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| 1 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 2 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 3 | ARPNET: attention region proposal network for 3D object detection显示文摘Dear editor,Three-dimensional(3D)object detection is a fundamental computer vision issue and demonstrates promising potential in intelligent surveillance,robot grasping,and autonomous driving.However,3D object detection remains a challenging problem because it must predict many object details in 3D space,i.e.,depth,shape,and orientation.Current 3D object detectors involve onestage and two-stage frameworks. | Yangyang YE Chi ZHANG Xiaoli HAO | 2019 | Science China(Information Sciences)2019，62，12： | 4 |
| 4 | Three-layer phosphorene-metal interfaces显示文摘Phosphorene 最近由于它的高级搬运人活动性和悦耳的直接 bandgap 在电子的 nanoscale 和 optoelectronic 设备作为其他的隧道材料吸引了许多注意。与单层(ML ) 相比 phosphorene,很少层(FL ) phosphorene 更容易准备,在实验是更稳定的,并且被期望在 phosphorene 金属接口形成更小的 Schottky 障碍高度(SBH ) 。用 ab initio ,电子结构计算和量搬运模拟,我们执行界面的性质的系统的研究三层( 3L ) phosphorene 领域效果晶体管(联邦货物税)与几普通金属联系了(艾尔, Ag , Au , Cu , Ti , Cr , Ni ,并且 Pd )第一次。从投射乐队在垂直方向获得的 SBH 3L phosphorene 金属系统组织到左 bilayer (2L ) phosphorenes 是可比较的,那些为 2L phosphorene 联邦货物税从量运输模拟在侧面的方向获得了。当分别地, Ag 和 Cu 被用作电极,p类型 Schottky 与 0.05 的洞 SBH 联系时,为 3L phosphorene 联邦货物税的量运输模拟证明 3L phosphorene 在侧面的方向与 0.16 和 0.28 eV 的电子 SBH 形成n类型 Schottky 接触, 0.11 , 0.20 ,在侧面的方向的 0.30 , 0.30 ,和 0.31 eV 当 Cr , Pd , Ni , Ti ,艾尔,和 Au 分别地被用作电极时。3L phosphorene 联邦货物税的计算极性和 SBH 通常与可得到的实验一致。 | Xiuying Zhang Yuanyuan Pan Meng Ye Ruge Quhe Yangyang Wang Ying Guo Han Zhang Yang Dan Zhigang Song Jingzhen Li Jinbo Yang Wanlin Guo Jing Lu | 2018 | Nano Research2018，11，2： | 2 |
| 5 | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is featured as enhanced catabolism of extracellular matrix(ECM)in the nucleus pulposus(NP),in which tumor necrosis factor-alpha(TNF-α)-related cell senescence is involved.Chromobox homolog protein 4(CBX4)exhibits anti-inflammatory effects and shows promising therapeutic potential.Thus,in the present study,we explore the role of CBX4 in IDD.Immunohistochemistry staining reveals that CBX4 expression is decreased in severe degenerative NP tissues compared to mild degenerative tissues,and real-time PCR and western blot analysis results show that CBX4 expression is downregulated under TNF-αstimulation in NP cells.siRNA and adenoviruses are used to knockdown or overexpress CBX4,respectively.The results demonstrate that CBX4 knockdown augments the catabolism of ECM in human NP cells,while CBX4 overexpression in rat NP cells restores the ECM degradation induced by TNF-α,as illustrated by immunofluorescence and western blot analysis.In addition,transcriptome sequencing results reveal the regulatory effect of CBX4 on the cell cycle,and further western blot analysis and senescence-associatedβ-galactosidase staining assay indicate that CBX4 overexpression alleviates cell senescence in the presence of TNF-α.Moreover,the phosphorylation of p65,which indicates the activation of NF-κB signaling,is measured by western blot analysis and immunofluorescence assay,and the results reveal that CBX4 overexpression reduces the TNF-α-induced increase in the p-p65/p65 ratio.In addition,the effect of CBX4 overexpression in NP cells is suppressed by NF-κB agonist.In summary,our results indicate that CBX4 overexpression can suppress TNF-α-induced matrix catabolism and cell senescence in the NP by inhibiting NF-κB activation.This study may provide new approaches for preventing and treating IDD. | Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 6 | High-performance sub-10-nm monolayer black phosphorene tunneling transistors显示文摘 | Hong Li Jun Tie Jingzhen Li Meng Ye Han Zhang Xiuying Zhang Yuanyuan Pan Yangyang Wang Ruge Quhe Feng Pan Jing Lu | 2018 | Nano Research2018，11，5： | 2 |
| 7 | Electrical contacts in monolayer blue phosphorene devices显示文摘半导体的单层(ML ) 蓝色 phosphorene (BlueP ) 与 ML 黑 phosphorene (BP ) 分享类似的稳定性,并且它最近有在 Au 表面上是成年的。潜在的 ML BlueP 设备经常与金属要求直接接触启用搬运人的注射。第一次,用 ab initio,电子结构计算和量搬运模拟我们在与在一只领域效果晶体管(联邦货物税) 跨越一个宽工作函数范围的金属的接触执行 ML BlueP 的界面的性质的系统的研究配置。ML BlueP 由于和五金属的强壮的相互作用经历了 metallization。与 0.42 的一个卡住的因素由于导致金属的差距状态(米格机) 在 ML BlueP 联邦货物税有强壮的费密水平(FLP ) ,卡住。分别地, ML BlueP 与 0.22, 0.22,和 0.80 eV 的电子 Schottky 障碍高度(SBH ) 与 Sc, Ag,和磅电极形成 n 类型 Schottky 接触并且与有 0.61 和 0.79 eV 的洞 SBH 的 Au 和 Pd 电极的 p 类型 Schottky 接触分别地。米格机被在 ML BlueP 和金属电极之间插入 graphene 消除,从强壮的 FLP 由转变伴随了到弱 FLP。我们的学习不仅提供卓见进 ML BlueP 金属接口,而且在 ML BlueP 设备的设计帮助。 | Jingzhen Li Xiaotian Sun Chengyong Xu Xiuying Zhang Yuanyuan Pan Meng Ye Zhigang Song Ruge Quhe Yangyang Wang Han Zhang Ying Guo Jinbo Yang Feng Pan Jing Lu | 2018 | Nano Research2018，11，4： | 2 |
| 8 | Vehicle emissions of primary air pollutants from 2009 to 2019 and projection for the 14th Five-Year Plan period in Beijing, China显示文摘Over the past decade,the emission standards and fuel standards in Beijing have been upgraded twice,and the vehicle structure has been improved by accelerating the elimination of 2.95 million old vehicles.Through the formulation and implementation of these policies,the emissions of carbon monoxide(CO),volatile organic compounds(VOCs),nitrogen oxides(NO_(x)),and fine particulate matter(PM_(2.5))in 2019 were 147.9,25.3,43.4,and 0.91 kton in Beijing,respectively.The emission factor method was adopted to better understand the emissions characteristics of primary air pollutants from combustion engine vehicles and to improve pollution control.In combination with the air quality improvement goals and the status of social and economic development during the 14th Five-Year Plan period in Beijing,different vehicle pollution control scenarios were established,and emissions reductions were projected.The results show that the emissions of four air pollutants(CO,VOCs,NO_(x),and PM_(2.5))fromvehicles in Beijing decreased by an average of 68% in 2019,compared to their levels in 2009.The contribution of NOx emissions from diesel vehicles increased from 35% in 2009 to 56% in 2019,which indicated that clean and energy-saving diesel vehicle fleets should be further improved.Electric vehicle adoption could be an important measure to reduce pollutant emissions.With the further upgrading of vehicle structure and the adoption of electric vehicles,it is expected that the total emissions of the four vehicle pollutants can be reduced by 20%-41% by the end of the 14th Five-Year Plan period. | Tongran Wu Yangyang Cui Aiping Lian Ye Tian Renfei Li Xinyu Liu Jing Yan Yifeng Xue Huan Liu Bobo Wu | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 9 | All‐Metallic Vertical Transistors Based on Stacked Dirac Materials显示文摘 | Yangyang Wang Zeyuan Ni Qihang Liu Ruge Quhe Jiaxin Zheng Meng Ye Dapeng Yu Junjie Shi Jinbo Yang Ju Li Jing Lu | 2015 | Adv. Funct. Mater2015，，： | 1 |
| 10 | In-depth research of multidrug resistance related cell surface glycoproteome in gastric cancer显示文摘 | Kai Li Zhen Sun Jianyong Zheng Yuanyuan Lu Yangyang Bian Mingliang Ye Xin Wang Yongzhan Nie Hanfa Zou Daiming Fan | 2013 | Journal of Proteomics2013，，： | 1 |
| 11 | Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells显示文摘Ginsenoside Rh3(GRh3)is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors.However,its antitumor role remains to be elucidated.The aim of this study is to explore the mechanisms underlying the tumor suppressive activity of GRh3 from the perspective of pyroptosis and ferroptosis.GRh3 eliminates colorectal cancer(CRC)cells by activating gasdermin D(GSDMD)-dependent pyroptosis and suppressing solute carrier family 7 member 11(SLC7A11),resulting in ferroptosis activation through the Stat3/p53/NRF2 axis.GRh3 suppresses nuclear factor erythroid 2-related factor 2(NRF2)entry into the nucleus,leading to the decrease of heme oxygenase 1(HO-1)expression,which in turn promotes NOD-like receptor thermal protein domain associated protein 3(NLRP3)and caspase-1 expression.Finally,caspase-1 activates GSDMD-dependent pyroptosis.Furthermore,GRh3 prevents NRF2 from entering the nucleus,which suppresses SLC7A11,causing the depletion of glutathione(GSH)and accumulation of iron,lipid reactive oxygen species(ROS)and malondialdehyde(MDA),and eventually leading to ferroptosis in CRC cells.In addition,GRh3 effectively inhibits the proliferation of CRC cells in vitro and in nude mouse models.Collectively,GRh3 triggers pyroptotic cell death and ferroptotic cell death in CRC cells via the Stat3/p53/NRF2 axis with minimal harm to normal cells,showing great anticancer potential. | Yingchao Wu Dajin Pi Shuyao Zhou Zhongjia Yi Yangyang Dong Wuhong Wang Huan Ye Yiliu Chen Qian Zuo Mingzi Ouyang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 1 |
| 12 | Conformal optical black hole for cavity显示文摘Whispering-gallery-mode(WGM)cavity is important for exploring physics of strong light-matter interaction.Yet it suffers from the notorious radiation loss universally due to the light tunneling effect through the curved boundary.In this work,we propose and demonstrate an optical black hole(OBH)cavity based on transformation optics.The radiation loss of all WGMs in the ideal OBH cavity is completely inhibited by an infinite wide potential barrier.Besides,the WGM field in the OBH cladding is revealed to follow 1/r decay rule based on conformal mapping,which is fundamentally different from the conventional Hankel-function distributions in a homogeneous cavity.Experimentally,a truncated OBH cavity is achieved based on the effective medium theory,and both the Q-factor enhancement and tightly confined WGM fields are measured in the microwave spectra which agree well with the theoretical results.The circular OBH cavity is further applied to the arbitrary-shaped cavities including single-core and multi-core structures with high-Q factor via the conformal mapping.The OBH cavity design strategy can be generalized to resonant modes of various wave systems,such as acoustic and elastic waves,and finds applications in energy harvesting and optoelectronics. | Qingtao Ba Yangyang Zhou Jue Li Wen Xiao Longfang Ye Yineng Liu Jin‑hui Chen Huanyang Chen | 2022 | eLight2022，2，1： | 1 |
| 13 | Epidermal growth factor receptor is overexpressed in neuroblastoma tissues and cells显示文摘Neuroblastoma 是在童年的最普通的腹的恶意的肿瘤。指向肿瘤房间表面受体的 Immunotoxin (信息技术) 是一条新增补治疗学的处理途径。如果信息技术治疗能被用来对待倔强的 neuroblastoma,这研究的目的是在 neuroblastoma 房间线和纸巾检测表皮的生长因素受体(EGFR ) 的表示,并且探索。在人的 neuroblastoma 织物样品的 EGFR 表示被 immunohistochemistry 检测 ? 染色。EGFR 表示的积极的率在 neuroblastoma 织物是 81.0% 并且 50.0% 在 gangliocytoma,分别地,但是没有在他们之间的统计意义(P ?>? 0.05 ) 。分别地,在有利类型和相反的类型的 EGFR 表示的积极的率是 62.5% 和 92.3% ,但是他们不是统计上不同的(P ?>? 0.05 ) 。从化疗前和化疗以后的样品的结果证明没有重要统计差别(P ?>? 0.05 ) 在他们之间在 EGFR 表示。而且,在五根 neuroblastoma 房间线的 EGFR 表示层次用基于房间的 ELISA 试金和西方的污点分析被测量。结果证明 EGFR 的表示在 KP-N-NS 是更高的并且是(2 )-C 在另外的房间比那些排队。我们的结果表明有在 neuroblastoma 纸巾以及在 neuroblastoma 房间线的 EGFR 的一致、普遍的表情,建议开发由在 EGFR 指向的 neuroblastoma 的未来处理策略是可能的。 | Chao Zheng Ruling Shen Kai Li Na Zheng Yuqing Zong Danrong Ye Qingcheng Wang Zuopeng Wang Lian Chen Yangyang Ma | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 0 |
| 14 | Ultrasound microbubbles combined with liposome-mediated pNogo-R shRNA delivery into neural stem cells显示文摘In the present study, ultrasound-mediated microbubble destruction (UMMD) alone and combined with liposome technology was used as a novel nonviral technique to transfect a Nogo receptor (Nogo-R) shRNA plasmid (pNogo-R shRNA) into neural stem cells (NSCs). Using green fluorescent protein as a reporter gene, transfection efficiency of NSCs was significantly higher in the group transfected with UMMD combined with liposomes compared with that of the group transfected with UMMD or liposomes alone, and did not affect cell vitality. In addition, Nogo-R mRNA and protein expression was dramatically decreased in the UMMD combined with liposome-mediated group compared with that of other groups after 24 hours of transfection. The UMMD technique combined with liposomes is a noninvasive gene transfer method, which showed minimal effects on cell viability and effectively increased transfer of Nogo-R shRNA into NSCs. | Weixia Ye Xueping Huang Yangyang Sun Hao Liu Jin Jiang Youde Cao | 2012 | Neural Regeneration Research2012，7，1： | 0 |
| 15 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
| 16 | Innate immune imprints in SARS-CoV-2 Omicron variant infection convalescents显示文摘SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people.The immune cells can be reprogrammed or“imprinted”by vaccination and infections to generate protective immunity against subsequent challenges.Considering the immune imprint in Omicron infection is unclear,here we delineate the innate immune landscape of human Omicron infection via single-cell RNA sequencing,surface proteome profiling,and plasma cytokine quantification.We found that monocyte responses predominated in immune imprints of Omicron convalescents,with IL-1β-associated and interferon(IFN)-responsive signatures with mild and moderate symptoms,respectively.Low-density neutrophils increased and exhibited IL-1β-associated and IFN-responsive signatures similarly.Mild convalescents had increased blood IL-1β,CCL4,IL-9 levels and PI3+neutrophils,indicating a bias to IL-1βresponsiveness,while moderate convalescents had increased blood CXCL10 and IFN-responsive monocytes,suggesting durative IFN responses.Therefore,IL-1β-or IFN-responsiveness of myeloid cells may indicate the disease severity of Omicron infection and mediate post-COVID conditions. | Zhiqing Li Xiaosu Chen Junyan Dan Tianju Hu Ye Hu Shuxun Liu Yangyang Chai Yansong Shi Jian Wu Hailai Ni Jiaqi Zhu Yanfeng Wu Nan Li Yizhi Yu Zhongfang Wang Jincun Zhao Nanshan Zhong Xianwen Ren Zhongyang Shen Xuetao Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 17 | Rosuvastatin suppresses TNF-α-induced matrix catabolism,pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α.Rosuvastatin,which is widely used in the clinic to reduce cholesterol levels,exerts anti-inflammatory effects,but whether rosuvastatin participates in IDD remains unclear.The current study aims to investigate the regulatory effect of rosuvastatin on IDD and the potential mechanism.In vitro experiments demonstrate that rosuvastatin promotes matrix anabolism and suppresses catabolism in response to TNF-αstimulation.In addition,rosuvastatin inhibits cell pyroptosis and senescence induced by TNF-α.These results demonstrate the therapeutic effect of rosuvastatin on IDD.We further find that HMGB1,a gene closely related to cholesterol metabolism and the inflammatory response,is upregulated in response to TNF-αstimulation.HMGB1 inhibition or knockdown successfully alleviates TNF-α-induced ECM degradation,senescence and pyroptosis.Subsequently,we find that HMGB1 is regulated by rosuvastatin and that its overexpression abrogates the protective effect of rosuvastatin.We then verify that the NF-κB pathway is the underlying pathway regulated by rosuvastatin and HMGB1.In vivo experiments also reveal that rosuvastatin inhibits IDD progression by alleviating pyroptosis and senescence and downregulating HMGB1 and p65.This study might provide new insight into therapeutic strategies for IDD. | Weijian Chen Zhihuai Deng Jianxiong Zhu Liang Yuan Shuangxing Li Yangyang Zhang Jiajun Wu Zhengqi Huang Tianyu Qin Wei Ye | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
| 18 | Traditional Chinese Medicine Constitution and Clinical Data Association with Machine Learning for Prediction of Spontaneous Abortion显示文摘Background:Early prevention of Spontaneous Abortion(SA)is essential for the treatment of recurrent spontaneous abortion.Objective:In this retrospective study,a variety of machine learning methods were used to develop predictive models and diagnose the potential risk of SA.Methods:A total of 663 pregnant women participated in the case-control study,586 of which were SA patients and 77 were normal parturition women.The research data included 25 features of Traditional Chinese Medicine(TCM)constitution and clinical data related to SA.This work utilized 8 machine learning techniques including logistic regression,gradient boosting decision tree,k-nearest neighbor,classification and r-egression tree,multilayer perceptron,support vector machine,random forest and XG-Boost to predict SA.The performances of the applied models were evaluated by using the method of 10-fold cross-validation and by computing the diagnostic test characteristics,including accuracy,precision,recall,��1 score,and the AUC of ROC curve.Results:The��1 scores of these eight machine learning techniques were all above 97.5%.Among them,gradient boosting decision tree had the best prediction result on SA.The accuracy,precision,recall,��1 score,and the AUC of ROC curve of gradient boosting decision tree were 97.9%,99%,98.6%,98.8%,and 97.3%,respectively.Conclusion:The paper has accurately predicted the risk of SA combined with TCM constitution and clinical data. | Yan Liu Yangyang Geng Liuqing Yang Shate Xiang Qiaotong Wang Lanyawen Hu Ping Ye | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，2： | 0 |
| 19 | Injectable Fiber Electronics for Tumor Treatment显示文摘Electrochemical therapy emerged as a low-cost and efective method for tumor ablation.However,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft tissues.Here,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor treatment.The design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through injection.Under a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor cells.The fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 days.The in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few minutes.The tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy. | Yang Zhao Chuanrui Chen Yangyang Qiu Tenglong Mei Lei Ye Huan Feng Ye Zhang Liyuan Wang Yue Guo Xuemei Sun Jiaxue Wu Huisheng Peng | 2022 | Advanced Fiber Materials2022，4，2： | 0 |
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