|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection显示文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery. | Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata Sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura | 2021 | World Journal of Gastroenterology2021，27，46： | 5 |
| 2 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 3 | Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study显示文摘 | Masaharu Yoshihara Toru Hiyama Shigeto Yoshida Masanori Ito Shinji Tanaka Yoshiyuki Watanabe Ken Haruma | 2007 | Scandinavian Journal of Gastroenterology2007，，6： | 2 |
| 4 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 5 | The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability显示文摘The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic subunits.Accumulating evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be established.In this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa cells.Flow cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted cells.Virtually,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase activity.Further analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT subunits.Importantly,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control cells.The formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted cells.Therefore,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA decay.We further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced apoptosis.Taken together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated apoptosis.We conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase. | Kentaro Ito Akinori Takahashi Masahiro Morita Toru Suzuki Tadashi Yamamoto | 2011 | Protein & Cell2011，2，9： | 1 |
| 6 | Incidence of com-plications associated with spinal endoscopic surgery:nationwide survey in 2007 by the Committee on Spinal Endoscopic Surgical Skill Qualification of Japanese Orthopaedic Association显示文摘 | Morio Matsumoto Toru Hasegawa Manabu Ito | 2010 | Orthopaedic Science2010，15，： | 1 |
| 7 | Clinicopathologic Features and Endoscopic Resection of Early Primary Nonampullary Duodenal Carcinoma显示文摘 | Shiro Oka Shinji Tanaka Shinji Nagata Toru Hiyama Masanori Ito Yasuhiko Kitadai Masaharu Yoshihara Ken Haruma Kazuaki Chayama | 2003 | Journal of Clinical Gastroenterology2003，，5： | 1 |
| 8 | Thoracic myelopathy due to idiopathic epidural ossifications in a child显示文摘 | Takaaki Urakawa Takui Ito Toru Hirano | 2008 | Spine2008，33，： | 1 |
| 9 | Effects of partial substitution of V and Ti for Fe on nitrogenation rate and magnetic properties of Sm2Fe17Nx anisotropic coarse powder显示文摘 | Mikio Ito Kazuhiko Majima Toru Shimuta Shigeru Katsuyama | 2003 | J Alloys and Compounds2003，349，： | 1 |
| 10 | Phase II trial of S-1 as third-line or further chemotherapy in patients with advanced non-small-cell lung cancer显示文摘 | Seigo Miyoshi Ryoji Ito Hitoshi Katayama Toru Kadowaki Shuichi Yano Akira Watanabe Masahiro Abe Hironobu Hamada Takafumi Okura Jitsuo Higaki | 2014 | International Journal of Clinical Oncology2014，，6： | 1 |
| 11 | Evaluation of thermal sprayed coating using ultrasonic inspection by means of bottom echo back reflection显示文摘Thermal spraying technique is widely used in various mechanical parts as a surface reforming technique.However,as demand to maintain superior mechanical performance in harsh operating environment increases,the need for non-destructive evaluation method for thermal spray coating becomes more important.For this purpose,we thinned the thickness of the thermal sprayed coating by abrasion with blasting and used ultrasonic inspection by means of bottom echo reflection for effective measurement of abrasion quantity in thermal sprayed coating.The results obtained are summarized as follows.When the thickness of thermal sprayed coating becomes thin,the echo height increases.This is because thermal sprayed coatings absorb ultrasonic energy.Ultrasonic energy absorbed by Al2O3 is smaller compared with Fe-13Cr coating.Thermal sprayed coatings submerged in water have a lower echo height compared with air.As mentioned above,the thermal sprayed coating thickness can be estimated using ultrasonic inspection by means of bottom echo back reflection. | Toshifumi KUBOHORI Toru ITO Wahidul lah WAHI Yasuyuki INUI Toshiro IKUTA | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 1 |
| 12 | Laparoscopic Intragastric Resection of Gastric Stromal Tumor Located at the Esophago-cardiac Junction显示文摘 | Fumihiro Uchikoshi Toshinori Ito Toshirou Nishida Toru Kitagawa Shunji Endo Hikaru Matsuda | 2004 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2004，，1： | 1 |
| 13 | Trimetallic nanoparticles having a Au-core structure 显示文摘 | Naoki Toshima Rei Ito Toru Matsushita | 2007 | Catalysis Today2007，122，34： | 1 |
| 14 | FORMATION OF POLYELECTROLYTE COMPLEXES BETWEEN CELLULOSE DERIVATIVES AND THEIR BLOOD COMPATIBILITY显示文摘 | Ito Hiraku Shibata Toru Miyamoto Takeaki etc | | Journal of Applied Polymer Science0，31，8： | 1 |
| 15 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 1 |
| 16 | Airborne electromagnetic and magnetic surveys for long tunnel construction design显示文摘 | Kenji Okazaki Toru Mogi Mitsuru Utsugi Yoshihiko Ito Hideki Kunishima Takashi Yamazaki Yukitsugu Takahashi Takeshi Hashimoto Yusuke Ymamaya Hisatoshi Ito Hideshi Kaieda Kazuhiro Tsukuda Youichi Yuuki Akira Jomori | 2011 | Physics and Chemistry of the Earth2011，，16： | 1 |
| 17 | Trimetallic nanoparticles having a Au-core structure显示文摘 | Naoki Toshima Rei Ito Toru Matsushita | 2007 | Catalyst To- day2007，122，： | 1 |
| 18 | C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn’s disease显示文摘 | Toshifumi Hibi Atsushi Sakuraba Mamoru Watanabe Satoshi Motoya Hiroaki Ito Noriko Sato Toru Yoshinari Kenta Motegi Yoshitaka Kinouchi Masakazu Takazoe Yasuo Suzuki Takayuki Matsumoto Kazuhiko Kawakami Takayuki Matsumoto Ichiro Hirata Shinji Tanaka Toshifu | 2014 | Journal of Gastroenterology2014，，2： | 1 |
| 19 | Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma显示文摘 | Yoshikazu Morimoto Yasuhiro Tanaka Toshinori Ito Masaaki Nakahara Hiroyuki Nakaba Toshiro Nishida Masahiro Fujikawa Toshikazu Ito Shigetaka Yamamoto Toru Kitagawa | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，6： | 1 |
| 20 | Trimetallic nanoparticles having a Au-core structure显示文摘 | Naoki Toshima Rei Ito Toru Matsushita | 2007 | Catalysis Today2007，122，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员