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| 1 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 2 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 3 | Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats显示文摘OBJECTIVE: To investigate the role of Eclipta prostrata (E. prostrata) extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. METHODS: Rats were divided into five groups, with 10 animals in each group. Aging rats were produced by treatment with 100 mg·kg-1·d-1 of D-galactose for 6 weeks. Rats in the E. prostrata treatment groups received an aqueous extract of E. prostrata orally at a concentration of 50, 100, or 200 mg·kg-1· d-1 for 3 weeks. Animals in both the normal and model groups were treated with similar volumes of saline. Spatial memory performance was measured using the Morris water maze. The mRNA levels and enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were analyzed using real- time quantitative PCR and spectrophotometry,respectively. The levels of induced nitric oxide synthase (iNOS), nitric oxide (NO), dopamine (DA), norepinephrine (NE), and serotonin (5-HT) were determined using enzyme-linked immunosorbent assay and spectrophotometry. RESULTS: Compared with the normal group, rats in the D-galactose-treated model group exhibited significant memory loss. There was severe damage to the hippocampal CA1 area, and expression levels of SOD, CAT, GPx, and GR were significantly decreased in the model group compared with the normal group. In the model group, levels of iNOS and NO were significantly increased compared with the normal group. However, treatment with E. prostrata extract reversed the conditions caused by D-galactose- induced aging, especially in the groups with higher treatment concentrations. Compared with the normal group, the levels of DA, NE, and 5-HT were significantly lower in the D-galactose-treated model group. In the E. prostrata extract-treated groups, however, there was a dose-dependent upregulation of DA, NE, and 5-HT expression. CONCLUSION: Our results suggest that administration of E. prostrata extract can result in an improvement in the learning and memory impairments that are induced by D-galactose treatment in rats. This improvement may be the result of enhanced antioxidative ability, decreased iNOS and NO levels, and the induction of DA, NE, and 5-HT expression in the brain. | Xia Xichao Yu Ruixue Wang Xiaowei Wei Mengwei Yi Li Wang Aimei Ma Yuhong Zhang Junfeng Ji Zhaohui Li Yuan Wang Qiong | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 4 | Reliable Medical Recommendation Based on Privacy-Preserving Collaborative Filtering显示文摘Collaborative filtering(CF)methods are widely adopted by existing medical recommendation systems,which can help clinicians perform their work by seeking and recommending appropriate medical advice.However,privacy issue arises in this process as sensitive patient private data are collected by the recommendation server.Recently proposed privacy-preserving collaborative filtering methods,using computation-intensive cryptography techniques or data perturbation techniques are not appropriate in medical online service.The aim of this study is to address the privacy issues in the context of neighborhoodbased CF methods by proposing a Privacy Preserving Medical Recommendation(PPMR)algorithm,which can protect patients’treatment information and demographic information during online recommendation process without compromising recommendation accuracy and efficiency.The proposed algorithm includes two privacy preserving operations:Private Neighbor Selection and Neighborhood-based Differential Privacy Recommendation.Private Neighbor Selection is conducted on the basis of the notion of k-anonymity method,meaning that neighbors are privately selected for the target user according to his/her similarities with others.Neighborhood-based Differential Privacy Recommendation and a differential privacy mechanism are introduced in this operation to enhance the performance of recommendation.Our algorithm is evaluated using the real-world hospital EMRs dataset.Experimental results demonstrate that the proposed method achieves stable recommendation accuracy while providing comprehensive privacy for individual patients. | Mengwei Hou Rong Wei Tiangang Wang Yu Cheng Buyue Qian | 2018 | Computers, Materials & Continua2018，，7： | 2 |
| 5 | A hexaazatriphenylene fused large discotic polycyclic aromatic hydrocarbon with selective and sensitive metal-ion sensing properties显示文摘A HAT based large PAH discotic molecule PN_(8)is developed. The enlarged chromophoric core and doping heteroatoms enable colorimetric and fluorometric sensing of Cu^(2+)and Zn^(2+)with highly appreciable optical changes, good selectivity and low detection limit. Moreover, PN_(8)was demonstrated as an excellent adsorbent to remove Cu^(2+)and Zn^(2+)from wastewater. | Wenxiu Qu Wei Yuan Mengwei Li Yulan Chen | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 6 | Identification of lipid droplets in gut bacteria显示文摘Dear Editor,The field of gut microbiota is progressing rapidly and thus,appellations like the last human organ,a separate organ,a forgotten organ,and a new organ have been applied to gut microbiota to emphasize its vital functions in our body(Chang and Kao,2019).Gut microbiota has been shown to play a central role in the regulation of human lipid metabolism and be associated with lipid metabolism disorders when aberrant,through composition and microbial metabolites. | Kai Zhang Chang Zhou Zemin Li Xuehan Li Ziyun Zhou Linjia Cheng Ahmed Hammad Mirza Yumeng Shi Bingbing Chen Mengwei Zhang Liujuan Cui Congyan Zhang Taotao Wei Xuelin Zhang Shuyan Zhang Pingsheng Liu | 2023 | Protein & Cell2023，14，2： | 0 |
| 7 | Nanopore sequencing of African swine fever virus显示文摘Dear Editor,African swine fever(ASF)is one of the most pathogenic viral diseases in pigs caused by African swine fever virus(ASFV).The fatality rate is almost 100%,which brings huge economic losses to the hog industry in countries with epiepidemics(Galindo and Alonso,2017).China was the first Asian country to have an ASF epidemic,and it spread quickly across the country after the first epidemic was re・ported in August 2018(Ge et al.,2018).After that,Mongolia,Vietnam,Cambodia and North Korea also reported on the ASF epidemic in succession(OIE,2019). | Lijia Jia Mengwei Jiang Ke Wu Juefu Hu Yang Wang Weipeng Quan Mengchan Hao Haizhou Liu Hongping Wei Wenhui Fan Wenjun Liu Rongliang Hu Depeng Wang Jing Li Jianjun Chen Di Liu | 2020 | Science China(Life Sciences)2020，63，1： | 0 |
| 8 | State diagram of spin-torque oscillator with perpendicular reference layer and planar field generation layer显示文摘The state diagram of spin-torque oscillator(STO) with perpendicular reference layer(REF) and planar field generation layer(FGL) was studied by a macrospin model and a micro-magnetic model. The state diagrams are calculated versus the current density, external field and external field angle. It was found that the oscillation in FGL could be controlled by current density combined with external field so as to achieve a wide frequency range. An optimized current and applied field region was given for microwave assisted magnetic recording(MAMR), considering both frequency and output field oscillation amplitude. The results of the macro-spin model were compared with those of the micro-magnetic model. The macro-spin model was qualitatively different from micro-magnetics and experimental results when the current density was large and the FGL was non-uniform. | Mengwei Zhang Longze Wang Dan Wei Kaizhong Gao | 2015 | Progress in Natural Science:Materials International2015，25，3： | 0 |
| 9 | Deep eutectic solvent-induced synthesis of Ni-Fe catalyst with excellent mass activity and stability for water oxidation显示文摘Ni-Fe bimetallic electrodes are currently recognized as a kind of benchmark transition metal-based oxygen evolution reaction(OER)electrocatalysts.Facile synthesis of Ni-Fe bimetallic electrode materials with excellent catalytic activity and satisfied stability by a simple and low-cost route is still a big challenge.Herein,well-defined Ni-Fe nanoparticles in-situ developed on a planar Fe substrate(Ni-Fe NPs/Fe)is fabricated via a facile one-step galvanic replacement reaction(GRR)carried out in an Ethaline-based deep eutectic solvent(DES).The prepared Ni-Fe NPs/Fe exhibits outstanding OER performance,which needs an overpotential of only 319 mV to drive a current density of 10 mA cm^(-2),with a small Tafel slope of 41.2 mV dec^(-1) in 1.0 mol L^(-1) KOH,high mass activity(up to 319.78 A g^(-1) at an overpotential of 300 mV)and robust durability for 200 h.Impressively,the Ni-Fe bimetallic oxygen-evolution electrode obtained from the Ethaline-based DES is catalytically more active and durable than that of its counterpart derived from the 4.2 mol L^(-1) NaCl aqueous solution.The reason for this is mainly related to the different morphology and surface state of the Ni-Fe catalysts obtained from these different solvent environments,particularly for the differences in phy-chemical properties,active species formed and deposition kinetics,offered by the Ethaline-based DES. | Ruichang Xue Mengwei Guo Zhuoming Wei Qibo Zhang | 2023 | Green Energy & Environment2023，8，3： | 0 |
| 10 | A gap-free and haplotype-resolved lemon genome provides insights into flavor synthesis and huanglongbing (HLB) tolerance显示文摘The lemon(Citrus limon;family Rutaceae)is one of the most important and popular fruits worldwide.Lemon also tolerates huan-glongbing(HLB)disease,which is a devastating citrus disease.Here we produced a gap-free and haplotype-resolved chromosome-scale genome assembly of the lemon by combining Pacific Biosciences circular consensus sequencing,Oxford Nanopore 50-kb ultra-long,and high-throughput chromatin conformation capture technologies.The assembly contained nine-pair chromosomes with a contig N50 of 35.6 Mb and zero gaps,while a total of 633.0 Mb genomic sequences were generated.The origination analysis identified 338.5Mb genomic sequences originating from citron(53.5%),147.4Mb frommandarin(23.3%),and 147.1Mb frompummelo(23.2%).The genome included 30528 protein-coding genes,and most of the assembled sequences were found to be repetitive sequences.Several significantly expanded gene families were associated with plant-pathogen interactions,plant hormone signal transduction,and the biosynthesis of major active components,such as terpenoids and f lavor compounds.Most HLB-tolerant genes were expanded in the lemon genome,such as 2-oxoglutarate(2OG)/Fe(II)-dependent oxygenase and constitutive disease resistance 1,cell wall-related genes,and lignin synthesis genes.Comparative transcriptomic analysis showed that phloem regeneration and lower levels of phloem plugging are the elements that contribute to HLB tolerance in lemon.Our results provide insight into lemon genome evolution,active component biosynthesis,and genes associated with HLB tolerance. | Yixue Bao Ziyan Zeng Wei Yao Xiao Chen Mengwei Jiang Akbar Sehrish Bo Wu Charles A.Powell Baoshan Chen Jianlong Xu Xingtan Zhang Muqing Zhang | 2023 | Horticulture Research2023，10，4： | 0 |
| 11 | The haplotype-resolved autotetraploid genome assembly provides insights into the genomic evolution and fruit divergence in wax apple(Syzygium samarangense(Blume)Merr.and Perry)显示文摘Wax apple(Syzygium samarangense)is an economically important fruit crop with great potential value to human health because of its richness in antioxidant substances.Here,we present a haplotype-resolved autotetraploid genome assembly of the wax apple with a size of 1.59 Gb.Comparative genomic analysis revealed three rounds of whole-genome duplication(WGD)events,including two independent WGDs after WGT-γ.Resequencing analysis of 35 accessions partitioned these individuals into two distinct groups,including 28 landraces and seven cultivated species,and several genes subject to selective sweeps possibly contributed to fruit growth,including the KRP1-like,IAA17-like,GME-like,and FLACCA-like genes.Transcriptome analysis of three different varieties during flower and fruit development identified key genes related to fruit size,sugar content,and male sterility.We found that AP2 also affected fruit size by regulating sepal development in wax apples.The expression of sugar transport-related genes(SWEETs and SUTs)was high in‘ZY’,likely contributing to its high sugar content.Male sterility in‘Tub’was associated with tapetal abnormalities due to the decreased expression of DYT1,TDF1,and AMS,which affected early tapetum development.The chromosome-scale genome and large-scale transcriptome data presented in this study offer new valuable resources for biological research on S.samarangense and shed new light on fruit size control,sugar metabolism,and male sterility regulatory metabolism in wax apple. | Xiuqing Wei Min Chen Xijuan Zhang Yinghao Wang Liang Li Ling Xu Huanhuan Wang Mengwei Jiang Caihui Wang Lihui Zeng Jiahui Xu | 2023 | Horticulture Research2023，10，12： | 0 |
| 12 | Development of an Agrobacterium-mediated CRISPR/Cas9 system in pea(Pisum sativum L.)显示文摘Pea(Pisum sativum L.)is an annual cool-season legume crop.Owing to its role in sustainable agriculture as both a rotation and a cash crop,its global market is expanding and increased production is urgently needed.For both technical and regulatory reasons,neither conventional nor transgenic breeding techniques can keep pace with the demand for increased production.In answer to this challenge,CRISPR/Cas9 genome editing technology has been gaining traction in plant biology and crop breeding in recent years.However,there are currently no reports of the successful application of the CRISPR/Cas9 genome editing technology in pea.We developed a transient transformation system of hairy roots,mediated by Agrobacterium rhizogenes strain K599,to validate the efficiency of a CRISPR/Cas9 system.Further optimization resulted in an efficient vector,PsU6.3-tRNA-PsPDS3-en35S-PsCas9.We used this optimized CRISPR/Cas9 system to edit the pea phytoene desaturase(PsPDS)gene,causing albinism,by Agrobacterium-mediated genetic transformation.This is the first report of successful generation of gene-edited pea plants by this route. | Guan Li Rong Liu Rongfang Xu Rajeev KVarshney Hanfeng Ding Mengwei Li Xin Yan Shuxian Huang Juan Li Dong Wang Yishan Ji Chenyu Wang Junguang He Yingfeng Luo Shenghan Gao Pengcheng Wei Xuxiao Zong Tao Yang | 2023 | The Crop Journal2023，11，1： | 0 |
| 13 | Circularly Polarized Luminescence from Chiral p-Terphenylene-Based Supramolecular Aggregates显示文摘Circularly polarized luminescent(CPL)materials with intense emission and high luminescenee dissymmetry factor(gjum)are highly desirable for their promisi ng applicati ons in comm un icatio n tech no logies,nano tech no logies,inn ovative materials,etc. | Titi Xie Wei Yuan Xiaopei Li Mengwei Li Yulan Chen | 2021 | Chinese Journal of Chemistry2021，39，8： | 0 |
| 14 | Flexible Broadband Light Absorbers with a Superhydrophobic Surface Fabricated by Ultraviolet-assisted Nanoimprint Lithography显示文摘We present a simple approach to fabricate a kind of composite films with a superhydrophobic and broadband light absorbing surface by ultraviolet-assisted nanoimprinting over a gradiently deposited composite matrix.The wettability and optical property of the resultant surfaces are tunable by the deposition time before polymerization(T_(s))and mold’s topography.Mechanically robust and elastomeric films exhibiting high sunlight absorptivity up to 98.13%and contact angle of their surfaces up to 150°are prepared under optimized conditions,as using a mold with a small pattern size(hexagonal periodic mold with cylinder diameter of ca.37μm)under T_(s)=10 min for imprinting the crosslinked poly[di(ethylene glycol)ethyl ether acrylate]and poly(isobornyl acrylate)in the presence of polypyrrole(PPy)nanoparticles.Such dual functions are found related to the hierarchical architecture of the surface,arising from the synergetic effects of the periodical patterned polymer substrate and spontaneously assembled PPy microstructures on the patterns.The current strategy based on the combination of ultraviolet-assisted nanoimprint lithography and hierarchical assembly of gradiently deposited black nano-fillers offers a new insight into the design of robust superhydrophobic and black surfaces,which is helpful to deepen our understanding of the relationship between liquid/light manipulation and micro/nanostructured surfaces. | WEI Wanyuan LI Mengwei CHEN Yulan | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 15 | The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis显示文摘DNA methylation,a conserved epigenetic mark,is critical for tuning temporal and spatial gene expression.The Arabidopsis thaliana DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)initiates active DNA demethylation and is required to prevent DNA hypermethylation at thousands of genomic loci.However,how ROS1 is recruited to specific loci is not well understood.Here,we report the discovery of Arabidopsis AGENET Domain Containing Protein 3(AGDP3)as a cellular factor that is required to prevent gene silencing and DNA hypermethylation.AGDP3 binds to H3K9me2 marks in its target DNA via its AGD12 cassette.Analysis of the crystal structure of the AGD12 cassette of AGDP3 in complex with an H3K9me2 peptide revealed that dimethylated H3 K9 and unmodified H3 K4 are specifically anchored into two different surface pockets.A histidine residue located in the methyllysine binding aromatic cage provides AGDP3 with pH-dependent H3K9me2 binding capacity.Our results uncover a molecular mechanism for the regulation of DNA demethylation by the gene silencing mark H3K9me2. | Xuelin Zhou Mengwei Wei Wenfeng Nie Yue Xi Li Peng Qijie Zheng Kai Tang Viswanathan Satheesh Yuhua Wang Jinyan Luo Xuan Du Rui Liu Zhenlin Yang Honggui La Yingli Zhong Yu Yang Jian-Kang Zhu Jiamu Du Mingguang Lei | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
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