|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Determination and vertical distribution of nitrogen species in sediments of Funan Rivers, Chengdu City, China显示文摘 | Yi WU Tingting WANG Qing XU Mengxia LIAO Tianong DENG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 4 |
| 2 | SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2显示文摘Dear Editor,SARS-coronavirus-2(SARS-CoV-2)Omicron variant(B.1.1.529)is of great concern to the world due to its multiple mutations that may have an impact on transmissibility and immune evasion.1 Compared to the wild type(WT),Omicron carries as many as 30 single point mutations,3 deletion mutation and one insertion mutation on its spike protein.Strikingly,there are 15 mutations observed in the Omicron receptor-binding domain(RBD),10 of which are in the receptor-binding motif(RBM)that human angiotensin-converting enzyme 2(ACE2)and most monoclonal antibodies(mAbs)interact directly with.As a comparison,the currently dominant variant Delta(B.1.617.2)has only 2 mutations(L452R and T478K)in its RBM and additional K417N and E484K mutations sometimes.Therefore,Omicron variant may significantly impact the binding affinity to ACE2 and effectiveness of currently available mAbs.Consequently,Omicron mutant has aroused wide concern,many countries have taken measures on entry restrictions to prevent its rapid spread.However,the transmissibility and immune evasion risk of Omicron have not been properly evaluated. | Leyun Wu Liping Zhou Mengxia Mo Tingting Liu Chengkun Wu Chunye Gong Kai Lu Likun Gong Weiliang Zhu Zhijian Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 3 | Agricultural soil monitoring of PCDD/Fs in the vicinity of a municipal solid waste incinerator in Eastern China:Temporal variations and possible sources显示文摘 | Xu Mengxia Yan Jianhua Lu Shengyong | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
| 4 | Coronavirus disease 2019 epidemic prediction in Shanghai under the “dynamic zero-COVID policy”using time-dependent SEAIQR model显示文摘It’s urgently needed to assess the COVID-19 epidemic under the“dynamic zero-COVID policy”in China,which provides a scientific basis for evaluating the effectiveness of this strategy in COVID-19 control.Here,we developed a time-dependent susceptible-exposed-asymptomatic-infected-quarantined-remov ed(SEAIQR)model with stage-specific interventions based on recent Shanghai epidemic data,considering a large number of asymptomatic infectious,the changing parameters,and control procedures.The data collected from March 1st,2022 to April 15th,2022 were used to fit the model,and the data of subsequent 7 days and 14 days were used to evaluate the model performance of forecasting.We then calculated the effective regeneration number(Rt)and analyzed the sensitivity of different measures scenarios.Asymptomatic infectious accounts for the vast majority of the outbreaks in Shanghai,and Pudong is the district with the most positive cases.The peak of newly confirmed cases and newly asymptomatic infectious predicted by the SEAIQR model would appear on April 13th,2022,with 1963 and 28,502 cases,respectively,and zero community transmission may be achieved in early to mid-May.The prediction errors for newly confirmed cases were considered to be reasonable,and newly asymptomatic infectious were considered to be good between April 16th to 22nd and reasonable between April 16th to 29th.The final ranges of cumulative confirmed cases and cumulative asymptomatic infectious predicted in this round of the epidemic were 26,477~47,749 and 402,254~730,176,respectively.At the beginning of the outbreak,Rt was 6.69.Since the implementation of comprehensive control,Rt showed a gradual downward trend,dropping to below 1.0 on April 15th,2022.With the early implementation of control measures and the improvement of quarantine rate,recovery rate,and immunity threshold,the peak number of infections will continue to decrease,whereas the earlier the control is implemented,the earlier the turning point of the epidemic will arrive.The proposed time-dependent SEAIQR dynamic model fits and forecasts the epidemic well,which can provide a reference for decision making of the“dynamic zero-COVID policy”. | Yifei Ma Shujun Xu Qi An Mengxia Qin Sitian Li Kangkang Lu Jiantao Li Lijian Lei Lu He Hongmei Yu Jun Xie | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 5 | Consensus on potential biomarkers developed for use in clinical tests for schizophrenia显示文摘Background Schizophrenia is a serious mental illness affecting approximately 20 million individuals globally.Both genetic and environmental factors contribute to the illness.If left undiagnosed and untreated,schizophrenia results in impaired social function,repeated hospital admissions,reduced quality of life and decreased life expectancy.Clinical diagnosis largely relies on subjective evidence,including self-reported experiences,and reported behavioural abnormalities followed by psychiatric evaluation.In addition,psychoses may occur along with other conditions,and the symptoms are often episodic and transient,posing a significant challenge to the precision of diagnosis.Therefore,objective,specific tests using biomarkers are urgently needed for differential diagnosis of schizophrenia in clinical practice.Aims We aimed to provide evidence-based and consensus-based recommendations,with a summary of laboratory measurements that could potentially be used as biomarkers for schizophrenia,and to discuss directions for future research.Methods We searched publications within the last 10 years with the following keywords:‘schizophrenia’,‘gene’,‘inflammation’,‘neurotransmitter’,‘protein marker’,‘gut microbiota’,‘pharmacogenomics’and‘biomarker’.A draft of the consensus was discussed and agreed on by all authors at a round table session.Results We summarised the characteristics of candidate diagnostic markers for schizophrenia,including genetic,inflammatory,neurotransmitter,peripheral protein,pharmacogenomic and gut microbiota markers.We also proposed a novel laboratory process for diagnosing schizophrenia in clinical practice based on the evidence summarised in this paper.Conclusions Further efforts are needed to identify schizophrenia-specific genetic and epigenetic markers for precise diagnosis,differential diagnosis and ethnicity-specific markers for the Chinese population.The development of novel laboratory techniques is making it possible to use these biomarkers clinically to diagnose disease. | Ping Lin Junyu Sun Xiaoyan Lou Dan Li Yun Shi Zhenhua Li Peijun Ma Ping Li Shuzi Chen Weifeng Jin Shuai Liu Qing Chen Qiong Gao Lili Zhu Jie Xu Mengyuan Zhu Mengxia Wang Kangyi Liang Ling Zhao Huabin Xu Ke Dong Qingtian Li Xunjia Cheng Jinghong Chen Xiaokui Guo | 2022 | General Psychiatry2022，35，1： | 1 |
| 6 | The genome sequence of star fruit(Averrhoa carambola)显示文摘Oxalidaceae is one of the most important plant families in horticulture,and its key commercially relevant genus,Averrhoa,has diverse growth habits and fruit types.Here,we describe the assembly of a high-quality chromosomescale genome sequence for Averrhoa carambola(star fruit).Ks distribution analysis showed that A.carambola underwent a whole-genome triplication event,i.e.,the gamma event shared by most eudicots.Comparisons between A.carambola and other angiosperms also permitted the generation of Oxalidaceae gene annotations.We identified unique gene families and analyzed gene family expansion and contraction.This analysis revealed significant changes in MADS-box gene family content,which might be related to the cauliflory of A.carambola.In addition,we identified and analyzed a total of 204 nucleotide-binding site,leucine-rich repeat receptor(NLR)genes and 58 WRKY genes in the genome,which may be related to the defense response.Our results provide insights into the origin,evolution and diversification of star fruit. | Shasha Wu Wei Sun Zhichao Xu Junwen Zhai Xiaoping Li Chengru Li Diyang Zhang Xiaoqian Wu Liming Shen Junhao Chen Hui Ren Xiaoyu Dai Zhongwu Dai Yamei Zhao Lei Chen Mengxia Cao Xinyu Xie Xuedie Liu Donghui Peng Jianwen Dong Yu-Yun Hsiao Shi-lin Chen Wen-Chieh Tsai Siren Lan Zhong-Jian Liu | 2020 | Horticulture Research2020，7，1： | 1 |
| 7 | Agricultural soil monitoring of PCDD/Fs in the vicinity of a municipal solid waste incinerator in Eastern China: temporal variations and possible sources显示文摘 | XU Mengxia YAN Jianhua LU Shengyong | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 8 | PCDD/Fs concentrations of agricultural soil in the vicinity of fluidized bed incinerators of co-firing MSW with coal in Hangzhou,China显示文摘 | YAN Jianhua XU Mengxia LU Shengyong | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 9 | Source i- dentification of PCDD/Fs in agricultural soils near to a Chi- nese MSWI plant through isomer-specific data analysis显示文摘 | XU Mengxia YAN Jianhua LU Shengyong | 2008 | Chemosphere2008，71，6： | 1 |
| 10 | Facet effect on the reconstructed Cu-catalyzed electrochemical hydrogenation of 5-hydroxymethylfurfural(HMF) towards 2,5-bis(hydroxymethy)furan (BHMF)显示文摘The electrochemical hydrogenation of HMF to BHMF is an elegant alternative to the conventio nal thermocatalytic route for the production of high-value-added chemicals from biomass resources.In virtue of the wide potential window with promising Faradic efficiency(FE) towards BHMF,Cu-based electrode has been in the center of investigation.However,its structure-activity relationship remains ambiguous and its intrinsic catalytic activity is still unsatisfactory.In this work,we develop a two-step oxidation-reduction strategy to reconstruct the surface atom arrangement of the Cu foam(CF).By combination of multiple quasi-situ/in-situ techniques and density functional theory(DFT) calculation,the critical factor that governs the reaction is demonstrated to be facet effect of the metallic Cu crystal:Cu(110) facet accounts for the most favorable surface with enhanced chemisorption with reactants and selective production of BHMF,while Cu(100) facet might trigger the accumulation of the by-product 5,5'-bis(hydroxy methy)hydrofurion(BHH).With the optimized composition of the facets on the reconstructed Cu(OH)_(2)-ER/CF,the performance could be noticeably enhanced with a BHMF FE of 92.3% and HMF conversion of 98.5% at a potential of -0.15 V versus reversible hydrogen electrode(vs.RHE) in 0.1 M KOH solution.This work sheds light on the incomplete mechanistic puzzle for Cu-catalyzed electrochemical hydrogenation of HMF to BHMF,and provides a theoretical foundation for further precise design of highly efficient catalytic electrodes. | Mengxia Li Tianxi Zheng Dongfei Lu Shiwei Dai Xin Chen Xinchen Pan Dibo Dong Rengui Weng Gang Xu Fanan Wang | 2023 | Journal of Energy Chemistry2023，，9： | 1 |
| 11 | Environmentally persistent free radicals in PM_(2.5):a review显示文摘Environmentally persistent free radicals(EPFRs)are a new class of pollutants that are long-lived in fine particles(PM_(2.5)),i.e.,their 1/e lifetime ranges from days to months(or even infinite).They are capable of producing harmful reactive oxygen species such as hydroxyl radicals.The redox cycling of EPFRs is considered as an important pathway for PM_(2.5) to induce oxidative stress inside the humans,causing adverse health effects such as respiratory and cardiovascular diseases.Conse-quently,research regarding their toxicity,formation and environmental occurrences in PM_(2.5) has attracted increasing atten-tions globally during the past two decades.However,literature data in this field remain quite limited and discrete.Hence,an extensive review is urgently needed to summarize the current understanding of this topic.In this work,we systematically reviewed the analytical methods and environmental occurrences,e.g.,types,concentrations,and decay behaviors,as well as possible sources of EPFRs in PM_(2.5).The types of pretreatment methods,g-values of common EPFRs and categories of decay processes were discussed in detail.Moreover,great efforts were made to revisit the original data of the published works of EPFRs in airborne particulate matter and provided additional useful information for comparison where possible,e.g.,their mean and standard deviation of g-values,line widths(ΔHp-p),and concentrations.Finally,possible research opportunities were highlighted to further advance our knowledge of this emerging issue. | Mengxia Xu Tao Wu Yu-Ting Tang Tong Chen Lavrent Khachatryan Poornima Ramesh Iyer Dengting Guo Anran Chen Miao Lyu Jinhu Li Jiaqi Liu Dan Li Yuxin Zuo Shihan Zhang Yiran Wang Yining Meng Fei Qi | 2019 | Waste Disposal and Sustainable Energy2019，1，3： | 0 |
| 12 | Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer显示文摘Background:Nuclear Yes1-associated transcriptional regulator(YAP1)promotes tumor progression.However,the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.Our research aimed to explore the biological function of cytoplasmic YAP1 in breast cancer cells and the possibility of cytoplasmic YAP1 as a predictive marker of breast cancer survival.Methods:We constructed cell mutant models,including NLS-YAP15SA(nuclear localized),YAP1S94A(incapable of binding to the TEA domain transcription factor family)and YAP1S127D(cytoplasmic localized),and used Cell Counting Kit-8(CCK-8)assays,5-ethynyl-2’-deoxyuridine(EdU)incorporation assays,and Western blotting(WB)analysis to detect cell proliferation and apoptosis.The specific mechanism of cytoplasmic YAP1-mediated endosomal sorting complexes required for transport III(ESCRT-III)assembly was studied by co-immunoprecipitation,immunofluorescence staining,and WB analysis.Epigallocatechin gallate(EGCG)was used to simulate YAP1 retention in the cytoplasm in in vitro and in vivo experiments to study the function of cytoplasmic YAP1.YAP1 binding to NEDD4-like E3 ubiquitin protein ligase(NEDD4L)was identified using mass spectrometry and was verified in vitro.Breast tissue microarrays were used to analyze the relationship between cytoplasmic YAP1 expression and the survival of breast cancer patients.Results:YAP1 was mainly expressed in the cytoplasm in breast cancer cells.Cytoplasmic YAP1 promoted autophagic death of breast cancer cells.Cytoplasmic YAP1 bound to the ESCRT-III complex subunits charged multivesicular body protein 2B(CHMP2B)and vacuolar protein sorting 4 homolog B(VPS4B),promoting assembly of CHMP2B-VPS4B and activating autophagosome formation.EGCG retained YAP1 in the cytoplasm,promoting the assembly of CHMP2B-VPS4B to promote autophagic death of breast cancer cells.YAP1 bound to NEDD4L,and NEDD4L mediated ubiquitination and degradation of YAP1.Breast tissue microarrays revealed that high levels of cytoplasmic YAP1 were beneficial to the survival of breast cancer patients.Conclusions:Cytoplasmic YAP1 mediated autophagic death of breast cancer cells by promoting assembly of the ESCRT-III complex;furthermore,we established a new breast cancer survival prediction model based on cytoplasmic YAP1 expression. | Yan Guo Yuqing Cui Yangyang Li Xiaoying Jin Dandan Wang Mengxia Lei Fengzhi Chen Yali Liu Jinwen Xu Guanyu Yao Guangchun Zeng Xuesong Chen | 2023 | Cancer Communications2023，43，5： | 0 |
| 13 | U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3'end processing core factors显示文摘In eukaryotic cells,both alternative splicing and alternative polyadenylation(APA)play essential roles in the gene regulation network.U1 small ribonucleoprotein particle(U1 snRNP)is a major component of spliceosome,and U1 snRNP complex can suppress proximal APA sites through crosstalking with 3end processing factors.However,here we show that both knockdown and overexpression of SNRPA,SNRPC,SNRNP70,and SNRPD2,the U1 snRNP proteins,promote the usage of proximal APA sites at the transcriptome level.SNRNP70 can drive the phase transition of PABPN1 from droplet to aggregate,which may reduce the repressive effects of PABPN1 on the proximal APA sites.Additionally,SNRNP70 can also promote the proximal APA sites by recruiting CPSF6,suggesting that the function of CPSF6 on APA is related with other RNA-binding proteins and cell context-dependent.Consequently,these results reveal that,on the contrary to U1 snRNP complex,the free proteins of U1 snRNP complex can promote proximal APA sites through the interaction with 3end processing machinery. | Zhijie Hu Mengxia Li Zhanfeng Huo Liutao Chen Susu Liu Ke Deng Xin Lu Shangwu Chen Yonggui Fu Anlong Xu | 2022 | Journal of Molecular Cell Biology2022，14，8： | 0 |
| 14 | Electrocatalytic CO_(2) reduction to C_(2)H_(4): From lab to fab显示文摘The global concerns of energy crisis and climate change,primarily caused by carbon dioxide(CO_(2)),are of utmost importance.Recently,the electrocatalytic CO_(2) reduction reaction(CO_(2)RR) to high value-added multi-carbon(C_(2+)) products driven by renewable electricity has emerged as a highly promising solution to alleviate energy shortages and achieve carbon neutrality.Among these C_(2+) products,ethylene(C_(2)H_(4))holds particular importance in the petrochemical industry.Accordingly,this review aims to establish a connection between the fundamentals of electrocatalytic CO_(2) reduction reaction to ethylene(CO_(2)RRto-C_(2)H_(4)) in laboratory-scale research(lab) and its potential applications in industrial-level fabrication(fab).The review begins by summarizing the fundamental aspects,including the design strategies of high-performance Cu-based electrocatalysts and advanced electrolyzer devices.Subsequently,innovative and value-added techniques are presented to address the inherent challenges encountered during the implementations of CO_(2)RR-to-C_(2)H_(4) in industrial scenarios.Additionally,case studies of the technoeconomic analysis of the CO_(2)RR-to-C_(2)H_(4) process are discussed,taking into factors such as costeffectiveness,scalability,and market potential.The review concludes by outlining the perspectives and challenges associated with scaling up the CO_(2)RR-to-C_(2)H_(4) process.The insights presented in this review are expected to make a valuable contribution in advancing the CO_(2)RR-to-C_(2)H_(4) process from lab to fab. | Zeyu Guo Fabao Yang Xiaotong Li Huiwen Zhu Hainam Do Kam Loon Fow Jonathan D.Hirst Tao Wu Qiulin Ye Yaqi Peng Hao Bin Wu Angjian Wu Mengxia Xu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 15 | Graphitic carbon nitride, a saturable absorber material for the visible waveband显示文摘For the first time to our knowledge, graphitic carbon nitride(g-C_3N_4) nanosheets are found to be an excellent saturable absorber material in the visible waveband. g-C_3N_4 exhibits much stronger saturable absorption in this region than in the near-infrared region, unlike other two-dimensional materials such as graphene and black phosphorus. By the Z-scan method, the nonlinear absorption coefficient β of the material is first measured at three visible wavelengths, and for g-C_3N_4 it is -2.05,-0.34, and -0.11 cm · GW^(-1) at 355, 532, and 650 nm,respectively. These are much larger than -0.06 cm · GW^(-1) at 1064 nm. | MENGXIA WANG FUKUN MA ZHENGPING WANG DAWEI HU XINGUANG XU XIAOPENG HAO | 2018 | Photonics Research2018，6，4： | 0 |
| 16 | Classification of vegetative types in Changbai Mountain based on optical and microwave remote sensing data显示文摘Highly accurate vegetative type distribution information is of great significance for forestry resource monitoring and management.In order to improve the classification accuracy of forest types,Sentinel-1 and 2 data of Changbai Mountain protection development zone were selected,and combined with DEM to construct a multi-featured random forest type classification model incorporating fusing intensity,texture,spectral,vegetation index and topography information and using random forest Gini index(GI)for optimization.The overall accuracy of classification was 94.60%and the Kappa coefficient was 0.933.Comparing the classification results before and after feature optimization,it shows that feature optimization has a greater impact on the classification accuracy.Comparing the classification results of random forest,maximum likelihood method and CART decision tree under the same conditions,it shows that the random forest has a higher performance and can be applied to forestry research work such as forest resource survey and monitoring. | YANG Ying XU Mengxia LI Sheng WANG Mingchang LIU Ziwei ZHAO Shijun | 2023 | Global Geology2023，26，2： | 0 |
| 17 | Two Comments on Predictive Picture Coding显示文摘TwoCommentsonPredictivePictureCodingXuMengxia(PekingUniversity,Beijing100871)AbstractTwocommentsonpredictivepicturecodingare... | Xu Mengxia(Peking University, Beijing 100871) | 1998 | 通信学报1998，19，5： | 0 |
| 18 | Oxygen defect modulating the charge behavior in titanium dioxide for boosting photocatalytic nitrogen fixation performance显示文摘Extremely high-temperature and high-pressure requirement of Haber-Bosch process motivates the search for a sustainable ammonia synthesis approach under mild conditions.Photocatalytic technology is a potential solution to convert N2 to ammonia.However,the poor light absorption and low charge carrier separation efficiency in conventional semiconductors are bottlenecks for the application of this technology.Herein,a facile synthesis of anatase TiO_(2)nanosheets with an abundance of surface oxygen vacancies(TiO_(2)-OV)via the calcination treatment was reported.Photocatalytic experiments of the prepared anatase TiO_(2)samples showed that TiO_(2)-OV nanosheets exhibited remarkably increased ammonia yield for solar-driven N2 fixation in pure water,without adding any sacrificial agents.EPR,XPS,XRD,UV-Vis DRS,TEM,Raman,and PL techniques were employed to systematically explore the possible enhanced mechanism.Studies revealed that the introduced surface oxygen vacancies significantly extended the light absorption capability in the visible region,decreased the adsorption and activation barriers of inert N2,and improved the separation and transfer efficiency of the photogenerated electronhole pairs.Thus,a high rate of ammonia evolution in TiO_(2)-OV was realized.This work offers a promising and sustainable approach for the efficient artificial photosynthesis of ammonia. | Mengxia Ji Nianhua Liu Kai Li Qing Xu Gaopeng Liu Bin Wang Jun Di Huaming Li Jiexiang Xia | 2023 | Materials Reports(Energy)2023，3，4： | 0 |
| 19 | Urban agriculture as nature-based solutions:Three key strategies to tackle emerging issues on food security in Chinese cities under climatic and non-climatic challenges显示文摘1Introduction Achieving food and water security,according to the United Nations Sustainable Development Goals(SDGs),only requires a minimal environmental cost(Batalini de Macedo et al.,2022).However,in terms of agriculture,blindly devoting efforts to offset low-productivity farming or production techniques and industries,without systematic water,fertiliser,farm residue,tillage,and fallow management,will eventually interrupt the carbon sink under the soil and escalate greenhouse gas emissions,which is not helpful to meeting global climate targets.Thus,sciencebased land management practices are essential to decouple agricultural productivity from greenhouse gas emissions(Buscardo et al.,2021). | Zhe ZHU Jiayu WANG Faith Ka Shun CHAN Yuyao XU Gang LI Mengxia XU Wei-Qiang CHEN Yong-Guan ZHU | 2023 | Frontiers of Engineering Management2023，10，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员