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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Analysis and Identification of Chemical Constituents of Fenugreek by UPLC-IT-MSn and UPLC-Q-TOF-MS显示文摘 | WANG Jiaqi JIANG Wenyue LIU Zhongying WANG Junhua FU Tianyue WANG Yongsheng | 2017 | Chemical Research in Chinese Universities2017，33，5： | 4 |
| 3 | Effects of Mn addition on the microstructure and mechanical properties of cast Mg-9Al-2Sn(wt.%)alloy显示文摘The microstructure and mechanical properties of cast Mg-9Al-2Sn-xMn(x=0,0.1,0.3 wt.%)alloys in as-cast,solution treated and aged conditions are investigated.The results reveal that Mn addition into Mg-9Al-2Sn alloy leads to the formation of Al8(Mn,Fe)5 phases,the grain refinement and the increase of discontinuous Mg17Al12 precipitates along the grain boundaries.0.1 wt.%Mn addition has an obvious effect on accelerating the aging behavior of Mg-9Al-2Sn alloy at the early aging period up to 8 h,while 0.3 wt.%Mn addition alloy has an comparable aging behavior with the Mn-free alloy.Mn addition has less influence on the fracture behavior of Mg-9Al-2Sn alloy,while the fracture pattern is mainly determined by the thermal conditions.Mg-9Al-2Sn-0.1Mn alloy has the best combination of strength and elongation when aged at 200℃ for 8 h and the yield strength,ultimate tensile strength and elongation are 154 MPa,292MPa and 5%,respectively. | Tianyu Zhu Penghuai Fu Liming Peng Xiaoyu Hu Shouru Zhu Wenjiang Ding | 2014 | Journal of Magnesium and Alloys2014，2，1： | 3 |
| 4 | Integrating the optical tweezers and spanner onto an individual single-layer metasurface显示文摘Optical tweezers(OTs)and optical spanners(OSs)are powerful tools of optical manipulation,which are responsible for particle trapping and rotation,respectively.Conventionally,the OT and OS are built using bulky three-dimensional devices,such as microscope objectives and spatial light modulators.Recently,metasurfaces are proposed for setting up them on a microscale platform,which greatly miniaturizes the systems.However,the realization of both OT and OS with one identical metasurface is posing a challenge.Here,we offer a metasurface-based solution to integrate the OT and OS.Using the prevailing approach based on geometric and dynamic phases,we show that it is possible to construct an output field,which promises a high-numerical-aperture focal spot,accompanied with a coaxial vortex.Optical trapping and rotation are numerically demonstrated by estimating the mechanical effects on a particle probe.Moreover,we demonstrate an on-demand control of the OT-to-OS distance and the topological charge possessed by the OS.By revealing the OT–OS metasurfaces,our results may empower advanced applications in on-chip particle manipulation. | TIANYUE LI XIAOHAO XU BOYAN FU SHUMING WANG BAOJUN LI ZHENLIN WANG SHINING ZHU | 2021 | Photonics Research2021，9，6： | 2 |
| 5 | How does cancer cell metabolism affect tumor migration and invasion?显示文摘 | Tianyu Han De Kang Daokun Ji Xiaoyu Wang Weihua Zhan Minggui Fu Hong-Bo Xin Jian-Bin Wang | 2013 | Cell Adhesion & Migration2013，，5： | 1 |
| 6 | A bio-inspired and self-powered triboelectric tactile sensor for underwater vehicle perception显示文摘Marine mammals relying on tactile perception for hunting are able to achieve a remarkably high prey capture rate without visual or acoustic perception.Here,a self-powered triboelectric palm-like tactile sensor(TPTS)is designed to build a tactile perceptual system for underwater vehicles.It is enabled by a three-dimensional structure that mimics the leathery,granular texture in the palms of sea otters,whose inner neural architecture provides additional clues indicating the importance of tactile information.With the assistance of palm structure and triboelectric nanogenerator technology,the proposed TPTS has the ability to detect and distinguish normal and shear external load in real-time and approximate the external stimulation area,especially not affected by the touch frequency,that is,it can maintain stable performance under high-frequency contact.The results show that the TPTS is a promising tool for integration into grippers mounted on underwater vehicles to complete numerous underwater tasks. | Peng Xu Jianhua Liu Xiangyu Liu Xinyu Wang Jiaxi Zheng Siyuan Wang Tianyu Chen Hao Wang Chuan Wang Xianping Fu Guangming Xie Jin Tao Minyi Xu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 7 | 3D hierarchical architecture collaborating with 2D/2D interface interaction in Ni Al-LDH/Ti_(3)C_(2) nanocomposite for efficient and selective photoconversion of CO_(2)显示文摘Photocatalytic conversion of CO_(2)into a special chemical fuel with high yield and selectivity is still a major challenge.Herein,a 3 D hierarchical Ni Al-LDH/Ti_(3)C_(2)MXene(LDH/TC)nanocomposite is constructed through in situ loading of Ti_(3)C_(2)nanosheets on the Ni Al-LDH scaffold during the hydrothermal process.The formation of a uniform and well-defined 2 D/2 D heterogeneous interface can be realized by optimizing the ratio of Ti_(3)C_(2)and the precursors for Ni Al-LDH.The 3 D hierarchical scaffold with high specific surface area contributes to the favourable photon adsorption and utilization.The intimate contact between Ti_(3)C_(2)and Ni Al-LDH with numerous interfaces effectively promotes the separation of the photoinduced electron-hole pairs in Ni Al-LDH.Together with the highly exposed oxidation-reduction active sites and the enhanced CO_(2)capture and activation.The maximum photocatalytic CO production rate on Ni AlLDH/Ti_(3)C_(2)reaches 11.82 lmol g^(-1)h^(-1)with 92%selectivity and superior stability.This work provides an effective approach for the development of an ideal photocatalyst by collaborative utilization of materials with different dimensionalities. | Qunrong Shi Xiaoyue Zhang Yong Yang Junjie Huang Xiaolong Fu Tianyu Wang Xiaodong Liu Aiwu Sun Jianhua Ge Jinyou Shen Yong Zhou Zuliang Liu | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 8 | Solidification Microstructure and Mechanical Properties of Cast Magnesium-Aluminum-Tin Alloys显示文摘 | Alan A. Luo Penghuai Fu Liming Peng Xiaoyu Kang Zhenzhen Li Tianyu Zhu | 2012 | Metallurgical and Materials Transactions A2012，，1： | 1 |
| 9 | NaNbO_(3) modulated phase transition behavior and antiferroelectric stability evolution in 0.88(Bi_(0.5)Na_(0.5))TiO_(3)-0.12BaTiO_(3) lead-free ceramics显示文摘Giant strains in(Bi_(0.5)Na_(0.5))TiO_(3) based ceramics are usually attributed to electric field induced nonpolar to polar phase transition.Whether it is an ergodic relaxor R3c/P4mm ferroelectric(FE)to long-range ordered FE phase transformation or a reversible P4bm antiferroelectric(AFE)to FE phase transition is still unclear.Herein,lead-free(0.88-x)(Bi_(0.5)Na_(0.5))TiO_(3)-0.12BaTiO_(3-x)NaNbO_(3) ceramics exhibit a compositionmodulated FE tetragonal P4mm to relaxor AFE tetragonal P4bm phase transition,in which double hysteresis loop,sprout-shaped S-E curves,near-zero quasi-static d33 together with a large volume change suggest the AFE characteristics of P4bm phase.An interesting finding is that the reversibility of fieldinduced AFE P4bm phase to FE P4mm phase transition strongly depends on the NN content,from being completely irreversible at x=0.01e0.02,to partially reversible at x=0.03e0.05,and finally to completely reversible at x=0.06e0.08.It is indicated that the variation of reversibility should be attributed to the change of relative free energy caused by decreasing the FE to AFE phase transition temperature with increasing the NN content. | Yi Zhang Jian Fu Aiwen Xie Tianyu Li Xuewen Jiang Ruzhong Zuo Dou Zhang | 2022 | Journal of Materiomics2022，8，5： | 1 |
| 10 | Ti-6Al-4V-5Cu synthesized for antibacterial effect in vitro and in vivo via contact sterilization显示文摘Implant-related infection is one of the most catastrophic complications after surgery,since it may trigger osteomyelitis and necessitate reoperation,increasing the pain suffered by and the burden placed on the patient.Producing a new alloy with an antibacterial effect for use as a biomedical material is an urgent requirement.In this article,Ti-6 Al-4 V-5 Cu was synthesized under two different heat treatment schemes(solution temperatures of 850℃and 950℃).Through comprehensive observation of the microstructure,phase,copper ion release,biocompatibility,corrosion resistance and antibacterial effect in vitro and in vivo,it was determined that cell viability and corrosion resistance of Ti-6 Al-4 V-5 Cu was better than Ti-6 Al-4 V.More importantly,the obtained alloy,especially samples treated at 850℃,showed prominent antibacterial ability.Meanwhile,we also found that the main antibacterial mechanism of the alloy was contact sterilization via the extensive precipitation of Ti_(2)Cu instead of Cu ion release,and the content,surface area of Ti_(2)Cu could affect the antibacterial effect.These findings provide a very promising scheme by which to balance the biocompatibility and antibacterial effect of Ti-based,Cu-bearing alloys,which could improve their performance in orthopedic and dental applications. | Duo Xu Tianyu Wang Zhiyuan Lu Yuanqi Wang Bin Sun Shudan Wang Qiang Fu Zhenggang Bi Shuo Geng | 2021 | Journal of Materials Science & Technology2021，，31： | 1 |
| 11 | 组蛋白H3泛素化通过影响H3K9甲基化进而调控肝脏发育相关基因表达的机制显示文摘文章简介肝脏的发育是一个多步骤并且受到严格调控的过程。过去的研究主要集中在个体出生前肝细胞如何分裂分化,并且多以转录因子和信号通路为研究对象。相比之下,肝脏在个体出生后直至成熟的过程中,虽然肝脏的发育并未停止,但是研究资料相对匮乏。 | Gaofeng Li Tong Ji Jiang Chen Yufei Fu Lidan Hou Yan Feng Tingyue Zhang Tianyu Song Jie Zhao Yoko Endo Hui Lin 蔡秀军 仓勇 | 2018 | 科学新闻2018，0，4： | 0 |
| 12 | Pressure-sensitive Transistor Fabricated from an Organic Semiconductor 1,1'-Dibutyl-4,4'-bipyridinium Diiodide显示文摘 | FU Xianwei LIU Yang LIU Zhi DONG Ning ZHAO Tianyu ZHAO Dan LIAN Gang WANG Qilong CUI Deliang | 2018 | Chemical Research in Chinese Universities2018，34，1： | 0 |
| 13 | A novel Hf-Si-O wire drawing phenomenon after ablation of SiC_(nws)/ HfC-SiC coating on C/C composites显示文摘A SiC_(nws)/HfC-SiC coating was fabricated by a two-step chemical vapor deposition.After introducing SiC nanowires,the fracture toughness of HfC-SiC coating increases by 228%.After ablation under oxyacetylene torch for 60s,a bone-like HfO_(2) reticular structure was formed in the central ablation area.Interestingly,a novel Hf-Si-O wire-drawing phenomenon was happened in the transition area of ablated SiC_(nws)/HfC-SiC coating,providing a new toughness mechanism under ablation environment.Moreover,HfO_(2) precipitated from Hf-Si-O glass wires to generate nanocrystalline grains during ablation,which explains the formation of bone-like HfO_(2) reticular structure observed from central ablation area. | Mingde Tong Qiangang Fu Shuotian Yao Tianyu Liu Tao Feng Dou Hu Lei Zhou | 2020 | Journal of Materiomics2020，6，2： | 0 |
| 14 | RIN enhances plant disease resistance via root exudate-mediated assembly of diseasesuppressive rhizosphere microbiota显示文摘The RIPENING-INHIBITOR(RIN)transcriptional factor is a key regulator governing fruit ripening.While RIN also affects other physiological processes,its potential roles in triggering interactions with the rhizosphere microbiome and plant health are unknown.Here we show that RIN affects microbiome-mediated disease resistance via root exudation,leading to recruitment of microbiota that suppress the soil-borne,phytopathogenic Ralstonia solanacearum bacterium.Compared with the wild-type(WT)plant,RIN mutants had different root exudate profiles,which were associated with distinct changes in microbiome composition and diversity.Specifically,the relative abundances of antibiosis-associated genes and pathogensuppressing Actinobacteria(Streptomyces)were clearly lower in the rhizosphere of rin mutants.The composition,diversity,and suppressiveness of rin plant microbiomes could be restored by the application of 3-hydroxyflavone and riboflavin,which were exuded in much lower concentrations by the rin mutant.Interestingly,RIN-mediated effects on root exudates,Actinobacteria,and disease suppression were evident from the seedling stage,indicating that RIN plays a dual role in the early assembly of diseasesuppressive microbiota and late fruit development.Collectively,our work suggests that,while plant disease resistance is a complex trait driven by interactions between the plant,rhizosphere microbiome,and the pathogen,it can be indirectly manipulated using'prebiotic'compounds that promote the recruitment of disease-suppressive microbiota. | Keming Yang Ruixin Fu Haichao Feng Gaofei Jiang Omri Finkel Tianyu Sun Mingchun Liu Baowen Huang Shan Li Xiaofang Wang Tianjie Yang Yikui Wang Shimei Wang Yangchun Xu Qirong Shen Ville-Petri Friman Alexandre Jousset Zhong Wei | 2023 | Molecular Plant2023，16，9： | 0 |
| 15 | Chaff Jamming Recognition of Radar显示文摘A modified chaff jamming recognition method of radar is investigated using grey relational analysis( GRA) based on the difference in echo correlation characteristics between a complex rigid target and chaff cloud in time domain. Slice method( SM),a novel modeling approach,is proposed to construct an electromagnetic scattering model of chaff cloud in a scenario with slowly moving platform that is targeted. The diffusion characteristics and echo characteristics of the chaff cloud are analyzed. The GRA of a real target and chaff cloud shows that the adjacent return waves have a good correlation for the target but a weak correlation for chaff cloud. Since the correlation degree of chaff cloud's echo is far lower than that of a complex rigid target's,the chaff jamming can be identified by setting a reasonable threshold. Simulation results are presented to verify the effectiveness of this method. | Min Xie Shuang Zhao Xiongjun Fu Tianyu Zhang Kaiqiang Liu | 2018 | Journal of Beijing Institute of Technology2018，27，1： | 0 |
| 16 | In-situ anion exchange based Bi_(2)S_(3)/OV-Bi_(2)MoO_(6)heterostructure for efficient ammonia production:A synchronized approach to strengthen NRR and OER reactions显示文摘Photocatalytic ammonia generation via nitrogen reduction reaction(NRR)is a green and prospective nitrogen fixation technique.However,NRR is often hampered by the high N_(2) adsorption/activation energies and is accompanied by a slow kinetics oxygen evolution reaction(OER).Herein,a robust Bi_(2)S_(3)/OVBi_(2)MoO_(6)S-scheme heterojunction is constructed using a simple in-situ anion exchange process,which enables oxygen vacancy(OVs)abundant Bi_(2)Mo O_(6) microspheres with surface deposited Bi_(2)S_(3).The asfabricated Bi_(2)S_(3)/OVBi_(2)MoO_(6) functioned as an effective photocatalyst to convert N_(2)-to-NH_(3) under mild conditions.The photocatalytic NH_(3)/NH_(4)^(+) production rate reached 126μmol g_(cat)^(-1)under visible light for2.5 h with 2%of Bi_(2)S_(3)/OVBi_(2)MoO_(6)photocatalyst,which was 8-fold higher than pristine Bi_(2)MoO_(6).Furthermore,the as-fabricated Bi_(2)S_(3)/Bi_(2)MoO_(6)heterojunction exhibited good selectivity,high stability and reproducibility.The excellent photocatalytic NRR performance was ascribed to the Bi_(2)S_(3)/Bi_(2)MoO_(6)heterojunction formed subsequent to the strong interaction between Bi_(2)S_(3)and Bi_(2)MoO_(6).The OVs facilitated the chemical adsorption process allowing activation of N_(2)molecule on the Bi_(2)S_(3)/Bi_(2)MoO_(6).Simultaneously,the S-scheme heterojunction prolonged the lifetime of photogenerated carriers,accelerated the electrons/holes spatial separation and accumulation on the Bi_(2)S_(3)(reduction)and Bi_(2)MoO_(6)side(oxidation),respectively,thus strengthening both OER and NRR half-reactions.This simple in-situ anion exchange method offers a novel technique for strengthening OER and NRR half-reactions in Bi-based photocatalysts for effective photocatalytic ammonia generation. | Yuanyuan Zhang Li Guo Yingxian Wang Tianyu Wang Taoxia Ma Zhuangzhuang Zhang Danjun Wang Bin Xu Feng Fu | 2022 | Journal of Materials Science & Technology2022，，15： | 0 |
| 17 | Hydraulic role in differential stomatal behaviors at two contrasting elevations in three dominant tree species of a mixed coniferous and broad-leaved forest in low subtropical China显示文摘Quantifying the variation in stomatal behavior and functional traits of trees with elevation can provide a better understanding of the adaptative strategies to a changing climate. In this study, six water-and carbon-related functional traits were examined for three dominant tree species, Schima superba, Pinus massoniana and Castanopsis chinensis, in a mixed coniferous and broad-leaved forest at two elevations(70 and 360 m above sea level,respectively) in low subtropical China. We hypothesized that trees at higher elevations would develop more efficient strategies of stomatal regulations and greater water transport capacity to cope with more variable hydrothermal conditions than those at lower elevations. Results show that the hydraulic conductivity did not differ between trees at the two elevations, contrary to our expectation. The C. chinensis trees had greater values of leaf mass per unit area(LMA), and the S. superba and C. chinensis trees had greater values of wood density(WD),relative stem water content(RWC), and ratio of sapwood area to leaf area(Hv) at the 360-m elevation than at 70-m elevation. The mean canopy stomatal conductance was greater and more sensitive to vapor deficit pressure at360 m than at 70 m for both S. superba and C. chinensis, while stomatal sensitivity did not differ between the two contrasting elevations for P. massoniana. The midday leaf water potential(ψL) in P. massoniana was significantly more negative at 360 m than at 70 m, but did not vary with increasing elevation in both S. superba and C. chinensis.Variations in Hvcan be related to the differential stomatal behaviors between the two elevations. The variations of stomatal behavior and ψLwith elevation suggested the isohydric strategy for the two broad-leaved species and the anisohydric strategy for the conifer species. The species-specific differences in LMA, WD, RWC, and Hvbetween the two elevations may reflect conservative resource use strategies at the higher elevation. Our findings revealed a close relationship between hydraulic and stomatal behavior and may help better understand the functional responses of forests to changing environmental conditions. | Liwei Zhu Tianyu Fu Jie Du Weiting Hu Yanqiong Li Xiuhua Zhao Ping Zhao | 2023 | Forest Ecosystems2023，10，1： | 0 |
| 18 | The effect of iron metabolism on anxiety disorder显示文摘Anxiety disorder is one of the most common emotional disorders,but its pathogenesis re-mains unclear.Research has shown that iron deficiency is more common in people with emotional disorders and that these disorders can improve after taking iron supple-ments.Many factors can cause anxiety disorders,includ-ing external stress,genetic factors,impaired neurodevel-opment,and abnormal monoamine metabolism.Studies have shown that abnormal monoamine metabolism and impaired neurodevelopment can contribute to the severity of emotional disorders.The synthesis of serotonin(5-HT)and dopamine(DA)require iron as a cofactor in the syn-thesis of monoamine metabolism,and the release of epi-nephrine(E)was potentially associated with labile iron in plasma.At the same time,iron is also directly involved in myelin synthesis as a cofactor in neural development.Therefore,iron maybe involved some of the main causes of the onset of anxiety disorders. | Xingguang Li Xuerui Fu Wei Zhang Caipeng Cao Hongbo Shang Yongchuan Wang Tianyu Dong | 2020 | Journal of Translational Neuroscience2020，5，4： | 0 |
| 19 | Accurate reconstruction algorithm for bilateral differential phase signals显示文摘Background The differential phase computed tomography(DP-CT)imaging is a kind of X-ray-phase-based CT methods,which is widely used in various X-ray imaging laboratories.At present,a collection of projections with the horizontal direc-tion(perpendicular to the sample rotation axis)DP information is often acquired in DP-CT.In an ideal experiment,if the background is zero,then we can accurately reconstruct the information of each direction of the sample with horizontal data only.Actually,background information will produce streaking artifacts to affect the resolution in directions other than the horizontal direction.Purpose To mitigate the streaking artifacts in the conventionally reconstructed DP-CT images.Method This study develops a novel analytical DP-CT reconstruction framework by jointly using the bilateral DP information obtained along two perpendicular directions.In addition,a new data acquisition scheme is also proposed to quickly acquire the bilateral DP signal without the need of changing the direction of refraction signal acquisition.Results Experimental results demonstrate that this new algorithm is able to greatly reduce the streaking artifacts on DP-CT images. | Qili He Yan Wang Panyun Li Chunxia Yao Jin Zhang Tianyu Fu Kai Zhang Qingxi Yuan Wanxia Huang Shanfeng Wang Peiping Zhu Peng Liu | 2021 | Radiation Detection Technology and Methods2021，5，3： | 0 |
| 20 | FPC-BTB detection and positioning system based on optimized YOLOv5显示文摘With the aim of addressing the visual positioning problem of board-to-board(BTB)jacks during the automatic assembly of flexible printed circuit(FPC)in mobile phones,an FPC-BTB jack detection method based on the optimized You Only Look Once,version 5(YOLOv5)deep learning algorithm was proposed in this study.An FPC-BTB jack real-time detection and positioning system was developed for the real-time target detection and pose output synchronization of the BTB jack.On that basis,a visual positioning experimental platform that integrated a UR5e manipulator arm and Hikvision industrial camera was built for BTB jack detection and positioning experiments.As indicated by the experimental results,the developed FPC-BTB jack detection and positioning system for BTB target recognition and positioning achieved a success rate of 99.677%.Its average detection accuracy reached 99.341%,the average confidence of the detected target was 91%,the detection and positioning speed reached 31.25 frames per second,and the positioning deviation was less than 0.93 mm,which conforms to the practical application requirements of the FPC assembly process. | Changyu Jing Tianyu Fu Fengming Li Ligang Jin Rui Song | 2023 | Biomimetic Intelligence & Robotics2023，3，4： | 0 |
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