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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury显示文摘 | Tibor Kempf Matthias Eden Jens Strelau Marian Naguib Christian Willenbockel J?rn Tongers J?rg Heineke Daniel Kotlarz Jian Xu Jeffery D. Molkentin Hans W. Niessen Helmut Drexler Kai C. Wollert | 2006 | Circulation Research2006，，3： | 3 |
| 3 | Differential sensitivity of murineastrocytes and neurons from different brain regions to injury 显示文摘 | Xu L Sapolsky RM Giffard RG | 2001 | Exp Neurol2001，169，2： | 1 |
| 4 | SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes显示文摘 | Ruf RG Xu PX Silvius D | 2004 | Proc Natl Acad Sci USA2004，101，21： | 1 |
| 5 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 6 | S1X1 mutations cause branchio--oto--renal syndrome by disruption of EYA1- SIXl-DNA complexes显示文摘 | Ruf RG Xu PX Silvius D | 2004 | Proe Natl Acad Sci USA2004，1018，090： | 1 |
| 7 | Epigenetic inheritance of paternally expressed imprinted genes in the testes of ICSI mice 显示文摘 | Xu XR Fu RG Wang LY | 2014 | Curr PharmDes2014，20，11： | 1 |
| 8 | Application of nasal bndoscopic mid-low-nasal meatus combined treatment with window for upchin simus aspergillus disease显示文摘 | XU SX WANG RG | 2001 | China Journal of Endoscopy2001，6，5： | 1 |
| 9 | SIX1 mutations cause branchiooto-renal syndrome by disruption of EYA1-SIX1-DNA complexes显示文摘 | Ruf RG Xu PX Silvius D | 2004 | Proc Natl Acad Sci U S A2004，10，21： | 1 |
| 10 | Prevalence and spectrum of PITX2c mutation associated with familial atrial fibrillation 显示文摘 | Yang YQ Xu YJ Li RG | 2013 | Int J Cardial2013，168，3： | 1 |
| 11 | Sex-related differences in leaf morphological and physiological responses in Hippophae rhamnoides along an altitudinal gradient 显示文摘 | Li CY Xu G Zang RG Korpelainen H Berninger F | 2007 | Tree Physiol2007，27，： | 1 |
| 12 | Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade显示文摘 | Xu L Yenari MA Steinberg GK Giffard RG | 2002 | J Cereb Blood Flow Metab2002，22，1： | 1 |
| 13 | Treatment of brackish produced water using carbon aerogel-based capacitive deionization technology显示文摘 | Pei Xu J?rg E. Drewes Dean Heil Gary Wang | 2008 | Water Research2008，，10： | 1 |
| 14 | Inhibition of woodchuck hepatitis virus gene expression in primary hepatocytes by siRNA enhances the cellular gene expression显示文摘 | Zhongji Meng Song Qiu Xiaoyong Zhang Jun Wu Thomas Schreiter Yang Xu Dongliang Yang Michael Roggendorf J?rg Schlaak Mengji Lu | 2008 | Virology2008，，1： | 1 |
| 15 | Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss 显示文摘 | Moon JM Xu L Giffard RG | 2013 | J Cereb Blood Flow Metab2013，33，12： | 1 |
| 16 | Differential sensitivity of murine astrocytes and neurons from different brain regions to injury显示文摘 | Xu L Sapolsky RM Giffard RG | 2001 | Exp Neurol2001，169，2： | 1 |
| 17 | Severe hypersensitivity dermatitis and liver dysfunction induced by occupational exposure to trichloroethvlene显示文摘 | Xu XY Yang RG Wu N | 2009 | Ind Health2009，47，： | 1 |
| 18 | Chaperones,protein aggregation,and brain protection from hypoxic/ischemic injury显示文摘 | Giffard RG Xu L Zhao H | 2004 | Exp Biol2004，207，18： | 1 |
| 19 | Subchronic 90-day oral (Garage) toxicity study of a Luo Han Guo mogroside extract in dogs显示文摘 | Xu Q Su x l Liang RG | 2006 | Food Chem Toxicol2006，44，12： | 1 |
| 20 | Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ显示文摘 | Joyce Y. Tung C. Marc Luetjens Joachim Wistuba Eugene Y. Xu Renee A. Reijo Pera J?rg Gromoll | 2006 | Development Genes and Evolution2006，，3： | 1 |
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