|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 2 | NS1 antigen: A new beam of light in the early diagnosis of dengue infection显示文摘Objective: To evaluate NS1 antigen detection ELISA for the early laboratory diagnosis of dengue virus infection. Methods: The present study was conducted to evaluate the overall positivity of NS1 antigen detection ELISA and its comparison with viral RNA detection via real time PCR and Ig M antibodies detection by ELISA. Results: A total of 1 270 serum samples were tested 86%(1 097/1 270) were detected positive by one or more than one diagnostic test. Out of 1 270, 64%(807/1 270) were positive by NS1 ELISA and 52%(662/1 270), 51%(646/1 270) were positive by real-time RT-PCR and Ig M ELISA respectively.Conclusions: NS1 antigen detection ELISA is highly suitable diagnostic tools and it also has great value for use in outbreak and epidemic situation. | Muhammad Suleman Rani Faryal Muhammad Masroor Alam Salmaan Sharif Shahzad Shaukat Uzma Bashir Aamir Adnan Khurshid Mehar Angez Massab Umair Mian Muhammad Sufian Yasir Arshad Ghulam Mujtaba Syed Sohail Zahoor Zaidi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 6 |
| 3 | Transjugular intrahepatic porto 全身的分流在老: 为门高血压的复杂并发症的减轻显示文摘 AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population group.METHODS:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and 2010.Twentyfive patients were referred for TIPS.We deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver disease.Of the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing TIPS.Sixteen of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 mo.Ascites and/or hydrothorax was controlled following technically successful procedures in 12 of 13 patients.Bleeding was controlled following technically successful procedures in 10 out of 11 patients.CONCLUSION:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients. | Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh Uzma Waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell | 2012 | World Journal of Hepatology2012，4，2： | 4 |
| 4 | Measurement of Plasma Parameters of Calcium and Silicon in a Rock Sample Using Laser Induced Breakdown Spectroscopy显示文摘Laser Induced Breakdown Spectroscopic(LIBS)technique was used to detect calcium and silicon in an unknown sample.In this method plasma was generated by Nd∶YAG laser of wavelength 1 064 nm with energy 400 mJ and pulse duration between 5~10ns.The method was applied for the qualitative as well as quantitative analysis.In the qualitative analysis,the electron number density(Ne)of plasma containing calcium and silicon is determined showing that Neof neutral particles is equivalent to 1016(cm-3)whereas for ionized particles it is 1017(cm-3).Plasma temperature is measured using Boltzmann plot method which must be greater than 10 000 k.Intensity ratio method is used for the quantitative analysis shows various elements in abundance with calcium and silicon in majority. | Uzma G M.Junaid Khalid Alamgir T Samina | 2017 | 光谱学与光谱分析2017，37，10： | 4 |
| 5 | 美国国家卒中协会对短暂性脑缺血发作诊治体系的推荐意见显示文摘短暂性脑缺血发作(transient ischemic attack,TIA)很常见,预示短期卒中风险很高。有关TIA患者紧急评价和治疗的循证推荐意见已经发表。然而,这些推荐意见的可靠和一致的执行需要对现有TIA诊治体系做出相应的改变。美国国家卒中协会召集了一个多学科专家小组,提出了医院内TIA诊治体系主要内容的推荐意见,以提高对TIA患者的诊疗质量。专家小组推荐医院制定标准化方案,以确保对TIA患者实施快速和完整的评价和处理,特别关注对卒中高危患者进行紧急而密切的观察。 | S. Claibome Johnston Gregory W. Albers Philip B. Gorelick Ethan Cumbler Jeffrey Klingman Michael A. Ross Meg Brisgs Jean Carlton Edward P. Sloan Uzma Vaince 李海峰(译) 洪宇(译) 王琦(译) | 2011 | 国际脑血管病杂志2011，19，9： | 3 |
| 6 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 7 | Association of post-traumatic stress disorder and work performance: A survey from an emergency medical service, Karachi, Pakistan显示文摘BACKGROUND: The purpose of the study was to explore the association between posttraumatic stress disorder(PTSD) and work performance of emergency medical services personnel in Karachi, Pakistan.METHODS: Emergency medical service personnel were screened for potential PTSD using Impact of Event Scale-Revised(IES-R). Work performance was assessed on the basis of fi ve variables: number of late arrivals to work, number of days absent, number of days sick, adherence to protocol, and patient satisfaction over a period of 3 months. In order to model outcomes like the number of late arrivals to work, days absent and days late, negative binomial regression was applied, whereas logistic regression was applied for adherence to protocol and linear for patient satisfaction scores.RESULTS: Mean scores of PTSD were 24.0±12.2. No association was found between PTSD and work performance measures: number of late arrivals to work(RRadj 0.99; 0.98–1.00), days absent(RRadj 0.98; 0.96–0.99), days sick(RRadj 0.99; 0.98–1.00), adherence to protocol(ORadj 1.01; 0.99–1.04) and patient satisfaction(β 0.001%–0.03%) after adjusting for years of formal schooling, living status, coping mechanism, social support, working hours, years of experience and anxiety or depression.CONCLUSION: No statistically significant association was found between PTSD and work performance amongst EMS personnel in Karachi, Pakistan. | Salima Kerai Omrana Pasha Uzma Khan Muhammad Islam Nargis Asad Junaid Razzak | 2017 | World Journal of Emergency Medicine2017，8，3： | 3 |
| 8 | Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer显示文摘 | Uzma Asghar Eliza Hawkes David Cunningham | 2010 | Clinical Colorectal Cancer2010，，5： | 2 |
| 9 | Filovirus emergence and vaccine development: A perspective for health care practitioners in travel medicine显示文摘 | Uzma N. Sarwar Sandra Sitar Julie E. Ledgerwood | 2010 | Travel Medicine and Infectious Disease2010，，3： | 2 |
| 10 | Evaluation of Darwin's fecundity advantage hypothesis in Parthenium beetle, Zygogramma bicolorata显示文摘在 Parthenium 甲壳虫, Zygogramma bicolorata Pallister (翘目:Chrysomelidae ) ,在身体尺寸的变化存在在之间并且在性以内。女性比男性大。达尔文(1874 ) 建议了肥沃优点假设,也就是说大尺寸的女性生产更多的子孙与支持的随后的研究,以及,反驳假设。因此,以便评估这个假设是否站在 Z。我们执行了的 bicolorata 试验在影响调查身体尺寸的角色:(i) 配对的交配;(ii ) 繁殖属性;并且(iii ) 后代的生长,开发和幸存。它是在这甲壳虫的第一次尝试。我们发现那种尺寸影响了配对的交配、繁殖输出和后代健康。更大的男性和女性作为配偶被喜欢甚于更小的。对,作为配偶有更大的成年人,有的更高的肥沃,当鸡蛋生存能力被男尺寸仅仅影响时。更大的父母的后代举办了快开发和更高的幸存,显示由由除了基因的更好的质量的男性的附件腺蛋白质的女性和供应的从而可能的更好滋养的分配。 | Omkar and Uzma Afaq | 2013 | Insect Science2013，20，4： | 2 |
| 11 | Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience显示文摘 | Jason N. Rogart Dhanpat Jain Uzma D. Siddiqui Tal Oren Joseph Lim Priya Jamidar Harry Aslanian | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 12 | Management of delayed edema formation after flbrinolytic therapy for intracerebral hematomas : pre- liminary experimental data 显示文摘 | Rohde V Uzma N Thiex R | 2008 | Acta Neurochir Suppl2008，105，： | 1 |
| 13 | Can an Industry Be Socially Responsible If Its Products Harm Consumers? The Case of Online Gambling显示文摘 | Mirella Yani-de-Soriano Uzma Javed Shumaila Yousafzai | 2012 | Journal of Business Ethics2012，，110： | 1 |
| 14 | EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles显示文摘 | Uzma D. Siddiqui Federico Rossi Lawrence S. Rosenthal Manmeet S. Padda Visvanathan Murali-Dharan Harry R. Aslanian | 2009 | Gastrointestinal Endoscopy2009，，6： | 1 |
| 15 | Effect of race and HIV co-infection upon treatment prescription for hepatitis C virus显示文摘 | Adeel A. Butt Joel Tsevat Anthony C. Leonard Obaid S. Shaikh Deborah McMahon Uzma A. Khan Zachariah Dorey-Stein Vincent Lo Re | 2008 | International Journal of Infectious Diseases2008，，4： | 1 |
| 16 | ASGE Technology Status Evaluation Report Wireless Capsule Endoscopy显示文摘 | Amy Wang Subhas Banerjee Bradley A. Barth Yasser M. Bhat Shailendra Chauhan Klaus T. Gottlieb Vani Konda John T. Maple Faris Murad Patrick R. Pfau Douglas K. Pleskow Uzma D. Siddiqui Jeffrey L. Tokar Amy Wang Sarah A. Rodriguez | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 17 | Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers显示文摘 | Adeel Butt Uzma Khan Obaid Shaikh Deborah McMahon Zachariah Dorey-Stein Joel Tsevat Vincent Lo Re III | 2009 | HIV Clinical Trials2009，，1： | 1 |
| 18 | A Single-Center Experience of Endoscopic Submucosal Dissection Performed in a Western Setting显示文摘 | Gabriel D. Lang Vani J. A. Konda Uzma D. Siddiqui Ann Koons Irving Waxman | 2015 | Digestive Diseases and Sciences2015，，2： | 1 |
| 19 | Diagnosis of enteric fever in the emergency department: a retrospective study from Pakistan显示文摘 | Uzma Rahim Khan Junaid A. Razzak Ali Faisal Saleem Adnan Ahmed Sabeena Jalal | 2010 | International Journal of Emergency Medicine2010，，1： | 1 |
| 20 | Is Organizational Learning about Conflict Management important or not in Organizational Effectiveness in- Tertiary Education? 显示文摘 | Uzma Mukhtar | 2011 | The International Journal of Interdisci- plinary Social Sciences2011，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员