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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 3 | Relationship between lifestyle factors and defecation in a Japanese population显示文摘 | Shigeyuki Nakaji Shoji Tokunaga Juichi Sakamoto Masahiro Todate Tadashi Shimoyama Takashi Umeda Kazuo Sugawara | 2002 | European Journal of Nutrition2002，，6： | 1 |
| 4 | 重症监护室内右旋美托咪啶引发的手术后药物热显示文摘盐酸右旋美托咪啶是一种有效的、高选择性的α-2受体激动剂,它作为一种镇静药在重症监护室(ICU)得到广泛的应用。本文我们报道一例由盐酸右旋美托咪啶引发的药物热。患者年龄59岁,因腹主动脉瘤破裂收入ICU。患者在开始应用盐酸右旋美托咪啶镇静后出现发热,体温超过39℃。停药7小时后,发热症状迅速缓解。其间排除其他可能引起发热的原因(如感染)。 | Tadashi Okabe Shinhiro Takeda Shinji Akada Takashi Hongo Atsuhiro Sakamoto 王斐(译) 王焱林(校) | 2010 | 麻醉与镇痛2010，，4： | 1 |
| 5 | Tight Heart Rate Control Reduces Secondary Adverse Events in Patients With Type B Acute Aortic Dissection显示文摘 | Kazuhisa Kodama Kazuhiro Nishigami Tomohiro Sakamoto Tadashi Sawamura Touitsu Hirayama Hiroyasu Misumi Koichi Nakao | 2008 | Circulation ( Suppl )2008，，14： | 1 |
| 6 | Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer显示文摘 | Yutaka Sugihara Hirokazu Taniguchi Ryoji Kushima Hitoshi Tsuda Daisuke Kubota Hiroshi Ichikawa Kano Sakamoto Yukiko Nakamura Takeshi Tomonaga Shin Fujita Tadashi Kondo | 2012 | Journal of Proteomics2012，，17： | 1 |
| 7 | μVNC: A proposal for intemet connectivity and interconnectivity of home appliances based on remote display framework 显示文摘 | Tomohiro Haraikawa Tadashi Sakamoto Tomohiro Hase | 2001 | IEEE Transactions on Consumer Electronics2001，47，3： | 1 |
| 8 | μVNC over PLC: A framework for GUI-based remote operation of home appliances through power-line communication显示文摘 | Tomohiro Haraikawa Tadashi Sakamoto Tomohiro Hase | 2002 | IEEE Transactions on Consumer Electronics2002，48，4： | 1 |
| 9 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 10 | Improvement of the positioning accuracy of a software2based GPS receiver using a 322bit embedded microprocessor显示文摘 | GO SATO TAKASHI ASAI TADASHI SAKAMOTO | 2000 | IEEE Transactions on Consumer Electronics2000，46，3： | 1 |
| 11 | NOx decomposition mechanism on the electrodes of a zirconia-based amperometric NOx sensor显示文摘 | Tadashi Nakamura Yoshiyuki Sakamoto Keiichi Saji | 2003 | Sensors and Actuators B2003，，93： | 1 |
| 12 | Cellulose esters as compatibilizers in wood/poly(lactic acid) composite显示文摘 | Masahiro Takatani Kohei Ikeda Kei Sakamoto Tadashi Okamoto | 2008 | Journal of Wood Science2008，，1： | 1 |
| 13 | Improvement of the positioning accuracy of a software-based GPS receiver using a 32-bit embedded microprocessor显示文摘 | Go Sato Takashi Asai Tadashi Sakamoto | 2000 | IEEE Transactions on Consumer Electronics2000，46，3： | 1 |
| 14 | Software Pixel Interpolation for Digital Still Camera Suitable for A 32-Bit MCU显示文摘 | Chikako Nakanishi Tomohiro Hase | 1998 | IEEE Trans on Consumer Electronics1998，44，4： | 1 |
| 15 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 16 | Acute esophageal necrosis caused by alcohol abuse显示文摘Acute esophageal necrosis (AEN) is extremely rare and the pathogenesis of this is still unknown. We report a case of AEN caused by alcohol abuse. In our case, the main pathogenesis could be accounted for low systemic perfusion caused by severe alcoholic lactic acidosis. After the healing of AEN, balloon dilatation was effective to manage the stricture. | Tetsu Endo Juichi Sakamoto Ken Sato Miyako Takimoto Koji Shimaya Tatsuya Mikami Akihiro Munakata Tadashi Shimoyama Shinsaku Fukuda | 2005 | World Journal of Gastroenterology2005，11，35： | 0 |
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