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| 1 | Distribution and genesis of the anomalously high porosity zones in the middle-shallow horizons of the northern Songliao Basin显示文摘High-quality reservoirs occur in the middle-shallow horizons of the northern Songliao Basin. The distribution and genesis of their anomalously high porosity zones were studied using measured porosities, examination of ordinary thin sections and blue epoxy resin-impregnated thin sections and by SEM. The results show that there are three anomalously high porosity zones at the depth of 450-900 m, 1,300-1,900 m, 2,050-2,350 m respectively, named zone i, zone ii and zone iii from top to bottom. Horizontally, zone i and zone ii are distributed all over the basin except in the Southeastern Uplift, while zone iii is only distributed in the Central Depression. Zone i was formed by meteoric water leaching as well as organic acid dissolution. Zones ii and iii were dominantly formed by organic acid dissolution. Additionally, clay mineral transformation generating H+ and hydrocarbon emplacement retarding the cementation of sandstones are also important for the formation of zones ii and iii. | Meng Yuanlin Liang Hongwei Meng Fanjin Wu Heyong Wang Cheng Xiu Hongwen Zhang Anda Li Yaguang Guo Rixin | 2010 | Petroleum Science2010，7，3： | 29 |
| 2 | Hypoxia-regulated microRNAs in human cancer显示文摘 | Guomin SHEN Xiaobo LI Yong-feng JIA Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 18 |
| 3 | Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-McI-1 signaling pathway显示文摘目的: 我们报导了在人的胃的癌症,白血病,鼻咽的癌症,和胆囊癌症显示出肿瘤镇压的活动的新奇 anticancer bioactive 肽(ACBP ) 。在这研究,我们在人的 colorectal 癌症和内在的 mechanisms.Methods 上调查了 ACBP 的效果: 人的 colorectal 肿瘤细胞线 HCT116 的细胞生长和 apoptosis 被测量分别地使用细胞增长试金和流动 cytometry。PARP, p53 和 Mcl1A 的表示层次与西方的弄污和 immunohistochemistry 被估计。为评估在里面 ACBP 的 vivo antitumor 活动, HCT116 异种皮移植裸体人老鼠与 ACBP 被对待(35 μ g/mL, ip ) 为 10 days.Results : 有 ACBP 的 HCT116 房间的治疗(35 μ g/mL ) 为 4-6,天显著地禁止了房间生长。而且,有 ACBP 的 HCT116 房间的治疗(35 μ g/mL ) 为 6-12, h 显著地提高了紫外导致 apoptosis,增加了 PARP 和 p53 的表示,并且减少 Mcl-1 的表示。 ACBP 的管理没改变 HCT116 异种皮移植裸体人鼠标的身体重量,但是减少在约43%的肿瘤生长,并且增加了 PARP 和 p53 的表达式,并且减少在异种皮移植鼠标肿瘤 tissues.Conclusion 的 Mcl-1 的表达式: ACBP 的管理禁止人的 colorectal 肿瘤房间生长并且通过 modulating 在 vitro 并且在 vivo 导致 apoptosis 发信号的 PARP-p53-Mcl-1 小径。 | Li-ya SU Ying-xu SHI Mei-rong YAN Yaguang XI Xiu-lan SU | 2015 | Acta Pharmacologica Sinica2015，36，12： | 17 |
| 4 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 5 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 6 | The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy显示文摘Regulatory T cells(Tregs) play an important role in maintaining self-tolerance and immune homeostasis, but they also play a negative role in evoking effective antitumour immune responses. There is ample evidence indicating that the depletion of Tregs or the inhibition of Treg function will enhance antitumour effects. However, it is unclear which surface molecules of Tregs are suitable targets for tumour immunotherapy with minimal toxic side effects, which is a central theme in the field of Treg-targeted immunotherapy. In this review, we focus on the regulatory mechanisms of Tregs, including intrinsic and extrinsic factors within the tumour microenvironment, and we address potential drug targets on Tregs for immunotherapy. | Shanshan Yan Yaguang Zhang Bing Sun | 2019 | Science China(Life Sciences)2019，62，2： | 11 |
| 7 | Achieving highly uniform two-dimensional PbI2 flakes for photodetectors via space confined physical vapor deposition显示文摘Two-dimensional(2D) PbI_2 flakes have been attracting intensive attention as one potential candidate for the modern optoelectronics. However, suffered from the instability of kinetics-driven growth, the fabricated 2D PbI_2 flakes have a wide dimensional distribution even under the same conditions. Herein, a novel facile space confined physical vapor deposition(PVD) process is provided to synthesize uniform triangle PbI_2 flakes with high quality. The confined space provides a relatively stable growth environment that renders more control on the growth kinetics, leading to highly uniform triangle PbI_2 flakes with the average size of 5 mm and thickness of 17 nm. Moreover, as-fabricated PbI_2-based photodetectors show promising stable and flexible optoelectronic performances to 470 nm light, including high responsivity(0.72 AW^(-1)), large on/off ratio up to 900, fast photoresponse speed(rise time of 13.5 ms and decay time of 20 ms) and high detectivity(1.04×10^(10) Jones). The well-controllable growth of the uniform triangle PbI_2 flakes and the detailed exploration of their optoelectronic properties are particularly valuable for their further practical applications. | Yaguang Wang Lin Gan Junnian Chen Rui Yang Tianyou Zhai | 2017 | Science Bulletin2017，62，24： | 10 |
| 8 | Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization显示文摘Background:Autologous platelet-rich plasma(PRP)has been suggested to be effective for wound healing.However,evidence for its use in patients with acute and chronic wounds remains insufficient.The aims of this study were to comprehensively examine the effectiveness,synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair.Methods:Full-thickness wounds were made on the back of C57/BL6 mice.PRP or saline solution as a control was administered to the wound area.Wound healing rate,local inflammation,angiogenesis,re-epithelialization and collagen deposition were measured at days 3,5,7 and 14 after skin injury.The biological character of epidermal stem cells(ESCs),which reflect the potential for re-epithelialization,was further evaluated in vitro and in vivo.Results:PRP strongly improved skin wound healing,which was associated with regulation of local inflammation,enhancement of angiogenesis and re-epithelialization.PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β.An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1.Moreover,PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs,and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14.Conclusion:PRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization.However,the underlying regulatory mechanism needs to be investigated in the future.Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration. | Pengcheng Xu Yaguang Wu Lina Zhou Zengjun Yang Xiaorong Zhang Xiaohong Hu Jiacai Yang Mingying Wang Binjie Wang Gaoxing Luo Weifeng He Biao Cheng | 2020 | Burns & Trauma2020，8，1： | 8 |
| 9 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 10 | MicroRNAs are involved in the development and progression of gastric cancer显示文摘MicroRNAs (miRNAs) are recognized as an essential component of the RNA family, exerting multiple and intricate biological functions, particularly in the process of tumorigenesis, proliferation, and metastatic progression. MiRNAs are altered in gastric cancer (GC), showing activity as both tumor suppressors and oncogenes, although their true roles have not been fully understood. This review will focus upon the recent advances of miRNA studies related to the regulatory mechanisms of gastric tumor cell proliferation, apoptosis, and cell cycle. We hope to provide an in-depth insight into the mechanistic role of miRNAs in GC development and progression. In particular, we summarize the latest studies relevant to miRNAs’ impact upon the epithelial- mesenchymal transition, tumor microenvironment, and chemoresistance in GC cells. We expect to elucidate the molecular mechanisms involving miRNAs for better understanding the etiology of GC, and facilitating the development of new treatment regimens for the treatment of GC. | Xiaolin Liu Ruixia Ma Bin Yi Adam I.Riker Yaguang Xi | 2021 | Acta Pharmacologica Sinica2021，42，7： | 8 |
| 11 | Characteristics of pantograph‐catenary arc under low air pressure and strong airflow显示文摘Pantograph‐catenary arc fault is the primary factor threatening the stability of the power transmission for high‐speed railway.The motion characteristics of the pantograph‐catenary arc under low air pressure and strong airflow is significantly different from the case under atmospheric pressure.In this paper,an experimental platform of panto-graph‐catenary arc was built to investigate arc root position‐time and arc column lon-gitudinal drift height‐time characteristic curves under different air pressures and airflow velocites.Via analysing the corresponding results,it can be found that there are different arc root-arc column traction mechanisms at different stages of arc development.The arcing time and arc root stagnation time under low air pressure are significantly longer than the case under atmospheric pressure,resulting in more serious electrode ablation.The arc column longitudinal drift velocity and height are greater with the increase of airflow velocity.Two typical irregular arc motion phenomena-arc root jumping and arc reignition are observed.To clarify the internal mechanism of the above phenomenon,a magnetohydrodynamics(MHD)model of the pantograph‐catenary arc was lauched,the influence mechanism of the pantograph‐catenary arc temperature and voltage are studied,and the physical process of arc temperature oscillation is analysed.The research results provide theoretical support for arc protection in high‐altitude areas. | Zhilei Xu Guoqiang Gao Wenfu Wei Zefeng Yang Wenhan Xie Keliang Dong Yaguang Ma Yan Yang Guangning Wu | 2022 | High Voltage2022，7，2： | 7 |
| 12 | Study of asphaltene deposition from Tahe crude oil显示文摘Borehole blockage caused by asphaltene deposition is a problem in crude oil production in the Tahe Oilfield, Xinjiang, China. This study has investigated the influences of crude oil compositions, temperature and pressure on asphaltene deposition. The asphaltene deposition trend of crude oil was studied by saturates, aromatics, resins and asphaltenes (SARA) method, and the turbidity method was applied for the first time to determine the onset of asphaltene flocculation. The results showed that the asphaltene deposition trend of crude oil by the turbidity method was in accordance with that by the SARA method. The asphaltene solubility in crude oil decreased with decreasing temperature and the amount of asphaltene deposits of T739 crude oil (from well T739, Tahe Oilfield) had a maximum value at 60 o C. From the PVT results, the bubble point pressure of TH10403CX crude oil (from well TH10403CX, Tahe Oilfield) at different temperatures can be obtained and the depth at which the maximum asphaltene flocculation would occur in boreholes can be calculated. The crude oil PVT results showed that at 50 , 90 and 130 o C, the bubble point pressure of TH10403CX crude oil was 25.2, 26.4 and 27.0 MPa, respectively. The depth of injecting asphaltene deposition inhibitors for TH10403CX was determined to be 2,700 m. | CHEN Chaogang GUO Jixiang AN Na REN Bo LI Yaguang JIANG Qingzhe | 2013 | Petroleum Science2013，10，1： | 5 |
| 13 | Regulatory effect of salicylic acid and methyl jasmonate supplementation on ergosterol production in Hericium erinaceus mycelia显示文摘We evaluated the biomass and ergosterol content of Hericium erinaceus mycelium, and extracellular enzyme activities in H. erinaceus liquid culture following salicylic acid(SA) and methyl jasmonic acid(Me JA)supplementation. The optimal SA concentration was100 lmoláL-1, where the highest ergosterol content of 2.33 mgág-1was obtained following 6-day cultivation with100 lmoláL-1SA supplementation, and which was significantly higher than the unsupplemented control(p \ 0.01). Following 4-day supplementation with50 lmoláL-1Me JA, the highest ergosterol content obtained was 1.988 mgág-1, which was 25.8 % higher than the unsupplemented control. Our data indicate that SA and Me JA supplementation improves ergosterol content in H.erinaceus mycelium. | Xiaodong Dai Yaguang Zhan Jiechi Zhang Piqi Zhang Zenghua Han Qingfang Ma Xianghui Kong Jianing Liu Yinpeng Ma | 2015 | Journal of Forestry Research2015，26，1： | 5 |
| 14 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 15 | The effect of nitrogen annealing on lithium ion intercalation in nickel-doped lithium trivanadate显示文摘The communication reports an exploratory experimental study on the effects of nitrogen annealing on lithium ion intercalation in nickel-doped lithium trivanadate cathodic electrodes for lithium ion batteries. It shows good rate performance with discharge capacities of 348.6,252.6, 191.9 and 96.7 m Ah g^(-1)at 0.2, 0.5, 1 and 5 C,respectively. Nitrogen annealing resulted in the formation of parasitic secondary-phase Li V_2O_5 and appreciably increased tetravalent vanadium ions compensated with oxygen vacancies, which would enhance the electronic conductivity and lithium ion diffusivity and promote the interface interaction and deintercalation process, and thus lead to the enhanced lithium ion intercalation properties.The possible impacts of the parasitic secondary-phase Li V_2O_5 on the lithium ion intercalation performance have also been discussed. | Yaguang Liu Cuiping Zhang Chaofeng Liu Huanqiao Song Xihui Nan Guozhong Cao | 2016 | Science Bulletin2016，61，8： | 4 |
| 16 | A Fluorescent Zirconium-Based Metal-Organic Framework for Selective Detection of Nitro Explosives and Metal Ions显示文摘 | YuanzheTang Hongliang Huang Yaguang Peng Qunqun Ruan KekeWang Pengda Yi Dahuan Liu Chongli Zhong | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 17 | MicroRNAs mediate therapeutic and preventive effects of natural agents in breast cancer显示文摘MicroRNAs(miRNAs) are a set of non-coding small RNA molecules that play a critical role in regulation of protein coding genes in cells. Mi RNAs have been extensively studied as novel biomarkers, therapeutic targets, and new drugs in various human diseases. Breast cancer is a one of the leading tumor types significantly affecting women health worldwide. Over the past decade, a number of natural agents, such as paclitaxel and curcumin, have been applied for treatment and prevention of breast cancer due to their relatively low toxicity. However, the mechanisms of action have not been completely understood. Investigation on mi RNAs is able to potentially provide a novel insight into better understanding the anticancer activities of these natural products. Given that a single miRNA can target multiple genes, theoretically, those genes involved in a certain phenotype can be clustered with one or a few miRNAs. Therefore, pleiotropic activities of natural agents should be interpreted by interactions between selected miRNAs and their targets. In this review, we summarize the latest publications related to the alterations of mi RNAs by two natural agents(paclitaxel and curcumin) that are currently used in intervention of breast cancer, and conclude that the mechanism involving the regulation of miRNA expression is one of the keys to understand pleiotropic activities of natural agents. | LIANG Zhipin XI Yaguang | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 4 |
| 18 | Metformin and cancer immunity显示文摘The immune system plays an essential and central role in tumor cell differentiation,proliferation,angiogenesis,apoptosis,invasion,and metastasis.Over the past decade,cancer therapy has rapidly evolved from traditional approaches,such as surgery,chemotherapy,and radiotherapy,to revolutionary new treatment options with immunotherapy.This new era of cancer treatment options has now been clinically tested and applied to many forms of human malignancies,often with quite dramatic results.As we develop more effective combinations of cancer treatment,several agents have been recently investigated,putatively identified as antica ncer age nts,or imm uno stimulatory molecules.One such age nt is metformin,originally developed as a fairly standard first-line therapy for patients with type-2 diabetes mellitus(T2DM).Given the underlying mechanisms of action,researchers began to exami ne the alter native function s and possible utility of metformin,finding that the can cer risk in patie nts with T2DM was reduced.It appears that metformin,at least in part,has an antitumor effect through activation of the 5'adenosine monophosphate-activated protein kinase(AMPK)signaling pathway.Moreover,numerous studies have demonstrated that metformin interferes with key immun opathological mecha nisms that are in volved in the pathological processes or associated with maligna nt progression.Such in sights may shed light on further analyzi ng whether metformi n enhances the effectiveness of the immuno therapy and overcomes the immunotherapy resista nee in the patients.Herein,we provide a comprehe nsive review of the literature exami ning the impact of metformin upon the host immune system and cancer immunity. | Ruixia Ma Bin Yi Adam I.Riker Yaguang Xi | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 19 | Molecular characterization of RAPD and SCAR marker linked to the frog-eye leaf spot resistance gene in soybean显示文摘Two fragments SCS362o and SCS3580 of the co-dominant marker OPS0362o&580 that were linked to the resistance gene of soybean frog-eye leaf spot have been completely sequenced. A significant insertion of 30 bp is the main reason of the polymorphism between the two fragments. The results of Southern hybridization indicate that SCS362o derives from a single- or low-copy sequence and can be used as an RFLP probe. A co-dominant SCAR marker SCSSeao&sao has been developed based on the sequences. The segregation of SCS362o&58o is similar to that of RAPD marker OPS03620&580. Significant polymorphism has been shown between resistant and susceptible genotypes when 62 soybean genotypes were surveyed for the SCAR marker. Therefore, the marker can be used in the resistance breeding of soybean frog-eye leaf spot by marker-assisted selection. | ZOU Jijun YANG Qingkai CHEN Shouyi CHEN Qingshan LIU Yaguang DONG Wei | 2000 | Chinese Science Bulletin2000，45，5： | 3 |
| 20 | A general bimetal-ion adsorption strategy to prepare nickel single atom catalysts anchored on graphene for efficient oxygen evolution reaction显示文摘Single-atom catalysts (SACs) supported on two-dimensional (2D) materials are highly attractive for maximizing their catalytic activity.However,graphene based SACs are primarily bonded with nitrogen and carbon sites,resulting in poor performance for the oxygen evolution reaction (OER).Herein,we develop a general bimetal-ion adsorption strategy for the synthesis of individually dispersed Ni SACs anchored on the oxygenated sites of ultrathin reduced graphene oxide as efficient OER electrocatalysts.The resultant Ni SACs for OER in alkaline electrolyte exhibit a highly stable overpotential of 328 mV at the current density of 10 mA cm^-2,and Tafel slope of 84 mV dec^-1 together with long-term durability and negligible degradation for 50 h,which is greatly outperform its counterparts of nitrogen bonded Ni SACs (564 mV,364 mV dec^-1) and Ni(OH)2 nanoparticles anchored on graphene (450 mV,142 mV dec^-1),and most reported Ni based OER electrocatalysts.Furthermore,the extended X-ray absorption fine structure at the Ni K-edge and theoretical simulation reveal that the nickel-oxygen coordination significantly boost OER performance.Therefore,this work will open numerous opportunities for creating novel-type 2D SACs via oxygen-metal bonding as highly robust OER catalysts. | Yingqi Xu Weifeng Zhang Yaguang Li Pengfei Lu Zhong-Shuai Wu | 2020 | Journal of Energy Chemistry2020，29，4： | 3 |
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