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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Soil phosphorus bioavailability assessed by XANES and Hedley sequential fractionation technique in a glacier foreland chronosequence in Gongga Mountain, Southwestern China显示文摘The primary productivity of terrestrial ecosystems is influenced by soil phosphorus bioavailability, which depends largely on chemical fractions of phosphorus. The sequential fractionation technique developed by Hedley et al. or its subsequent modification is a well-known method to determine soil phosphorus forms. Hedley sequential fractionation technique separates the phosphorus into fractions based on their different chemical solubilities in extractants with certain chemical properties. Recently, synchrotron-based X-ray absorption near edge structure(XANES) spectroscopy has been employed to measure soil phosphorus species directly and non-invasively. The XANES method provides information concerning local structure and chemical information of target elements at a molecular level. Thus, it can distinguish phosphorus fractions bound by metal oxides or hydroxides(such as Fe, Al, and Ca). In this present work, the phosphorus speciation of topsoil along a glacial foreland chronosequence in Gongga Mountain is determined using these two methods. The changes in soil phosphorus bioavailability along the 120-year-old chronosequence are assessed based on comparisons of the results obtained by these two methods. The results indicate that Hedley sequential fractionation technique shows a greater ability to determine soil bioavailable phosphorus(Resin-P and NaCHO3-P), while XANES is effective in distinguishing phosphorus bound by metal compounds. In the chronosequence, Ca- and Al-bound phosphorus were derived mainly from primary minerals, whose phosphorus contents decreased within 120 years of moraine weathering and soil development. The content of soil bioavailable phosphorus increased rapidly after 30 years since deglaciation. The increasing phosphorus bioavailability promoted the colonizing and primary succession vegetation. | WU YanHong Jrg PRIETZEL ZHOU Jun BING HaiJian LUO Ji YU Dong SUN ShouQin LIANG JianHong SUN HongYang | 2014 | Science China Earth Sciences2014，57，8： | 6 |
| 3 | Nano hemostat solution: immediate hemostasis at the nanoscale 显示文摘 | Ellis-Behnke RG Liang YX | 2006 | Nanomedicine2006，2，： | 1 |
| 4 | In vivo studies of strialal vescles containing the vesicular monoanine transporter (VMAT2):rat versus mouse difference in sequestuation of 1-methyl-4-phenylpyridinium显示文摘 | Staal RG Hogan KA Liang CL | 2000 | J Pharacol Exp Ther2000，293，： | 1 |
| 5 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 6 | Regulation of bim in glu- cocorticoid-mediated osteoblast apoptosis 显示文摘 | Espina B Liang M Russell RG | 2008 | J Cell Physiol2008，215，2： | 1 |
| 7 | Modulating effects of post-training epinephrine on memory:involvement of the amygdala noradrenergic system显示文摘 | Liang KC Juler RG McGaugh JL | 1986 | Brain Res1986，368，1： | 1 |
| 8 | Nano neuro knitring: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 9 | Subchronic 90-day oral (Garage) toxicity study of a Luo Han Guo mogroside extract in dogs显示文摘 | Xu Q Su x l Liang RG | 2006 | Food Chem Toxicol2006，44，12： | 1 |
| 10 | Vimentin combined CK, EpCAM used in the detection of circulating tumor cells in patients with middle and advanced breast cancer显示文摘 | Liang RG Shi LY Shi Y | 2016 | J Guangxi Medi Univer2016，33，1： | 1 |
| 11 | Nano neuro knitting : peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision 显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 12 | Nano neuro knitting:peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Nat Acad Sci USA2006，103，13： | 1 |
| 13 | Machining process monitor- ing and control: the state - of- the- art显示文摘 | Liang SY Hecker RL Landers RG | 2004 | Journal of Manu- facturing Science and Engineering2004，126，2： | 1 |
| 14 | Nano neuro knitting:peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | El is-Behnke RG Liang YX You SW | | 0，，： | 1 |
| 15 | Nano neuro knitting:Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，19： | 1 |
| 16 | Nano knitting :Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis -Behnke RG Liang YX | 2006 | Proc Natl Acad Sci2006，103，13： | 1 |
| 17 | Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Nail Acad Sci U S A2006，103，13： | 1 |
| 18 | Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional realm of vision 显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Natl Acad Sci U S A2006，103，13： | 1 |
| 19 | Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX You SW | 2006 | Proc Natl Acad Sci U S A2006，103，13： | 1 |
| 20 | Nano neuro knitting:Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision显示文摘 | Ellis-Behnke RG Liang YX | 2006 | Proc Nail Acad Sci2006，103，： | 1 |
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