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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Preparation of esters of gallic acid with higher primary alcohols 显示文摘 | KERK G J M van der VERBEEK J H CLETON J C F | 1951 | Rec Tray Chim1951，70，： | 1 |
| 3 | Recent Developments in Thelano-mechanical Processing of Proteinous Bioplastics显示文摘 | VERBEEK C | 2009 | Recent Patents on Ma- terials Science2009，2，3： | 1 |
| 4 | Learning col- or names for real-world applications 显示文摘 | van de WEIJER J SCHMID C VERBEEK J | 2009 | IEEE Transactions on Im- age Processing2009，18，7： | 1 |
| 5 | Mechanism of dehydration inactivation of Lactobacillus plantarum显示文摘 | LIEVENSE L C VERBEEK M A M NOOMEN A | 2007 | Appl Microbiol Biotechnol2007，41，： | 1 |
| 6 | Formal semantics and analysis of control flow in WS-BPEL显示文摘 | OUYANG C VERBEEK E AALST van der W | 2007 | Science of Computer Programming2007，67，23： | 1 |
| 7 | Formal semantics and analysis of control flow in WSBPEL显示文摘 | OUYANG C VERBEEK E VAN DER AALST W M P | 2007 | Science of Computer Programming2007，67，23： | 1 |
| 8 | Freeman-code probabilities of object boundary quantized contours显示文摘 | Groen F C A Verbeek P W | 1978 | Computer Graphics and Image Processing1978，7，3： | 1 |
| 9 | Mechanism of dehydration inactivation of Lactobacillus plantaum显示文摘 | Lievense L C Verbeek M A M Noomen A | 1994 | Applied Microbiology and Biotechnology1994，41，： | 1 |
| 10 | Learning Color Names for Real-World Applications 显示文摘 | Van d W J Schmid C Verbeek J | 2009 | IEEE Transactions on Image Processing(S1057-7149)2009，18，7： | 1 |
| 11 | Formal se- mantics and analysis of control flow in WS-BPEL显示文摘 | Ouyang C Verbeek E Van Der Aalst W M P | 2007 | Science of Computer Programming2007，67，2： | 1 |
| 12 | The use of molecular beacons combined with NASBA for the sensitive de-tection of Sugarcane yellow leaf virus显示文摘 | Goncalves M C Klerks M M Verbeek M | | 0，，05： | 1 |
| 13 | Predicting the needfor abdominal hemorrhage control in major pelvic fracture pa-tients: The importance of quantifying the amount of free fluid显示文摘 | Verbeek DO’Zijlstra IA Vander Leij C etal | 2014 | J Trauma Acute Care Surg2014，76，5： | 1 |
| 14 | Density and flexural strength of phosphogypsum-ploymer composites 显示文摘 | VERBEEK C J R DU PLESSIS B J G W | 2005 | Construction and Building Materials2005，19，4： | 1 |
| 15 | The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib显示文摘 | Albers C Leischner H Verbeek M | 2013 | Leukemia2013，27，6： | 1 |
| 16 | Gloves, extra gloves or special types of gloves for preventing percutaneous exposure injuries in heahhcare personnel 显示文摘 | Mischke C Verbeek JH Saarlo A | 2014 | Cochrane Database Syst Rev2014，3，00： | 1 |
| 17 | On scheduling a single machine with resource dependent release times显示文摘 | JANSSEN M C VERBEEK R J D VOLGENANT A | 2011 | Comput Oper Res2011，38，3： | 1 |
| 18 | Murine igGl complexes trigger immune effector functions predominantly via Fc gamma RⅢ(CD16显示文摘 | Hazenbos W L Heijnen I A Meyer D Hofhuis F M Renardel de Lavalette C R Schmidt R E Capel P J van de Winkel J G Gessner J E van den Berg T K Verbeek J S | | 0，，06： | 1 |
| 19 | The positive column of low-pressure Hg/Ne and Hg/Ne/Ar discharges 显示文摘 | Verbeek T G Drop P C | 1974 | J Phys D1974，7，12： | 1 |
| 20 | A gas-liquid chromatographic method for analysis of methionine and of methionine sulfoxide in proteins显示文摘 | Bos K D Verbeek C Slump P | 1983 | Journal of Food and Agricultural Chemistry1983，31，： | 1 |
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