|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 2 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 2 |
| 3 | Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Atherosclerosis Depending on Smoking Status in a Japanese General Population显示文摘 | Nozomu Inamoto Tomohiro Katsuya Yoshihiro Kokubo Toshifumi Mannami Takashi Asai Shunroku Baba Jun Ogata Hitonobu Tomoike Toshio Ogihara | 2003 | Stroke: Journal of the American Heart Association2003，，7： | 2 |
| 4 | Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer显示文摘A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer(T3N2M0 Stage Ⅲ) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation,including redness,erosion,edema,bleeding,friability,and exudate with white plaques; and multiple depressions in the residual esophagus. Radiographical examination revealed numerous fine,gastrografinfilled projections and an anastomotic stricture. Biopsy specimens from the area of the anastomotic stricture revealed inflammatory changes without signs of malignancy. Candida glabrata was detected with a culture test of the biopsy specimens. The stricture was diagnosed as a benign stricture that was caused by esophageal intramural pseudodiverticulosis. Accordingly,endoscopic balloon dilatation was performed and antifungal therapy was started in the hospital. Seven weeks later,endoscopic examination revealed improvement in the mucosal inflammation; only the pseudodiverticulosis remained. Consequently,the patient was discharged. At the latest follow-up,the patient was symptomfree and the pseudodiverticulosis remained in the residual esophagus without any signs of stricture or inflammation. | Nobuyoshi Takeshita Naoki Kanda Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Masaya Uesato Tetsutaro Sazuka Tetsuro Maruyama Naohiro Aida Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 5 | Improvement of the positioning accuracy of a software2based GPS receiver using a 322bit embedded microprocessor显示文摘 | GO SATO TAKASHI ASAI TADASHI SAKAMOTO | 2000 | IEEE Transactions on Consumer Electronics2000，46，3： | 1 |
| 6 | ASK1 regulates influenza virus infection-induced apoptotic cell death显示文摘 | Shuichiro Maruoka Shu Hashimoto Yasuhiro Gon Hideki Nishitoh Ikuko Takeshita Yasukiyo Asai Kenji Mizumura Kazufumi Shimizu Hidenori Ichijo Takashi Horie | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 7 | Intubating laryngeal mask for fibreptic intubation particularly useful during neck stabilization显示文摘 | Takashi Asai Yoshitaka Eguchi Kohei Murao | 2000 | Can J Anaesth2000，47，9： | 1 |
| 8 | Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma显示文摘BACKGROUND The prognosis of hepatocellular carcinoma(HCC)patients remains poor despite advances in treatment modalities and diagnosis.It is important to identify useful markers for the early detection of HCC in patients.Preneoplastic antigen(PNA),originally reported in a rat carcinogenesis model,is increased in the tissues and serum of HCC patients.AIM To determine the diagnostic value of PNA for discriminating HCC and to characterize PNA-positive HCC.METHODS Patients with hepatitis C virus(HCV)-related hepatic disorders were prospectively enrolled in this study,which included patients with hepatitis,with cirrhosis,and with HCC.A novel enzyme-linked immunosorbent assay was developed to measure serum PNA concentrations in patients.RESULTS Serum PNA concentrations were measured in 89 controls and 141 patients with HCV infections(50 hepatitis,44 cirrhosis,and 47 HCC).Compared with control and non-HCC patients,PNA was increased in HCC.On receiver operating characteristic curve analysis,the sensitivity of PNA was similar to the HCC markers des-γ-carboxy-prothrombin(DCP)andα-fetoprotein(AFP),but the specificity of PNA was lower.There was no correlation between PNA and AFP and a significant but weak correlation between PNA and DCP in HCC patients.Importantly,the correlations with biochemical markers were completely different for PNA,AFP,and DCP;glutamyl transpeptidase was highly correlated with PNA,but not with AFP or DCP,and was significantly higher in PNA-high patients than in PNA-low patients with HCV-related HCC.CONCLUSION PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed but AFP or DCP is weakly or negatively expressed. | Satoyoshi Yamashita Akira Kato Toshitaka Akatsuka Takashi Sawada Tomohide Asai Noriyuki Koyama Kiwamu Okita | 2020 | World Journal of Gastroenterology2020，26，13： | 1 |
| 9 | Improvement of the positioning accuracy of a software-based GPS receiver using a 32-bit embedded microprocessor显示文摘 | Go Sato Takashi Asai Tadashi Sakamoto | 2000 | IEEE Transactions on Consumer Electronics2000，46，3： | 1 |
| 10 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 1 |
| 11 | Endothelin-1 Gene Variant Associates with Blood Pressure in Obese Japanese Subjects: The Ohasarna Study 显示文摘 | Takashi Asai Takayoshi Ohkubo Tomohiro Katsuya | 2001 | Hypertension2001，38，： | 1 |
| 12 | Nanometer stepping drives of surface acoustic wave motor显示文摘 | Minoru Kuribayashi Kurosawa Katsuhiko Asai | 2003 | Ultrasonics2003，50，4： | 1 |
| 13 | Physical activity and immune senescence in men显示文摘 | SHOJI SHINKAI HIDEAKI KOHNO KEI KIMURA TAKASHI KOMURA HIDENORI ASAI REIKO INAI KEIZO OKA YOSHIKA KUROKAWA ROY J. SHEPHARD | 1995 | Medicine & Science in Sports & Exercise1995，，11： | 1 |
| 14 | Videolaryngoscopes: Do They Truly Have Roles in Difficult Airways?显示文摘 | Takashi Asai | 2012 | Anesthesiology2012，，3： | 1 |
| 15 | FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression显示文摘 | Guilan Jin Hiromichi Matsushita Satomi Asai Hideo Tsukamoto Ryoichi Ono Tetsuya Nosaka Takashi Yahata Shinichiro Takahashi Hayato Miyachi | 2009 | Biochemical and Biophysical Research Communications2009，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员