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| 1 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 2 | 有表面机械磨损处理辅助的合金钢强化渗硼动力学显示文摘用表面机械磨损处理(SMAT)在AISI H13钢上制备一层纳米结构的表面层。研究了这种SMAT试样的渗硼性能和粗晶粒对应物的比较。SMAT试样的硼扩散深度在600℃,2 h渗硼后的峰值是8μm,比粗晶粒试样深得多。在SMAT试样上用600℃接着更高温度的双重渗硼处理能合成厚得多的渗硼层。而且SMAT试样的活化能是1403 kJ/mol,比粗晶粒的209.4 kJ/mol低得多。结果表明,用双重渗硼处理的SMAT试样能明显增强渗硼动力学。而且热疲劳试验表明,具有优良抗氧化性和高温机械强度的渗硼层能有效延迟热疲劳裂纹的萌生,阻碍它们的传播。所以经双重渗硼处理的H13钢的热疲劳性能可以大大提升。 | Haopeng Yang Xiaochun Wu Zhe Yang Shengjun Pu Hongbin Wang | 2014 | 热处理技术与装备2014，35，2： | 7 |
| 3 | Transcriptome Survey of the Contribution of Alternative Splicing to Proteome Diversity in Arabidopsis thaliana显示文摘 | Haopeng Yu Caihuan Tian Yang Yu Yuling Jiao | 2016 | Molecular Plant2016，9，5： | 4 |
| 4 | Characteristics of in situ stress field at Qingshui coal mine显示文摘In this study, the characteristics of geological structure at Qingshui coal mine were analyzed. And the hollow inclusion strain cell overcoring method was used to obtain the in situ stress. The effect of in situ stress on the stability of soft rock roadway was analyzed. The results show that the maximum principal stress is in the horizontal direction with a northeast orientation and has a value of about 1.2–1.9 times larger than gravity; the right side of roadway roof and floor is easily subject to serious deformation and failure, and the in situ stress is found to be a major factor. This paper presents important information for developing countermeasures against the large deformation of the soft rock roadway at Qingshui coal mine. | Yang Xiaojie Pang Jiewen Lou Haopeng Fan Lipeng | 2015 | International Journal of Mining Science and Technology2015，25，3： | 3 |
| 5 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 6 | The Study on Plasma Boriding of H13 Steel at Low Temperature Assisted by Surface Nanocrystallization Technology显示文摘Plasma boriding treatment was carried out at low temperature for the hot work die steel H13 assisted by surface nanocrystallization technology in this paper.At the same time,the thermal fatigue property of it was investigated through thermal fatigue testing with 3000 continuous cycles from room temperature to 700℃.The changes of structure and grain size in surface layer were characterized by high-resolution transmission electron microscopy(HRTEM).After plasma boriding at 580℃ for 4 h,the phase composition,morphology and in-situ nanomechanical property of boride layer were investigated by X-ray diffraction spectroscopy(XRD),scanning electron microscope(SEM),nanoindentation test,respectively.The results show that the boride layer with about thickness of 5μm is composed with two phases of Fe2B and FeB.The nanohardness of boride layer is as high as 21 GPa.Furthermore,thermal fatigue testing shows that the boride layer with excellent oxidation resistance and mechanical strength at elevated temperatures could effectively delay the crack initiation and impede the crack propagation.Therefore,the thermal fatigue property of H13 can be remarkably improved. | Yang Haopeng Wu Xiaochun Wu Tianrong | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 7 | Object registration using an RGB-D camera for complex product augmented assembly guidance显示文摘Background Augmented assembly guidance aims to help users complete assembly operations more efficiently and quickly through augmented reality technology,breaking the limitations of traditional assembly guidance technology which is single in content and boring in way.Object registration is one of the key technologies in augmented assembly guidance process,which can affect the location and direction of virtual assembly guidance information in real assembly environment.Methods This paper presents an object registration method based on RGB-D camera,which combines Lucas-Kanade(LK)optical flow algorithm and Iterative Closet Point(ICP)algorithm.An augmented assembly guidance system for complex products through this method is built.Meanwhile,in order to compare the effectiveness of the proposed method,we also implemented object registration based on an open source augmented reality SDK Vuforia.Results An engine model and a complex weapon cabin equipment are taken as an case to verify this work.The result shows that the registration method proposed in this paper is more accurate and stable compared with that based on Vuforia and the augmented assembly guidance system through this method greatly improves the user's time compared with the traditional assembly.Conclusions Therefore,we can conclude that the object registration method mentioned in this paper can be well applied in the augmented assembly guidance system,which can do enhance the efficiency of assembly considerably. | Kangkang YANG Yu GUO Pengzhou TANG Haopeng ZHANG Han LI | 2020 | Virtual Reality & Intelligent Hardware2020，2，6： | 2 |
| 8 | Synthe sis and strong red photoluminescence of europium oxide nanotubes and nanowires using carbon nanotubes as templates显示文摘 | Yang Haopeng Zhang Dengsong Shi Liyi v | 2008 | Acta Materialia2008，56，： | 1 |
| 9 | QoS-Aware Power Allocation Scheme for Relay Satellite Networks显示文摘This paper investigated a QoS-aware power allocation for relay satellite networks.For the given QoS requirements,we analyzed the signal model of relay transmission and formulated the power minimization problem which is non-convex and difficult to solve.To find the optimal solution to the considered problem,we first analyzed the optimization problem and equivalently turn it into a convex optimization problem.Then,we provided a Lagrangian dual-based method to obtain the closed-form of the power allocation and provided an iterative algorithm to the optimal solution.Moreover,we also extended the results to the cooperative transmission mode.Finally,simulation results were provided to verify the superiority of the proposed algorithm. | Jin’ao Yu Xiaogang Tang Shibing Zhu Haopeng Sun Lunxin Zhong Guangyu Yang | 2021 | Journal of Beijing Institute of Technology2021，30，1： | 1 |
| 10 | Enhanced boronizing kinetics of alloy steel assisted by surface mechanical attrition treatment显示文摘 | Yang Haopeng Wu Xiaochun Yang Zhe | 2014 | Journal of Alloys and Compounds2014，590，2： | 1 |
| 11 | Shape primitive histogram: Lowlevel face representation for face recognition 显示文摘 | Huang Sheng Yang Dan Zhang Haopeng | 2014 | Biometrics IET2014，3，4： | 1 |
| 12 | A protective AAV vaccine for SARS-CoV-2显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the COVID-19 pandemic,with more than 528 million infections and 6.2 million deaths.To fight against this rapidly spreading pandemic,prophylactic vaccines have been developed using different techniques,such as inactivated virus,messenger RNAs,recombinant proteins,and viral-vectored vaccines.However,rapidly spreading variants of SARS-CoV-2,such as alpha,beta,delta,and omicron variants,have been emerging. | Simeng Zhao Junzi Ke Boyu Yang Fangzhi Tan Jie Yang Chao-Po Lin Haopeng Wang Guisheng Zhong | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 13 | Proliferation and differentiation of reactive nestin^+/GFAP^+ cells in an adult rat model of compression-induced spinal cord injury显示文摘BACKGROUND:Studies have demonstrated that astrocytes may possess similar properties to neural stem cells/neural precursor cells and have the potential to differentiate into neurons. OBJECTIVE:To observe neuroepithelial stem cell protein(nestin) and glial fibrillary acidic protein (GFAP) expression following spinal cord injury,and to explore whether nestin^+/GFAP^+ cells,which are detected at peak levels in gray and white matter around the ependymal region of the central canal in injured spinal cord,possess similar properties of neural stem cells. DESIGN,TIME AND SETTING:A randomized,controlled experiment.The study was performed at the Key Laboratory of Environment and Genes Related to Diseases(Xi'an Jiaotong University), Ministry of Education between January 2004 and December 2006. MATERIALS:Rabbit anti-rat nestin,β-tubulinⅢ,mouse anti-rat GFAP,galactocerebroside(GaLC) antibodies were utilized,as well as flow cytometry. METHODS:A total of 60 male,Sprague Dawley rats,aged 8 weeks,were randomly assigned to control(n = 12) and model(n = 48) groups.The spinal cord injury model was established in the model group by aneurysm clip compression,while the control animals were not treated.The gray and white matter around the ependymal region of the central canal exhibited peak expression of nestin^+/GFAP^+ cells.These cells were harvested and prepared into single cell suspension,followed by primary and passage cultures.The cells were incubated with serum-containing neural stem cell complete medium. MAIN OUTCOME MEASURES:Nestin and GFAP expression in injured spinal cord was determined using immunohistochemistry and double-labeled immunofluorescence at 1,3,5,7,14,28,and 56 days post-injury.In addition,cell proliferation and differentiation were detected using immunofluorescence cytochemistry and flow cytometry. RESULTS:Compared with the control group,the model group exhibited significantly increased nestin and GFAP expression(P<0.05),which reached peak levels between 3 and 7 days.The majority of cells in the ependymal region around the central canal were nestin^+/GFAP^- cells,while the gray and white matter around the ependymal region were full of nestin^+/GFAP^+ cells,with an astrocytic-like appearance.A large number of nestin^+/GFAP^+ cells were observed in the model group cell culture,and the cells formed clonal spheres and displayed strong nestin-positive immunofluorescence staining.Following induced differentiation,a large number of GaLC-nestin,β-tubulinⅢ-nestin,and GFAP-nestin positive cells were observed.However,no obvious changes were seen in the control group.Cells in S stage,as well as the percentage of proliferating cells,in the model group were significantly greater than in the control group(P<0.01). CONCLUSION:Spinal cord injury in the adult rat induced high expression of nestin^+/GFAP^+ in the gray and white matter around the ependymal region of the central canal.These nestin^+/GFAP^+ cells displayed the potential to self-renew and differentiate into various cells.The cells could be neural stem cells of the central nervous system. | Pinglin Yang Xijing He Haopeng Li Binshang Lan Guoyu Wang Yiheng Liu | 2009 | Neural Regeneration Research2009，4，10： | 1 |
| 14 | CAR trafficking does matter:prospects of‘Chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy’显示文摘Chimeric antigen receptor(CAR)is a synthetic antigen receptor containing a specific antigen-recognition ectodomain to make T cells selectively attack cancer cells,a hinge-transmembrane region to confer stable surface expression,and one or more intracellular signaling domains to regulate T-cell activation.CAR T-cell therapy has produced unprecedented clinical outcomes for treating cancers,particularly B-cell malignancies.However,increasing clinic data reveal some limitations of current CAR T therapies.For example,>30%of B-cell malignancy patients who initially achieved complete remission encountered relapses after 1-year infusion of CAR T cells.In case of solid tumors,most of the patients did not benefit from CAR T treatment(Park et al.,2018;Schmidts and Maus,2018).CAR T-cell persistence,defined as how long CAR T cells could survive in vivo after infusion into patients,is one of the major factors affecting the clinical outcomes of CAR T therapy(Porter et al.,2015).Therefore,it is important to understand the molecular mechanism(s)controlling the persistence of CAR T cells. | Wentao Li Han Yang Li Li Haopeng Wang | 2020 | Journal of Molecular Cell Biology2020，12，9： | 1 |
| 15 | Spatial-Temporal Change of Phytoplankton Biomass in the East China Sea with MODIS Data显示文摘A ten-year chlorophyll-a concentration dataset from Moderate Resolution Imaging Spectro-radiometer(MODIS) were used to analyze the variation of phytoplankton biomass and its potential relation with climate in the East China Sea. The result indicated that the phytoplankton biomass generally had a regular pattern every year, and phytoplankton bloom mainly occurred between May and July. The highest phytoplankton biomass appeared near the Yangtze River Estuary. The lowest phytoplankton biomass located near the Taiwan Strait. In general, the starting bloom time was earlier in the south than in the north, and the span time of the former was also longer. During the recent ten years, the phytoplankton biomass around the Yangtze River Estuary decreased obviously. The change of phytoplankton biomass was found to be related with the Ni?o3.4 Index. The correlation between the intensity of phytoplankton bloom with the number and square of red tide were 0.63 and 0.74, respectively. | WU Yumei ZHU Haopeng DANG Xiaoyan CHENG Tianfei YANG Shenglong WANG Lin HUANG Liangmin CUI Xuesen | 2021 | Journal of Ocean University of China2021，20，2： | 1 |
| 16 | Synthesis and strong red photoluminescence of europium oxide nanotubes and nanowires using carbon nanotubes as templates显示文摘 | Yang Haopeng Zhang Dengsong Shi Liyi | 2008 | Acta Materialia2008，56，5： | 1 |
| 17 | Enhanced boronizing kinetics of alloy steel assisted by surface mechanical attrition treatment显示文摘 | YANG Haopeng WU Xiaochun YANG Zhe | 2014 | Journal of Alloys and Compounds2014，590，5： | 1 |
| 18 | The role of fatty acid metabolism and lipotoxicity in pancreatic β-cell injury:Identification of potential therapeutic targets显示文摘Over the last 20 years,intensive research has been focused on the specific mechanisms mediating the pancreatic β-cell injury.Both the decreased viability and the dysfunction of β-cells have become the key factors in the development of dia betes mellitus.Thus,it is of utmost importance to elucidate the discrete pathological changes in pancreatic β-cells within the context of the various lipotoxicity models.The goal of these studies is to generate evidence to improve not only the clinical treatment for dia betics,but also modulate the diet and activities of groups at high risk for diabetes.In this regard,we review the role of lipotoxicity in pancreatic β-cell injury and identify potential therapeutic targets in this cell model. | Haopeng Yang Xuejun Li | 2012 | Acta Pharmaceutica Sinica B2012，2，4： | 0 |
| 19 | A core epitope targeting antibody of SARS-CoV-2显示文摘Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different strategies.However,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes. | Simeng Zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen Zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong | 2023 | Protein & Cell2023，14，1： | 0 |
| 20 | Epidemiology and early screening strategies for colorectal cancer in China显示文摘China ranks the first worldwide in the number of new colorectal cancer(CRC) cases and CRC-related deaths. The increasing incidence of early-onset CRC in recent years highlights the challenges related to CRC screening and prevention. High-quality colonoscopy is the universally used gold standard for CRC screening. Risk assessment combined with a two-step screening strategy based on colonoscopy and non-invasive examinations was proven to be highly effective. However, systematic use of well-established risk factors associated with CRC, beyond age, could better identify those who might harbor advanced colorectal neoplasia, improve the diagnostic yield of current screening modalities, and optimize the selection of individuals who might benefit most from preventive strategies.“Personalization” and “Standardization” are the future development directions of CRC screening, from the initiation of screening in those at high risk for CRC to follow-up after treatment, which are the key to ensure the screening efficiency. | Yong Yang Zhaoya Gao An Huang Jingyi Shi Zhuang Sun Haopeng Hong Jin Gu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
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