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| 1 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 2 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 3 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 4 | 脑卒中血栓切除术后血压与短期和长期功能转归的相关性显示文摘缺血性脑卒中机械性血栓切除术后的转归可能受血压的影响。该研究旨在评估全身麻醉期间和清醒镇静期间血压变化与机械性血栓切除术后功能性转归的关系。血管内治疗脑卒中的镇静与气管插管研究是一项涉及血压目标值的,比较在全身麻醉与在清醒镇静的条件下行机械血栓切除疗效的单中心随机试验。 | 刘青 叶鹏 Schnenberger S Uhlmann L Ungerer M Pfaff J Nagel S Klose C Bendszus M Wick W Ringleb PA Kieser M Mhlenbruch MA Bsel J | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 5 | G-decomposition of Kn, where G has four vertices of less显示文摘 | Bermond J C Schnheim J | 1977 | Discrete Math1977，19，： | 2 |
| 6 | Syndromes of Vibrio vulnificus infection clinical and epidemiologic features in Florida cases, 1981 1987 显示文摘 | Klontz K C L ieb S Sch reiber M | 1988 | Ann Intern Med1988，，： | 1 |
| 7 | Imaging the enzymatic digestion of bacterial cellulose ribbons reveals the endo character of the cellobiohydrolase Cel6A from Humicola insolens and its mode of synergy with cellobiohydrolase Cel7A显示文摘 | Boisset C Fraschini C Schülein M | 2000 | Applied and Environmental Microbiology2000，66，4： | 1 |
| 8 | Estimating the support of a high-dimensional distribution显示文摘 | Platt J C Shawe-Taylor J | 2001 | Neural Computation2001，13，7： | 1 |
| 9 | The Idea of the hybrid text intranslation:contact as conflict显示文摘 | SCH FFNER C ADAB B | 2001 | Across Languages and Cultures2001，，16： | 1 |
| 10 | Physicalmapping and identification of a candidate for the leafrust resistance gene Lr1 of wheat显示文摘 | Qiu J W Schürch A C Yahiaoui N | 2007 | Theoreticaland Applied Genetics2007，115，： | 1 |
| 11 | Anastomotic leak- age follow low anterior resection results of a standard ized di- agnostic and the rap eutic approach显示文摘 | Eckm ann C Kujath P Sch iedeck TH | 2004 | Int J ColorectalD is2004，19，2： | 1 |
| 12 | Patient derived cell culture and isolation of CD133+ putative cancer stem cells from melanoma显示文摘 | Welte Y Davies C Sch~fer R | 2013 | J Vis Exp2013，13，73： | 1 |
| 13 | Cloning,sequencing,and characterization of a heat-and alkali-stable type Ⅰ pullulanase from Anaerobranca gottschalkii显示文摘 | Bertoldo C Armbrecht M Becker F Sch(a)fer T Antranikian G Liebl W | | 0，，06： | 1 |
| 14 | Shor tcoming in the diagnosis of TPMT deficiency in a patient with Crohn's disease using phenotying only 显示文摘 | Sch wabM Sehaeffeler E Marx C | 2001 | Gastroenterology2001，121，2： | 1 |
| 15 | New support vector algorithms显示文摘 | Smola A J Williamson B C | 2000 | Neural Computation2000，12，5： | 1 |
| 16 | Quantum Dot in the Kondo Regime Coupled to Superconductors显示文摘 | BUITELAAR M R NUSSBAUMER T SCH O¨NENBERGER C | 2002 | Phys Rev Lett2002，89，25： | 1 |
| 17 | A chromatin-modifying function of JNK during stem cell differentiation显示文摘 | Tiwari V K Stadler M B Wirbelauer C Paro R Schübeler D Beisel C | | 0，，： | 1 |
| 18 | Using the international 10-20 EEG system for positioning of transcranial magnetic stimulation 显示文摘 | HERWIG U SATRAPI P SCH? NFELDT-LECUONA C | 2003 | Brain Topogr2003，16，2： | 1 |
| 19 | Somatosensory evoked potential phase reversal and direct motor cortex stimula- tion during surgery in and around the central region显示文摘 | CEDZICH C TANIQUCHI M SCH?FER S | 1996 | Neuro- surgery1996，38，5： | 1 |
| 20 | Role of adipose tissue as an inflammatory or- gan in human diseases 显示文摘 | SCHAFFLER A MULLER-LADNER U SCH()LMERICH J BOCHLER C | 2005 | Endocr Rev2005，27，5： | 1 |
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