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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Effect of artificial aeration on the performance of vertical-flow constructed wetland treating heavily polluted river water显示文摘Three lab-scale vertical-flow constructed wetlands(VFCWs),including the non-aerated(NA),intermittently aerated(IA) and continuously aerated(CA) ones,were operated at different hydraulic loading rates(HLRs) to evaluate the effect of artificial aeration on the treatment efficiency of heavily polluted river water.Results indicated that artificial aeration increased the dissolved oxygen(DO) concentrations in IA and CA,which significantly favored the removal of organic matter and NH 4 +-N.The DO grads caused by intermittent aeration formed aerobic and anoxic regions in IA and thus promoted the removal of total nitrogen(TN).Although the removal efficiencies of COD Cr,NH 4 +-N and TN in the three VFCWs all decreased with an increase in HLR,artificial aeration enhanced the reactor resistance to the fluctuation of pollutant loadings.The maximal removal efficiencies of COD Cr,NH 4 +-N and total phosphorus(TP)(i.e.,81%,87% and 37%,respectively) were observed in CA at 19 cm/day HLR,while the maximal TN removal(i.e.,57%) was achieved in IA.Although the improvement of artificial aeration on TP removal was limited,this study has demonstrated the feasibility of applying artificial aeration to VFCWs treating polluted river water,particularly at a high HLR. | Huiyu Dong Zhimin Qiang Tinggang Li Hui Jin Weidong Chen | 2012 | Journal of Environmental Sciences2012，24，4： | 38 |
| 3 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 4 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 5 | Heat-treated microstructure and mechanical properties of laser solid forming Ti-6Al-4V alloy显示文摘The effects of heat treatment on the microstructure and mechanical properties of laser solid forming (LSF) Ti-6Al-4V alloy were investigated. The influences of the temperature and time of solution treatment and aging treatment were analyzed. The results show that the microstructure of LSFed samples consists of Widmanstatten α laths and a little acicular in columnar prior β grains with an average grain width of 300 μm, which grow epitaxially from the substrate along the deposition direction (Z). Solution treatment had an important effect on the width, aspect ratio, and volume fraction of primary and secondary α laths, and aging treatment mainly affects the aspect ratio and volume fraction of primary α laths and the width and volume fraction of secondary α laths. Globular α phase was first observed in LSFed samples when the samples were heat treated with solution treatment (950°C, 8 h/air cooling (AC)) or with solution treatment (950°C, 1 h/AC) and aging treatment (550°C, above 8 h/AC), respectively. The coarsening and globularization mechanisms of α phase in LSFed Ti-6Al-4V alloy during heat treatment were presented. To obtain good integrated mechanical properties for LSFed Ti-6Al-4V alloys, an optimized heat treatment regimen was suggested. | ZHANG Shuangyin LIN Xin CHEN Jing HUANG Weidong | 2009 | Rare Metals2009，28，6： | 22 |
| 6 | Flow Characteristics Diagnosis and Optimization for Dust Collectors Inflow Duct in Thermal Power Plants显示文摘火电厂烟风道用于输送烟气、冷风等介质,其设计优化水平不但影响火电厂烟风系统阻力的大小,而且影响与烟风道直接相连的各个设备的运行状态。某600MW机组除尘器前烟道设计不合理,存在磨损严重、进入除尘器烟气分配不均等问题,文中采用标准缸￡模型,利用Fluent求解器对该部分烟道的流场进行数值计算,诊断分析其存在的主要问题,提出的3个改造方案均可使烟道阻力大幅度下降、烟道磨损减轻、进入除尘器烟气分配均匀。同时,研究了缓转半径及烟气流速对该段烟道阻力和烟气分配的影响情况,计算结果表明该段烟道缓转半径宜选在0.875以上,烟气流速对该段烟道的性能基本没有影响。 | LIU Ming MENG Guixiang YAN Junjie CHEN Weixiong LI Weidong CHONG Daotong LIU Jiping | 2013 | 中国电机工程学报2013，33，11： | 22 |
| 7 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 8 | Hermetia illucens larvae as a potential dietary protein source altered the microbiota and modulated mucosal immune status in the colon of finishing pigs显示文摘Background: Insects, such as Hermetia illucens larvae, are rich in chitin and proteins, and represent a suitable feed ingredient replacement for animals. However, little is known about the effect of administering H. illucens larvae on intestinal microbiota, bacterial metabolite profiles, and mucosal immune status in animals. This study aimed to investigate the effects of administering H. illucens larvae on colonic microbiota and bacterial metabolites production in finishing pigs. Seventy-two crossbred(Duroc × Landrace × Large White) female pigs(initial body weight, 76.0 ± 0.52 kg) were randomly allocated to three different dietary treatments: a control diet(Control group) and two diets corresponding to 4%(H1 group) and 8%(H2 group) H. illucens larvae inclusion levels, respectively. Each treatment consisted of eight pens(replicates), with three pigs per pen. After 46 days of feeding, eight pigs per treatment(n =8) were slaughtered, and the colonic digesta and mucosa were collected for microbial composition and microbial fermentation products, and genes expression analyses.Results: The results showed that the H1 diet significantly increased the abundance of Lactobacillus,Pseudobutyrivibrio, Roseburia, and Faecalibacterium compared with those in the control group(P < 0.05), with a decrease in the abundance of Streptococcus. The numbers of Lactobacillus, Roseburia, and Clostridium cluster XIVa were significantly greater in the H1 group than in the control group(P < 0.05). Meanwhile, H2 diet increased the number of Clostridium cluster XIVa compared with the control group(P < 0.05). For colonic metabolites, total short chain fatty acids, butyrate, and isobutyrate concentrations were significantly higher in the H1 group than those in the control group(P < 0.05);the H1 treatment caused a striking decrease in protein fermentation compared with the control group, as the concentrations of total amines, cadaverine, tryptamine, phenol, p-cresol, and skatole were significantly lower(P < 0.05). Additionally, H2 diet also increased butyrate concentration compared with control group(P < 0.05), while decreased the concentrations of phenol, p-cresol, and skatole(P < 0.05). Pigs in the H1 group down-regulated the expression of TLR-4 and pro-inflammatory cytokines(IFN-γ) compared with pigs in the control group(P < 0.05), and up-regulated anti-inflammatory cytokine(IL-10) and intestinal barrier genes(ZO-1, occludin, and mucin-1). H2 diet up-regulated the expression of ZO-1 compared with control group(P < 0.05). Furthermore, the changes in the colonic mucosal gene expression were associated with changes in the bacterial composition and their metabolites.Conclusions: Collectively, dietary inclusion of Hermetia illucens larvae may enhance mucosal immune homeostasis of pigs via altering bacterial composition and their metabolites. These findings provide a new perspective on insect meal as a sustainable protein source rich in nutrient ingredients for swine. | Miao Yu Zhenming Li Weidong Chen Ting Rong Gang Wang Xianyong Ma | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 21 |
| 9 | Target observations for improving initialization of high-impact ocean-atmospheric environmental events forecasting显示文摘In this paper, we emphasize the importance of accurate initial conditions in predicting high-impact ocean-atmospheric environmental events, such as El Nin?o-Southern Oscillation(ENSO), Indian Ocean Dipole(IOD), tropical cyclone(TC), and Kuroshio large meander(KLM), by reviewing recent progresses toward target observations for improving the initialization of these events forecasting. Since ield observations are costly and will never be dense enough to fully cover the vast space of these events, it is necessary to develop methodologies that guide the design of eicient and efective observation strategy. Of particular interest is a method called conditional non-linear optimal perturbation(CNOP), which has been shown to be very useful in determining the sensitive areas for target observations applicable to the predictions of ENSO, IOD, TC, and KLM. Further studies are needed to understand the predictability of these events under the inluence of climate change, and to explore the possibility of implementing ield programs of target observations. hese studies are challenging but are crucially important for improving our forecast skill of the high-impact ocean-atmospheric environmental events, and thus for disaster prevention,climate change mitigation, and sustainable socio-economic development. | Mu Mu Wansuo Duan Dake Chen Weidong Yu | 2015 | National Science Review2015，2，2： | 21 |
| 10 | CLASSIFICATION OF MPSK SIGNALS USING CUMULANT INVARIANTS显示文摘A new feature based on higher order statistics is proposed for classification of MPSKsignals, which is invariant with respect to translation (shift), scale and rotation transforms of MPSK signal constellations, and can suppress additive color or white Gaussian noise. Application of the new feature to classification of MPSK signals, at medium signal-to-noise ratio with specified sample size, results in high probability of correct identification. Finally, computer simulations and comparisons with existing algorithms are given. | Yang Shaoquan Chen Weidong (School of Electronic Engineering, Xidian University, Xi’an 710071) | 2002 | Journal of Electronics(China)2002，19，1： | 20 |
| 11 | Status quo of soil petroleum contamination and evolution of bioremediation显示文摘Along with the rapid development of oil industries internationally,petroleum prospecting and exploitation activities are growing intensively.Especially in China,with the fastest economic growth in the world and shortage of petroleum resources,we are leading the practices of petroleum deep exploitation.Obviously,the risk of damage to the natural environment from these activities is high.Oil contamination in soils and groundwater is becoming a big issue along with pesticide pollution,which makes organic pollution prevention and control (OPPC) much more complex.In this paper,based on recent research on oil-contaminated soil at home and abroad,we make comments on the remediation technologies for polluted soil,emphasizing bioremediation techniques and degradation mechanisms in order to push forward research into bound organic pollution prevention and control (OPPC),especially in China. | Du Weidong Wan Yunyang Zhong Ningning Fei Jiajia ZhangZhihuan Chen Lijun Hao Jiming | 2011 | Petroleum Science2011，8，4： | 19 |
| 12 | Size distribution and diffuse pollution impacts of PAHs in street dust in urban streams in the Yangtze River Delta显示文摘Particles of dust washed off streets by stormwater are an important pathway of polyaromatic hydrocarbons(PAHs) into urban streams.This article presented a comprehensive assessment of the size distribution of PAHs in street dust particles,the potential risks of the particles in urban streams,and the sources and sinks of PAHs in the stream network.This assessment was based on measurements of 16 PAHs from the USEPA priority list in street dust particles and river sediments in Xincheng,China.The content of total PAHs ranged from 1629 to 8986 μg/kg in street dust particles,where smaller particles have a higher concentrations.Approximately 55% of the total PAHs were associated with particles less than 250 μm which accounted for 40% of the total mass of street dust.The PAH quantities increased from 2.41 to 46.86 μg/m2 in the sequence of new residential,rising through main roads,old town residential,commercial and industrial areas.The sediments in stream reaches in town were found to be sinks for street dust particle PAHs.The research findings suggested that particle size,land use and the hydrological conditions in the stream network were the factors which most influenced the total loads of PAH in the receiving water bodies. | ZHAO Hongtao YIN Chengqing CHEN Meixue WANG Weidong Jefferies Chris SHAN Baoqing | 2009 | Journal of Environmental Sciences2009，21，2： | 17 |
| 13 | Discharge Characteristics of Long SF6 Gas Gap with and Without Insulator in GIS Under VFTO and LI显示文摘Gas insulator switchgears(GISs),widely used in electric power systems for decades,have many advantages due to their compactness,minimal environmental impact,and long maintenance cycles.However,very fast transient overvoltage(VFTO)increases caused by a rise in voltage levels can lead to GIS insulation failures.In this paper,a generating system of VFTO and standard lightning impulse(LI)is established.The insulation characteristics of SF6 gas with and without insulators under VFTO and standard LI are investigated.Experimental results show that the 50%breakdown voltages of the inhomogeneous electric field rod-plane gap under positive VFTO and standard LI are higher than that under negative VFTO and standard LI.The research shows that the 50%breakdown voltage under VFTO could be lower than that under standard LI at 0.5 MPa for the negative polarity.Moreover,the polarity effect of the insulator without defect is different from that with defect.Similarly,the breakdown voltage of the defective insulator under VFTO could be lower than that under standard LI by 8%.The flashover channel under VFTO is seen as more than that under standard LI.Based on the analysis of discharge images and experimental results,it is concluded that the polarity effect is related to the distortion effect of ion clusters formed by SF6 on the electric field.Additionally,the steepness and front time of impulse plays an important role in the initiation and further development of discharge on insulator surface.Finally,the research shows that different discharge characteristics between VFTO and standard LI may be caused by different wave fronts and oscillation on the tails of the impulses. | Tao Wen Qiaogen Zhang Jingtan Ma Can Guo Haoyang You Yifan Qin Yu Yin Weidong Shi Weijiang Chen | 2015 | CSEE Journal of Power and Energy Systems2015，1，3： | 17 |
| 14 | Adakitic rocks associated with the Shilu copper–molybdenum deposit in the Yangchun Basin,South China,and their tectonic implications显示文摘South China is famous for the extensive magmatism and polymetallic mineralization that took place there in the Mesozoic. Shilu is a large porphyry–skarn Cu–Mo deposit in the Yangchun Basin, South China. The lithology of the Shilu intrusion is granodiorite and quartz diorite, both of which are high-K calc-alkaline series, with high Sr([400 ppm) content along with low Y and Yb contents. Most of the samples have characteristics of adakite except for a few samples that have slightly higher Y and Yb contents, which may be plausibly explained by crustal contamination. Laser Ablation Inductively Coupled Plasma Mass Spectrometry zircon U–Pb dating revealed ages between 106.6 ± 1.3 and 103.9 ± 0.5 Ma, with multiple magmatic pulses. Molybdenite Re–Os isochron age of 102.2 ± 2.9 Ma(MSWD = 9.4) was determined, which is identical to the youngest zircon U–Pb age(103.9 ± 0.5 Ma) within error.The Shilu intrusion has high oxygen fugacity as indicated by high zircon Ce^(4+)/Ce^(3+) and Eu_N/Eu_N* ratios. Considering the geochemical characteristics(high Sr, and low Y and Yb contents), high oxygen fugacity, and copper mineralization of the Shilu intrusion, it was most likely formed by partial melting of a subducted young oceanic slab. Whole-rock Sr–Nd isotope-, zircon Hf isotope-, and whole-rock trace element analyses show that Shilu adakitic magmas may have interacted with type II enriched mantle and/or crustal materials during ascent. South China was affected by the Pacific tectonic regime to the east and the Neo-Tethys tectonic regime to the south in the Cretaceous. Based on the Pacific Plate drifting and rotation history, it is hard to explain how the Pacific Plate would have subducted and melted, forming adakitic rocks in the Shilu region. Considering the tectonic history of Southeast Asia and the South China Sea, the Neo-Tethys trench should have been much closer to the South China Block in the Cretaceous, and thus have had a greater impact on the South China Block. Based on the subduction direction, time of subduction,and distance between the Neo-Tethys subduction zone and the Shilu deposit, subduction of the Neo-Tethys ridge is the best mechanism for explaining the Shilu adakitic rocks and Cu–Mo mineralization. | Lipeng Zhang Yongbin Hu Jinlong Liang Trevor Ireland Youliang Chen Rongqing Zhang Saijun Sun Weidong Sun | 2017 | Acta Geochimica2017，36，2： | 15 |
| 15 | Influence of α/β interface phase on the tensile properties of laser cladding deposited Ti–6Al–4V titanium alloy显示文摘Laser cladding deposited Ti–6Al–4V titanium alloy universally shows more complex microstructures,each of which has significant effect on mechanical properties. Of particular α/β interface phase has been observed in this paper under certain conditions. It demonstrates that the influence of the α/β interface phase on the tensile properties is closely associated with dislocations and twin substructure through comparison experiments. The results show that the α/β interface phase hinders dislocation motion and decreases effective slip length. In addition, the twin substructure has been activated in the α/β interface phase during tensile process and has acted somehow like grain boundaries. Therefore, the strength and the work-hardening rate of the laser cladding deposited Ti–6Al–4V titanium alloy have been significantly improved due to the dynamic Hall–Petch effect. Besides, the α/β interface phase leads to more uniform dislocations distribution, which implies that relative lower local concentrated stress will be produced along the α/β interface phase or colony boundary after the same amount of plastic deformation. Moreover,the twinning-induced plasticity effects in the α/β interface phase further increase the plastic deformation capacity. These results in higher elongation for the laser cladding deposited Ti–6Al–4V titanium alloy.It can be concluded that the current work suggests an effective method to simultaneously improve the strength and plasticity of laser cladding deposited Ti–6Al–4V titanium alloy based on the α/β interface phase. | Zhuang Zhao Jing Chen Shuai Guo Hua Tan Weidong Huang | 2017 | Journal of Materials Science & Technology2017，33，7： | 15 |
| 16 | Long-term changes of phytoplankton community in Xiagu waters of Xiamen,China显示文摘Long-term changes of phytoplankton community by water sampling method in Xiagu Sea waters of Xiamen,China,were investigated in this study.Species composition of the phytoplankton community in these waters changed greatly since the 1950s.The numbers of Dinophyta species increased significantly,although Bacillariophyta species are generally dominant.The succession of dominant species in phytoplankton community is obvious: large-size dominant species such as Biddulphia sinensis of the 1950s were gradually replaced by small-size ones such as Cyclotella striata and Nitzschia closterium,and species that still maintain dominant such as Skeletonema costatum are also small ones,leading the whole phytoplankton community of smaller size.Cell density of phytoplankton community increased greatly,among which cell density of the most dominant species Skeletonema costatum have been increasing in exponent function.Margalef index of phytoplankton community decreased,indicating decline of biodiversity of the community,and dominant character of Skeletonema costatum increased.Generally,the structure of the entire phytoplankton community is becoming more and more singular and unstable,which makes the occurrence of red tides more frequent.The succession in the phytoplankton community is related to the long-term changes in marine environment,influenced by human activities and global climate changes,especially the increases of nutrient content. | CHEN Baohong XU Zhuhua ZHOU Qiulin CHEN Changping GAO Yahui YANG Shengyun JI Weidong | 2010 | Acta Oceanologica Sinica2010，29，6： | 14 |
| 17 | High-precision timing of the Quaternary standard samples with thermal ionization mass spectrometry (TIMS) U-series method显示文摘Two national stalagmite standard (GBW04412, GBW04413) and one international coral standard (RKM4) have been determined by using thermal ionization mass spectrometry (TIMS) method. The values of ( 234 U/ 238 U) act , ( 230 Th/ 234 U) act and age are all consistent in error range with the standard values obtained by using α spectrometry. | Peng Zicheng Wang Zhaorong Sun Weidong Ma Zhibang Xia Ming Zhang Chenhui Chen Wenji Zhang Zhonglu An Zhisheng | 1998 | Chinese Science Bulletin1998，43，4： | 14 |
| 18 | Therapeutic targets of Traditional Chinese Medicine for colorectal cancer显示文摘OBJECTIVE: To explore the role of Traditional Chinese Medicine(TCM) in the prevention and treatment of colorectal cancer and identify possible therapeutic targets of TCM to provide clues for the use of TCM for colorectal cancer prevention and treatment in the clinic and to find novel directions for new drug discovery for colorectal cancer.METHODS: We used Pub Med and Google to search for and collect scientific publications for a full evaluation of current evidence in the literature indicating the potential role of Chinese herbal medicines and their respective ingredients as effective candidatesforcolorectalcancerpreventionandtreatment.RESULTS: We extracted a detailed description of potential therapeutic Chinese herbal medicines and their constituent ingredients that target different mechanisms in colorectal cancer such as gene mutation, dysregulation of signaling pathways, metabolism disorders, and the inflammatory microenvironment, including both conventional and non-conventional approaches.CONCLUSION: TCM may be a promising complementary and alternative therapy for the treatment of colorectal cancer. | Li Weidong Li Chunsheng Zheng Honggang Chen Guohong Hua Baojin | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 14 |
| 19 | Different dietary starch sources alter the carcass traits, meat quality, and the profile of muscle amino acid and fatty acid in finishing pigs显示文摘Background: With increasing health awareness among consumers, the demand for healthier, tastier, higher quality and nutritional value pork is increasing. It has been shown that different dietary starch sources can alter the carcass traits and meat quality. However, research on the effects of different starch sources with clear different amylose/amylopectin ratio on the amino acid and fatty acid composition in Longissimus thoracis(L. thoracis) muscle of pigs is limited. This study aimed to investigate the effects of different dietary starch sources on carcass traits, meat quality, muscle amino acid and fatty acid composition, and the mRNA expression levels of genes involved in lipid metabolism and muscle fiber characteristics in finishing pigs. A total of 72 Duroc × Landrace × Large White barrows were randomly allocated to 3 different dietary treatment groups with 8 replicate pens/group and 3 pigs per pen.Tapioca starch(TS), corn starch(CS), and pea starch(PS), with amylose/amylopectin ratio of 0.11, 0.25, and 0.44,respectively, were used as their dietary starch sources for 40 days.Results: Results showed that the PS diet significantly increased(P < 0.05) the final body weight, average daily gain,loin-eye area, and fat-free lean index compared with the TS diet, but significantly decreased(P < 0.05) the feed to gain ratio and backfat thickness. Compared with the TS diet, PS diet also increased(P < 0.05) the pH45 min, marbling scores, the content of intramuscular fat and inosine monophosphate in the L. thoracis, and decreased(P < 0.05) the drip loss and shear force. In addition, compared with the TS diet, PS diet increased(P < 0.05) the proportions of flavor amino acids, DHA, EPA, and n-3 polyunsaturated fatty acid(PUFA) in the L. thoracis compared with TS diet,but decreased(P < 0.05) the ratio of n-6/n-3 PUFA. Furthermore, compared with the TS diet, PS diet also upregulated(P < 0.05) the lipogenic genes(FAS, LPL, SCD, ACCα) and myosin heavy-chain(MyHC)-IIa mRNA expression levels compared with the TS diet, but downregulated(P < 0.05) the CPT1 B and MyHC-IIb mRNA levels.Conclusions: In conclusion, these results provided compelling evidence that the different dietary starch source altered the carcass traits, meat flavor and quality in finishing pigs, and consumption of a diet with higher amylose/amylopectin ratio results in the production of a healthy, higher quality, and nutritional value pork. | Miao Yu Zhenming Li Ting Rong Gang Wang Zhichang Liu Weidong Chen Jiazhou Li Jianhao Li Xianyong Ma | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 13 |
| 20 | Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV显示文摘 | Dongfang Liu Shuo Tian Kai Zhang Wei Xiong Ndongala Michel Lubaki Zhiying Chen Weidong Han | 2017 | Protein & Cell2017，8，12： | 11 |
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