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| 1 | Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury显示文摘Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants and the leading cause of cerebral palsy. PVL is characterized by selective white-matter damage with prominent oligodendroglial injury. The maturation-dependent vulnerability of developing and premyelinating oligodendrocytes to excitotoxic, oxidative, and inflammatory forms of injury is a major factor in the pathogenesis of PVL. Recent studies using mouse models of PVL reveal that synapses between axons and developing oligodendrocytes are quickly and profoundly damaged in immature white matter. Axon-glia synapses are highly vulnerable to white-matter injury in the developing brain, and the loss of synapses between axons and premyelinating oligodendrocytes occurs before any cellular loss in the immature white matter. Microglial activation and astrogliosis play important roles in triggering white-matter injury. Impairment of white-matter development and function in the neonatal period contributes critically to functional and behavioral deficits. Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities. | Xiao-Bo Liu Yan Shen Jennifer M.Plane Wenbin Deng | 2013 | Neuroscience Bulletin2013，29，2： | 17 |
| 2 | Mesozoic-Cenozoic Basin Features and Evolution of Southeast China显示文摘对早第三纪(T_3-E ) 晚三叠纪盆占据 143100 km2 的一个区域,是 SE 中国的全部的第六个区域;同步 granitoid 的全部的区域是 about127300 km^2;它为理解华南的构造进化提供一把钥匙。从 SE 中国的中生代新生代盆的一张 new1:1500000 地质图,与分析结合了几何并且 petrological 特征,盆 tectonics 的一些新卓见被获得。Advancesinclude petrotectonic 集合,地球动力学的盆分类,几何特征,盆和范围的关系。根据形成盆的地球动力学的机制, SE 中国的 theMesozoic 新生代盆能也就是被划分成三种类型:1 ) 形成从的帕拉低岬盆对在有压缩性的条件下面的早侏罗记(T_3-J_1 ) 晚三叠纪;2 ) 在中间的侏罗记(J_2 ) 期间形成在下面的裂缝盆一强烈前紧张的设定;并且 3 ) 在背弧扩展下面在早白垩纪期间形成到早第三纪(K_1-E ) 的指责的消沉行动。盆的 Fromthe 岩石集合,指责的消沉能被细分进主要在早白垩纪(K_1 ) 期间形成的 avolcanic 沉积的类型和从迟了的白垩纪形成到早第三纪(K_2-E ) 的一种红床类型。统计数据建议 allpara 低岬盆(T_3-J_1 ) 的区域是 15120 km^2,裂缝盆(J_2 ) 之一包括 37850 km^2 的 K_2-E 红床的盆占据 4640 km^2,和等于 124330 km^2 的所有指责的消沉。EarlyMesozoic (T_3-J_1 ) 盆和花岗石主要在一个碰撞以后的压缩背景下面被共同产生,当从到早第三纪(J_2-E ) 的侏罗记主要是的中间的盆由地区性的前抑制了紧张的 tectonics 时。三地质并且地理带也就是被调查:1 ) 把古地理学和气候的地区与中间的侏罗记分开到的 Wuyishan 第三级;2 ) 中间的侏罗记裂缝地区;并且 3 ) 近来分开地区的 Ganjiang 中生代火山作用。盆花岗石关系的 Threetypes 被识别了,包括有压缩性(一些) ,走向滑倒(一些) ,和前紧张(普通) 。SE-Chinabasin 的三阶段的地球动力学的进化被提出:一个早中生代盆花岗石框架;过渡中间的侏罗记构造政体;intracontinental 扩展和红床的指责的消沉自从迟了的白垩纪。 | SHU Liangshu ZHOU Xinmin DENG Ping ZHU Wenbin | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 15 |
| 3 | Battery Technologies for Grid-Level Large-Scale Electrical Energy Storage显示文摘Grid-level large-scale electrical energy storage(GLEES) is an essential approach for balancing the supply–demand of electricity generation, distribution, and usage. Compared with conventional energy storage methods, battery technologies are desirable energy storage devices for GLEES due to their easy modularization, rapid response, flexible installation, and short construction cycles. In general, battery energy storage technologies are expected to meet the requirements of GLEES such as peak shaving and load leveling, voltage and frequency regulation, and emergency response, which are highlighted in this perspective. Furthermore, several types of battery technologies, including lead–acid, nickel–cadmium, nickel–metal hydride, sodium–sulfur, lithium-ion, and flow batteries, are discussed in detail for the application of GLEES. Moreover, some possible developing directions to facilitate efforts in this area are presented to establish a perspective on battery technology, provide a road map for guiding future studies, and promote the commercial application of batteries for GLEES. | Xiayue Fan Bin Liu Jie Liu Jia Ding Xiaopeng Han Yida Deng Xiaojun Lv Ying Xie Bing Chen Wenbin Hu Cheng Zhong | 2020 | Transactions of Tianjin University2020，26，2： | 11 |
| 4 | Electrochemical measurements used for assessment of corrosion and protection of metallic materials in the field:A critical review显示文摘Corrosion degradation is detrimental to metal structures as it shortens their lifetime and leads to huge economic losses and unexpected disasters.Therefore,the detection and monitoring of corrosion degradation is of great importance.Herein,we briefly review the state-of-the-art electrochemical methods,instrumentation(based on virtual instrumentation),and advanced sensor/probes that are used in the field for the assessment of corrosion damage.Typical corrosion monitoring results,some of which have been obtained at Tianjin University in the past 30 years,for metallic materials and organic coating/metal systems in atmospheric,marine,and soil conditions in the field are presented.Detection methods,data analysis,and theoretical and mathematical models regarding each corrosion system are discussed,and the challenges,problems and possible solutions for each case are suggested.Lastly,future developments,such as wireless,intelligent,and automatic electrochemical measurement,that will augment the present electrochemical methods of evaluating corrosion degradation are summarized. | Da-Hai Xia Cheng-Man Deng Digby Macdonald Sina Jamali Douglas Mills Jing-Li Luo Michael G.Strebl Mehdi Amiri Weixian Jin Shizhe Song Wenbin Hu | 2022 | Journal of Materials Science & Technology2022，，17： | 8 |
| 5 | Heterogeneous lamellar-edged Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray for efficient and stable seawater oxidation显示文摘Development of efficient non-precious catalysts for seawater electrolysis is of great significance but challenging due to the sluggish kinetics of oxygen evolution reaction(OER)and the impairment of chlorine electrochemistry at anode.Herein,we report a heterostructure of Ni_(3)S_(2)nanoarray with secondary Fe-Ni(OH)_(2)lamellar edges that exposes abundant active sites towards seawater oxidation.The resultant Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray works directly as a free-standing anodic electrode in alkaline artificial seawater.It only requires an overpotential of 269 mV to afford a current density of 10 mA·cm^(-2)and the Tafel slope is as low as 46 m V·dec^(-1).The 27-hour chronopotentiometry operated at high current density of 100 mA·cm^(-2)shows negligible deterioration,suggesting good stability of the Fe-Ni(OH)_(2)/Ni_(3)S_(2)@NF electrode.Faraday efficiency for oxygen evolution is up to〜95%,revealing decent selectivity of the catalyst in saline water.Such desirable catalytic performance could be benefitted from the introduction of Fe activator and the heterostructure that offers massive active and selective sites.The density functional theory(DFT)calculations indicate that the OER has lower theoretical overpotential than Cl_(2) evolution reaction in Fe sites,which is contrary to that of Ni sites.The experimental and theoretical study provides a strong support for the rational design of high-performance Fe-based electrodes for industrial seawater electrolysis. | Baihua Cui Zheng Hu Chang Liu Siliang Liu Fangshuai Chen Shi Hu Jinfeng Zhang Wei Zhou Yida Deng Zhenbo Qin Zhong Wu Yanan Chen Lifeng Cui Wenbin Hu | 2021 | Nano Research2021，14，4： | 7 |
| 6 | Intensive phototherapy vs.exchange transfusion for the treatment of neonatal hyperbilirubinemia:a multicenter retrospective cohort study显示文摘Background:Intensive phototherapy(IPT)and exchange transfusion(ET)are the main treatments for extreme hyperbilirubinemia.However,there is no reliable evidence on determining the thresholds for these treatments.This multicenter study compared the effectiveness and complications of IPT and ET in the treatment of extreme hyperbilirubinemia.Methods:This retrospective cohort study was conducted in seven centers from January 2015 to January 2018.Patients with extreme hyperbilirubinemia that met the criteria of ET were included.Patients were divided into three subgroups(low-,medium-,and high-risk)according to gestational week and risk factors.Propensity score matching(PSM)was performed to balance the data before treatment.Study outcomes included the development of bilirubin encephalopathy,duration of hospitalization,expenses,and complications.Mortality,auditory complications,seizures,enamel dysplasia,ocular motility disorders,athetosis,motor,and language development were evaluated during follow-up at age of 3 years.Results:A total of 1164 patients were included in this study.After PSM,296 patients in the IPT only group and 296 patients in the IPT plus ET group were further divided into the low-,medium-,and high-risk subgroups with 188,364,and 40 matched patients,respectively.No significant differences were found between the IPT only and IPT plus ET groups in terms of morbidity,complications,and sequelae.Hospitalization duration and expenses were lower in the low-and medium-risk subgroups in the IPT only group.Conclusions:In this study,our results suggest that IPT is a safe and effective treatment for extreme hyperbilirubinemia.The indication of ET for patients with hyperbilirubinemia could be stricter.However,it is necessary to have a contingency plan for emergency ET as soon as IPT is commenced especially for infants with risk factors.If IPT can be guaranteed and proved to be therapeutic,ET should be avoided as much as possible. | Meng Zhang Yang He Jun Tang Wenbin Dong Yong Zhang Benjin Zhang Hong Wan Quanmin Deng Lirong Guan Bin Xia Zhong Chen Min Ge Jing Zhao Wenxing Li Jingjun Pei Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，5： | 7 |
| 7 | Thermal Shock-Activated Spontaneous Growing of Nanosheets for Overall Water Splitting显示文摘Nanomaterials based on nickel foam(NF) have been widely applied in energy conversion and storage field.Traditional synthesis methods such as hydrothermal method which is dangerous and high cost limited the scalable developments.Herein,we report a fast,simple,and low-cost synthesis method of nanomaterials based on NF by Joule-heating and water soaking treatment.Thin carbon-coated CoS on NF(NF-C/CoS) was synthesized by Joule-heating for a few seconds with rapid cooling.And then,NF-C/CoS/NiOOH with core-shell heterostructure was fabricated by soaking treatment of NF-C/CoS in water on which NiOOH nanosheets grew spontaneously.The formation mechanism is proposed that the coordination complex precursor converts into C/CoS on NF driven by Joule-heating,and the nickel on the surface of NF is activated to form metastable nickel simultaneously.The metastable nickel reacting with water leads to the formation of NiOOH,and the induction of CoS makes NiOOH grow continuously.This synthesis technology provides a new route to manufacture NF-based nanostructures,and the as-fabricated NF-C/CoS/NiOOH exhibits great potential as electrocatalyst for oxygen evolution reaction and hydrogen evolution reaction. | Han Wu Qi Lu Jinfeng Zhang Jiajun Wang Xiaopeng Han Naiqin Zhao Wenbin Hu Jiajun Li Yanan Chen Yida Deng | 2020 | Nano-Micro Letters2020，12，11： | 6 |
| 8 | Environmentally Tough and Stretchable MXene Organohydrogel with Exceptionally Enhanced Electromagnetic Interference Shielding Performances显示文摘Conductive hydrogels have potential applications in shielding electromagnetic(EM)radiation interference in deformable and wearable electronic devices,but usually suffer from poor environmental stability and stretching-induced shielding performance degradation.Although organohydrogels can improve the environmental stability of materials,their development is at the expense of reducing electrical conductivity and thus weakening EM interference shielding ability.Here,a MXene organohydrogel is prepared which is composed of MXene network for electron conduction,binary solvent channels for ion conduction,and abundant solvent-polymer-MXene interfaces for EM wave scattering.This organohydrogel possesses excellent anti-drying ability,low-temperature tolerance,stretchability,shape adaptability,adhesion and rapid self-healing ability.Two effective strategies have been proposed to solve the problems of current organohydrogel shielding materials.By reasonably controlling the MXene content and the glycerol-water ratio in the gel,MXene organohydrogel can exhibit exceptionally enhanced EM interference shielding performances compared to MXene hydrogel due to the increased physical cross-linking density of the gel.Moreover,MXene organohydrogel shows attractive stretching-enhanced interference effectiveness,caused by the connection and parallel arrangement of MXene nanosheets.This well-designed MXene organohydrogel has potential applications in shielding EM interference in deformable and wearable electronic devices. | Yuanhang Yu Peng Yi Wenbin Xu Xin Sun Gao Deng Xiaofang Liu Jianglan Shui Ronghai Yu | 2022 | Nano-Micro Letters2022，14，5： | 6 |
| 9 | Electron Probe Microanalysis of Monazite and Its Applications to U-Th-Pb Dating of Geological Samples显示文摘Electron probe microanalysis(EPMA) dating of monazite has been developed over decades. However, limited by the detectability and analytical sensitivity of dating-related elements(Th, Pb, U and Y), the EPMA dating has been restricted to geological research. In this study, various probe currents, beam diameters and counting times have been utilized on a JEOL JXA-8230 electron microprobe to determine the optimal experimental conditions for measuring Th, Pb, U and Y in monazite. The optimal conditions are:(1) accelerating voltage is 15 k V;(2) probe current is 100 n A;(3) beam diameter is 1 μm;(4) the peak and background counting time of U and Pb are 200 and 100 s;and(5) the peak and background counting time of Th and Y are 100 and 50 s. We apply this method to monazite from garnet-bearing biotite gneiss in the Zanhuang area of the Central Orogenic Belt of the North China Craton. The Pb O-Th O2* isochron age calculated by EPMA data is 1 812±17 Ma(MSWD=2.06), which is similar to the weighted mean 207 Pb/206 Pb age(1 805±12 Ma, MSWD=1.07) obtained by LA-ICP-MS. This study suggests that EPMA dating of monazite as a powerful dating technique can be widely used in geochronological study. | Wenbin Ning Junpeng Wang Deng Xiao Fenfang Li Bo Huang Dong Fu | 2019 | Journal of Earth Science2019，30，5： | 5 |
| 10 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 11 | Carbon-based cathode materials for rechargeable zinc-air batteries: From current collectors to bifunctional integrated air electrodes显示文摘Rechargeable zinc-air batteries(ZABs)have attracted much attention as the next-generation energy conversion and storage devices due to the abundance and environmental friendliness of zinc(Zn)for anode materials,as well as the safety and low cost of aqueous electrolytes.However,rational design of nonprecious and low-cost integrated air cathode materials with a desirable bifunctional oxygen electrocatalytic performance remains a great challenge for the commercialization of rechargeable ZABs.In previous research studies,various cost-effective carbon-supported electrocatalysts and light-weight carbon-based current collectors for air cathodes have been developed,showing vast potential in the application of carbon-based materials.To improve the bifunctional performance and integration of air cathodes,efforts with respect to the design of morphology,defects,and synergistic effects of carbon-based materials have been made.In this perspective,the general understanding of the air cathode construction and the battery working mechanism is discussed.The recent progress in the design of carbon-based materials for air cathodes in rechargeable ZABs is summarized.Several possible future research directions and the expected development trends are also discussed,aiming to facilitate the commercialization of advanced rechargeable ZABs in our life. | Jingkun Wu Bin Liu Xiayue Fan Jia Ding Xiaopeng Han Yida Deng Wenbin Hu Cheng Zhong | 2020 | Carbon Energy2020，2，3： | 4 |
| 12 | CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma显示文摘To the Editor:CD19-targeting chimeric antigen receptor T(CAR-T)cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage malignancies.However,relapse with CD19-negative tumor after treatment with anti-CD19 CAR-T cells has been reported in different types of B-cell lymphoid malignancies,with a percentage exceeding 10% in patients with acute lymphoblastic leukemia[1]and up to 38% in patients with non-Hodgkin lymphoma(NHL)[2]. | Wenhai Deng Panpan Chen Wen Lei Yang Xu Nengwen Xu Jeffrey J.Pu Aibin Liang Wenbin Qian | 2021 | Cancer Communications2021，41，9： | 4 |
| 13 | Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/ Cas9-mediated knock-in显示文摘In mammalian cells,long noncoding RNAs(lncRNAs)form complexes with proteins to execute various biological functions such as gene transcription,RNA processing and other signaling activities.However,methods to track endogenous lncRNA dynamics in live cells and screen for lncRNA interacting proteins are limited.Here,we report the development of CERTIS(CRISPR-mediated Endogenous lncRNA Tracking and Immunoprecipitation System)to visualize and isolate endogenous lncRNA,by precisely inserting a 24-repeat MS2 tag into the distal end of lncRNA locus through the CRISPR7Cas9 technology.In this study,we show that CERTIS effectively labeled the paraspeckle lncRNA NEAT1 without disturbing its physiological properties and could monitor the endogenous expression variation of NEAT1.In addition,CERTIS displayed superior performance on both short-and long-term tracking of NEAT1 dynamics in live cells.We found that NEAT1 and paraspeckles were sensitive to topoisomerase I specific inhibitors.Moreover,RNA Immunoprecipitation(RIP)of the MS2-tagged NEAT1 lncRNA successfully revealed several new protein components of paraspeckle.Our results support CERTIS as a tool suitable to track both spatial and temporal lncRNA regulation in live cells as well as study the lncRNA-protein interactomes. | Bohong Chen Shengcheng Deng Tianyu Ge Miaoman Ye Jianping Yu Song Lin Wenbin Ma Zhou Songyang | 2020 | Protein & Cell2020，11，9： | 4 |
| 14 | Mitochondrial translocator protein(TSPO),astrocytes and neuroinflammation显示文摘Mitochondrial translocator protein(TSPO)has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system(CNS).However,recent findings using conditional knockout animal models contradict the long-held view that TSPO | Olga V.Chechneva Wenbin Deng | 2016 | Neural Regeneration Research2016，11，7： | 3 |
| 15 | 利用COSMIC数据研究顶部电离层O~+扩散流的统计特征显示文摘从等离子体运动方程出发,利用COSMIC星座的掩星数据,借助相关经验模式,计算了太阳活动低年顶部电离层O^+场向扩散速度和扩散通量,并分析了其全球分布和日变化特征.结果表明,白天等离子体扩散速度的方向随高度增加由向下(极向)逐步变为向上(赤道向),方向转变的高度一般在h_mF_2+80 km以下.在白天较高高度,南北磁纬10°~20°存在着向上方向的最大扩散速度和扩散通量;而在夜间,南北磁纬30°~40°存在向下方向的最大扩散速度和扩散通量.在分点,南北半球的扩散通量和扩散速度大致对称;而在至点,扩散通量存在着明显的南北半球不对称现象.另外,不同纬度的扩散速度有着不同的日变化特征. | 陈光明 徐寄遥 Wang Wenbin Lei Jiuhou Deng Yue | 2010 | 空间科学学报2010，30，2： | 2 |
| 16 | Recent advances in Pb-Sn mixed perovskite solar cells显示文摘Organic-inorganic hybrid lead-tin perovskite solar cells(Pb-Sn PSCs)have attracted much attention because of their advantages of low toxicity,variable bandgap,and feasibility for all-perovskite tandem solar cells,and the current power conversion efficiency(PCE)has exceeded 23%.However,due to the rambunctious crystallization process,easily oxidized Sn(Ⅱ)and inadequate energy level arrangement,there are many defects in perovskite films resulting in serious carrier recombination,which makes PCE still lag Pb-based PSCs.The quality of perovskite films is an important factor affecting the overall device performance.The selection and optimization of transport layers not only determines the interface energy level arrangement but also affects the carrier transport.In this paper,the research progress in improving performance of Pb-Sn PSCs in recent years is reviewed from aspects of perovskite layer and transport layers.The profound understanding of different promotion methods is summarized as well.These results have certain guiding significance for the future development and commercial application of Pb-Sn PSCs. | Yanyu Deng Guanhua Ren Danao Han Wenbin Han Zhuowei Li Chunyu Liu Wenbin Guo | 2022 | Journal of Energy Chemistry2022，31，10： | 2 |
| 17 | Engineering cobalt sulfide/oxide heterostructure with atomically mixed interfaces for synergistic electrocatalytic water splitting显示文摘It remains challenging to develop economical and bifunctional electrocatalysts toward oxygen/hydrogen evolution reactions(OER/HER).Herein,we construct Co_(9)S_(8) nanoflakes decorated Co_(3)O_(4) nanoarrays with enriched heterogeneous interface zones on Ni foam(Co_(9)S_(8)@CO_(3)O_(4)/NF)via a novel step-wise approach.The Co_(9)S_(8)@Co_(3)O_(4)/NF hybrid manifests excellent performance with low overpotentials of 130 mV for HER(10 mA·cm^(-2))and 331 mV for OER(100 mA·cm^(-2)),delivering a small voltage of 1.52 V for water splitting at 10 mA·cm^(-2) as well as outstanding catalytic durability,which surpasses precious metals and previously reported earth-abundant nanocatalysts.Further experimental and theoretical investigations demonstrate that the excellent performance is attributed to the followings:(i)Highly conductive Ni facilitates the efficient charge transfer;(ii)porous core-shell nanoarchitecture benefits the infiltration and transportation of gases/ions;(iii)heterogeneous interface zones synergistically lower the chemisorption energy of hydrogen/oxygen intermediates.This work will shed light on the controllable synthesis and engineering of heterostructure nanomaterials for clean energy storage and conversion technologies. | Xiaoyang Wang Yu He Xiaopeng Han Jun Zhao Lanlan Li Jinfeng Zhang Cheng Zhong Yida Deng Wenbin Hu | 2022 | Nano Research2022，15，2： | 2 |
| 18 | Association of human leukocyte antigen-DR-DQ-DP haplotypes with the risk of hepatitis B virus-related hepatocellular carcinoma显示文摘Aim:Genetic polymorphisms of human leukocyte antigen(HLA)class II molecules are associated with chronic hepatitis B virus(HBV)infection.We aimed to investigate the impacts of HLA-II haplotypes on viral evolution and the risks of HBV-caused liver diseases.Methods:HLA-DR-DQ-DP haplotypes were estimated in 1210 healthy controls,296 HBV clearance subjects,301 asymptomatic hepatitis B surface antigen carriers,770 chronic hepatitis B patients,443 HBV-related liver cirrhosis(LC)patients,and 1037 HBV-related hepatocellular carcinoma(HCC)patients.HBV mutations were determined by sequencing.The associations of HLA-DR-DQ-DP haplotypes with viral mutations and the risks of liver diseases were assessed by multivariate logistic regression.Results:Compared to HBV-free subjects,the haplotypes CCAACG,CCGACG,TCAATA,and TCGATA were associated with decreased HCC risk,with an odds ratio(OR)[95%confidence interval(CI)]of 0.62(0.40-0.95),0.60(0.39-0.92),0.73(0.54-0.98),and 0.58(0.42-0.78),respectively.CCAACG,CCGACG,and TCAATA were significantly associated with decreased frequencies of the HCC-risk HBV mutations:preS1 deletion,APOBECsignature HBV mutations in the core promoter and preS regions,A51C/T,G104C/T,and G146C/T.TCGATA and TTAACG were associated with increased LC risk,with an OR(95%CI)of 1.54(1.03-2.30)and 2.23(1.50-3.33),respectively.However,TCGATA and TTAACG were not consistently associated with the cirrhosis-risk HBV mutations.Conclusion:CCAACG,CCGACG,and TCAATA are inversely associated with HCC risk,possibly because they are involved in creating an immune microenvironment attenuating the generation of HCC-risk HBV mutations.TCGATA and TTAACG might predispose the polarity of immunity towards Th17 isotype related to LC. | Yifan Chen Jiansheng Lin Yang Deng Wenbin Liu Zishuai Li Xinyu Zhou Shiliang Cai Rui Pu Jianhua Yin Xiaojie Tan Jun Zhao Xue Han Guangwen Cao | 2022 | Hepatoma Research2022，8，1： | 2 |
| 19 | Empowering sonic hedgehog to rescue brain cells after ischemic stroke显示文摘Ischemic stroke occurs when blood supply to the brain is interrupted.This can cause irreversible injury to the central nervous system(CNS)tissue.Each year in the United States almost 800,000 people experience a new or recurrent stroke.15%of stroke patients die shortly after insult and only 10%recover completely,leaving the | Olga V.Chechneva Wenbin Deng | 2015 | Neural Regeneration Research2015，10，3： | 2 |
| 20 | Geochemistry and Geochronology of Diorite in Pengshan Area of Jiangxi Province:Implications for Magmatic Source and Tectonic Evolution of Jiangnan Orogenic Belt显示文摘Magmatic activities associated with tectonic events play a significant role in understanding the evolution of an orogenic belt.The Jiangnan orogenic belt has been regarded as the collisional suture zone between the Yangtze Block and the Cathaysia Block.Although the magmatic activities during the period of intra-plate extension after the collision have been well studied in recent years,some remaining issues,including source nature and geodynamic mechanism,need to be further addressed.In this paper,based on a detailed field geological,petrological,geochemical and geochronological study,we focus our work on diorites in the Pengshan area located at the northwestern margin of the Jiangnan orogenic belt.The mineral assemblages are mainly composed of plagioclase(55 vol.%-65 vol.%)and hornblende(35 vol.%-45 vol.%).One diorite sample yields zircon^(206)Pb/^(238)U mean age of 768±8 Ma(MSWD=0.29).The diorites have enriched large ion lithophile elements(Ba,K and Rb)and incompatible elements(Th and U),and are depleted in high field-strength elements including Ta,Ti and Nb.Diorites in this study have relatively high MgO content(6.56 wt.%-7.58 wt.%,7.07 wt.%on average)and Mg number values(65-67,65.8 on average).The diorites are metaluminous,high K calc-alkaline series rocks with high contents of K_2O(1.59 wt.%-1.97 wt.%)and total alkali(Na_2O+K_2O=5.56 wt.%-6.05 wt.%).The Nd/Th ratio(4.34-5.27)is higher than that of crust-derived rocks and lower than mantle-derived rocks.The Rb/Sr ratio(0.19-0.22)is slightly lower than crust,but significantly higher than upper mantle.Based on the above geochemical and geochronological analyses,we suggest that the diorites in the Pengshan area were mainly derived from crustal materials with a small amount of mantleoriginated materials involved,and possibly produced from an extensional tectonic setting after the collision between the Yangtze Block and Cathaysia Block. | Hongfeng Shi Junpeng Wang Yuan Yao Jing Zhang Song Jin Yingxin Zhu Kang Jiang Xiaolong Tian Deng Xiao Wenbin Ning | 2020 | Journal of Earth Science2020，31，1： | 2 |
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