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| 1 | Pre-illness changes in dietary habits and diet as a risk factor for inflammatory bowel disease: A case-control study显示文摘AIM: To evaluate whether symptoms of inflammatory bowel disease (IBD), before diagnosis modify dietary habits, and to investigate the pre-illness diet in patients with recent IBD in comparison with an age-matched healthy control group. METHODS: Overall, 83 new cases of IBD (41 ulcerative colitis, 42 Crohn's disease) and 160 healthy controls were studied. Portions per week of 34 foods and beverages before onset of symptoms were recorded using a validated questionnaire. Duration of symptoms before IBD diagnosis, presence of specific symptoms and their impact on subjective changes in usual dietary habits were also recorded. The association between diet and IBD was investigated by multiple logistic regression and dietary patterns were assessed by factor analysis. RESULTS: Changes in dietary habits, due to the presence of symptoms, were reported by 38.6% of patients and were not significantly related to specific symptoms, rather to long duration of symptoms, only in Crohn's disease patients. In IBD patients who did not change dietary habits, moderate and high consumption of margarine (OR = 11.8 and OR = 21.37) was associated with ulcerative colitis, whilst high consumption of red meat (OR = 7.8) and high intake of cheese were associated with Crohn's disease. CONCLUSION: More than one third of IBD patients change dietary habits before diagnosis. Margarine, red meat and cheese increase the risk of ulcerative colitis and Crohn's disease. | Giovanni Maconi Sandro Ardizzone Claudia Cucino Cristina Bezzio Antonio Giampiero Russo Gabriele Bianchi Porro | 2010 | World Journal of Gastroenterology2010，16，34： | 10 |
| 2 | Comprehensive review on EUS-guided biliary drainage显示文摘Feasibility of endoscopic retrograde cholangiopancreatography(ERCP) for biliary drainage is not always applicable due to anatomical alterations or to inability to access the papilla. Percutaneous transhepatic biliary drainage has always been considered the only alternative for this indication. However,endoscopic ultrasonography-guided biliary drainage represents a valid option to replace percutaneous transhepatic biliary drainage when ERCP fails. According to the access site to the biliary tree,two kinds of approaches may be described: the intrahepatic and the extrahepatic. Endoscopic ultrasonography-guided rendezvous transpapillary drainage is performed where the second portion of the duodenum is easily reached but conventional ERCP fails. The recent introduction of self-expandable metal stents and lumen-apposing metal stents has improved this field. However,the role of the latter is still controversial. Echoendoscopic transmural biliary drainage can be challenging with potential severe adverse events. Therefore,trained endoscopists,in both ERCP and endoscopic ultrasonography are needed with surgical and radiological backup. | Raffaele Salerno Sophia Elizabeth Campbell Davies Nicolò Mezzina Sandro Ardizzone | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 4 |
| 3 | Endoscopic retrograde cholangiopancreatography,lights and shadows:Handle with care显示文摘The role of endoscopic retrograde cholangiopancreatography(ERCP) has dramatically changed in the last years, mainly into that of a therapeutic procedure. The treatment of benign biliary disease, like 'difficult'choledocolithiasis, with endoscopic papillary large balloon dilation combined with endoscopic sphinterotomy has proven an effective and safe technique.Moreover, safety in ERCP has improved as well, with the prevention of postERCP pancreatitis and patient-to-patient transmission of infections. The advent of self-expandable metal stenting has radically changed the management of biliopancreatic malignant strictures, while the role for therapy of benign strictures is still controversial. In addition, cholangioscopy(though the direct visualization of the biliopancreatic ductal system) has allowed for characterization of indeterminate biliary strictures and facilitated rescue therapy of large biliary stones deemed removable. Encouraging data from tissue ablation techniques, such as photodynamic therapy and radiofrequency ablation, need to be confirmed by large sample size clinical controlled trials. On the other hand, we have no drug-coated stents yet available to implant and evidence for the use of biodegradable stents is still weak. The competency and privileging of ERCP and endoscopic ultrasonography have been analyzed longer but the switch between the two procedures, at the same time, is becoming ordinary; as such, the endoscopist interested in this field should undergo parallel edification through training plans. Finally, the American Society for Gastrointestinal Endoscopy's statement on non-anesthesiologist administration of propofol for gastrointestinal endoscopy is not actually endorsed by the European Society of Anaesthesiology,having many medical-legal implications in some European countries. | Raffaele Salerno Nicolò Mezzina Sandro Ardizzone | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 3 |
| 4 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 5 | Glucose intolerance and diabetes mellitus in ulcerative colitis: Pathogenetic and therapeutic implications显示文摘Diabetes mellitus is one of the most frequent co-morbidities of ulcerative colitis patients.The epidemiological association of these diseases suggested a genetic sharing and has challenged gene identification.Diabetes co-morbidity in ulcerative colitis has also relevant clinical and therapeutic implications,with potential clinical impact on the follow up and outcome of patients.These diseases share specific complications,such as neuropathy,hepatic steatosis,osteoporosis and venous thrombosis.It is still unknown whether the coexistence of these diseases may increase their occurrence.Diabetes and hyperglycaemia represent relevant risk factors for postoperative complications and pouch failure in ulcerative colitis.Medical treatment of ulcerative colitis in patients with diabetes mellitus may be particularly challenging.Corticosteroids are the treatment of choice of active ulcerative colitis.Their use may be associated with the onset of glucose intolerance and diabetes,with difficult control of glucose levels andwith complications in diabetic patients.Epidemiologic and genetic evidences about diabetes co-morbidity in ulcerative colitis patients and shared complications and treatment of patients with these diseases have been discussed in the present review. | Giovanni Maconi Federica Furfaro Roberta Sciurti Cristina Bezzio Sandro Ardizzone Roberto de Franchis | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 6 | Combined therapeutic approach:Inflammatory bowel diseases and peripheral or axial arthritis显示文摘Inflammatory bowel diseases(IBDs), particularly Crohn's disease(CD) and ulcerative colitis(UC), are associated with a variety of extra-intestinal manifestations(EIMs).About 36% of IBD patients have at least one EIM, which most frequently affect the joints, skin, eyes and the biliary tract.The EIMs associated with IBD have a negative impact on patients with UC and CD, and the resolution of most of them parallels that of the active IBD in terms of timing and required therapy;however, the clinical course of EIMs such as axial arthritis, pyoderma gangrenosum, uveitis, and primary sclerosing cholangitis is independent of IBD activity.The peripheral and axial arthritis associated with IBD have traditionally been treated with simple analgesics, non-steroidal anti-inflammatory drugs, steroids, sulfasalazine, methotrexate, local steroid injections and physiotherapy, but the introduction of biological response modifi ers such as tumor necrosis factor-α blockers, has led to further improvements. | Fabiola Atzeni Sandro Ardizzone Luca Bertani Marco Antivalle Alberto Batticciotto Piercarlo Sarzi-Puttini | 2009 | World Journal of Gastroenterology2009，15，20： | 2 |
| 7 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 8 | Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis显示文摘 | Sandro Ardizzone Andrea Cassinotti Piergiorgio Duca Cristina Mazzali Chiara Penati Gianpiero Manes Riccardo Marmo Alessandro Massari Paola Molteni Giovanni Maconi Gabriele Bianchi Porro | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 9 | Use of double-balloon enteroscopy in the management of patients with Crohn’s disease: feasibility and diagnostic yield in a high-volume centre for inflammatory bowel disease显示文摘 | Gianpiero Manes Venerina Imbesi Sandro Ardizzone Andrea Cassinotti Stefano Pallotta Gabriele Bianchi Porro | 2009 | Surgical Endoscopy2009，，12： | 1 |
| 10 | Transperineal Perineal Ultrasound Versus Magnetic Resonance Imaging In the Assessment of Perianal Crohn?s Disease显示文摘 | Giovanni Maconi Massimo Tonolini Michela Monteleone Cristina Bezzio Federica Furfaro Chiara Villa Alessando Campari Alessandra Dell?Era Gianluca Sampietro Sandro Ardizzone Roberto de Franchis | 2013 | Inflammatory Bowel Diseases2013，，： | 1 |
| 11 | Prevalence of Pancreatic Insufficiency in Inflammatory Bowel Diseases. Assessment by Fecal Elastase-1显示文摘 | Giovanni Maconi Roberto Dominici Mirko Molteni Sandro Ardizzone Matteo Bosani Elisa Ferrara Silvano Gallus Mauro Panteghini Gabriele Bianchi Porro | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 12 | Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study显示文摘 | Gianpiero Manes Sandro Ardizzone Giovanni Lombardi Generoso Uomo Oreste Pieramico Gabriele Bianchi Porro | 2007 | Gastrointestinal Endoscopy2007，，7： | 1 |
| 13 | Rheumatic manifestations in inflammatory bowel disease显示文摘 | Fabiola Atzeni Caterina Defendenti Maria Chiara Ditto Alberto Batticciotto Donatella Ventura Marco Antivalle Sandro Ardizzone Piercarlo Sarzi-Puttini | 2013 | Autoimmunity Reviews2013，，： | 1 |
| 14 | Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)显示文摘 | Shaji Sebastian Vincent Hernández P?r Myrelid Revital Kariv Epameinondas Tsianos Murat Toruner Marc Marti-Gallostra Antonino Spinelli Andrea E. van der Meulen-de Jong Elif Sar?tas Yuksel Christoph Gasche Sandro Ardizzone Silvio Danese | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 15 | New onset of atrial fibrillation after introduction of azathioprine in ulcerative colitis: case report and review of the literature显示文摘 | Andrea Cassinotti Alessandro Massari Elisa Ferrara Salvatore Greco Matteo Bosani Sandro Ardizzone Gabriele Bianchi Porro | 2007 | European Journal of Clinical Pharmacology2007，，9： | 1 |
| 16 | Biologic targeting in the treatment of inflammatory bowel diseases显示文摘 | Sandro Ardizzone | 2008 | Biologics: Targets and Therapy (default)2008，，： | 1 |
| 17 | ABO histo-blood group might modulate predisposition to Crohn’s disease and affect disease behavior显示文摘 | Diego Forni Isabelle Cleynen Marc Ferrante Andrea Cassinotti Rachele Cagliani Sandro Ardizzone Severine Vermeire Maria Fichera Marta Lombardini Giovanni Maconi Roberto de Franchis Rosanna Asselta Mara Biasin Mario Clerici Manuela Sironi | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 18 | Prevalence of Pancreatic Insufficiency in Inflammatory Bowel Diseases. Assessment by Fecal Elastase-1显示文摘 | Giovanni Maconi Roberto Dominici Mirko Molteni Sandro Ardizzone Matteo Bosani Elisa Ferrara Silvano Gallus Mauro Panteghini Gabriele Bianchi Porro | 2008 | Digestive Diseases and Sciences2008，，： | 1 |
| 19 | Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis显示文摘 | Sandro Ardizzone Andrea Cassinotti Piergiorgio Duca Cristina Mazzali Chiara Penati Gianpiero Manes Riccardo Marmo Alessandro Massari Paola Molteni Giovanni Maconi Gabriele Bianchi Porro | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 1 |
| 20 | Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)显示文摘 | Shaji Sebastian Vincent Hernández P?r Myrelid Revital Kariv Epameinondas Tsianos Murat Toruner Marc Marti-Gallostra Antonino Spinelli Andrea E. van der Meulen-de Jong Elif Sar?tas Yuksel Christoph Gasche Sandro Ardizzone Silvio Danese | 2014 | Journal of Crohn’s and Colitis2014，，1： | 1 |
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