar cells while depicting a high-power conversion efficiency.The multifunctional molecule 4-[(trifluoromethyl)sulphanyl]-aniline(4TA)with trifluoromethyl(-CF_(3))and aniline(-NH_(2))moieties is meticulously designed to modulate the perovskite.The-CF_(3) and-NH_(2) functional groups have strong interaction with perovskite to suppress surface defects to improve device stability,as well as obtain large crystal grains through delaying crystallization.Moreover,this-CF_(3) forms a hydrophobic barrier on the surface of the perovskite to prevent cell decomposition.Consequently,the performance of the perovskite solar cells is remarkably improved with the efficiency increased from 18.00% to 20.24%.The perovskite solar cells with multifunctional molecular maintaining 93% of their original efficiency for over 30 days(-55%humidity)in air without device encapsulation,exhibiting a high long-term stability.Moreover,the lead leakage issue of perovskite solar cells has also been suppressed by the built-in 4TA molecule,which is beneficial to environment-friendly application.Ultimately,we believe this multifunctional small molecule provides an available way to achieve high performance perovskite solar cells and the related design strategy is helpful to further develop more versatile materials for perovskite-based optoelectronic devices. | Xin Li Jinyue Du Hui Duan Haoyan Wang Lin Fan Yunfei Sun Yingrui Sui Jinghai Yang Fengyou Wang Lili Yang | 2022 | Nano Research2022，15，2： | 1 |
| 8 | SOAPZ: an improved ultrafast tool for short read alignment 显示文摘 | Li Ruiqiang Yu Chang Li Yingrui | 2009 | Biolnformatics2009，25，15： | 1 |
| 9 | SOAP2:an improved ultrafast tool for short read alignment显示文摘 | LI Ruiqiang YU Chang LI Yingrui | 2009 | Bioinformatics2009，25，： | 1 |
| 10 | Long-term tribocorrosion resistance and failure tolerance of multilayer carbon-based coatings显示文摘Current tribocorrosion research of metallic materials and their surface protective coatings mainly focuses on their short-term properties,with test time of 0.5‒2.0 h and a sliding distance 50‒500 m,which may significantly deviate from the practical long-term service condition and thus cause a catastrophe of marine equipments.In this study,three carbon-based multilayer coatings(Ti/DLC,TiC_(x)/DLC,and Ti‒TiC_(x)/DLC)were deposited on S32750 substrates,and both short-term and long-term tribocorrosion behaviors were investigated.The experimental results indicate that the coatings substantially improve the tribocorrosion resistance of the S32750 stainless steel.During the short-term tribocorrosion test,TiC_(x)/DLC exhibited the best tribocorrosion resistance owing to its high hardness.During the long-term tribocorrosion test,however,Ti‒TiC_(x)/DLC coating indicated the best anti-tribocorrosion performance owing to its excellent fracture toughness together with high hardness.Moreover,under 5 N,Ti‒TiC_(x)/DLC can withstand a long-term test of more than 24 h.Additionally,under a higher load of 20 N,the Ti‒TiC_(x)/DLC with a corresponding sliding distance of approximately 1,728 m maintained a low friction coefficient of approximately 0.06.However,the coating was completely worn out;this is attributable to the formation of tribocorrosion products consisting of graphitized carbon and nanocrystalline Fe_(x)O_(y). | Hao LI Linlin LIU Peng GUO Lili SUN Jing WEI Yingrui LIU Shuyu LI Shuyuan WANG Kwang-Ryeol LEE Peiling KE Aiying WANG | 2022 | Friction2022，10，10： | 1 |
| 11 | SOAP:Short Oligonucleotide Alignment Program显示文摘 | Li Ruiqiang Li Yingrui Kristiansen K | 2008 | Bio-informatics2008，24，5： | 1 |
| 12 | SOAP: Short oligonucleotide alignment program显示文摘 | Li Ruiqiang Li Yingrui | 2008 | Bioinformatics2008，1，： | 1 |
| 13 | SOAP2:An Improved Ultrafast Tool for Short Read Alignment显示文摘 | Li Ruiqiang Yu Chang Li Yingrui | 2009 | Bioinformatics2009，25，15： | 1 |
| 14 | SOAP2 : An improved ultratast tool for short rend alignmen显示文摘 | Li Ruiqiang Yu Chang Li Yingrui | 2009 | Bioinformatics2009，25，： | 1 |
| 15 | Accelerated deterioration mechanism of 316L stainless steel in NaCl solution under the intermittent tribocorrosion process显示文摘In this research,the tribocorrosion behavior of 316L stainless steel in simulated seawater was investigated under continuous and intermittent sliding at open circuit potential.The tribocorrosion mechanism was discussed in terms of wear morphologies,mechanical property as well as chemical composition.Meanwhile,microstructure evolution inside the wear track and open circuit potential recorded after sliding were analyzed to quantify the repassivation kinetics and evaluate the impact of the regenerated passive film on wear.The results showed that the wear rate increased under intermittent sliding when the pause time is long enough to repassivate after sliding.Repeated sliding promoted the refinement of the grain inside the sliding area,which was beneficial to the generation of the thicker and more compact passive film inside the wear track.The ruptured passive film often acted as abrasives during subsequent sliding.Therefore,the accelerated material loss under intermittent sliding was attributed to the periodic mechanical removal of the thickened passive film and the enhanced abrasive wear inside the wear track. | Yingrui Liu Linlin Liu Shuyu Li Rujia Wang Peng Guo Aiying Wang Peiling Ke | 2022 | Journal of Materials Science & Technology2022，，26： | 1 |
| 16 | SOAP:short oligonucle-otide alignment program显示文摘 | Li Ruiqiang Li Yingrui Karsten K | | 0，，05： | 1 |
| 17 | Simultaneous de-termination of arsenic,antimony,selenium and telluriumin pure copper by hydride generation-four-channel non-dispersive atomic fluorescence spectrometry显示文摘 | Ni Yingrui Li Zhongxi Li Haitao | | Metallur-0，，： | 1 |
| 18 | SOAP2: animproved ultrafast tool for short read alignment显示文摘 | LI Ruiqiang YU Chang LI Yingrui | 2009 | Bioin-formatics2009，25，15： | 1 |
| 19 | An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia显示文摘Children with severe aplastic anemia(SAA)face heterogeneous prognoses after immunosuppressive therapy(IST).There are few models that can predict the long-term outcomes of IST for these patients.The objective of this paper is to develop a more effective prediction model for SAA prognosis based on clinical electronic medical records from 203 children with newly diagnosed SAA.In the early stage,a novel model for long-term outcomes of SAA patients with IST was developed using machine-learning techniques.Among the indicators related to long-term efficacy,white blood cell count,lymphocyte count,absolute reticulocyte count,lymphocyte ratio in bone-marrow smears,C-reactive protein,and the level of IL-6,IL-8 and vitamin B12 in the early stage are strongly correlated with long-term efficacy(P<.05).Taken together,we analyzed the long-term outcomes of rabbit antithymocyte globulin and cyclosporine therapy for children with SAA through machine-learning techniques,which may shorten the observation period of therapeutic effects and reduce treatment costs and time. | Lixian Chang Mingchen Yan Jingliao Zhang Binghang Liu Li Zhang Ye Guo Jing Sun Yang Wan Meihui Yi Yang Lan Yuli Cai Yuanyuan Ren Haihui Zheng Aoli Zhang Zhenyu Li Jian Wang Yingrui Li Xiaofan Zhu | 2023 | Blood Science2023，5，3： | 0 |
| 20 | IMPA2 blocks cervical cancer cell apoptosis and induces paclitaxel resistance through p53-mediated AIFM2 regulation显示文摘Cervical cancer continues to be a concern,and the prognosis of locally advanced cervical cancer remains poor.IMPA2 was previously identified as a potential oncogene and regulator of tumor apoptosis.In this study,we aim to further elucidate the underlying mechanisms of IMPA2 gene in the regulation of cervical cancer apoptosis.First,we identify AIFM2 as an upregulated gene in IMPA2-silenced cervical cancer cells,and inhibition of AIFM2 reverses IMPA2 knockdown-induced apoptosis.Further study reveals that AIFM2 regulates cell apoptosis in a mitochondrial-dependent manner with a redistribution of mitochondrial membrane potential and intracellular Ca^(2+) levels.However,the analysis of the STRING database and our experimental results show that AIFM2 has little effect on cervical cancer progression and survival.Further mechanistic study demonstrates that IMPA2 and AIFM2 silencing inhibits apoptosis by activating p53.Meanwhile,the knockdown of IMPA2 enhances the chemosensitivity of cervical cancer cells by strengthening paclitaxel-induced apoptosis.Based on the above results,the IMPA2/AIFM2/p53 pathway may be a new molecular mechanism for paclitaxel treatment of cervical cancer and an effective strategy to enhance the sensitivity of cervical cancer cells to paclitaxel.Our findings display a novel function of IMPA2 in regulating cell apoptosis and paclitaxel resistance mediated by a disturbance of AIFM2 and p53 expression,potentially making it a novel therapeutic target for cervical cancer treatment. | Kexin Xie Lei Liu Min Wang Xianping Li Bingqi Wang Sheng Yin Wanxin Chen Yingrui Lin Xiaolin Zhu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
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