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| 1 | Mediterranean dietary components are inversely associated with advanced colorectal polyps:A case-control study显示文摘AIM To evaluate the association between the Mediterranean diet(MD) pattern and its components, and advanced colorectal polyps(adenoma and serrated adenoma).METHODS A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia(HGD) or villous histology], advanced serrated adenoma(> 10 mm or with dysplasia) or multiple(≥ 3) non-advanced adenomas or serrated adenomas. Cases of non-advanced adenomas were defined as adenomas < 10 mm, without features of HGD or villous histology. Controls were defined as those without polyps at the current colonoscopy and without a history of colorectal polyps. Data collection included: anthropometrics measured according to a standardized protocol, fasting blood tests performed at the same lab, medical history recorded by a structured interview and dietary intake evaluated by a 116-item food frequency questionnaire. Adherence to the MD components was evaluated according to intake above/below the sample median, for potentially beneficial/detrimental components respectively, as accepted. RESULTS We recruited 206 cases with advanced polyps, 192 cases with non-advanced adenoma and 385 controls. The number of adhered MD components was inversely associated with a diagnosis of advanced polyps in a dose-response manner(OR = 0.34, 95%CI: 0.17-0.65; OR = 0.22, 95%CI: 0.11-0.43; and OR = 0.18, 95%CI: 0.07-0.47 for 3-4, 5-7 and 8-10 components, respectively), but not with non-advanced adenomas(OR = 0.54, 95%CI: 0.25-1.13; OR = 0.48, 95%CI: 0.23-0.99; and OR = 0.43, 95%CI: 0.16-1.12 for 3-4, 5-7 and 8-10 components, respectively). Low intake of sugar-sweetened beverages and red meat, as well as high intake of fish, were inversely associated with advanced polyps(OR = 0.56, 95%CI: 0.36-0.87; OR = 0.63, 95%CI: 0.42-0.95; and OR = 0.66, 95%CI: 0.44-0.99, respectively), while only low intake of red meat was inversely associated with non-advanced adenomas(OR = 0.71, 95%CI: 0.49-0.97). CONCLUSION A better adherence to the MD, specifically low intake of sugar-sweetened beverages and red meat as well as high intake of fish, is related to lower odds for advanced polyps. | Naomi Fliss-Isakov Revital Kariv Muriel Webb Dana Ivancovsky Dana Margalit Shira Zelber-Sagi | 2018 | World Journal of Gastroenterology2018，24，24： | 3 |
| 2 | Preoperative Colorectal Neoplasia Increases Risk for Pouch Neoplasia in Patients With Restorative Proctocolectomy显示文摘 | Revital Kariv Feza H. Remzi Lei Lian Ana E. Bennett Ravi P. Kiran Yehuda Kariv Victor W. Fazio Ian C. Lavery Bo Shen | 2010 | Gastroenterology2010，，3： | 3 |
| 3 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 4 | Impact of Clostridium difficile infection in patients with ulcerative colitis显示文摘 | Revital Kariv Udayakumar Navaneethan Preethi G.K. Venkatesh Rocio Lopez Bo Shen | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 5 | Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer显示文摘AIM To study factors associated with esophageal and nonesophageal cancer morbidity among Barrett's esophagus(BE) patients. METHODS A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Cancer morbidity was obtained from the national cancer registry. Main outcomes were BE related(defined as esophagus and cardia) and non-BE related cancers(all other cancers). Cancer incidence and all-causemortality were compared between patients with highgrade dysplasia(HGD) and with low-grade or no dysplasia(non-HGD) using Kaplan-Meier curves and cox regression models.RESULTS Of the 386 patients, 12 had HGD, 7 had a BE related cancer. There were 75(19.4%) patients with 86 cases of lifetime cancers, 76 of these cases were non-BE cancers. Seven(1.8%) and 18(4.7%) patients had BE and non-BE incident cancers, respectively. Twelve(3.1%) patients had HGD as worst histologic result. Two(16.7%) and 16(4.4%) incident non-BE cancers occurred in the HGD and non-HGD group, respectively. Ten-year any cancer and non-BE cancer free survival was 63% and 82% in the HGD group compared to 93% and 95% at the non-HGD group, respectively. Log-rank test for patients with more than one endoscopy, assuring longer follow up, showed a significant difference(P < 0.001 and P = 0.017 respectively). All-cause mortality was not significantly associated with BE HGD.CONCLUSION Patients with BE and HGD, may have a higher risk for all-cause cancer morbidity. The implications on cancer prevention recommendations should be further studied. | Nir Bar Naama Schwartz Michal Nissim Naomi Fliss-Isacov Shira Zelber-Sagi Revital Kariv | 2018 | World Journal of Gastroenterology2018，24，39： | 2 |
| 6 | Re-evaluation of se-rum alanine aminotransferase upper normal limit and itsmodulating factors in a large-scale popu-lation study显示文摘 | Kariv R Leshno M Beth-Or A | 2006 | Liver Int2006，26，4： | 1 |
| 7 | A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases显示文摘 | Shaked G M Shaked Y Kariv I Z | 2001 | J Biol Chem2001，276，31： | 1 |
| 8 | An algorithmic approach to network location problems显示文摘 | Kariv O Hakimi S L | 1979 | SIAM Journal on Applied Mathematics1979，37，3： | 1 |
| 9 | Transnational Networking and Business Performance: Ethnic Entrepreneurs in Canada 显示文摘 | KARIV D MENZIES T V BRENNER G A | 2009 | Entrepreneur- ship and Regional Development2009，21，3： | 1 |
| 10 | An algorithmic approach to network location problems--( I ) the p-centers 显示文摘 | KARIV O HAKIM1 S L | 1979 | SIAM J Appl Math1979，37，： | 1 |
| 11 | An algorithmic approach to network location problems显示文摘 | Kariv Hakimi | 1979 | Applying Mathematics1979，，37： | 1 |
| 12 | An algorithmic approach to network location problems显示文摘 | Kariv Hakimi | 1979 | Applying Mathematics1979，，37： | 1 |
| 13 | Long-term outcome after laparoseopie and open surgery for rectal prolapse: a case control study显示文摘 | Kariv Y Delaney CP Casillas S et ai | 2006 | Surg Endose2006，20，1： | 1 |
| 14 | Algorithms for finding p-centers on a weighted tree ( for relatively small p) 显示文摘 | JEGER M KARIV O | 1985 | Networks1985，15，3： | 1 |
| 15 | Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia显示文摘 | Paul M Kariv G Goldberg E | 2010 | J Antimicrob Chemother2010，65，： | 1 |
| 16 | An Algorithmic Approach to Network Location Problems,Part Ⅱ:p-medians显示文摘 | O Kariv S L Hakimi | 1979 | SIAM Journal on Applied Math1979，37，： | 1 |
| 17 | Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line 显示文摘 | Kariv R Enden A Zvibel I | 2003 | Liver Int2003，23，3： | 1 |
| 18 | Chiral electrode显示文摘 | Watkinls B F Behling J R Kariv E | 1975 | J Am Chem Soc1975，97，12： | 1 |
| 19 | An Experimen- tal Test of Advice and Social Learning 显示文摘 | Boahan elen Kariv Shachar Schotter Andrew | 2010 | Management Science2010，56，10： | 1 |
| 20 | Experimental intrauterine growth retardation alters renal development显示文摘 | Bassan H Trejo L L Kariv N | 2000 | Pediatric Nephrol2000，15，： | 1 |
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