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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 3 | Immunopathogenesis of chronic hepatitis B显示文摘Chronic hepatitis B(CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus(HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special attention to the replication capacity of HBV in host cells, which is associated with cellular changes that reflect presentation of viral antigens and variability of HBV antigen features. In addition, specific HBV proteins have an immune-modulating ability to initiate molecular mechanisms that 'avoid' control by the immune system. The relationship between immunological shifts and chronic infection stages has been intensively studied since it was recognized that the immune system is a direct participant in the recurrent(cyclic) nature of CHB. Understanding the wide diversity of molecular pathways and the crosstalk between innate and adaptive immune system components will provide fresh insight into CHB immune pathogenesis and the possibilities of developing new treatment strategies for this disease. | Irina P Balmasova Nikolay D Yushchuk Ospan A Mynbaev Nageswara R Alla Elena S Malova Zhongjie Shi Chang-Lu Gao | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 4 | 中国社区健康素养与高血压治疗之间的关系:回顾性队列研究显示文摘健康素养较低与临床预后差相关。健康素养与血压之间的关系研究结果不一致。该研究调查了健康素养的决定因素和健康素养与高血压管理之间的潜在关系。方法:对360例高血压患者进行回顾性队列研究。基于标准方案进行测量、体检和实验室检查。 | 刘莉 叶鹏 Shi D Li J Wang Y Wang S Liu K Shi R Zhang Q Chen X | 2017 | 中华高血压杂志2017，25，5： | 14 |
| 5 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 6 | Structure and Property of Bamboo Fiber显示文摘The chemical composition, fiber characteristics, crystalline structure, mechanical properties and thermal behavior of the five species of bamboo (Phyllostachys edulis cv.Pachyloe, Bambusa tootisk, Arundinaia amabilis, B.vulgaris cv. Vittata, and Dendrocalamus affinis) were studied with IR, X-ray, DSC and chemical analyses. The results indicated that the benzene-ethanol extractive content of bamboo was higher than that of wood, the content of lignin and the content of pentosan were 19.1% - 25.3% and 14.9% - 22.6%, respectively. Except for Ph. edulis cv. Pachyloe, the cellulose content in the other 4 species was over 50%. The average length of fiber of D. affinis was the longest (1.861 mm). The length/ width ratio of bamboo fiber was also higher than that of wood, and it was the highest for B.tootisk, which reached 142. The results of IR and X-ray confirmed that crystalline structure of bamboo fibers was cellulose, and A. amabilis had the highest crystallinity index. The differential thermal analysis (DSC) can be one of the methods to identify various fiber materials. After steam explosive pretreatment, cellulose content of D. affinis had increased from 50.5% to 69.2%, the crystallinity index had increased and the breaking tenacity of bamboo fibers was suitable for producing textile products, indicating that steam explosion is an useful pretreatment for bamboo fibers made into composite materials and textiles. | JIANG Jianxin1 YANG Zhongkai2 ZHU Liwei1 SHI Limin2 YAN Lijie1 1. College of Materials Science and Technology, Beijing Forestry University, Beijing100083, P. R. China 2 .Beijing Municipal Key Laboratory of Clothing Materials R & D and Assessment, Beijing Institute of Clothing Technology, Beijing 100029, P. R. China. | 2008 | Chinese Forestry Science and Technology2008，7，2： | 8 |
| 7 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 8 | 东澳大利亚悉尼盆地南部二叠纪的地层、沉积环境与盆地演化显示文摘晚石炭世末期 三叠纪东澳大利亚的鲍恩 冈尼达 悉尼 (Bowen Gunnedah Sydney)盆地系是位于拉克伦 (Lachlan )褶皱带和新英格兰 (NewEngland )褶皱带之间的一个长条形的构造盆地。从北部的冈尼达 (Gunnedah)到南部的巴特曼斯 (Batemans)湾 ,悉尼盆地是鲍恩 冈尼达 悉尼盆地系南端的一个次级盆地。悉尼盆地的二叠系包括河流、三角洲、滨浅海沉积岩和火山岩地层。悉尼盆地的西南部二叠系不整合覆盖于变形变质的拉克伦褶皱带之上。二叠系由下部的塔拉特郎群 (TallaterangGroup)、中部的肖尔黑文群 (ShoalhavenGroup )和上部的伊勒瓦拉煤系 (IllawarraCoalMeasures)组成。从晚石炭世末到中三叠世悉尼盆地经历了弧后扩张到典型的前陆盆地的不同阶段 :弧后扩张阶段、被动热沉降阶段和挤压挠曲负载阶段。 | 杜远生 Guang R SHI | 2003 | 古地理学报2003，5，2： | 3 |
| 9 | The Class IV Semaphorin CD100 Plays Nonredundant Roles in the Immune System显示文摘 | Wei Shi Atsushi Kumanogoh Chie Watanabe Junji Uchida Xiaosong Wang Teruhito Yasui Kazunori Yukawa Masahito Ikawa Masaru Okabe Jane R Parnes Kanji Yoshida Hitoshi Kikutani | 2000 | Immunity2000，，5： | 2 |
| 10 | CHARGING OF DUST GRAINS IN COMETARY PLASMA ENVIRONMENTS | Shi Zhi-dong Li Zhong-yuan( University of science and Technology of China, Hefei, 230026, P. R , C . ) (Advanced center for Earht Science and Astronomy, Third World Academy of Science) | 1998 | 紫金山天文台台刊1998，，2： | 2 |
| 11 | High reliability SOS pressure sensor显示文摘 | Chen Q Shi R Teng Z | 1990 | Semiconductor Technol1990，4，： | 2 |
| 12 | Local influence in ridge regression modal显示文摘 | SHI L WANG X R | 1999 | Computational Statistics and Data Analysis1999，31，1： | 2 |
| 13 | Phycocyanin aggregation:A small angle neutron scattering and size exclusion chromatographic study显示文摘 | Shi Y Y Yun R H Van Gunsteren W F | 1988 | J Mol Biol1988，200，： | 1 |
| 14 | Light alkenes from syngas via dimethyl ether 显示文摘 | CAIG Y LIU Z M SHI R M | 1995 | Applied Catalysis A: General1995，125，1： | 1 |
| 15 | Electrochemical and oxygen desorption properties of nanostructured ternary compound NaxMnO2 directly templated from mesoporous SBA-15显示文摘 | Zhao J J Chen H R Shi J L | 2008 | Microporous and MesoporousMaterials2008，116，13： | 1 |
| 16 | Detection of coastal saline land uses with multi-temporal landsat images in Shangyu city, China 显示文摘 | SHI Z HUANG M X WANG R C | 2002 | Environmental Management2002，30，1： | 1 |
| 17 | Detection of streptomycin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by denaturing HPLC analysis and DNA sequencing显示文摘 | Shi R Zhang J Li C | 2007 | Microbes Infect2007，9，1415： | 1 |
| 18 | Comparative Advertising:Effects of Structural Alignability on Target Brand Evaluations显示文摘 | Zhang Shi Frank R Kardes Maria L Cronley | 2002 | Journal of Consumer Psychology2002，12，4： | 1 |
| 19 | C64 H4 : production, i-solation,and structural characterizations of a stable unconventional fulleride显示文摘 | Wang C R Shi Z Q Wan L J | 2006 | J Am Chem Soc2006，128，20： | 1 |
| 20 | Transient receptor potential chan- nels in cardiovascular function and disease 显示文摘 | Inoue R Jensen LJ Shi J | 2006 | Circ Res2006，99，： | 1 |
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