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| 1 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 2 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 3 | BMPs functionally replace KLf4, and support efficient reprogramming of mouse fibroblasts by Oct4 alone显示文摘由定义因素的导致的 pluripotent 干细胞的产生成为了一个有用模型调查 reprogramming 和房间命运决心的机制。然而,基于因素的 reprogramming 的精确机制仍然保持不清楚。这里,我们证明 Klf4 主要在 reprogramming 的起始的阶段行动开始 mesenchymal-to-epithelial 转变并且能是机能上地由骨头代替了形态基因的蛋白质(BMP ) 。BMP 增加了老鼠的 Oct4/Sox2-mediated reprogramming 的效率胚胎的成纤维细胞(MEF ) 到 ~1% 。BMP 也支持了 MEF 和尾巴的单个因素的基于 Oct4 的 reprogramming 胫骨的成纤维细胞。我们的研究在 reprogramming 澄清 Klf4 的贡献并且在区分的房间作为 pluripotency 的单个 setter 建立 Oct4。 | Jiekai Chen Jing Liu Jiaqi Yang You Chen Jing Chen Su Ni Hong Song Lingwen Zeng Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，1： | 26 |
| 4 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 5 | Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP)显示文摘 | Jing-wei ZHANG Ke SU Wen-tao SHI Ying WANG Peng-chao HU Yang WANG Lei WEI Jin XlANG Fang YANG | 2013 | Acta Pharmacologica Sinica2013，34，8： | 13 |
| 6 | VIBRATION CHARACTERISTICS OF FLUID-STRUCTURE INTERACTION OF CONICAL SPIRAL TUBE BUNDLE显示文摘Heat transfer enhancement is achieved by flow-induced vibration in elastic tube bundles heat exchangers.For a further understanding of heat transfer enhancement mechanism and tube structure optimization,it is of importance to study the vibration characteristics of fluid-structure interaction of tube bundles.The finite element method is applied in the study of fluid-structure interaction of a new type elastic heat transfer element,i.e.,the dimensional conical spiral tube bundle.The vibration equation and element matrix for the tube are set up by the regulation of different helical angles and coordinate transformation,together with the simplification of the joint body of the two pipes.The vibration characteristics of conical spiral tube bundle are analyzed at different velocities of the tube-side flow,and the critical velocity of vibration buckling is obtained.The results show that the natural frequency of the tube bundle decreases as the flow speed increases,especially for the first order frequency,and the critical velocity of vibration buckling is between 1.2665 m/s-1.2669 m/s.The vibration mode of conical spiral tube bundle is mainly z-axial,which is feasible to be induced and controlled. | YAN Ke GE Pei-qi BI Wen-bo SU Yan-cai HU Rui-rong | 2010 | Journal of Hydrodynamics2010，22，1： | 13 |
| 7 | GGE biplot analysis of yield stability and test location representativeness in proso millet (Panicum miliaceum L.) genotypes显示文摘The experiments were conducted for three consecutive years across 14 locations using 9 non-waxy proso millet genotypes and 16 locations using 7 waxy proso millet genotypes in China. The objectives of this study were to analyze yield stability and adaptability of proso millets and to evaluate the discrimination and representativeness of locations by analysis of variance(ANOVA) and genotype and genotype by environment interaction(GGE) biplot methods. Grain yields of proso millet genotypes were significantly influenced by environment(E), genotype(G) and their interaction(G×E)(P<0.1%). G×E interaction effect was six times higher than G effect in non-waxy group and seven times in waxy group. N04-339 in non-waxy and Neimi 6(NM6) in waxy showed higher grain yields and stability compared with other genotypes. Also, Neimi 9(NM9, a non-waxy cultivar) and 90322-2-33(a waxy cultivar) showed higher adaptability in 7 and in 11 locations, respectively. For non-waxy, Dalat, Inner Mongolia(E2) and Wuzhai, Shanxi(E5) were the best sites among all the locations for maximizing the variance among candidate cultivars, and Yanchi, Ningxia(E10) had the best representativeness. Wuzhai, Shanxi(e9) and Yanchi, Ningxia(e14) were the best representative locations, and Baicheng, Jilin(e2) was better discriminating location than others for waxy genotypes. Based on our results, E10 and e14 have enhanced efficiency and accuracy for non-waxy genotypes and waxy genotypes selection, respectively in national regional test of proso millet varieties. | ZHANG Pan-pan SONG Hui KE Xi-wang JIN Xi-jun YIN Li-hua LIU Yang QU Yang SU Wang FENG Nai-jie ZHENG Dian-feng FENG Bai-li | 2016 | Journal of Integrative Agriculture2016，15，6： | 13 |
| 8 | Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats显示文摘 | Wen-ya HUANG Xin ZOU Fu-er LU Hao SU Chu ZHANG Yan-lin REN Ke FANG Li-jun XU Kai- fu WANG Qing-jie CHEN Hui DONG | 2018 | Current Medical Science2018，38，4： | 13 |
| 9 | Prognostic factors of spontaneously ruptured hepatocellular carcinoma显示文摘AIM: To evaluate the prognostic factors in patients with spontaneously ruptured hepatocellular carcinoma(HCC). METHODS: Seventy-nine patients experiencing spontaneous rupture of HCC between April 2004 and August 2014 were enrolled in this study. The clinical features, treatment modalities and outcomes were reviewed. The statistical methods used in this work included univariate analysis, Kaplan-Meier survival analysis with log-rank tests, and multivariate analysis using a Cox regression hazard model. RESULTS: Of the 79 patients with HCC rupture, 17(21.5%) underwent surgery, 32(40.5%) underwent transarterial embolization(TAE), and 30(38%) received conservative treatment. The median survival time was 125 d, and the mortality rate at 30 d was 27.8%. Multivariate analysis revealed that lesion length(HR = 1.46, P < 0.001), lesion number(HR = 1.37, P = 0.042), treatment before tumor rupture(HR = 4.36, P = 0.019), alanine transaminase levels(HR = 1.0, P = 0.011), bicarbonate levels(HR = 1.18, P < 0.001), age(HR = 0.96, P = 0.026), anti-tumor therapy during the followup period(HR = 0.21, P = 0.008), and albumin levels(HR = 0.89, P = 0.010) were independent prognostic factors of survival after HCC rupture. The BarcelonaClinic Liver Cancer(BCLC) stage was also an important prognostic factor; the median survival times for BCLC stages A, B and C were 251, 175 and 40 d, respectively(P < 0.001).CONCLUSION: Anti-tumor therapy during the followup period, without a history of anti-tumor therapy prior to HCC rupture, small tumor length and number, and early BCLC stage are the most crucial predictors associated with satisfactory overall survival. Other factors play only a small role in overall survival. | Xiang-Jun Han Hong-Ying Su Hai-Bo Shao Ke Xu | 2015 | World Journal of Gastroenterology2015，21，24： | 11 |
| 10 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 11 | Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella显示文摘Indoxacarb 和 metaflumizone 属于钠隧道 blocker 杀虫药剂(SCBI ) 的一个相对新的班。由于 indoxacarb 的集中的使用,演变地的 indoxacarb 抵抗在几个鳞翅类的害虫被报导了,包括有菱形斑纹的蛾 Plutella xylostella,饰有十字架的庄稼的一个严肃的害虫。特别地, P 的 BY12 人口。xylostella,从 Baiyun 镇定,在 2012 的中国的广东省,对 indoxacarb 和对 metaflumizone 更抵抗的 70 褶层更抵抗的 750 褶层与易受影响的 Roth 相比拉紧。编码 Roth 和 BY12 的钠隧道基因的互补 DNA 序列的比较在 PxNa 在 BY 人口的 v 蛋白质。两个变化位于被预言基于哺乳动物的钠隧道涉及局部麻醉和 SCBI 的有约束力的地点的一个高度保存的顺序区域以内。重要关联在在变异的等位基因(Y1845 或 I1848 ) 之间的 10 张地镇定的人口之中被观察频率(1.7% ~ 52.5%) 和到 indoxacarb (到 870 褶层的 34-) 和 metaflumizone (到 70 褶层的 1-) 的抵抗层次。二个变化从来没被发现在 PxNa 建议他们独立地产生了的 v , 。这是钠隧道变化与抵抗的高水平被联系了到 SCBI 的第一次。F1845Y 和 V1848I 是为在有菱形斑纹的蛾并且可能监视另外的昆虫害虫种类的抵抗的分子的标记。 | Xing-Liang Wang Wen Su Jian-Heng Zhang Yi-Hua Yang Ke Dong Yi-Dong Wu | 2016 | Insect Science2016，23，1： | 10 |
| 12 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 13 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 14 | Surface plasmon resonance of layer-by-layer gold nanoparticles induced photoelectric current in environmentally-friendly plasmon-sensitized solar cell显示文摘Layer-by-layer gold nanoparticles are used to generate photocurrent in an environmentally-friendly plasmon-sensitized solar cell towing to surface plasmon resonance.The efficiency of the photoelectric conversion of gold nanoparticle layers is increased as the intensity of surface plasmon resonance increases.We also explain the experimental results by modeling the phenomenon of charge separation and photocurrent formation,and the relationship between surface plasmon resonance and photocurrent formation,which has potential application in plasmon-sensitized solar cells and plasmonic solar cells in the future. | Yen-Hsun Su Yuan-Feng Ke Shi-Liang Cai Qian-Yu Yao | 2012 | Light(Science & Applications)2012，1，1： | 10 |
| 15 | An improved empirical wavelet transform method for rolling bearing fault diagnosis显示文摘Empirical wavelet transform(EWT)based on the scale space method has been widely used in rolling bearing fault diagnosis.However,using the scale space method to divide the frequency band,the redundant components can easily be separated,causing the band to rupture and making it difficult to extract rolling bearing fault characteristic frequency effectively.This paper develops a method for optimizing the frequency band region based on the frequency domain feature parameter set.The frequency domain feature parameter set includes two characteristic parameters:mean and variance.After adaptively dividing the frequency band by the scale space method,the mean and variance of each band are calculated.Sub-bands with mean and variance less than the main frequency band are combined with surrounding bands for subsequent analysis.An adaptive empirical wavelet filter on each frequency band is established to obtain the corresponding empirical mode.The margin factor sensitive to the shock pulse signal is introduced into the screening of empirical modes.The empirical mode with the largest margin factor is selected to envelope spectrum analysis.Simulation and experiment data show this method avoids over-segmentation and redundancy and can extract the fault characteristic frequency easier compared with only scale space methods. | HUANG HaiRun LI Ke SU WenSheng BAI JianYi XUE ZhiGang ZHOU Lang SU Lei PECHT Michael | 2020 | Science China(Technological Sciences)2020，63，11： | 10 |
| 16 | Portalsystemic hemodynamic changes in chronic severe hepatitis B: An ultrasonographic study显示文摘AIM:To evaluate portalsystemic hemodynamic changes in chronic severe hepatitis B. METHODS:Hemodynamic parameters included portal vein diameter (PVD), portal vein peak velocity (PVPV), portal vein volume (PVV), spleen length (SPL), spleen vein diameter (SPVD), spleen vein volume (SPVV) and umbilical vein recanalization. They were measured by Color Doppler ultrasonography in 36 patients with chronic severe hepatitis B, compared with 51 normal controls, 61 patients with chronic hepatitis B, 46 patients with compensable cirrhosis, and 36 patients with decompensable cirrhosis. RESULTS:In the group of chronic severe hepatitis B, PVD (12.38 ± 1.23 mm) was significantly different from the normal control, compensable cirrhosis and decompensable cirrhosis groups (P = 0.000-0.026), but not significantly different from the chronic hepatitis group. PVPV (16.15 ± 3.82 cm/s) dropped more significantly in the chronic severe hepatitis B group than the normal control, chronic hepatitis B and compensable cirrhosis groups (P = 0.000-0.011). PVV (667.53 ± 192.83 mL/min) dropped significantly as compared with the four comparison groups (P = 0.000-0.004). SPL (120.42 ± 18.36 mm) and SPVD (7.52 ± 1.52 mm) were longer in the normal control and chronic hepatitis B groups (P = 0.000-0.009), yet they were significantly shorter than those in the decompensable cirrhosis group (P = 0.000). SPVV (242.51 ± 137.70 mL/min) was also lower than the decompensable cirrhosis group (P = 0.000). The umbilical vein recanalization rate (75%) was higher than the chronic hepatitis B and compensable cirrhosis groups. In the course of progression from chronic hepatitis to decompensable cirrhosis, PVD, SPL and SPVD gradually increased and showed significant differences between every two groups (P = 0.000-0.002). CONCLUSION:Patients with chronic severe hepatitis B have a tendency to develop acute portal hypertension, resulting in significantly reduced portal vein perfusion. Observation of the portalsystemic hemodynamic changes may be contributed to the disease progression of chronic liver disease. | Zhong-Zhen Su Hong Shan Wei-Min Ke Bing-Jun He Rong-Qin Zheng | 2008 | World Journal of Gastroenterology2008，14，5： | 9 |
| 17 | Strengths, weaknesses, opportunities and threats (SWOT) analysis of reinitiation into methamphetamine abusers: qualitative findings from an exploration of methamphetamine abusers in Shanghai, China显示文摘Background Despite high relapse rate among methamphetamine (MA) abusers, there still have been little empirical data to date detecting the risk factors related to craving and relapse from the perspective of MA abusers. Therefore, the aim of this study was to use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors that could facilitate or impede individuals' abstinence in a real-life context from the perspectives of MA abusers. Aim To use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors relating to individuals' abstinence in a real-life context. Method Semistructured interviews were conducted with 32 MA abusers recruited in Shanghai guided by open-ended questions on narrating the real-life catalysts and inhibitors related to craving, initiation, relapse and abstinence. All data were transcribed verbatim and analysed using a strengths, weaknesses, opportunities and threats (SWOT) analysis. Results The results of the SWOT analysis revealed that contextual factors including peer influence, prevalence and availability of MA, familiar venue of MA use, discrimination, sexual behaviours, alcohol, emotional states and their attitudes towards smoking MA were important factors that contribute to reinitiation and relapse. Surveillance systems, antidrug social workers, vocational skills trainings, moving to another city and family responsibility might serve as counter measures targeti叩 those mentioned weaknesses and threats above. Conclusion This SWOT analysis highlights the complex nature of relapse. Comprehensive interventions strengtheni叩 coping skills such as virtual reality techniques are desperately needed to facilitate individuals1 sustained abstinence. | Youwei Zhu Na Zhong Hang Su Xiaolu Ruan Jiayi Bao Lei Zhang Jiang Du Ding Xu Rongjie Ding Ke Xiao Min Zhao | 2019 | General Psychiatry2019，32，3： | 9 |
| 18 | Genomic sequencing and analysis of the first imported Middle East Respiratory Syndrome Coronavirus(MERS CoV) in China显示文摘Dear Editors,Middle East Respiratory Syndrome(MERS)has spread to more than 23 countries since the first case of a MERS coronavirus(MERS Co V)infection was confirmed in Sep2012[1].Because MERS Co V has led to mortality as high as 40%,it has become one of the most important emerging pathogens threatening human health.Recently,the outbreak of MERS Co V,which resulted in 172 infections and | XIE Qian CAO YuJuan SU Juan WU XianBo WAN ChengSong KE ChangWen ZHAO Wei ZHANG Bao | 2015 | Science China(Life Sciences)2015，58，8： | 8 |
| 19 | Notch signaling pathway mediates the immunomodulatory mechanism of Yangfei Huoxue decoction alleviating bleomycin-induced pulmonary fibrosis in rats显示文摘OBJECTIVE: To investigate the immunomodulatory mechanism by which Yangfei Huoxue decoction(YHD) alleviates bleomycin(BLM)-induced pulmonary fibrosis(PF) in rats.METHODS: Rats were randomly divided into two time-point groups(day 14 and 28), and each timepoint group comprised the following six subgroups: control, BLM, dexamethasone(DXM), YHD high dose(YHD-H), YHD middle dose(YHD-M), and YHD low dose(YHD-L). Haematoxylin and eosin and Masson staining, flow cytometry, enzymelinked immunosorbent assay, Western blotting and UPLC-QT of analyses were examined.RESULTS: The results showed that YHD reduced the degree of alveolar inflammation and fibrosis;downregulated the expression of CD28, CD80,CD86, Delta-like 1, Notch2, and Notch3;and upregulated the proportions of Th1/Th2 and Tc1/Tc2. The seven components of YHD were detected.CONCLUSION: The current study indicates that YHD mainly functions by regulating the immune system and that the molecular mechanism may be related to the regulation of the Notch signaling pathway. | Chen Hui Liu Xiao Su Yinxu Chang Ke Wu Haotian Su Guangbao Gong Jiening | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 7 |
| 20 | Y-chromosome evidence for no independent origin of modern human in China显示文摘East Asia is one of the few regions in the world where a large number of human fossils have been unearthed. The continuity of hominid fossils in East Asia, particularly in China has been presented as strong evidence supporting an independent origin of modern humans in this area. To search for such evidence of a possible independent origin of modern humans in China, a total of 9988 male individuals were sampled across China. Three Y-chromosome biallelic markers (M89, M130 and YAP), which were located at the non-re-combinant region of Y-chromosome, were typed among the samples. Our result showed that all the individuals carry a mutation at one of the three loci. The three mutations (M89T, M130T, YAP+) coalesce to another mutation (M168T), which was originally derived from Africa about 31000 to 79000 years ago. In other words, all Y-chromosome samples from China, with no exception, were originally derived from a lineage of African origin. Hence, we conclude that even a very minor contribution of in situ hominid origin in China cannot be supported by the Y-chromosome evidence. | KE Yuehai SU Bing LI Hongyu CHEN Lifeng QI Chunjian GUO Xinjun HUANG Wei JIN Jianzhong LU Daru JIN Li | 2001 | Chinese Science Bulletin2001，46，11： | 7 |
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