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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Identification of coop- erating oncogenes in E mu-myc transgenic mice by provirus tagging 显示文摘 | van-Lohuizen M Verbeek S Scheijen B | 1991 | Cell1991，65，5： | 1 |
| 3 | O (6)- Methylguanine-DNA methyhransferase (MGMT) in normal tissues and tumors : enzyme activity, promoter methylation and immunohistochemistry 显示文摘 | Christmann M Verbeek B Roos WP | 2011 | Biochim Biophys Acta2011，1816，2： | 1 |
| 4 | The potential for selecting wheat varieties strongly competitive against weeds显示文摘 | Lemerle D Verbeek B Cousens R D | 1996 | Weed Reserch1996，36，6： | 1 |
| 5 | Traces of prior art : an analysis of non - patent references found in patent documents显示文摘 | Callaert J Van Looy B Verbeek A Debackere K Thijs B | 2006 | Scientometrics2006，69，1： | 1 |
| 6 | O(6)-Methylgua nine-DNA methyltransferase(MGMT)in normal tissues and tu mors:Enzyme activity,promoter methylation and immunohisto chemistry显示文摘 | Christmann M Verbeek B Roos WP | | 0，，02： | 1 |
| 7 | O6-methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors:Enzyme activity, promoter methylation and immunohistochemistry显示文摘 | Christmann M Verbeek B Roos WP | 2011 | Biochim Biophys Acta2011，1816，2： | 1 |
| 8 | Coherence collapse in single- mode semiconductor lasers due to optical feedback显示文摘 | Lenstra D Verbeek B Den Boer A | 1985 | IEEE Journal of Quantum Electronics1985，21，6： | 1 |
| 9 | Traces of prior art: An analysis of non-patent references found in patent documents 显示文摘 | Callaert J Van Looy B Verbeek A | 2006 | Scientometrics2006，69，1： | 1 |
| 10 | Density and flexural strength of phosphogypsum-ploymer composites 显示文摘 | VERBEEK C J R DU PLESSIS B J G W | 2005 | Construction and Building Materials2005，19，4： | 1 |
| 11 | Efficient greedy learning of Gaussian mxiture models显示文摘 | Verbeek J J Vlassis N Krose B | 2003 | Neural Computation2003，15，2： | 1 |
| 12 | The potential for selecting wheat varieties strongly competitive against weeds显示文摘 | Lemerle D Verbeek B Cousens R D | 1996 | Weed Research1996，36，6： | 1 |
| 13 | Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging 显示文摘 | Van-Lohuizen M Verbeek S Scheijen B | 1991 | Cel1991，65，： | 1 |
| 14 | The PSD transfer function显示文摘 | MICHIEL B VERBEEK P W TEENVOORDEN G K | 2002 | IEEE Trans Electron Devices2002，49，1： | 1 |
| 15 | Combined endostatin/sFlt-1 antiangiogenic gene therapy is highly effective in a rat model of HCC显示文摘 | Graepler F Verbeek B Graeter T | 2005 | Hepatology2005，41，4： | 1 |
| 16 | Active appearance-based robot localization using stereo vision显示文摘 | Porta J Verbeek J Krose B | 2005 | Autonomous Robots2005，18，1： | 1 |
| 17 | O^6-Methylguanine-DNA methyhransferase inactivation and themotherapy显示文摘 | Verbeek B Southgate TD Gilham DE | 2008 | Br Med Bull2008，85，1： | 1 |
| 18 | Flow map layout via spiraltrees 显示文摘 | Verbeek K Buchin K Speckmann B | 2011 | IEEE Transactions on Visualization and ComputerGraphics2011，17，25： | 1 |
| 19 | O6-methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors:Enzyme activity, promoter methylation and immunohistochemistry显示文摘 | Christmann M Verbeek B Roos WP | 2011 | Biochim Biophys Acta2011，1816，2： | 1 |
| 20 | A k-segments algorithm for finding principal curves 显示文摘 | Verbeek J J Vlassis N Krose B | 2002 | Patten Recognition Letters2002，23，3： | 1 |
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