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| 1 | Predictive value of C-reactive protein/albumin ratio in acute pancreatitis显示文摘BACKGROUND:Serum C-reactive protein(CRP) increases and albumin decreases in patients with inflammation and infection.However,their role in patients with acute pancreatitis is not clear.The present study was to investigate the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis patients.METHODS:This study was performed retrospectively with 192 acute pancreatitis patients between January 2002 and June 2015.Ranson scores,Atlanta classification and CRP/albumin ratios of the patients were calculated.RESULTS:The CRP/albumin ratio was higher in deceased patients compared to survivors.The CRP/albumin ratio was positively correlated with Ranson score and Atlanta classification in particular and with important prognostic markers such as hospitalization time,CRP and erythrocyte sedimentation rate.In addition to the CRP/albumin ratio,necrotizing pancreatitis type,moderately severe and severe Atlanta classification,and total Ranson score were independent risk factors of mortality.It was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.52 times in mortality risk.A prediction value about CRP/albumin ratio >16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58.0% specificity.It was seen that Ranson and Atlanta classification were higher in patients with CRP/albumin ratio >16.28 compared with those with CRP/albumin ratio ≤16.28.Patients with CRP/albumin ratio >16.28 had a 19.3 times higher chance of death.CONCLUSION:The CRP/albumin ratio is a novel but promising,easy-to-measure,repeatable,non-invasive inflammationbased prognostic score in acute pancreatitis. | Mustafa Kaplan Ihsan Ates Muhammed Yener Akpinar Mahmut Yuksel Ufuk Baris Kuzu Sabite Kacar Orhan Coskun Ertugrul Kayacetin | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 53 |
| 2 | Fintech investments in European banks:a hybrid IT2 fuzzy multidimensional decision‑making approach显示文摘Financial technology(Fintech)makes a significant contribution to the financial system by reducing costs,providing higher quality services and increasing customer satisfaction.Hence,new studies play an essential role to improve Fintech investments.This study evaluates Fintech-based investments of European banking services with an application of an original methodology that considers interval type-2(IT2)fuzzy decision-making trial and evaluation laboratory and IT2 fuzzy TOPSIS models.Empirical findings are controlled for consistency by applying the VIKOR method.Moreover,we conduct a sensitivity analysis by considering six distinct cases.This study contributes to the existing literature by identifying the most important Fintech-based investment alternatives to improve the financial performance of European banks.Our empirical findings illustrate that results are coherent,reliable,and identify“competitive advantage”as the most important factor among Fintech-based determinants.Moreover,“payment and money transferring systems”are the most important Fintech-based investment alternatives.It is recommended that,among Fintech-based investments,European banks should mainly focus on payment and money transferring alternatives to attract the attention of customers and satisfy their expectations.This is also believed to have a positive impact on the ease of bank’receivable collection.Another important point is that Fintech-based investments in money transferring systems could help to decrease costs. | Gang Kou Ozlem Olgu Akdeniz Hasan Dincer Serhat Yuksel | 2021 | Financial Innovation2021，7，1： | 38 |
| 3 | CO_(2) utilization: Developments in conversion processes显示文摘Carbon dioxide capture,utilization and storage(CCUS)eincluding conversion to valuable chemicals-is a challenging contemporary issue having multi-facets.The prospect to utilize carbon dioxide(CO_(2))as a feedstock for synthetic applications in chemical and fuel industries-through carboxylation and reduction reactions-is the subject of this review.Current statute of the heterogeneously catalyzed hydrogenation,as well as the photocatalytic and electrocatalytic activations of conversion of CO_(2) to value-added chemicals is overviewed.Envisaging CO_(2) as a viable alternative to natural gas and oil as carbon resource for the chemical supply chain,three stages of development;namely,(i)existing mature technologies(such as urea production),(ii)emerging technologies(such as formic acid or other single carbon(C1)chemicals manufacture)and(iii)innovative explorations(such as electrocatalytic ethylene production)have been identified and highlighted.A unique aspect of this review is the exploitations of reactions of CO2 ewhich stems from existing petrochemical plants-with the commodity petrochemicals(such as,methanol,ethylene and ethylene oxide)produced at the same or nearby complex in order to obtain value-added products while contributing also to CO_(2) fixation simultaneously.Exemplifying worldwide ethylene oxide facilities,it is recognized that they produce about 3 million tons of CO2 annually.Such a CO_(2) resource,which is already separated in pure form as a requirement of the process,should best be converted to a value-added chemical there avoiding current practice of discharging to the atmosphere.The potential utilization of CO_(2),captured at power plants,should also been taken into consideration for sustainability.This CO_(2) source,which is potentially a raw material for the chemical industry,will be available at sufficient quality and at gigantic quantity upon realization of on-going tangible capture projects.Products resulting from carboxylation reactions are obvious conversions.In addition,provided that enough supply of energy from non-fossil resources,such as solar[1],is ensured,CO_(2) reduction reactions can produce several valuable commodity chemicals including multi-carbon compounds,such as ethylene and acrylic acid,in addition to C1 chemicals and polymers.Presently,there are only few developing technologies which can find industrial applications.Therefore,there is a need for concerted research in order to assess the viability of these promising exploratory technologies rationally. | Erdogan Alper Ozge Yuksel | 2017 | Petroleum2017，3，1： | 13 |
| 4 | Does vitamin D affect disease severity in patients with ankylosing spondylitis?显示文摘 | Bekir Durmus Zuhal Altay Ozlem Baysal Yuksel Ersoy | 2012 | Chinese Medical Journal2012，，14： | 10 |
| 5 | Flow structure at the downstream of a one-line riparian emergent tree along the floodplain edge in a compound open-channel flow显示文摘This study focuses on the effects of one-line emergent natural tree(Cupressus Macrocarpa) planted at the edge of the floodplain in a compound open-channel flow. The flow velocity and water level are measured and used to analyze the flow structure. The time averaged and depth-averaged streamwise velocity distributions with root mean square(rms) and time series of streamwise velocity distrbution are analyzed. The velocity distribution considerably changes along the compound channel. The streamwise velocity distribution fits with logarithmic distribution in the non-vegetated case, but for vegetated cases, the streamwise velocity distribution shows S shaped profile at the 1/3 part of floodplain(/3)B_f and main channel(/3)B_m close to the boundary between floodplain and main channel. Additionally, it is obtained that the presence of tree line increases turbulence intensity over the compound open-channel. Moreover, an oscillation period is obtained in the flow caused by tree line by analyzing time series of the streamwise velocity distribution. The oscillation is present everywhere in the floodplain and present at almost/3 B_m part of the main channel which is close to the junction between floodplain and main channel. | Ayse Yuksel Ozan | 2018 | Journal of Hydrodynamics2018，30，3： | 8 |
| 6 | Effectiveness of breathing exercises during the second stage of labor on labor pain and duration: a randomized controlled trial显示文摘BACKGROUND: Some research exists on the effect of non-pharmacological approaches for labor pain relief. However, there is limited information about effectiveness of breathing exercises in pregnant women to reduce maternal pain during labor.OBJECTIVE: To determine whether breathing exercises for pregnant women during the second stage of labor have beneficial effects on maternal pain, duration of labor, and the first-minute Appearance, Pulse, Grimace, Activity and Respiration(APGAR) scores. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This randomized clinical trial involved 250 pregnant women, who were randomly divided into two groups: intervention group(IG; n = 125) and control group(CG; n = 125). IG received one session breathing exercise training and performed breathing exercises during the second stage of labor versus the CG that did not receive any breathing exercise training.MAIN OUTCOME MEASURES: The effects of breathing exercises on maternal pain were determined by Visual Analogue Scale(VAS), duration of the second stage of labor, and the first-minute APGAR scores.RESULTS: The mean age of the participants was(23.2 ± 4.2)(range: 18 to 42) years. Both IG and CG had similar baseline characteristics in terms of age, education level, occupation, and smoking(P > 0.05). The mean VAS scores of IG and CG were(88.2 ± 6.3) and(90.5 ± 7.0), respectively(P < 0.001). The duration of the second stage of labor was(369.6 ± 92.0) s for IG and(440.7 ± 142.5) s for CG(P < 0.001). The mean first-minute APGAR scores were(8.84 ± 0.50) for IG and(8.73 ± 0.89) for CG(P > 0.05).CONCLUSION: Based on this study, breathing exercises with deep inhalation and exhalation in pregnant women are effective in reducing the perception of labor pain and shortening the duration of the second stage of delivery. Therefore, we recommend breathing exercises as an effective modality for labor pain management and shortening the duration of labor.TRIAL REGISTRATION: This study is registered on the website of ClinicalT rials.gov(www.clinicaltrials.gov) with the number of NCT03066973. | hilal yuksel yasemin cayir zahide kosan kenan tastan | 2017 | Journal of Integrative Medicine2017，15，6： | 6 |
| 7 | Reflection and Transmission of Regular Waves from/Through Single and Double Perforated Thin Walls显示文摘In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes.Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests' results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method(MDBEM)with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data. | Nadji CHIOUKH Esin CEVIK Yalcin YUKSEL | 2017 | China Ocean Engineering2017，31，4： | 4 |
| 8 | Effects of vernal and allergic conjunctivitis on severity of keratoconus显示文摘AIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). ·METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. · RESULTS: The median age at presentation was significantly lower in group B (P <0.001). According to the median SE (P =0.003), BCVA(P =0.022), Km(P <0.001), CCT (P =0.015) and Amsler-Krumeich classification (P < 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P =0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. · CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease. | Abdullah Kursat Cingu Yasin Cinar Fatih Mehmet Turkcu Alparslan Sahin Seyhmus Ari Harun Yuksel Muhammed Sahin Ihsan Caca | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 4 |
| 9 | Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey显示文摘AIM:The eradication rate of Helicobacter pylori (H pylon) shows variation among countries and regimens of treatment.We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication.METHODS:One hundred and sixty-four Hpylori positivepatients (68 males, 96 females; mean age:48±12 years)with duodenal or gastric ulcer without a smoking history were included in the study. The patients were divided into three groups according to the treatment regimens. Omeprazole 20mg, clarithromycin 500mg, amoxicillin 1g were given twice daily for 1 week (Group I) and 2 weeks (Group Ⅱ).Patients in Group Ⅲ received bismuth subsitrate 300mg,tetracyline 500 mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus, and histopathologically evaluated.Eradication was assumed to be successful if no Hpylorus was detected from four biopsy specimens taken after treatment. The effects of factors like age, sex, Hpyloridensity on antrum and corpus before treatment, the total Hpylori density, and the inflammation scores on the rate of Hpylori eradication were evaluated.RESULTS:The overall eradication rate was 42%. The rates in groups Ⅱ and Ⅲ were statistically higher than that in group I (P<0.05). The rates of eradication were 24.5%,40.7% and 61.5% in groups Ⅰ, Ⅱ and Ⅲ, respectively. The eradication rate was negatively related to either corpus Hpylori density or total Hpyloridensity (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55yr vs 39yr, P<0.001). No correlation between sex and Hpylori eradication was found.CONCLUSION: Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high Hpyloridensity are negative predictive factors for the rate of Hpylorieradication. | Yuksel Gumurdulu Ender Serin Birol zer Fazilet Kayaselcuk Kursat Ozsahin Arif Mansur Cosar Murat Gursoy Gurden Gur Ugur Yilmaz Sedat Boyacioglu | 2004 | World Journal of Gastroenterology2004，10，5： | 4 |
| 10 | New approach: removal of silicone oil and trocar assisted sutureless scleral fixated intraocular lens implantation at the same session显示文摘Dear Sir,Iam Dr.Remzi Karadag,from the Department of Ophthalmology,Istanbul Medeniyet University School of Medicine,Istanbul,Turkey.I write to present two case reports of removal of silicone oil and trocar assisted sutureless scleral fixated intraocular lens implantation at the same session. | Yuksel Totan Remzi Karadag | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 11 | Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment显示文摘BackgroundLevodopa 是在有 Parkinson 疾病(PD ) 的病人的中间的治疗的不可缺少的选择。因为 L-dopa 治疗被显示增加浆液 homocysteine 层次,为心血管的混乱的一个著名风险因素,有在 L-dopa 治疗下面的 PD 的病人将在为未来的增加的风险心血管的事件。这研究的目的是在 levodopa treatment.MethodsThe 学习下面与 PD 在病人评估心血管的风险人口在 L-dopa 治疗下面与自发的 PD 由 65 个病人组成了。控制组包括了 32 年龄,性匹配没有认知衰落的个人。Echocardiographic 大小,浆液 homocysteine 层次和主动脉的有弹性的参数与 PD 和 controls.ResultsAs 在病人之间被作比较 L-dopa 治疗的一个期望的特征, Parkinson 组有显著地更高的 homocystein 层次(15.1 ±3.9 µ mol/L 对 11.5 ±3.2 µ mol/L, P = 0.02 ) 。当时,大动脉的膨胀性在有 PD 的病人是显著地更低的与控制相比(4.8 ±1.5 dyn/cm 2 对 6.2 ±1.9 dyn/cm 2, P = 0.016 ) 。另外,有 PD 的病人有更高大动脉的紧张和大动脉的僵硬索引(13.4%±6.4% 对 7.4%±3.6% , P <0.001 和 7.3 ±1.5 对 4.9 ±1.9, P <0.001 分别地) 。而且,浆液 homocysteine 层次被发现断然与大动脉的僵硬索引被相关,在浆液 homocysteine 的大动脉的膨胀性和层次之间有否定关联(r = 0.674, P <0.001;r =− 0.602, P <0.001,分别地) 有在 L-dopa 治疗下面的 PD 的 .ConclusionsThe 病人增加了大动脉的僵硬并且与健康个人相比损害了心脏舒张的功能。提高的浆液 homocysteine 层次可以是可能的 pathophysiological 机制。 | Zeki Yuksel Gunaydln Fahriye Feriha Ozer Ahmet Karagoz Osman Bektas Mehmet Baran Karatas Ash Vural Adil Bayramoglu Abdullah Celik Mehmet Yaman | 2016 | Journal of Geriatric Cardiology2016，13，1： | 3 |
| 12 | Prevalence of amebiasis in inflammatory bowel disease in Turkey显示文摘AIM: To explore the prevalence of amebiasis in inflammatory bowel disease (IBD) in Turkey.METHODS: In this study, amoeba prevalence in 160 cases of IBD, 130 of ulcerative colitis and 30 of Crohn′s disease were investigated in fresh faeces by means of wet mount+Lugol′s iodine staining, modified formol ethyl acetate and trichrome staining methods and to compare the diagnostic accuracy of wet mount+Lugol′s iodine staining,modified formol ethyl acetate and trichrome staining methods in the diagnosis of Entamoeba histolytica (E. histolytica)/Entamoeba dispar (E. dispar).RESULTS: E. histolytica/E. dispar cysts and trophozoites were found in 14 (8.75 %) of a total of 160 cases, 13 (10.0 %)of the 130 patients with ulcerative colitis and 1 (3.3 %) of the 30 patients with Crohn′s disease. As for the 105 patients in the control group who had not any gastrointestinal complaints, 2 (1.90 %) patients were found to have E.histolytica/E. dispar cysts in their faeces. Parasite prevalence in the patient group was determined to be significantly higher than that in the control group (Fischer′s Exact Test, P<0.05).When the three methods of determining parasites were compared with one another, the most effective one was found to be trichrome staining method (Kruskal-Wallis Test, P<0.01).CONCLUSION: Consequently, amoeba infections in IBD cases have a greater prevalence compared to the normal population. The trichrome staining method is more effective for the detection of E. histolytica/E. dispar than the wet mount+Lugol′s iodine staining, modified formol ethyl acetate methods. | Sebnem Ustun Hande Dagci Umit Aksoy Yuksel Guruz Galip Ersoz | 2003 | World Journal of Gastroenterology2003，9，8： | 3 |
| 13 | Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy显示文摘AIM: To determine whether Helicobacter pylori ( H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B12, serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.METHODS: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of Hpylori4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B12, folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after Hpylorieradication therapy were compared.RESULTS: The group with a successful eradication of Hpylori had significantly higher serum vitamin B12 and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs237±94pg/mL, P<0.O01 and 442±212 ng/mL vs 539±304 ng/mL,P = 0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0±2.4 ng/mL,P= 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B12, serum folate and erythrocyte folate levels. | Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 14 | Incidence of accessory ossicles and sesamoid bones in the feet: a radiographic study of the Turkish subjects显示文摘 | Nigar Coskun Mehtap Yuksel Metin Cevener R. Yavuz Arican Hakan Ozdemir Oguz Bircan Timur Sindel Sezgin Ilgi Muzaffer Sindel | 2009 | Surgical and Radiologic Anatomy2009，，1： | 3 |
| 15 | Late in-the-bag spontaneous IOL dislocation: risk factors and surgical outcomes显示文摘AIM: To evaluate the possible predisposing risk factors for late in-the-bag spontaneous IOL dislocations and to study the early surgical and visual outcomes of repositioning and exchange surgeries.METHODS: Medical and surgical records of 39 eyes of 39 patients who underwent IOL repositioning or exchange surgery for dislocation between 2010 and 2018 were reviewed. Possible predisposing risk factors and some characteristics of late in-the-bag spontaneous IOL dislocations;outcomes of IOL repositioning and exchange surgeries, including visual acuity, refractive status before and after surgery and postoperative complications were evaluated.RESULTS: The predisposing factors for late in-the-bag spontaneous IOL dislocations were pseudoexfoliation [PEX;12/39(30.8%)], previous vitreoretinal surgery [7/39(17.9%)], axial myopia [3/39(7.7%)], both PEX and axial myopia [1/39(2.6%)], both previous vitreoretinal surgery and axial myopia [2/39(5.1%)] and uveitis (1/39(2.6%))The mean interval between cataract and dislocation surgery was 7.23 y, greater in PEX positive group(8.63 y). The mean best corrected visual acuity(BCVA) improved significantly after dislocation surgery(P<0.001) and also improved significantly after exchange surgery(P=0.001). The mean value of spherical equivalant decreased significantly after dislocation surgery(P=0.011), whereas corneal astigmatism increased but this difference was not significant after dislocation surgery and exchange surgery(P=0.191, P=0.074, respectively).CONCLUSION: The most prevelant risk factors for late inthe-bag spontaneous IOL dislocations are PEX, previous vitreoretinal surgery and axial myopia. In the management of IOL dislocations, exchange surgery with small corneal incision seemed effective with improved BCVA and safety with low postoperative complications. | Sevgi Subasi Nursen Yuksel V.Levent Karabas Busra Yilmaz Tugan | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 16 | Comparison of the Diagnostic Accuracy of Five Different Stool Antigen Tests for the Diagnosis of Helicobacter pylori Infection显示文摘 | Huseyin Korkmaz Recep Kesli Pinar Karabagli Yuksel Terzi | 2013 | Helicobacter2013，，5： | 2 |
| 17 | A hybrid heterogeneous Pythagorean fuzzy group decision modelling for crowdfunding development process pathways of fintech‑based clean energy investment projects显示文摘This study aims to evaluate the crowdfunding alternatives regarding new service development process pathways of clean energy investment projects.In this framework,a new model has been generated by considering the consensus-based group decisionmaking with incomplete preferences,Pythagorean fuzzy decision-making trial and evaluation laboratory(DEMATEL)and technique for order preference by similarity to ideal solution(TOPSIS).Moreover,a comparative evaluation has been performed with Vise Kriterijumska Optimizacija I.Kompromisno Resenje methodology and sensitivity analysis has been made by considering 4 different cases.The main contribution is to identify appropriate crowdfunding-based funding alternatives for the improvement of the clean energy investments with a novel MCDM model.By considering the iteration technique and consensus-based analysis,the missing parts in the evaluations can be completed and opposite opinion problems can be reduced.Furthermore,with the help of hybrid MCDM model by combining DEMATEL and TOPSIS,more objective results can be reached.It is concluded that the analysis results are coherent and reliable.The findings indicate that the full launch is the most significant criterion for equity and debt-based crowdfunding alternatives.On the other side,the analysis has the highest weight for reward and donation-based alternatives whereas design is the most essential item regarding the royalty-based alternative.Additionally,it is also defined that equity-based crowdfunding alternative is the most significant for the service development process of clean energy investment projects.In this way,it will be possible to provide a continuous resource for clean energy investment projects.On the other hand,by providing financing with equity,there will be no fixed financing cost for clean energy investors.If these investors make a profit,they distribute dividends with the decision of their authorized bodies. | Yue Meng Haoyue Wu Wenjing Zhao Wenkuan Chen Hasan Dincer Serhat Yuksel | 2021 | Financial Innovation2021，7，1： | 2 |
| 18 | Neuroprotective effect of edaravone in experimental glaucoma model in rats: a immunofluorescence and biochemical analysis显示文摘AIM: To evaluate the neuroprotective activity of systemically administered edaravone in early and late stage of experimental glaucoma in rats.METHODS: In this study, 60 Wistar albino rats were used. Experimental glaucoma model was created by injecting hyaluronic acid to the anterior chamber once a week for 6wk in 46 of 60 subjects. Fourteen subjects without any medication were included as control group.Edaravone administered intraperitoneally 3 mg/kg/d to the 15 of 30 subjects starting at the onset of glaucoma induction and also administered intraperitoneally3 mg/kg/d to the other 15 subjects starting at three weeks after the onset of glaucoma induction. The other16 subjects who underwent glaucoma induction was administered any therapy. Retinal ganglion cells(RGCs)have been marked with dextran tetramethylrhodamine(DTMR) retrograde at the end of the sixth week and after48 h, subjects were sacrificed by the method of cardiac perfusion. Alive RGC density was assessed in the wholemount retina. Whole-mount retinal tissues homogenized and nitric oxide(NO), malondialdehyde(MDA) and total antioxidant capacity(TAC) values were measured biochemically.RESULTS: RGCs counted with Image-Pro Plus program, in the treatment group were found to be statistically significantly protected, compared to the glaucoma group(Bonferroni,P <0.05). The neuroprotective activity of edaravone was found to be more influential byadministration at the start of the glaucoma process.Statistically significant lower NO levels were determined in the glaucoma group comparing treatment groups(Bonferroni, P <0.05). MDA levels were found to be highest in untreated glaucoma group, TAC levels were found to be lower in the glaucoma induction groups than the control group(Bonferroni, P <0.05).CONCLUSION: Systemic administration of edaravone in experimental glaucoma showed potent neuroprotective activity. The role of oxidative stress causing RGC damage in glaucoma was supported by this study results. | Arzu Toruk Aksar Nursen Yuksel Mustafa Gok Mustafa Cekmen Yusuf Caglar | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 2 |
| 19 | Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture显示文摘AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(H.pylori) isolation and diagnosis.METHODS:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy samples.Homogenized biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic environment.Additionally,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of H.pylori and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the content.Results obtained by CC,CLO test,and HE were compared with those of MC.The diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and CI.RESULTS:H.pylori was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy samples.In 25(25/26) patient biopsy samples,H.pylori was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,H.pylori was isolatedby CC.CLO test and HE were found positive in 17(17/26) patient biopsy samples.Comparing the results of the isolation of H.pylori by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for H.pylori has high diagnostic sensitivity compared with CC,HE,and CLO tests. | Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel Emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 20 | A geriatric patient with diffuse idiopathic skeletal hyperostosis显示文摘The most frequent health problems seen in senility are chronic and degenerative diseases. A 75-year-old male patient with the complaints of weight loss and difficulty in swallowing was admitted to our hospital from a nursing home. Upper system fiber-optic gastrointestinal endoscopy was performed and a mass at the junction of the hypopharynx and esophagus just below recessus piriformis obstructing almost the whole of the lumen and blocking the distal passage was detected. Computed tomography revealed marked narrowing secondary to osseous hypertrophy in the air column of the hypopharynx and proximal esophagus. Diffuse idiopathic skeletal hyperostosis or Forestier’s disease is an idiopathic disease characterized by the ossification of the anterior longitudinal ligament of vertebra and some of the extraspinal ligaments. In the present case we aim to discuss an elderly patient who suffered from dysphagia and weight loss and the diagnostic stages. | Berrin Karadag Huseyin Cat Selma Aksoy Banu Ozulu Ali Osman Ozturk Sukru Oguz Yuksel Altuntas | 2010 | World Journal of Gastroenterology2010，16，13： | 2 |
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