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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edsfncup9fp0bqu60ow.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edsfncup9fp0bqu60ow.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edsfncup9fp0bqu60ow.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 3 | TD-AltBOC:A new COMPASS B2 modulation显示文摘AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal. | TANG ZuPing ZHOU HongWei WEI JiaoLong YAN Tao LIU YuQi RAN YiHang ZHOU YanLing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 20 |
| 4 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 5 | mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3b/MMPs显示文摘Golgi membrane protein 1(GOLM1/GP73)is a serum marker of hepatocellular carcinoma(HCC).We have previously shown that mTOR promoted tumorigenesis of HCC through stimulating GOLM1 expression.In this study,we demonstrated that the mammalian target of rapamycin(mTOR)was a negative regulator of microRNA-145(miR-145)expression.miR-145 inhibited GOLM1 expression by targeting a coding sequence of GOLM1 gene.GOLM1 and miR-145 were inversely correlated in human HCC tissues.GOLM1-enriched exosomes activated the glycogen synthase kinase-3β/matrix metalloproteinases(GSK-3β/MMPs)signaling axis of recipient cells and accelerated cell proliferation and migration.In contrast,miR-145 suppressed tumorigenesis and metastasis.We suggest that mTOR/miR-145/GOLM1 signaling pathway should be targeted for HCC treatment. | Xiaochen Gai Bufu Tang Fangming Liu Yuting Wu Fang Wang Yanling Jing Fuqiang Huang Di Jin Ling Wang Hongbing Zhang | 2019 | Journal of Genetics and Genomics2019，46，5： | 13 |
| 6 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 7 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 8 | Effective NH2- grafting on mesoporous SBA-15 surface for adsorption of heavy metal ions显示文摘 | Zhao Yanling Gao Qiang Tang Tao | 2011 | Mater Lett2011，65，6： | 1 |
| 9 | A highly efficient visible-light-activated photocatalyst based on bismuth-and Sulfur-Codoped TiO显示文摘 | Wang Ying Wang Yan Meng Yanling Ding Hanming Shan Yongkui Zhao Xian Tang Xiaozhen | 2008 | Journal of Physical Chemistry C2008，112，： | 1 |
| 10 | Impacts of meteorology and emission variations on the heavy air pollution episode in North China around the 2020 Spring Festival显示文摘Based on the Weather Research and Forecasting model and the Models-3 community multi-scale air quality model(WRF-CMAQ),this study analyzes the impacts of meteorological conditions and changes in air pollutant emissions on the heavy air pollution episode occurred over North China around the 2020 Spring Festival(January to Februray 2020).Regional reductions in air pollutant emissions required to eliminate the PM2.5 heavy pollution episode are also quantified.Our results found that meteorological conditions for the Beijing-Tianjin-Hebei and surrounding'2+26'cities are the worst during the heavy pollution episode around the 2020 Spring Festival as compared with two other typical heavy pollution episodes that occurred after 2015.However,because of the substantial reductions in air pollutant emissions in the'2+26'cities in recent years,and the32%extra reduction in emissions during January to February 2020 compared with the baseline emission levels of the autumn and winter of 2019 to 2020,the maximum PM2.5 level during this heavy pollution episode around the 2020 Spring Festival was much lower than that in the other two typical episodes.Yet,these emission reductions are still not enough to eliminate regional heavy pollution episodes.Compared with the actual emission levels during January to February 2020,a 20%extra reduction in air pollutant emissions in the'2+26'cities(or a 45%extra reduction compared with baseline emission levels of the autumn and winter of 2019 to 2020)could help to generally eliminate regionwide severe pollution episodes,and avoid heavy pollution episodes that last three or more consecutive days in Beijing;a 40%extra reduction in emissions(or a 60%extra reduction compared with baseline emission levels of the autumn and winter of 2019 to 2020)could help to generally eliminate regionwide and continuous heavy pollution episodes.Our analysis finds that during the clean period after the heavy pollution episode around the 2020 Spring Festival,the regionwide heavy pollution episode would only occur with at least a 10-fold increase in air pollutant emissions. | Wenbo XUE Xurong SHI Gang YAN Jinnan WANG Yanling XU Qian TANG Yanli WANG Yixuan ZHENG Yu LEI | 2021 | Science China Earth Sciences2021，64，2： | 1 |
| 11 | Five-Stage Model of the Palaeozoic Crustal Evolution in Xinjiang显示文摘The great majority of the Palaeozoic orogenjc belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitional crust-oceanic crust-convergent transitional crust-new continental crust model. The stage for the extensional transitional crust is a pretty long, independent and inevitable phase. The dismembering mechanism of the basal continental crust becoming an extensional continental crust is delineated by the simple shear model put forward by Wernike (1981). The continental margins on the sides of a gently dipping detachment zone and moving along it are asymmetric: one side is of the nonmagmatic type and the other of the magmatic type with a typical bimodal volcanic formation. In the latter case, however, they were often confused with island arcs. This paper discusses the five-stage process of the crustal evolution of some typical orogenic belts in Xinjiang. | LIU Dequan TANG Yanling ZHOU Ruhong | 1998 | Acta Geologica Sinica(English Edition)1998，72，4： | 1 |
| 12 | Evaluation of fatty liver fibrosis in rabbits using real-time shearwave elastography显示文摘 | Yongping Lu Jia Wei Yueyue Tang Yuan Yuan Yanling Huang Yong Zhang Yunyan Li | 2014 | Experimental and Therapeutic Medicine2014，，2： | 1 |
| 13 | Emerging two-dimensional material nanozymes for theranostic nanomedicine显示文摘Nanomaterials-based artificial enzymes(nanozymes)with valuable enzyme-like catalytic properties have been booming during the past few years.Promoted by the advances in biological medicine and nanotechnology,nanozymes possess the potential to serve as an emerging agent for biosensing,immunoassays,detection and diagnosis,catalytic therapeutics,and other applications in the biomedicine field.Two-dimensional(2D)nanomaterials are of considerable interest in biomedical applications due to their ultrathin layered structure and unique physiochemical properties.Inspired by the diversified catalytic performance of 2D nanomaterials,scientists extensively have developed 2D materials as bioactive nanozymes for theranostic nanomedicine.Here,recent advances in enzyme-like 2D nanomaterials design and construction are comprehensively presented.Additionally,we exhibit that,with the synergistic effect of catalytic activities and desirable physicochemical performances,2D nanozymes can serve as versatile platforms with extensive applications from target detection to in vivo theranostic.It is believed that such promising alternatives towards natural enzymes will be of vital significance in the field of nanotechnology and biomedicine. | Yanling You Zhongmin Tang Han Lin Jianlin Shi | 2021 | Biophysics Reports2021，7，3： | 1 |
| 14 | miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease显示文摘 | Wang-Xia Wang Bernard R. Wilfred Sindhu K. Madathil Guiliang Tang Yanling Hu James Dimayuga Arnold J. Stromberg Qingwei Huang Kathryn E. Saatman Peter T. Nelson | 2010 | The American Journal of Pathology2010，，： | 1 |
| 15 | An organic-inorganic hybrid thermochromic ferroelastic with multi-channel switches显示文摘Multifunctional switchable materials are attracting tremendous interest because of their great application potential in signal processing,information encryption,and smart devices.Here,we reported an organic-inorganic hybrid thermochromic ferroelastic crystal,[TMIm][CuCl_(4)](TMIm=1,1,3,3-tetramethylimidazolidinium),which undergoes two reversible phase transitions at 333 K and 419 K,respectively.Intriguingly,these three phases experience a remarkable ferroelastic-paraelastic-ferroelastic(2/m-mmm-2/m)transition,which remains relatively unexplored in ferroelastics.Moreover,the ferroelastic domains can be simultaneously switched under temperature and stress stimuli.Meanwhile,[TMIm][CuCl_(4)]exhibits thermochromic phenomenon,endowing it with extra spectral encryption possibilities during information processing.Combined with dielectric switching behavior,[TMIm][Cu Cl_(4)]are promising for practical applications in memory devices,next-generation sensors,and encryption technology. | Yipiao Zeng Junchao Liu Lin Zhou Xin Deng Wenli Yang Xin Yan Yanling Luo Xuan Zhu Xiaoyun Huang Xianjiang Song Yuanyuan Tang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 16 | Design,application and verification of a novel system utilizing bacteria and microalgae to treat swine farm wastewater and produce value-added biomass显示文摘Swine farm wastewater is extremely harmful to the environment if not treated before it is discharged.In this study,a system was developed and optimized for testing the high levels of organic matter in swine farm wastewater utilizing a microalgae/bacteria co-culture combined with a novel closed-loop extraction and dilution process.Importantly,the system produces biomass that also could be harvested and used in value-added applications.The efficacy of biomass as a biofertilizer was demonstrated by using a model plant of Arabidopsis.In addition,the analysis of biomass indicates that it also has potential as a source for biofuel.After a 20-d cultivation period,a yield of biomass was achieved to 2.063 g/L of wastewater.The highest removal rates recorded in steady state conditions were:13.8 mg/L·d of Total Nitrogen(TN);11.5 mg/L·d of Ammonia Nitrogen(NH_(4)^(+)-N);24.8 mg/L·d of Chemical Oxygen Demand(COD);and 16.9 mg/L·d of Total Phosphorus(TP).After cultivation,the composition of the biomass was analyzed on a dry basis;the major components were protein(44.9%),lipids(24.6%),carbohydrates(19.9%),Chlorophyll-A(2.75%),Chlorophyll-B(1.66%),and carotenoids(0.57%).This biomass was diluted with water(5%by weight)and used as a biofertilizer to grow Arabidopsis.The results showed that the average root and stem lengths of Arabidopsis were 43.0%and 55.0%longer compared to those of the control group.Additionally,the number of leaves and the maximum leaf length increased by 30.2%and 39.7%;and the fresh and dry leaf weights increased by 44.0%and 33.7%,respectively.These results demonstrate the efficacy of this system for treating swine farm wastewater whilst simultaneously producing a value-added microalgae/bacteria biomass.This paper also demonstrated the use of biomass as a fertilizer for cultivating a value-added crop and,based on the compositional analyses,propose that the biomass could be used as a raw material for biofuel production due to its high lipid content of 24.6%.By constructing a microalgae/bacteria symbiosis system,Swine farm wastewater can be treated as resources utilizing producing value-added biomass with demonstrated efficacy as a biofertilizer. | Xin Zhen Yali Li Jingwen Qiang Manyu Tang Wei Hua Wanqing Wang Shuang Wu Phil Perkins Roger Ruan Yanling Cheng | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 17 | Problems and Recommendations for Export of Guizhou Tea in the Context of Rural Revitalization Strategy显示文摘As a traditional advantageous industry in Guizhou and an important export product,tea plays an important role in the rural revitalization strategy.This paper first introduces the current situation of tea industry and export in Guizhou,then analyzes the problems that arise in the export process,and finally comes up with corresponding countermeasures and recommendations for the export development of tea,hoping to provide certain guidance and reference to the development of tea industry in Guizhou Province. | Yanling REN Tao WANG Jinyu ZHAO Yao LIU Mei LI Jian TANG Xiaolei JI Jing PENG | 2023 | Asian Agricultural Research2023，15，7： | 0 |
| 18 | Precise absolute positioning for a single-frequency user显示文摘A new strategy to realize precise absolute positioning for a single-frequency user is presented. In the presented strategy, the receiver clock and ambiguities are removed using the satelliteand epoch-differenced (SDED) algorithm. As a further development of the SDED algorithm, a regional augmentation network is used to generate the SDED atmospheric delays at the user. The weakened mathematic property due to the epoch-differenced operation is improved by adding the generated atmospheric delays and applying the robust estimation. To test the new approach, the 24-h data at 5 Continuous Operation Reference Station (CORS) stations in Shanghai is processed. The results show a more than 96% success rate, defined as the case where three directions achieve the desired positioning accuracy of 10 cm, when the observation is longer than 20 min. The 20-min static results show that the new method can reach an accuracy of 3.42, 4.76 and 9.26 cm in the North, East and Up directions, respectively. An experiment was carried out to assess the kinematic positioning. The results show that the kinematic positioning accuracy is 4.11, 5.31 and 4.05 cm in the north-south, east-west and height directions,respectively. | LI HaoJun TANG GuiFeng HE Feng WU Bin HU XiaoGong CHEN YanLing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 0 |
| 19 | Transportation of citrinin is regulated by the CtnC gene in the medicinal fungus Monascus purpureus显示文摘Monascus is one of the most essential microbial resources in China,with thousands of years of history.Modern science has proved that Monascus can produce pigment,ergosterol,monacolin K,-aminobutyric acid,and other functionally active substances.Currently,Monascus is used to produce a variety of foods,health products,and pharmaceuticals,and its pigments are widely used as food additives.However,Monascus also makes a harmful polyketide component called citrinin in the fermentation process;citrinin has toxic effects on the kidneys such as teratogenicity,carcinogenicity,and mutagenicity(Gong et al.,2019).The presence of citrinin renders Monascus and its products potentially hazardous,which has led many countries to set limits and standards on citrinin content. | Yanling GUI Guangfu TANG Haiqiao MAN Jiao WANG Jie HAN Jiehong ZHAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 20 | Hypercompact CRISPR–Cas12j2 (CasF) enables genome editing, gene activation, and epigenome editing in plants显示文摘CRISPR-Cas9,-Cas12a,-Cas12b,and-Cas13 have been harnessed for genome engineering in human and plant cells(Liu et al.,2022).However,the large size of these Cas proteins(e.g.190 kDa for SpCas9)makes them difficult to deliver into cells via a viral vector.The development of smaller Cas proteins will lead to reduced viral vector sizes that can be more widely adopted in versatile genome engineering systems.Recently,a CRISPR-Cas12j2(CasF)system was discovered in huge phages and developed into a hypercompact genome editor due to the small size of Cas12j2(80 kDa)(Pausch et al.,2020).Unfortunately,the gene editing efficiency of Cas12j2 in Arabidopsis protoplasts using ribonucleoprotein delivery was less than one percent(Pausch et al.,2020).Further optimization of this system is clearly required if CRISPR-Cas12j2-mediated editing in plant genomes is to be adopted by the plant sciences community. | Shishi Liu Simon Sretenovic Tingting Fan Yanhao Cheng Gen Li Aileen Qi Xu Tang Yang Xu Weijun Guo Zhaohui Zhong Yao He Yanling Liang Qinqin Han Xuelian Zheng Xiaofeng Gu Yiping Qi Yong Zhang | 2022 | Plant Communications2022，3，6： | 0 |
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