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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | The potential for selecting wheat varieties strongly competitive against weeds显示文摘 | Lemerle D Verbeek B Cousens R D | 1996 | Weed Reserch1996，36，6： | 1 |
| 3 | Acute management of hemodynamically unstable pelvic trauma patients:Time for a change?Multicenter review of recent practice显示文摘 | Verbeek D Sugrue M Balogh Z | 2008 | World J Surgery2008，32，8： | 1 |
| 4 | Reciprocal inter- actions between sleep, circadian rhythms and Alzheimer's disease:focus on the role of hypocretin and melatonin显示文摘 | Slats D Claassen JA Verbeek MM | 2013 | Ageing Research Reviews2013，12，1： | 1 |
| 5 | Learning Color Names for Real-World Applications 显示文摘 | Van d W J Schmid C Verbeek J | 2009 | IEEE Transactions on Image Processing(S1057-7149)2009，18，7： | 1 |
| 6 | The need for pel-vic angiographic embolisation in stable pelvic fracture patientswith a “blush,,on computed tomography 显示文摘 | Verbeek D() Ponsen KJ Carel Goslings J | 2014 | Injury2014，3，14： | 1 |
| 7 | Coherence collapse in single- mode semiconductor lasers due to optical feedback显示文摘 | Lenstra D Verbeek B Den Boer A | 1985 | IEEE Journal of Quantum Electronics1985，21，6： | 1 |
| 8 | The potential for selecting wheat varieties strongly competitive against weeds显示文摘 | Lemerle D Verbeek B Cousens R D | 1996 | Weed Research1996，36，6： | 1 |
| 9 | On scheduling a single machine with resource dependent release times显示文摘 | JANSSEN M C VERBEEK R J D VOLGENANT A | 2011 | Comput Oper Res2011，38，3： | 1 |
| 10 | Murine igGl complexes trigger immune effector functions predominantly via Fc gamma RⅢ(CD16显示文摘 | Hazenbos W L Heijnen I A Meyer D Hofhuis F M Renardel de Lavalette C R Schmidt R E Capel P J van de Winkel J G Gessner J E van den Berg T K Verbeek J S | | 0，，06： | 1 |
| 11 | A gas-liquid chromatographic method for analysis of methionine and of methionine sulfoxide in proteins显示文摘 | Bos K D Verbeek C Slump P | 1983 | Journal of Food and Agricultural Chemistry1983，31，： | 1 |
| 12 | Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine显示文摘 | Schuurhuis D H van Monffoort N loan-Facsinay A Jiawan R Camps M Nouta J Melief C J Verbeek J S Os | | 0，，08： | 1 |
| 13 | Improved determination of phytate by ion-exchange chromatography显示文摘 | Bos K D Verbeek C Van Eeden C H P | 1991 | Agriculture and Biochemistry1991，39，10： | 1 |
| 14 | Development of a multiplex AmpliDel RNA for the simultaneous detection of Potato leafroll virus and Potato virus Y in potato tubers 显示文摘 | Klerks M M Leone G O M Verbeek M van den Heuvel J F J M Schoen C D | 2001 | Journal of Virological Methods2001，93，12： | 1 |
| 15 | ,Time-lapse seismic analysis of Fulmar field显示文摘 | Johnston D H Mckenney R S Verbeek J | 1998 | The Leading Edge1998，17，10： | 1 |
| 16 | Acute management of hemodynamically unstable pelvic trauma patients:Time for a change? Multicenter review of recent practice显示文摘 | Verbeek D Sugrue M Balogh Z | 2008 | World J Surgery2008，32，8： | 1 |
| 17 | Learning cohn' names for re- al-world applications 显示文摘 | Weijer J V D Schmid C Verbeek J | 2009 | hnage Processing IEEE Transactions on2009，18，7： | 1 |
| 18 | The potential for selecting wheat varieties strongly competitive against weeds显示文摘 | Lemerle D Verbeek B Cousens R D | 1996 | Weed Research1996，36，： | 1 |
| 19 | Serial prehospital 12-lead electrocardiograms increase identification of ST-segment elevation myocardial infarction显示文摘 | Verbeek PR Ryan D Turner L | 2012 | Prehosp Emerg Care2012，16，1： | 1 |
| 20 | The role of personal ity traits in insomnia显示文摘 | van de Laar M Verbeek I Pevernagie D | 2010 | Sleep Med Rev2010，14，1： | 1 |
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