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| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 3 | Novel redox potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol- producing capability显示文摘 | Du, CY Zhang, YP Li, Y Cao, Z | 2007 | 中国生物学文摘2007，21，10： | 15 |
| 4 | 杏仁核-海马环路参与抑郁症的发病机制显示文摘慢性应激常可引发抑郁症。临床资料显示,抑郁症病人的腹侧海马CA1区(vCA1)n体积减小。vCA1是否参与抑郁症的发病?vCA1通过什么环路起作用?其分子机制如何?是本文要回答的科学问题。研究者利用慢性不可预见性温和应激(CUMS),构建小鼠抑郁症模型。主要结果如下:(1)与对照组相比,CUMS组vCA1中表达c-Fos的兴奋性神经元的比例降低。采用化学遗传学方法激活vCA1内兴奋性神经元,可明显缓解抑郁样行为。因此,海马vCA1内兴奋性神经元的活性降低,介导抑郁症的发生。 | 刘风雨(译) Ma H Li CY Wang JP | 2021 | 中国疼痛医学杂志2021，27，2： | 9 |
| 5 | 慢性药物性肝损伤生化学未缓解的列线图预测模型的建立显示文摘【据Hepatology 2021年12月报道】题:慢性药物性肝损伤生化学未缓解的列线图预测模型的建立(作者Wang CY等)药物性肝损伤(DILI)已被公认为急性和慢性肝病的重要原因。虽然大多数经历DILI的患者在停用可疑药物后可获得临床和生化学的完全缓解,但仍有8%~20%的患者可进展为慢性DILI。反复出现生化学未缓解(BNR)的DILI患者可能进展至肝硬化甚至肝衰竭,生活质量差。目前慢性DILI的诊断仍然具有很大的挑战性,肝活检虽然有助于DILI诊断的正确性,但其临床应用受到了有创性及高成本的限制。此外,DILI的组织学及生化特征与预后的关系尚不明确。 | 纪冬 WANG CY DENG Y LI P | 2022 | 临床肝胆病杂志2022，38，1： | 8 |
| 6 | On abiogenic natural gas显示文摘NATURAL gases usually refer to the inflammable gases dominated by methane from the angle of research on energy gases. Three genetic types of natural gases can be recognized according to the process of methane generation: (ⅰ) biogenic (bacterial) gas, mainly the gas formed by the decomposition of organic matter in sediments under the action of anaerobic bacteria; (ⅱ) thermogenic gas, mainly the gas formed by the degradation of organic matter in sediments under the action of certain temperature and pressure; (ⅲ) abiogenic gas, mainly the | Wang, XB Li, CY Chen, JF Xia, XY Guo, ZQ Xie, HS | 1997 | Chinese Science Bulletin1997，42，16： | 5 |
| 7 | RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform显示文摘我们以前报导了人的 ACAT1 基因通过从染色体抄录的二不连续的 RNA 处理的 interchromosomal 生产妄想的 mRNA 1 和 7。妄想的 mRNA 把 AUG1397-1399 和 GGC1274-1276 用作翻译开始 codons 分别地,与在人的房间是确实地在场的后者生产正常 50-kDa ACAT1 和新奇酶地活跃的 56-kDa isoform,包括人的导出单核白血球的巨噬细胞。在这个工作,我们报导位于 GGC1274-1276 codon 的附近的 RNA 第二等的结构为 56-kDa isoform 的生产被要求。三预言的茎环(nt 1255-1268, 1286-1342 和 1355-1384 ) 的效果被 transfecting 表示 plasmids 个别地测试进包含的房间野类型,删除或变异的茎环序列连接了到一个部分 ACAT1 8 月开的读物框架(ORF ) 或到另外的基因的 ORF。表示模式被西方的污点分析监视。我们发现从染色体 7 的在上游的 stem-loop1255-1268 和从染色体 1 的下游的 stem-loop1286-1342 为 56-kDa isoform 的生产被需要,而从染色体 1 的最后 stem-loop1355-1384 是非必需的。用有一个稳定的发卡的 monocistronic 和 bicistronic 向量的实验的结果证明从 GGC1274-1276 codon 的那翻译开始被一个内部核糖体入口地点(怒火) 调停。进一步的实验表明从 GGC1274-1276 codon 的那翻译开始要求在上游的组成 AU 的 RNA 第二等的结构和下游地 GC 富有的结构。这个机械学的工作为人的 ACAT1 抄本的妄想的性质的生物意义提供进一步的支持。 | Jia Chen Xiao-Nan Zhao Li Yang Guang-Jing Hu Ming Lu Ying Xiong Xin-Ying Yang Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2008 | Cell Research2008，18，9： | 5 |
| 8 | TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve显示文摘TRHmicroinjectionintoDVCenhancesmotilityofrabbitsgalbladderviavagusnerveLIUChuanYong,LIUJingZhang,ZHOUJianHua,WANGHanRu,... | Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ | 1998 | World Journal of Gastroenterology1998，4，2： | 4 |
| 9 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 10 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 11 | Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene显示文摘拼接 Trans,包含劈开并且二个分开的抄本加入的一个过程,能在优核质扩展 transcriptome 和 proteome。拼接 trans 产生的妄想的 RNA 逐渐地在文学被描述。在自然环境和人的肠的抗菌素抵抗基因的普遍存在为公共健康正在成为重要挑战。某些抗菌素抵抗基因,例如氨比西林抵抗基因(安培 r ), 经常在 recombinant plasmids 被使用。直到现在,拼接 trans 包含 recombinant 导出 plasmid 的外长的抄本和内长的细胞的 RNA 没被报导。Acyl-CoA:cholesterol acyltransferase (ACAT1 ) 1 是涉及细胞的胆固醇动态平衡的关键酶。4.3-kb 人 ACAT1 妄想的 mRNA 能与不同酶的活动生产 50-kDa 和 56-kDa isoforms。这里,我们证明人的 ACAT1 56-kDa isoform 从通过安培 r ( asAmp )现在在普通安培 r -plasmids 和 4.3-kb 内长的 ACAT1 妄想的 mRNA ,它大概通过 interchromosomal 拼接trans 的一个优先的事件被处理。惊人地,与一个在上游的重新结合的神秘倡导者一起包含 asAmp 的 DNA 碎片和相应外长的 asAmp 抄本在人的房间被检测了。我们的调查结果使人的 ACAT1 56-kDa isoform 生产的机制清楚些,揭示一个外长内长的拼接 trans 系统,在 recombinant,导出 plasmid 的外长的抄本在人的房间与内长的细胞的 RNA 被连接,并且建议外长的 DNA 可能影响在 DNA 和 RNA 层次的人的基因表示。 | Guang-Jing Hu Jia Chen Xiao-Nan Zhao Jia-JiaXu Dong-Qing Guo Ming Lu Ming Zhu Ying Xiong Qin Li Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2013 | Cell Research2013，23，8： | 4 |
| 12 | Effect of angiotensin II type I receptor blocker losartan on bone deterioration in orchiectomized male hypertensive and normotensive rats显示文摘 | ZHANG Ya-feng QIN Ling Timothy CY Kwok Benson HY Yeung LI Guo-dong LIU Fan | 2013 | Chinese Medical Journal2013，，14： | 3 |
| 13 | Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/ Zn mine tailings at Lechang, Guangdong, China显示文摘 | Tan GL Shu WS Hallberg KB Li F Lan CY Huang LN | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 14 | Radiation activates HIF - 1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules 显示文摘 | Moeller BJ Cao Y Li CY | 2004 | Cancer Cell2004，4，： | 1 |
| 15 | Comparison of two types of alginate microcapsules on stability and biocompatibility in vitro and in vivo显示文摘 | Li HB Jiang H Wang CY | 2006 | Biomed Mater2006，，1： | 1 |
| 16 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 17 | Low birth weight and high birth weight infants are both at an increased risk to have type2diabetes a-mong school children in Taiwan显示文摘 | WEI JN SUNG FC LI CY | 2003 | Diabet Care2003，26，2： | 1 |
| 18 | Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus显示文摘 | Wong CK Ho CY Li EK | 2002 | Clin Exp Immunol2002，130，2： | 1 |
| 19 | Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Li YH Wang CY Sun JY | 2005 | Analytica Chimica Acta2005，550，12： | 1 |
| 20 | Genistein and its synthetic analogs as anticancer agents显示文摘 | Li Qs Li CY Li ZL | 2012 | A nti-cancer agents in medicinal chemistry2012，12，3： | 1 |
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