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| 1 | 开放式空气CO_2浓度增高对水稻冠层微气候的影响显示文摘利用位于江苏省无锡市安镇的我国唯一的农田开放式空气CO2 浓度增高 (FACE)系统平台 ,于2 0 0 1年 8月 2 6日至 10月 13日 (水稻抽穗至成熟期 )进行水稻作物冠层微气候连续观测 ,以研究FACE对水稻冠层微气候特征的影响 .结果表明 ,FACE降低了水稻叶片的气孔导度 ,FACE与对照水稻叶片气孔导度的差异上层叶片大于下层叶片 ,生长前期大于生长后期 .FACE使白天水稻冠层和叶片温度升高 ,这种差异生长前期大于生长后期 ;但FACE对夜间水稻冠层温度的影响不明显 .在水稻旺盛生长的抽穗开花期 ,晴天正午前后FACE水稻冠层温度比对照高 1.2℃ ;从开花至成熟期 ,FACE水稻冠层白天平均温度比对照高 0 .4 3℃ .FACE对冠层空气温度也有影响 ,白天水稻冠层空气温度FACE高于对照 ,这种差异随太阳辐射增强而增大且冠层中部大于冠层顶部 ;冠层中部空气温度FACE与对照的差异 (Tface-Tambient)日最大值在 0 .4 7~ 1.2℃之间 ,而冠层顶部的Tface-Tambient日最大值在 0 .37~ 0 .8℃之间 .夜间水稻冠层空气温度FACE与对照差别不大 ,变化在± 0 .3℃之内 .而FACE对水稻冠层空气湿度无显著影响 ,表明FACE使水稻叶片气孔导度降低 ,从而削弱了植株的蒸腾降温作用 ,导致水稻冠层温度和冠层空气温度升高 。 | 罗卫红 Mayumi Yoshi moto 戴剑峰 朱建国 韩勇 刘刚 | 2002 | 应用生态学报2002，13，10： | 28 |
| 2 | Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer显示文摘AIM:To investigate human epidermal growth factor receptor 2(HER2)-phosphatidylinositol 3-kinase(PI3K)-vAkt murine thymoma viral oncogene homolog signaling pathway.METHODS:We analyzed 231 formalin-fixed,paraffinembedded gastric cancer tissue specimens from Japanese patients who had undergone surgical treatment.The patients' age,sex,tumor location,depth of invasion,pathological type,lymph node metastasis,and pathological stage were determined by a review of the medical records.Expression of HER2 was analyzed by immunohistochemistry(IHC) using the HercepTest TM kit.Standard criteria for HER2 positivity(0,1+,2+,and 3+) were used.Tumors that scored 3+ were considered HER2-positive.Expression of phospho Akt(pAkt) was also analyzed by IHC.Tumors were considered pAkt-positive when the percentage of positive tumor cells was 10% or more.PI3K,catalytic,alpha polypeptide(PIK3CA) mutations in exons 1,9 and 20 were analyzed by pyrosequencing.Epstein-Barr virus(EBV) infection was analyzed by in situ hybridization targeting EBV-encoded small RNA(EBER) with an EBER-RNA probe.Microsatellite instability(MSI) was analyzed by polymerase chain reaction using the mononucleotide markers BAT25 and BAT26.RESULTS:HER2 expression levels of 0,1+,2+ and 3+ were found in 167(72%),32(14%),12(5%) and 20(8.7%) samples,respectively.HER2 overexpression(IHC 3+) significantly correlated with intestinal histological type(15/20 vs 98 /205,P = 0.05).PIK3CA mutations were present in 20 cases(8.7%) and significantly correlated with MSI(10/20 vs 9/211,P < 0.01).The mutation frequency was high(21%) in T4 cancers and very low(6%) in T2 cancers.Mutations in exons 1,9 and 20 were detected in 5(2%),9(4%) and 7(3%) cases,respectively.Two new types of PIK3CA mutation,R88Q and R108H,were found in exon1.All PIK3CA mutations were heterozygous missense singlebase substitutions,the most common being H1047R(6/20,30%) in exon20.Eighteen cancers(8%) were EBV-positive and this positivity significantly correlated with a diffuse histological type(13/18 vs 93/198,P = 0.04).There were 7 cases of lymphoepithelioma-like carcinomas(LELC) and 6 of those cases were EBV-positive(percent/EBV:6/18,33%;percent/all LELC:6/7,86%).pAkt expression was positive in 119(53%) cases but showed no correlation with clinicopathological characteristics.pAkt expression was significantly correlated with HER2 overexpression(16/20 vs 103/211,P < 0.01) but not with PIK3CA mutations(12/20 vs 107/211,P = 0.37) or EBV infection(8/18 vs 103/211,P = 0.69).The frequency of pAkt expression was higher in cancers with exon20 mutations(100%) than in those with exon1(40%) or exon9(56%) mutations.One case showed both HER2 overexpression and EBV infection and 3 cases showed both PIK3CA mutations and EBV infection.However,no cases showed both PIK3CA mutations and HER2 overexpression.One EBVpositive cancer with PIK3CA mutation(H1047R) was MSI-positive.Three of these 4 cases were positive for pAkt expression.In survival analysis,pAkt expression significantly correlated with a poor prognosis(hazard ratio 1.75;95%CI:1.12-2.80,P = 0.02).CONCLUSION:HER2 expression,PIK3CA mutations and EBV infection in gastric cancer were characterized.pAkt expression significantly correlates with HER2 expression and with a poor prognosis. | Yasutaka Sukawa Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Kunimoto Hiromu Suzuki Yasushi Adachi Mayumi Nakazawa Takayuki Nobuoka Mariko Kawayama Masashi Mikami Takashi Matsuno Tadashi Hasegawa Koichi Hirata Kohzoh Imai Yasuhisa Shinomura | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 3 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 4 | Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD. | Mayumi Kawada Atsuko Arihiro Emiko Mizoguchi | 2007 | World Journal of Gastroenterology2007，13，42： | 12 |
| 5 | 采用共轭梯度法的管内壁温度导热反问题求解显示文摘建立了采用共轭梯度法的非稳态二维导热反问题数学模型,并利用FORTRAN语言编写了程序进行计算求解,由同心圆管外壁温度随时间的变化得到管内壁温度随时间的变化。计算结果表明,计算值与准实验值吻合,共轭梯度法能够准确地计算得到管内壁不同位置温度随时间的变化。 | 张有为 李辉 姜培学 KIMINOBU Hojo MAYUMI Ochi KOICHI Tanimoto | 2009 | 工程热物理学报2009，30，7： | 12 |
| 6 | Consensus of primary care in acute pancreatitis in Japan显示文摘在日本的尖锐胰腺炎的发生正在增加并且每百万张人口从 187 ~ 347 个盒子。盒子命运是 0.2% 为对温和中等,并且 9.0% 为在在 2003 的日本的严重尖锐胰腺炎。在日本的胰腺炎的专家做了与尖锐胰腺炎在病人的早管理集中于实际方面的这个文件。尖锐胰腺炎和严厉层化的正确诊断应该为尖锐胰腺炎的诊断用标准在所有病人被做并且多,因素得分系统尽早由胰的难处理的疾病的研究委员会求婚了。与尖锐胰腺炎诊断的所有病人应该在医院里被管理。血压监视,脉搏和呼吸率,体温,时时尿的体积,和血氧饱和水平在如此的病人的管理是必要的。早精力旺盛的静脉内的水和具有最前的重要性稳定循环动力学。有鸦片剂的足够的疼痛地势也是重要的。在严重尖锐胰腺炎,在一个早阶段的抗菌素的预防静脉内的管理被推荐。一旦尖锐胰腺炎的诊断被证实,朊酶禁止者的管理应该被开始。如果没有肠塞痛并且胃肠的流血的清楚的症状,从早舞台用非肠道的营养喂的肠内的联合被推荐。有严重尖锐胰腺炎的病人应该尽早被转移到 ICU 执行象朊酶的连续地区性的动脉的注入那样的特殊措施禁止者和抗菌素,和连续牙齿过敏过滤。日本政府为难处理的疾病作为关于措施的研究的工程之一为严重尖锐胰腺炎盖住医疗保健开销。 | Makoto Otsuki Masahiko Hirota Shinju Arata Masaru Koizumi Shigeyuki Kawa Terumi Kamisawa Kazunori Takeda Toshihiko Mayumi Motoji Kitagawa Tetsuhide Ito Kazuo Inui Tooru Shimosegawa Shigeki Tanaka Keisho Kataoka Hiromitsu Saisho Kazuichi Okazaki Yosikazu Kuroda Norio Sawabu Yoshifumi Takeyama | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 7 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 8 | 开放式空气CO_2浓度增高对水稻冠层能量平衡的影响显示文摘大气CO2 浓度升高对植物冠层能量平衡的影响是导致植物生长发育和水分利用率发生变化的环境物理原因 .利用位于江苏省无锡市安镇的农田自由开放式空气CO2 浓度增高 (FACE)系统平台 ,进行水稻冠层微气候和土壤热通量的连续观测 ,并结合能量平衡分析 ,研究了FACE对水稻冠层能量平衡的影响 .结果表明 ,水稻冠层显热和潜热通量FACE与对照的差异日最大值出现在 14∶0 0左右 ,与空气相对湿度日最低值出现时间一致 ;潜热通量FACE与对照的差异日最大值变化在 - 15~ - 65J·m-2 ·s-1之间 ,显热通量FACE与对照的差异最低值变化在 12~ 5 5J·m-2 ·s-1之间 ;显热和潜热通量FACE与对照的差异日最大值随冠层上方辐射平衡增加而增大 .水稻冠层白天总显热通量FACE均高于对照 ,而总潜热通量FACE均低于对照 .白天总显热和潜热通量FACE与对照的差异在同一生育期内随冠层上方净辐射增强而增大 ,在不同生育期随生育期推进而减少 .开花期至蜡熟期 ,水稻冠层白天总潜热通量FACE比对照平均低 6.7% .FACE使水稻冠层白天总显热通量及其占冠层上方辐射平衡的比例减少 ,而使总潜热通量及其占冠层上方辐射平衡的比例增大 ,但对土壤热通量及夜间显热和潜热通量的影响不大 .开花期至蜡熟期水稻冠层白天总显热。 | 罗卫红 Mayumi Yoshimoto 戴剑锋 朱建国 韩勇 刘刚 | 2003 | 应用生态学报2003，14，2： | 5 |
| 9 | TG13 flowchart for the management of acute cholangitis and cholecystitis显示文摘 | Fumihiko Miura Tadahiro Takada Steven M. Strasberg Joseph S. Solomkin Henry A. Pitt Dirk J. Gouma O. James Garden Markus W. Büchler Masahiro Yoshida Toshihiko Mayumi Kohji Okamoto Harumi Gomi Shinya Kusachi Seiki Kiriyama Masamichi Yokoe Yasutoshi Kimura | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，1： | 4 |
| 10 | Distal pancreatectomy withen bloc resection of the celiac artery for carcinoma of the body and tail of the pancreas显示文摘 | Toshihiko Mayumi Yuji Nimura Junichi Kamiya Satoshi Kondo Masato Nagino Michio Kanai Masahiko Miyachi Katsura Hamaguchi Naokazu Hayakawa | 1997 | International Journal of Gastrointestinal Cancer1997，，1： | 4 |
| 11 | Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma显示文摘AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection.METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC.CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC. | Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida | 2005 | World Journal of Gastroenterology2005，11，46： | 3 |
| 12 | Bowel preparation for colonoscopy using standard vs reduced doses of sodium phosphate: A single-blind randomized controlled study显示文摘AIM: To evaluate the efficacy of a colonoscopy prepa-ration that utilizes a reduced dose of sodium phosphate(NaP) and an adjunct.METHODS: Sixty-two patients requiring screening colonoscopies were studied. Each patient was randomly allocated to receive either 50 NaP tablets(50 g) or 30 NaP tablets(30 g) with 10 mL of 0.75% sodium pico-sulfate for bowel preparation. NaP was administered at a rate of five tablets(5 g) or three tablets(3 g) every 15 min with 200 mL of water, beginning five to six hours before colonoscopy. The sodium picosulfate was administered with 200 mL of water on the night before the procedure. Both groups were compared in term of the efficacies of colonic cleansing, the time required for completion of the bowel preparation, and acceptability of the preparation.RESULTS: Sixty patients(n = 30 for each group) were analyzed. The cleansing efficacy tended to be higher in the 30 g NaP plus sodium picosulfate group as as-sessed by the mean total Ottawa scale score(50 g NaP6.70 ± 1. 42 vs 30 g NaP plus sodium picosulfate 6.17 ± 1.18 P = 0.072). The mean time for bowel prepara-tion tended to be shorter in the 30 g NaP plus sodium picosulfate group(50 g NaP 189.9 ± 64.0 min vs 30 g NaP plus sodium picosulfate 161.8 ± 57.6 min, P = 0.065). There were no significant differences between the two groups in the acceptability of the preparations(50 g NaP 83.3% vs 30 g NaP plus sodium picosulfate 86.7%, P = 0.500). There were no adverse events re-lated to bowel preparation in either of the groups.CONCLUSION: The colonoscopy preparation that uti-lized 30 g NaP with sodium picosulfate was comparable to that utilizing 50 g NaP. This novel bowel preparation might be useful before colonoscopy. | Tatsuya Koshitani Mayumi Kawada Toshikazu Yoshikawa | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 3 |
| 13 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 14 | Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids显示文摘AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers.METHODS:DNA was extracted from undiluted pancreatic and biliary fluids.As a surrogate for a genomewide hypomethylation assay,levels of long interspersed nuclear element-1(LINE-1) methylation were analyzed using bisulfite pyrosequencing.CpG island hypermethylation of 10 tumor-associated genes,aryl-hydrocarbon receptor repressor,adenomatous polyposis coli,calcium channel,voltage dependent,T type α1G subunit,insulin-like growth factor 2,O-6-methyl-guanine-DNA methyltransferase,neurogenin 1,CDKN2A,runt-related transcription factor 3(RUNX3),secreted frizzled-related protein 1,and ubiquitin carboxyl-terminal esterase L1(UCHL1),was analyzed using MethyLight.To examine the role of CpG methylation and histone deacetylation in the silencing of UCHL1,human gallbladder carcinoma cell lines and pancreatic carcinoma cell lines were treated with 2 or 5 μmol/L 5-AZA-dC for 72 h or 100 nmol/L Trichostatin A for 24 h.After the treatment,UCHL1 expression was analyzed by real-time reverse transcription-polymerase chain reaction.RESULTS:Pancreatobiliary cancers exhibited significantly lower LINE-1 methylation levels in pancreatic and biliary fluids than did noncancerous pancreatobiliary disease(58.7% ± 4.3% vs 61.7% ± 2.2%,P = 0.027;53.8% ± 6.6% vs 57.5% ± 1.7%,P = 0.007);however,LINE-1 hypomethylation was more evident in pancreatic cancer tissues than in pancreatic fluids(45.4% ± 5.5% vs 58.7% ± 4.3%,P < 0.001).CpG island hypermethylation of tumor-associated genes was detected at various frequencies,but it was not correlated with LINE-1 hypomethylation.Hypermethylation of the UCHL1 gene was cancer-specific and most frequently detected in pancreatic(67%) or biliary(70%) fluids from patients with pancreatobiliary cancer.As a single marker,hypermethylation of the UCHL1 gene in pancreatic and biliary fluids was most useful for the detection of pancreatic and pancreatobiliary cancers,respectively(100% specificity).Hypermethylation of the UCHL1 and RUNX3 genes in pancreatic and biliary fluids was the most useful combined marker for pancreatic(87% sensitivity and 100% specificity) and pancreatobiliary(97% sensitivity and 100% specificity) cancers.Treatment with a demethylating agent,5-AZA-2'-deoxycytidine,restored UCHL1 expression in pancreatobiliary cancer cell lines.CONCLUSION:Our results suggest that hypermethylation of UCHL1 and RUNX3 in pancreatobiliary fluid might be useful for the diagnosis of pancreatobiliary cancers. | Norihiro Kato Hiroyuki Yamamoto Yasushi Adachi Hirokazu Ohashi Hiroaki Taniguchi Hiromu Suzuki Mayumi Nakazawa Hiroyuki Kaneto Shigeru Sasaki Kohzoh Imai Yasuhisa Shinomura | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 15 | Helicobacter pylori infection induces gastric cancer in Mongolian gerbils显示文摘 | Takeshi Watanabe Mayumi Tada Hirofumi Nagai Satoshi Sasaki Masafumi Nakao | 1998 | Gastroenterology1998，，3： | 3 |
| 16 | Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines显示文摘 | Keita Wada Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Fumihiko Miura Masahiro Yoshida Toshihiko Mayumi Steven Strasberg Henry A. Pitt Thomas R. Gadacz Markus W. Büchler Jacques Belghiti Eduardo de Santibanes Dirk J. Gouma Horst Neuhaus Christos Derven | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，1： | 2 |
| 17 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Miho Sekimoto Tadahiro Takada Yoshifumi Kawarada Koichi Hirata Toshihiko Mayumi Masahiro Yoshida Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Shuji Isaji Masaru Koizumi Makoto Otsuki Seiki Matsuno | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，： | 2 |
| 18 | Differential effects on D 2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary显示文摘 | Atsuko Inoue Mayumi Seto Sayori Sugita Izumi Hide Tsuyoshi Hirose Nobuyuki Koga Tetsuro Kikuchi Yoshihiro Nakata | 1998 | Molecular Brain Research1998，，2： | 2 |
| 19 | A Novel DNA Virus (TTV) Associated with Elevated Transaminase Levels in Posttransfusion Hepatitis of Unknown Etiology显示文摘 | Tsutomu Nishizawa Hiroaki Okamoto Keiko Konishi Hiroshi Yoshizawa Yuzo Miyakawa Makoto Mayumi | 1997 | Biochemical and Biophysical Research Communications1997，，1： | 2 |
| 20 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
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