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| 1 | Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions显示文摘Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classifica-tion is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes in-cluding PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distri-bution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and hap-lotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM. | Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang Chunjie Xiao | 2010 | Journal of Genetics and Genomics2010，37，6： | 36 |
| 2 | The development of China's Yangtze River Economic Belt:how to make it in a green way?显示文摘The Yangtze River is one of the largest and longest rivers in Asia.The river originates in the Tibet-Qinghai Plateau(headwater reach),passes through the mountainous provinces of Sichuan,Yunnan and Chongqing(upper reach),flows into the Central Plain(middle reach)and Lower Plain(lower reach),and finally empties into the East China Sea in Shanghai(estuary).The Yangtze River Economic Belt(YREB;Fig.1)has a surface area of 2.1 | Yushun Chen Shuanghu Zhang Desheng Huang Bai-Lian Li Junguo Liu Wenjin Liu Jing Ma Fang Wang Yong Wang Shengjun Wu Yegang Wu Jinyue Yan Chuanbo Guo Wei Xin Hao Wang | 2017 | Science Bulletin2017，62，9： | 20 |
| 3 | Effect of Trichoderma viride biofertilizer on ammonia volatilization from an alkaline soil in Northern China显示文摘Ammonia(NH3) volatilization is one of the primary pathways of nitrogen(N) loss from soils after chemical fertilizer is applied, especially from the alkaline soils in Northern China, which results in lower efficiency for chemical fertilizers. Therefore, we conducted an incubation experiment using an alkaline soil from Tianjin(p H 8.37–8.43) to evaluate the suppression effect of Trichoderma viride(T. viride) biofertilizer on NH3 volatilization, and compared the differences in microbial community structure among all samples. The results showed that viable T. viride biofertilizer(T) decreased NH_3 volatilization by 42.21% compared with conventional fertilizer((CK), urea), while nonviable T. viride biofertilizer(TS) decreased NH_3 volatilization by 32.42%. NH_3 volatilization was significantly higher in CK and sweet potato starch wastewater(SPSW) treatments during the peak period. T. viride biofertilizer also improved the transfer of ammonium from soil to sweet sorghum. Plant dry weights increased 91.23% and 61.08% for T and TS, respectively, compared to CK. Moreover, T. viride biofertilizer enhanced nitrification by increasing the abundance of ammonium-oxidizing archaea(AOA) and ammonium-oxidizing bacteria(AOB). The results of high-throughput sequencing indicated that the microbial community structure and composition were significantly changed by the application of T. viride biofertilizer. This study demonstrated the immense potential of T. viride biofertilizer in reducing NH_3 volatilization from alkaline soil and simultaneously improving the utilization of fertilizer N by sweet sorghum. | Xia Wang Shengjun Xu Shanghua Wu Shugeng Feng Zhihui Bai Guoqiang Zhuang Xuliang Zhuang | 2018 | Journal of Environmental Sciences2018，30，4： | 15 |
| 4 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 5 | Digital Extraction of Altitudinal Belt Spectra in the West Kunlun Mountains Using SPOT-VGT NDVI and SRTM DEM显示文摘In this paper,a digital identification method for the extraction of altitudinal belt spectra of montane natural belts is presented.Acquiring the sequential spectra of digital altitudinal belts in mountains at an acceptable temporal frequency and over a large area requires extensive time and work if traditional methods of field investigation are to be used.Such being the case,often the altitudinal belts of a whole mountain or the belts at a regional scale are represented by single points.However,single points obviously cannot accurately reflect the spatial variety of altitudinal belts.In this context,a digital method was developed to extract the spectra of altitudinal belts from remote sensing data and SRTM DEM in the West Kunlun Mountains.By means of the 1km resolution SPOT-4 vegetation 10-day composite NDVI,the horizontal distribution of altitudinal belts were extracted through supervised classification,with a total classification accuracy of 72.23%.Then,a way of twice-scan was used to realize the automatic transition of horizontal maps to vertical belts.The classification results of remote-sensing data could thus be transformed automatically to sequential spectra of digital altitudinal belts.The upper and lower lines of the altitudinal belts were then extracted by vertical scanning of the belts.Relationships between the altitudinal belts based on the montane natural zones concerning vegetation types and the geomorphological altitudinal belts were also discussed.As a tentative method,the digital extraction method presented here is effective at digitally identifying altitudinal belts,and could be helpful in rapid information extraction over large-scale areas. | XIAO Fei LING Feng DU Yun XUE Huaiping WU Shengjun | 2010 | Journal of Mountain Science2010，7，2： | 8 |
| 6 | Illegal Radio Station Localization with UAV-Based Q-Learning显示文摘This paper proposes a novel unmanned aerial vehicle(UAV)-based illegal radio station(IRS) localization scheme, where the transmit power of the IRS, the channel model and the noise model are unknown to the UAV. A direction-aware Q-learning algorithm is developed to process received signal strength(RSS) values collected by a directional antenna, as well as directions corresponding to the RSS values. This algorithm determines the direction the UAV flies towards and thereby finds the IRS. The proposed scheme is compared to two baseline schemes. One baseline locates the IRS by a UAV equipped with an omnidirectional antenna, where conventional Q-learning is exploited to process the measured RSS and determine the UAV's trajectory. The other baseline locates the IRS by a directional-antenna UAV, where the UAV flies towards the direction with respect to the maximum RSS value. Numerical results show that, especially for a low receive SNR, the proposed scheme can outperform the two baselines in terms of the localization efficiency, providing a smoother trajectory for the UAV. | Shengjun Wu | 2018 | China Communications2018，15，12： | 7 |
| 7 | 有表面机械磨损处理辅助的合金钢强化渗硼动力学显示文摘用表面机械磨损处理(SMAT)在AISI H13钢上制备一层纳米结构的表面层。研究了这种SMAT试样的渗硼性能和粗晶粒对应物的比较。SMAT试样的硼扩散深度在600℃,2 h渗硼后的峰值是8μm,比粗晶粒试样深得多。在SMAT试样上用600℃接着更高温度的双重渗硼处理能合成厚得多的渗硼层。而且SMAT试样的活化能是1403 kJ/mol,比粗晶粒的209.4 kJ/mol低得多。结果表明,用双重渗硼处理的SMAT试样能明显增强渗硼动力学。而且热疲劳试验表明,具有优良抗氧化性和高温机械强度的渗硼层能有效延迟热疲劳裂纹的萌生,阻碍它们的传播。所以经双重渗硼处理的H13钢的热疲劳性能可以大大提升。 | Haopeng Yang Xiaochun Wu Zhe Yang Shengjun Pu Hongbin Wang | 2014 | 热处理技术与装备2014，35，2： | 7 |
| 8 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 9 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 10 | Peptide-specific,allogeneic T cell response in vitro induced by a self-peptide binding to HLA-A2显示文摘The role of the bound peptide in alloreactive T-cell recognition is controversial, ranging from pep-tide-independent to peptide-specific recognition of alloreactive T-cells. The aim of this study is to find the evidence that there exist peptide/MHC complex (pMHC)-specific CTLs among alloreactive T cells generated with long-term mixed lymphocytes culture (LTMLC). A single pMHC was manipulated by loading the TAP-defective, HLA-A2 expressing T2 cells with a viral peptide (LMP2A426-434) or a self-peptide (Tyr369-377). The PBLs samples from 4 HLA-A2 positive (HLA-A2+ve) and 4 HLA-A2 negative (HLA-A2-ve) donors were included in this study. The HLA-A2+ve PBL co-cultured with the LMP2A426-434 pulsed T2 (T2/LMP) stands for the nominal T-cell response to a viral antigen, and the HLA-A2-ve PBLs co-cultured with the Tyr369-377 pulsed T2 (T2/Tyr) for alloreactive T-cell response to an allogeneic antigen. The specificity of the expanded CTLs after the LTMLC was detected by their specific cytotoxicity and binding ability to specific pMHC-tetramer. An HLA-A2 restricted, HIV peptide (Gag77-85)was included for control. The cultural bulk of HLA-A2+ve PBLs with the T2/LMP showed an elevated specific cytotoxicity against the T2/LMP compared to that against the T2/HIV (26.52%±3.72% vs 7.01%±0.87%, P<0.001), and an increased frequency of binding to LMP-tetramer compared to that binding to HIV-tetramer (0.98%±0.33% vs 0.05%±0.01%, P=0.0014). The cultural bulk of HLA-A2-ve PBLs with the T2/Tyr showed a more active cytotoxicity against the T2/Tyr than that against T2/HIV (28.07%±2.58% vs 6.87%±0.01 %, P<0.001), and a higher frequency of binding to the Tyr-tetramer than that binding to the HIV-tetramer (0.88%±0.3% vs 0.06%±0.03%, P=0.0018). Our results indicate that the LTMLC is able to expand the viral antigen-specific CTLs as well as allogeneic antigen-specific CTLs. A relatively large proportion of alloreactive CTLs should be pMHC-specific, i.e., the specificity of the alloreactive lines depends on both the bound peptide and the allotype of MHC. Our observations support the hypothesis that the cumulative effect of T cells specific to each peptide epitope could account for the strength and diversity of the alloresponse. The method using manipulated pMHC and the LTMLC to generate pMHC-specific, alloreactive CTLs is of potential importance for adoptive T-cell immunotherapy. | WENG XiuFang, LIANG ZhiHui, LU XiaoLing, ZHONG MaoHua, LU ShengJun, ZHANG CaiE, DENG Jing, WU XiongWen & GONG FeiLi Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China | 2007 | Science China(Life Sciences)2007，50，2： | 2 |
| 11 | Ecological selection of bacterial taxa with larger genome sizes in response to polycyclic aromatic hydrocarbons stress显示文摘Polycyclic aromatic hydrocarbons(PAHs)are ubiquitous priority pollutants that cause great damage to the natural environment and health.Average genome size in a community is critical for shedding light on microbiome's functional response to pollution stress within an environment.Here,microcosms under different concentrations were performed to evaluate the selection of PAHs stress on the average genome size in a community.We found the distinct communities of significantly larger genome size with the increase of PAHs concentration gradients in soils,and consistent trends were discovered in soils at different latitudes.The abundance of Proteobacteria and Deinococcus-Thermus with relatively larger genomes increased along with PAHs stress and well adapted to polluted environments.In contrast,the abundance of Patescibacteria with a highly streamlined and smaller genome decreased,implying complex interactions between environmental selection and functional fitness resulted in bacteria with larger genomes becoming more abundant.Moreover,we confirmed the increased capacity for horizontal transfer of degrading genes between communities by showing an increased connection number per node positively related to the nid A gene along the concentration gradients in the co-occurrence network.Our findings suggest PAHs tend to select bacterial taxa with larger genome sizes,with significant consequences for community stability and potential biodegradation strategies. | Yuzhu Dong Shanghua Wu Haonan Fan Xianglong Li Yijing Li Shengjun Xu Zhihui Bai Xuliang Zhuang | 2022 | Journal of Environmental Sciences2022，34，2： | 2 |
| 12 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 13 | A Novel Route to Prepare Nanocomposites in Larger Scale显示文摘准备 nanocomposites 的一条新奇线路通过润滑油的 preparingoverbased 钙石油 sulfonate 被说明净化在旋转 packedbed ( RPB )代替常规反应 vessel.The 被用作反应堆的地方,结果证明 thecarbonation 效率被改进,原料消费被减少,并且 thedispersibilities ,在 overbased 的 缩放nano 的 CaCO3 粒子的尺寸和形态学净化的 areenhanced.It 相当被推出这条线路能是广泛地 | Wei WU Lailong LUO Guangwen CHU Shengjun BAI Haikui ZOU Jianfeng CHEN | 2007 | Journal of Materials Science & Technology2007，23，3： | 2 |
| 14 | Development of HEP-XXMF Series Hall Thrusters in BICE显示文摘Hall thruster is a type of electric propulsion thruster which is often regarded as a moderate specific impulse space propulsion technology and is used primarily for station keeping and orbit maintenance tasks. Magnetic field is the most important aspect in Hall thruster's design. Each time the performance improvement of Hall thrusters is accompanied with the regeneration of magnetic field design. Now, all the major space nations treat the magnetic field design as the key technology for Hall thrusters, and many Hall thrusters have emerged in recent years, for example, BPT-4000 and NASA-173 M. In China, based on magnetic focus technology, the Beijing Institute of Control Engineering(BICE) has been developing Hall thrusters ranged from hundreds of watts to 5 kilowatts, including the 1500 W HEP-100 MF and the 5 k W HEP-140 MF Hall thrusters. This paper briefly reviews the development of the HEP-XXMF series Hall thruster. The principle of the Hall thruster, the design methods and the current status of HEP-100 MF and HEP-140 MF are discussed in the paper. | HU Yantin HU Dawei WU Pengan LI Shengjun ZANG Juanwei MAO Wei SHAN Shihua YANG Jian | 2016 | Aerospace China2016，17，2： | 2 |
| 15 | Ginseng stem leaf saponins(GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot and-mouth disease in mice显示文摘 | Xiaoming Song Shengjun Ban Lihua Wu | 2009 | Vaccine2009，27，1： | 1 |
| 16 | Inhibition of enzymatic browning of the meat of Clanis bilineata(Lepidoptera)by glutathione显示文摘 | Wu Shengjun | 2013 | Food Science and Technology Research2013，19，3： | 1 |
| 17 | A necessary and sufficient criterion for multipartite separable states显示文摘 | Wu Shengjun Chen Xuemei Zhang Yongde | 2000 | Phys Lett A2000，275，： | 1 |
| 18 | Using pullulan-based edible coatings to extend shelf-life of fresh-cut ‘Fuji’ apples显示文摘 | Shengjun Wu Jinhua Chen | 2013 | International Journal of Biological Macromolecules2013，，： | 1 |
| 19 | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis显示文摘 | Xinyi Tang Xinyu Tian Yue Zhang Wei Wu Jie Tian Ke Rui Jia Tong Liwei Lu Huaxi Xu Shengjun Wang E. Shevach | 2013 | Clinical and Developmental Immunology2013，，： | 1 |
| 20 | Cellulase-assisted extraction and antioxidant activity of the polysaccharides from garlic显示文摘 | Saikun Pan Shengjun Wu | 2014 | Carbohydrate Polymers2014，，： | 1 |
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