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| 1 | Entropy generation extremum and entransy dissipation extremum for heat exchanger optimization显示文摘The applicability of the extremum principles of entropy generation and entransy dissipation is studied for heat exchanger optimization. The extremum principle of entransy dissipation gives better optimiza-tion results when heat exchanger is only for the purpose of heating and cooling, while the extremum principle of entropy generation is better for the heat exchanger optimization when it works in the Brayton cycle. The two optimization principles are approximately equivalent when the temperature drops of the streams in a heat exchanger are small. | LIU XiongBin MENG JiAn GUO ZengYuan | 2009 | Chinese Science Bulletin2009，54，6： | 49 |
| 2 | Small envelope protein E of SARS:cloning,expression, purification, CD determination, and bioinformatics analysis显示文摘AIM:To obtain the pure sample of SARS small envelope E protein (SARS E protein), study its properties and analyze its possible functions. METHODS: The plasmid of SARS E protein was constructed by the polymerase chain reaction (PCR), and the protein was expressed in the E coli strain. The secondary structure feature of the protein was determined by circular dichroism (CD) technique. The possible functions of this protein were annotated by bioinformatics methods, and its possible three-dimensional model was constructed by molecular modeling. RESULTS: The pure sample of SARS E protein was obtained. The secondary structure feature derived from CD determination is similar to that from the secondary structure prediction. Bioinformatics analysis indicated that the key residues of SARS E protein were much conserved compared to the E proteins of other coronaviruses. In particular, the primary amino acid sequence of SARS E protien is much more similar to that of murine hepatitis virus(MHV) and other mammal coronaviruses. The transmembrane (TM) segment of the SARS E protein is relatively more conserved in the whole protein than other regions. CONCLUSION: The success of expressing the SARS E protein is a good starting point for investigating the structure and functions of this protein and SARS coronavirus itself as well. The SARS E protein may fold in water solution in a similar way as it in membrane-water mixed environment. It is possible that β-sheet I of the SARS E protein interacts with the membrane surface via hydrogen bonding, this β-sheet may uncoil to a random structure in water solution. | SHENXu XUEJian-Hua YUChang-Ying LUOHai-Bin QINLei YUXiao-Jing CHENJing CHENLi-Li XIONGBin YUELi-Duo CAIJian-Hua SHENJian-Hua LUOXiao-Min CHENKai-Xian SHITie-Liu LIYi-Xue HUGeng-Xi JIANGHua-Liang | 2003 | Acta Pharmacologica Sinica2003，24，6： | 17 |
| 3 | Putative hAPN receptor binding sites in SARS_CoV spike protein显示文摘AIM:To obtain the information of ligand-receptor binding between thd S protein of SARS_CoV and CD13, identify the possible interacting domains or motifs related to binding sites, and provide clues for studying the functions of SARS proteins and designing anti-SARS drugs and vaccines. METHODS: On the basis of comparative genomics, the homology search, phylogenetic analyses, and multi-sequence alignment were used to predict CD13 related interacting domains and binding sites sites in the S protein of SARS_CoV. Molecular modeling and docking simulation methods were employed to address the interaction feature between CD13 and S protein of SARS_CoV in validating the bioinformatics predictions. RESULTS:Possible binding sites in the SARS_CoV S protein to CD13 have been mapped out by using bioinformatics analysis tools. The binding for one protein-protein interaction pair (D757-R761 motif of the SARS_CoV S protein to P585-A653 domain of CD13) has been simulated by molecular modeling and docking simulation methods. CONCLUSION:CD13 may be a possible receptor of the SARS_CoV S protein which may be associated with the SARS infection. This study also provides a possible strategy for mapping the possible binding receptors of the proteins in a genome. | YUXiao-Jing LUOCheng LinJian-Cheng HAOPei HEYou-Yu GUOZong-Ming QINLei SUJiong LIUBo-Shu HUANGYin NANPeng LIChuan-Song XIONGBin LUOXiao-Min ZHAOGuo-Ping PEIGang CHENKai-Xian SHENXu SHENJian-Hua ZOUJian-Ping HEWei-Zhong SHITie-Liu ZHONGYang JIANGHua-Liang LIYi-Xue | 2003 | Acta Pharmacologica Sinica2003，24，6： | 13 |
| 4 | Experimental Determination of Significant Waveheight by OSMAR071: Comparison with Results from Buoy显示文摘OSMAR071 is the latest product of the OSMAR (ocean state monitor and analysis radar) series of high frequency surface wave radar (HFSWR), which was developed by the Radiowave Propagation Laboratory of Wuhan University. It adopts a modified Barrick waveheight inversion model. The modifications are introduced to improve the model's performances under the effect of noises and interferences and in the case of broad beam radar detection. The two unknown coefficients in the modified model are figured out by fitting the HFSWR significant waveheight results to those output from a wave buoy located in the radiating coverage of the radar site. The model is applied to inverse the waveheights from radar data for the duration from Dec. 1st, 2008 to Feb. 25th, 2009, and then the radar waveheights are compared with the buoy measurements. Results show that the rms difference between radar-derived significant waveheights and those from the buoy is 0.38 m and the correlation coefficient between the two series is 0.66. This study describes OSMAR071 observation of significant waveheight with relatively satisfactory accuracy during about three months. | WU Xiongbin LI Lun SHAO Yixie LI Yan GUO Tai | 2009 | Wuhan University Journal of Natural Sciences2009，14，6： | 9 |
| 5 | Identification of probable genomic packaging signal sequence from SARS—CoV genome by bioinformatics analysis显示文摘AIM:To predict the probable genomic packaging signal of SARS-CoV by bioinformatics analysis. The derived packaging signal may be used to design antisense RNA and RNA interfere (RANi) drugs treating SARS. methods: Based on the studies about the genomic packaging signals of MHV and BCoV, especially the information about primary and secondary structures, the putative genomic packaging signal of SARS_CoV were analyzed by using bioinformatic tools. Multi-alignment for the genomic sequences was performed among SARS-CoV,MHV,BCoV, PEDV and HCoV 229E. Secondary structures of RNA sequences were also predicted for the identification fo the possible genomic packaging signals. Meanwhile, the N and M proteins of all five viruses were analyzed to study the evolutionary relationship with genomic packaging signals. RESULTS: The putative genomic packaging signal of SARS-CoV locates at the 3′ end of ORF1b near that of MHV and BCoV, where is the most variable region of this gene. The RNA secondary structure of SARS-CoV genomic packaging signal is very similar to that of MHV and BCoV. The same result was also obtained in studying the genomic packaging signals of PEDV and HCoV 229E. Further more, the genomic sequence multi-alignment indicated that the locations of packaging signals of SARS-CoV, PEDV, and HCoV overlaped each other. It seems that the mutation rate of packaging signal sequences is much higher than the N protein, while only subtle variations for the M protein. CONCLUSIONS: The probable genomic packaging signal of SARS-CoV is analogous to that of MHV and BCoV, with the corresponding secondary RNA structure locating at the similar region of ORF1b. The positions where genomic packaging signals exist have suffered rounds of mutations, which may influence the primary structures of the N and M proteins consequently. | QINLei XIONGBin LUOCheng GUOZong-Ming HAOPei SUJiong NANPeng FENGYing SHIYi-Xiang YUXiao-Jing LUOXiao-Min CHENKai-Xian SHENXu SHENJian-Hua ZOUJian-Ping ZHAOGuo-Ping SHITie-Liu HEWei-Zhong ZHONGYang JIANGHua-Liang LIYi-Xue | 2003 | Acta Pharmacologica Sinica2003，24，6： | 9 |
| 6 | N^6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development显示文摘N6-Methyladenosine(m6 A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6 A modification methyltransferase, demethylase and proteins that preferentially recognize m6 A modification as 'writers', 'erasers' and 'readers', respectively. Altered expression levels of the m6 A modification key regulators substantially affect their function, leading to significant phenotype changes in the cell and organism. Recent studies have proved that the m6 A modification plays significant roles in regulation of metabolism, stem cell self-renewal, and metastasis in a variety of human cancers. In this review, we describe the potential roles of m6 A modification in human cancers and summarize their underlying molecular mechanisms. Moreover, we will highlight potential therapeutic approaches by targeting the key m6 A modification regulators for cancer drug development.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhp0wc6fno6xbw6vcf.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Yi Niu Arabella Wan Ziyou Lin Xiongbin Lu Guohui Wan | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 7 | A Comprehensive Approach for the Clustering of Similar-Performance Cells for the Design of a Lithium-Ion Battery Module for Electric Vehicles显示文摘An energy-storage system comprised of lithium-ion battery modules is considered to be a core component of new energy vehicles,as it provides the main power source for the transmission system.However,manufacturing defects in battery modules lead to variations in performance among the cells used in series or parallel configuration.This variation results in incomplete charge and discharge of batteries and non-uniform temperature distribution,which further lead to reduction of cycle life and battery capacity over time.To solve this problem,this work uses experimental and numerical methods to conduct a comprehensive investigation on the clustering of battery cells with similar performance in order to produce a battery module with improved electrochemical performance.Experiments were first performed by dismantling battery modules for the measurement of performance parameters.The kmeans clustering and support vector clustering(SVC)algorithms were then employed to produce battery modules composed of 12 cells each.Experimental verification of the results obtained from the clustering analysis was performed by measuring the temperature rise in the cells over a certain period,while air cooling was provided.It was found that the SVC-clustered battery module in Category 3 exhibited the best performance,with a maximum observed temperature of 32℃.By contrast,the maximum observed temperatures of the other battery modules were higher,at 40℃for Category 1(manufacturer),36℃for Category 2(manufacturer),and 35℃for Category 4(k-means-clustered battery module). | Wei Li Siqi Chen Xiongbin Peng Mi Xiao Liang Gao Akhil Garg Nengsheng Bao | 2019 | Engineering2019，5，4： | 4 |
| 8 | Review of materials used in laser-aided additive manufacturing processes to produce metallic products显示文摘Rapid prototyping (RP) or layered manufacturing (LM) technologies have been extensively used to manufacture prototypes composed mainly of plastics, polymers, paper, and wax due to the short product development time and low costs of these technologies. However, such technologies, with the exception of selective laser melting and sintering, are not used to fabricate metallic products because of the resulting poor life, short cycle, poor surface finish, and low structural integrity of the fabricated parts. The properties endowed by these parts do not match those of functional parts. Therefore, extensive research has been conducted to develop new additive manufacturing (AM) technologies by extending existing RP technologies. Several AM technologies have been developed for the fabrication of metallic objects. These technologies utilize materials, such as Ni-, A1-, and Ti-based alloys and stainless steel powders, to fabricate high-quality functional components. The present work reviews the type of materials used in laserbased AM processes for the manufacture of metallic products. The advantages and disadvantages of processes and different materials are summarized, and future research directions are discussed in the final section. This review can help experts select the ideal type of process or technology for the manufacturing of elements composed of a given alloy or material (Ni, Ti, Al, Pb, and stainless steel). | Xiaodong NIU Surinder SINGH Akhil GARG Harpreet SINGH Biranchi PANDA Xiongbin PENG Qiujuan ZHANG | 2019 | Frontiers of Mechanical Engineering2019，14，3： | 4 |
| 9 | A Fast Charging–Cooling Coupled Scheduling Method for a Liquid Cooling-Based Thermal Management System for Lithium-Ion Batteries显示文摘Efficient fast-charging technology is necessary for the extension of the driving range of electric vehicles.However,lithium-ion cells generate immense heat at high-current charging rates.In order to address this problem,an efficient fast charging–cooling scheduling method is urgently needed.In this study,a liquid cooling-based thermal management system equipped with mini-channels was designed for the fastcharging process of a lithium-ion battery module.A neural network-based regression model was proposed based on 81 sets of experimental data,which consisted of three sub-models and considered three outputs:maximum temperature,temperature standard deviation,and energy consumption.Each sub-model had a desirable testing accuracy(99.353%,97.332%,and 98.381%)after training.The regression model was employed to predict all three outputs among a full dataset,which combined different charging current rates(0.5C,1C,1.5C,2C,and 2.5C(1C=5 A))at three different charging stages,and a range of coolant rates(0.0006,0.0012,and 0.0018 kg·s^(-1)).An optimal charging–cooling schedule was selected from the predicted dataset and was validated by the experiments.The results indicated that the battery module’s state of charge value increased by 0.5 after 15 min,with an energy consumption lower than 0.02 J.The maximum temperature and temperature standard deviation could be controlled within 33.35 and 0.8C,respectively.The approach described herein can be used by the electric vehicles industry in real fast-charging conditions.Moreover,optimal fast charging-cooling schedule can be predicted based on the experimental data obtained,that in turn,can significantly improve the efficiency of the charging process design as well as control energy consumption during cooling. | Siqi Chen Nengsheng Bao Akhil Garg Xiongbin Peng Liang Gao | 2021 | Engineering2021，7，8： | 3 |
| 10 | miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase显示文摘 | Yunfei Zhou Guohui Wan Riccardo Spizzo Cristina Ivan Rohit Mathur Xiaoxiao Hu Xiangcang Ye Jia Lu Fan Fan Ling Xia George A. Calin Lee M. Ellis Xiongbin Lu | 2014 | Molecular Oncology2014，，1： | 3 |
| 11 | Phosphor-free single chip GaN-based white light emitting diodes with a moderate color rendering index and significantly enhanced communications bandwidth显示文摘To achieve high quality lighting and visible light communication(VLC)simultaneously,Ga N based white light emitting diodes(WLEDs)oriented for lighting in VLC has attracted great interest.However,the overall bandwidth of conventional phosphor converted WLEDs is limited by the long lifetime of phosphor,the slow Stokes transfer process,the resistance-capacitance(RC)time delay,and the quantum-confined Stark effect(QCSE).Here by adopting a self-assembled In Ga N quantum dots(QDs)structure,we have fabricated phosphor-free single chip WLEDs with tunable correlated color temperature(CCT,from 1600 K to 6000 K),a broadband spectrum,a moderate color rendering index(CRI)of 75,and a significantly improved modulation bandwidth(maximum of150 MHz)at a low current density of 72 A∕cm^2.The broadband spectrum and high modulation bandwidth are ascribed to the capture of carriers by different localized states of In Ga N QDs with alleviative QCSE as compared to the traditional In Ga N/Ga N quantum well(QW)structures.We believe the approach reported in this work will find its potential application in Ga N WLEDs and advance the development of semiconductor lighting-communication integration. | Rongqiao Wan Xiang Gao Liancheng Wang Shuo Zhang Xiongbin Chen Zhiqiang Liu Xiaoyan Yi Junxi Wang Junhui Li Wenhui Zhu Jinmin Li | 2020 | Photonics Research2020，8，7： | 3 |
| 12 | Incorporating Equity Concerns into Transportation Planning and Policies in Urban China: The Status Quo of Practice and Implications显示文摘Transportation equity is one of the most recent concerns toward sustainable urban development, which aims to help municipalities or local planning authorities incorporate equity issues into transportation planning and policies, avoiding multifaceted potential inequity outcomes. As for the urbanizing China, do the mainstream planning approaches fail to take equity issues into account? What are outcomes and the potential countermeasures based on Chinese cities' spatial and policy contexts? From the perspective of transportation equity, this article aims to examine the multidimensional effects related to equity concerns of urban transportation planning and policies in China. It suggests that the municipal government should enhance the service level of public transit and efficiently address the inequity issues of transportation systems. The potential measures include: building a multi-modal transit system, linking affordable housing to the transportation system, highlighting the role of non-motorized mode, and offering proper parking spaces around transit stations. | Lin Xiongbin Liu Jiayan(校) | 2019 | China City Planning Review2019，28，1： | 3 |
| 13 | Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo-/immunotherapy显示文摘Bacterial outer membrane vesicles(OMVs)are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine.In this study,OMVs are demonstrated as promising antitumor therapeutics.OMVs can lead to beneficial M2-to-M1 polarization of macrophages and induce pyroptosis to enhance antitumor immunity,but the therapeutic window of OMVs is narrow for its toxicity.We propose a bioengineering strategy to enhance the tumor-targeting ability of OMVs by macrophage-mediated delivery and improve the antitumor efficacy by co-loading of photosensitizer chlorin e6(Ce6)and chemotherapeutic drug doxorubicin(DOX)into OMVs as a therapeutic platform.We demonstrate that systemic injection of the DOX/Ce6-OMVs@M therapeutic platform,providing combinational photodynamic/chemo-/immunotherapy,eradicates triple-negative breast tumors in mice without side effects.Importantly,this strategy also effectively prevents tumor metastasis to the lung.This OMVs-based strategy with bioengineering may serve as a powerful therapeutic platform for a synergic antitumor therapy. | Yongjiang Li Junyong Wu Xiaohan Qiu Suhe Dong Jun He Jihua Liu Wenjie Xu Si Huang Xiongbin Hu Da-Xiong Xiang | 2023 | Bioactive Materials2023，，2： | 2 |
| 14 | Numerical simulation and inversion of offshore area depth based on x-band microwave radar显示文摘A detection method of offshore area depth utilizing the x-band microwave radar is proposed. The method is based on the sea clutter imaging mechanism of microwave radar, and combined with dispersion equation of the liner wave theorem and least square method(LSM), consequently get the inversion results of water depth in the detected region. The wave monitoring system OSMAR-X exploited by the Ocean State Laboratory, Wuhan University, based on a microwave radar has proven to be a powerful tool to monitor ocean waves in time and space. Numerical simulation and inversion of offshore area depth are carried out here; since JONSWAP model can give description of stormy waves in different growth phase, it is suitable for simulation. Besides, some results from measured data detected by OSMAR-X x-band radar located at Longhai of Fujian Province, China, validates this method. The tendency of the average water depths inferred from the radar images is in good agreement with the tide level detected by Xiamen tide station. These promising results suggest the possibility of using OSMAR-X to monitor operationally morphodynamics in coastal zones. This method can be applied to both shore-based and shipborne x-band microwave radar. | WANG Li WU Xiongbin PI Xiaoshan MA Ketao LIU Jianfei TIAN Yun | 2015 | Acta Oceanologica Sinica2015，34，3： | 2 |
| 15 | Surface tidal currents in the open sea area to the east of the Zhoushan Islands measured with high frequency surface wave radar显示文摘Based on the quasi-harmonic analysis of 11 d vector ocean currents obtained from two high frequency surface wave radars located at Zhujiajian Island and Shengshan Island,the spatial distribution characteristics of surface tidal currents in the open sea area to the east of the Zhoushan Islands of Zhejiang Province,China are studied.The following conclusions are drawn from the analysis:the tidal current pattern in the open sea area to the east of Zhoushan Islands is primarily regular semidiurnal,which is significantly affected by the shallow water constituents.The directions of the major axes of tidal current ellipses of M2lie approximately in the NW-SE direction.With the increasing of distance away from the coast,the directions of the tidal current ellipses gradually shift toward the E-W direction.The tidal currents are mainly reversing currents.The spatial distribution of probable maximum current velocities decreases gradually from northeast to southwest which is basically in accordance with the spatial distribution of measured maximum current velocities.The residual currents near the coast are larger than those far away from the coast.The directions of the residual currents are basically north by east,and the angle to the due north increases gradually with the increasing distance away from the coast.The topography shows a certain impact on the spatial distribution of shallow water constituents,the rotation of tidal currents,the probable maximum currents and the residual currents. | SHEN Zhiben WU Xiongbin FEI Yuejun XU Xing'an CHEN Xiaofeng | 2013 | Acta Oceanologica Sinica2013，32，10： | 2 |
| 16 | The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways显示文摘 | Xiongbin Lu Thuy-Ai Nguyen Sung-Hwan Moon Yolanda Darlington Matthias Sommer Lawrence A. Donehower | 2008 | Cancer and Metastasis Reviews2008，，2： | 1 |
| 17 | Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D显示文摘 | Robert C. Castellino Massimiliano Bortoli Xiongbin Lu Sung-Hwan Moon Thuy-Ai Nguyen Mark A. Shepard Pulivarthi H. Rao Lawrence A. Donehower John Y. H. Kim | 2008 | Journal of Neuro - Oncology2008，，3： | 1 |
| 18 | From Prosperity to Disappearance:Social and Spatial Transformation of Shuangqiao Village in the City of Ningbo,China显示文摘In the process of gradual transitioning from a planned economy to a market economy, villages in China have experienced dramatic social and spatial transformation. However, among the abundant literature of the formation and regeneration strategies of urban villages, few of them are on the complete life cycle of an urban village. In order to provide a case for better understanding the social and spatial transformation in China's urban villages, with the help of fieldwork and government statistics, this paper examines the social and spatial dynamics of the Shuangqiao Village in China's Ningbo City. The study includes its prosperity, resulting from studentification, and its disappearance, stemming from urban regeneration, both from a perspective of a complete life cycle analysis. In light of this case study, the paper in the end proposes possible planning measures for urban regeneration. | Lin Xiongbin Li Caige | 2016 | China City Planning Review2016，25，1： | 1 |
| 19 | Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability,localization, and activity显示文摘 | Lynette M Xiongbin Lu Nader G | 2007 | Mech Ageing Dev2007，128，1112： | 1 |
| 20 | Application of LQR techniques to the anti-sway controller of overhead crane显示文摘 | YangBin XiongBin | 2010 | Advanced materials research2010，，： | 1 |
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