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| 1 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 2 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 3 | Electronic Structure and Physical Characteristics of Dioxin Under External Electric Field显示文摘Dioxin is a highly toxic and caustic substance,which widely existed in the atmosphere,soil and water with tiny particles.Dioxin pollution has become a major problem that concerns the survival of mankind,which must be strictly controlled.The bond length,bond angle,energy,dipole moment,orbital energy level distribution of dioxin under the external field are investigated using DFT(density functional theory)on basis set level of B3LYP/6-31G(d,p).The results indicate that with the increase of the electric field,the length of one Carbon-Oxygen bond increases while another Carbon-Oxygen bond decreases.The energy gradually decreases with the electric field,while the change of the dipole moment has an opposite trend.In the infrared spectra,the vibration frequency decreases with the electric field increasing and shows an obvious red shift.Moreover,the ultraviolet-visible absorption spectra under different electric fields are analyzed with TD-DFT(time-dependent density functional theory)method.The wavelength of the strongest absorption peak increases and occurs red shift with the increase of the electric field.All the above results can provide reference for further research on the properties of dioxin under different external electric field. | Wenyi Yin Xiangyun Zhang Bumaliya Abulimiti Yuzhu Liu Yihui Yan Fengbin Zhou Feng Jin | 2018 | Computers, Materials & Continua2018，，4： | 2 |
| 4 | Edge detection of magnetic tile cracks,based on wavelet显示文摘In order to extract the defect edge information on the magnetic tile surface with low contrast and textured background,an edge detection algorithm based on image weighted information entropy and wavelet modulus maxima is proposed.At first,a new Butterworth high pass filter(BHPF) with adaptive cutoff frequency is produced,because the clarity and complexity of the textured background are described by the weighted information entropy of the image gradient variance quantitatively,and the filter can change its parameters through matching the non-linear relationship between the information entropy and the cutoff frequency.And then,the best decomposition scale is obtained by the level determination function to prevent edge information from missing.At last,edge points are got by double threshold after obtaining the wavelet modulus maxima,and then the edge image is linked by the edge points to ensure the edge continuity and veracity.Experiment results indicate that the proposed algorithm outperforms the conventional Canny and Sobel algorithm,and the edge detection algorithm can also detect other defects,and lays the foundation for defecting auto- recognition. | 林丽君 He Mingge Yin Ying Yin Xiangyun Yin Guofu | 2015 | High Technology Letters2015，21，3： | 2 |
| 5 | Carbon-Based Electrode Materials for Supercapacitor: Progress, Challenges and Prospective Solutions显示文摘 | Xian Jian Shiyu Liu Yuqi Gao Wei Tian Zhicheng Jiang Xiangyun Xiao Hui Tang Liangjun Yin | 2016 | Journal of Electrical Engineering2016，4，2： | 2 |
| 6 | 3D finite-element modeling of Earth induced electromagnetic field and its potential applications for geomagnetic satellites显示文摘The accumulated large amount of satellite magnetic data strengthens our capability of resolving the electrical conductivity of Earth’s mantle.To invert these satellite magnetic data,accurate and efficient forward modeling solvers are needed.In this study,a new finite-element based forward modeling solver is developed to accurately and efficiently compute the induced electromagnetic field for a realistic 3D Earth.Firstly,the nodal-based finite element method with linear shape function on tetrahedral grid is used to assemble the final system of linear equations for the magnetic vector potential and electric scalar potential.The FGMRES solver with algebraic multigrid(AMG)preconditioner is used to quickly solve the final system of linear equations.The weighted moving least-square method is employed to accurately recover the electromagnetic field from the numerical solutions of magnetic vector and electric scalar potentials.Furthermore,a local mesh refinement technique is employed to improve the accuracy of the estimated electromagnetic field.At the end,two synthetic models are used to verify the accuracy and efficiency of our newly developed forward modeling solver.A realistic 3D Earth model is used to simulate the induced magnetic field at 450 and 200 km altitudes which are the planned flying altitudes of Macao’s geomagnetic satellites.The simulation indicates that(1)the amplitude of the mantle-induced magnetic field can reach 10–30 nT at 450 km altitude,which is 10–30%of the primary magnetic field.The induced magnetic field at 200 km altitude has larger amplitudes.These mantleinduced magnetic fields can be measured by Macao geomagnetic satellites;(2)the amplitude of the ocean-induced magnetic field can reach 5–30 nT at satellite altitudes,which needs to be carefully considered in the interpretation of satellite magnetic data.We are confident that our newly developed forward modeling solver will become a key tool for interpreting satellite magnetic data. | Hongbo YAO Zhengyong REN Jingtian TANG Yufeng LIN Changchun YIN Xiangyun HU Qinghua HUANG Keke ZHANG | 2021 | Science China Earth Sciences2021，64，10： | 1 |
| 7 | Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production显示文摘 | Jingyun Li Qiumei Du Rui Hu Yanbing Wang Xiangyun Yin Haisheng Yu Peishuang Du Joel Plu-mas Laurence Chaperot Yong-jun Liu Liguo Zhang | 2016 | Protein & Cell2016，7，4： | 1 |
| 8 | Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons显示文摘 | Lei Zhang Jiu-Chao Yin Hana Yeh Ning-Xin Ma Grace Lee Xiangyun Amy Chen Yanming Wang Li Lin Li Chen Peng Jin Gang-Yi Wu Gong Chen | 2015 | Cell Stem Cell2015，，： | 1 |
| 9 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway.Recent studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and localization.However,the specific deubiquitinase that affects NOTCH1 protein stability remains unestablished.Here,we report that ubiquitin-specific protease 7(USP7)can stabilize NOTCH1.USP7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of NOTCH1.USP7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this interaction.Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein level.Similarly,pharmacologic inhibition of USP7 led to apoptosis of T-ALL cells.More importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these findings.Overall,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes NOTCH1.Therefore,USP7 may be a promising therapeutic target in the currently incurable T-ALL. | Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin Tong Li Zhou Hanzhang Xu Yingli Wu | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 10 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 11 | 碳离子辐照联合免疫抗体对三阴乳腺癌荷瘤小鼠的效应研究显示文摘Radiotherapy combined with chemotherapy and immunotherapy is the development trend of precise cancer treatment.As an advanced radiotherapy method,carbon ion therapy can activate the immune response of cancer cells,and its combination with immunotherapy is expected to further improve the effect of cancer control and improve the survival of cancer patients.In this study,anti-PD-L1,anti-HER-2 and R848 immune antibodies were selected to study the changes of weight and volume of tumors in mice bearing triple negative breast cancer 4T1-4P cells.Anti-HER-2 was further selected in different groups(control group,carbon ion group,immune treatment group and combined treatment group).T cell population analysis was carried out in combination with R848 and carbon ion group. | Zhao Ting Yin Xiangyun Chen Weiqiang Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 12 | 建立具有体内胚内和胚外发育潜能的多能干细胞显示文摘文章简介在已知的体外培养的干细胞类型当中,多能干细胞具有最高的发育潜能,能够形成构成成年个体的所有细胞类型。但是,多能干细胞很难在体内发育过程中形成胚外的胎盘组织。 | Yang Yang Bei Liu Jun Xu Jinlin Wang Jun Wu Cheng Shi Yaxing Xu Jiebin Dong Chengyan Wang Weifeng Lai Jialiang Zhu Liang Xiong Dicong Zhu Xiang Li Weifeng Yang Takayoshi Yamauchi Atsushi Sugawara Zhongwei Li Fangyuan Sun Xiangyun Li Chen Li Aibin He Yaqin Du Ting Wang Chaoran Zhao Haibo Li Xiaochun Chi Hongquan Zhang Yifang Liu Cheng Li Shuguang Duo Ming Yin 沈浣 Juan Carlos Izpisua Belmonte 邓宏魁 | 2018 | 科学新闻2018，0，4： | 0 |
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