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| 1 | Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review显示文摘BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of malignancies.However,these inhibitors also cause immune-related adverse events.Hepatobiliary disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 inhibitors.Recent studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are unclear.AIM To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the literature.METHODS The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in English.We scanned the references of the selected literature to identify any further relevant studies.Six cases previously studied by us,including three that have not yet been published,were included in this review.RESULTS Thirty-one PD-1 inhibitor-related SC cases were evaluated.Median age of patients was 67 years(range,43–89),with a male to female ratio of 21:10.The main disease requiring PD-1 inhibitor treatment was non-small cell lung cancer.Agents that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent symptom.Blood serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin G4.Biliary dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were noted.In 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells in the bile duct or peribiliary tract.Although corticosteroids were mainly used for PD inhibitor-related SC treatment,the response rate was 11.5%(3/26).CONCLUSION Some clinical and pathological features of PD-1 inhibitor-related SC were revealed.To establish diagnostic criteria for PD-1 inhibitor-related SC,more cases need to be evaluated. | Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto | 2020 | World Journal of Gastroenterology2020，26，3： | 7 |
| 2 | Essentials of Proteolytic Machineries in Chloroplasts显示文摘质体是能响应环境、发展的刺激改变他们的结构和功能的唯一的细胞器。叶绿体是质体的一种类型并且是为各种各样的新陈代谢的过程的地点,包括光合作用。为最佳的光合的活动,叶绿体 proteome 必须适当地通过调整解朊作用和蛋白质质量控制机制被塑造并且维持。酶的功能和活动被包含连续解朊的反应的蛋白质成熟过程授与。蛋白质丰富被平衡蛋白质合成和降级优化,它正在取决于新陈代谢的地位。失灵的蛋白质即时被降级。二十叶绿体解朊的机械迄今为止被描绘了。明确地,处理 peptidases 和精力驱动的 processive 朊酶,改变是在叶绿体 proteome 生物的续生说的主要播放器,和维护。最近识别的通常认为的朊酶是光合的功能的潜在的管理者。这里,我们提供叶绿体蛋白质降级机械的更新的、全面概述并且为光合作用讨论他们的重要性。尽可能,我们也提供结构的卓见进实现底层蛋白质 / 肽的调整解朊作用的叶绿体朊酶。 | Kenji Nishimura Yusuke Kato Wataru Sakamoto | 2017 | Molecular Plant2017，10，1： | 6 |
| 3 | Micro RNA ‐148a is downregulated in gastric cancer, targets MMP 7, and indicates tumor invasiveness and poor prognosis显示文摘 | Naoya Sakamoto Yutaka Naito Naohide Oue Kazuhiro Sentani Naohiro Uraoka Htoo Zarni Oo Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Wataru Yasui | 2014 | Cancer Sci2014，，2： | 2 |
| 4 | Molecular pathology of gastric cancer: Research and practice显示文摘 | Wataru Yasui Kazuhiro Sentani Naoya Sakamoto Katsuhiro Anami Yutaka Naito Naohide Oue | 2011 | Pathology - Research and Practice2011，，10： | 2 |
| 5 | Novel electro-rheological nanocrystalline dielectric particles modified with or embedded in organics显示文摘 | Toshinobu Yogo Wataru Sakamoto | 2004 | Journal of European Ceramic Society2004，24，： | 1 |
| 6 | Functional characterization of key structural genes in rice flavonoid biosynthesis显示文摘 | Chun Hat Shih Hung Chu Lee Kwan Tang Wataru Sakamoto Masahiko Maekawa Ivan K. Chu Mingfu Wang Clive Lo | 2008 | Planta2008，，6： | 1 |
| 7 | Effects of Bi203 seeding layer on crystallinity and electrical properties of CSD-derived Bi4-xLaxTi3Ol2 ferroelectric thin films显示文摘 | HAYASHI Takashi TOGAWA Daichi SAKAMOTO Wataru | 2004 | J Eur Ceram Soc2004，24，6： | 1 |
| 8 | Phototropin-and photosynthesis-dependent mitochondrial positioning in Arabidopsis thaliana mesophyll cells^FA显示文摘Mitochondria are frequently observed in the vicinity of chloroplasts in photosynthesizing cells, and this association is considered necessary for their metabolic in-teractions. We previously reported that, in leaf palisade cel s of Arabidopsis thaliana, mitochondria exhibit blue-light-dependent redistribution together with chloroplasts, which conduct accumulation and avoidance responses under the control of blue-light receptor phototropins. In this study, precise motility analyses by fluorescent micro-scopy revealed that the individual mitochondria in palisade cel s, labeled with green fluorescent protein, exhibit typical stop-and-go movement. When exposed to blue light, the velocity of moving mitochondria increased in 30 min, whereas after 4 h, the frequency of stoppage of mi-tochondrial movement markedly increased. Using different mutant plants, we concluded that the presence of both phototropin1 and phototropin2 is necessary for the early acceleration of mitochondrial movement. On the contrary, the late enhancement of stoppage of mitochondrial movement occurs only in the presence of phototropin2 and only when intact photosynthesis takes place. A plasma-membrane ghost assay suggested that the stopped mi-tochondria are firmly adhered to chloroplasts. These re-sults indicate that the physical interaction between mi-tochondria and chloroplasts is cooperatively mediated by phototropin2- and photosynthesis-dependent signals. The present study might add novel regulatory mechanism for light-dependent plant organel e interactions. | Md Sayeedul Islam Toan Van Nguyen Wataru Sakamoto Shingo Takagi | 2020 | Journal of Integrative Plant Biology2020，62，9： | 1 |
| 9 | Review on acute pancreatitis attributed to COVID-19 infection显示文摘The coronavirus disease 2019(COVID-19)is known to cause gastrointestinal symptoms.Recent studies have revealed COVID-19-attributed acute pancreatitis(AP).However,clinical characteristics of COVID-19-attributed AP remain unclear.We performed a narrative review to elucidate relation between COVID-19 and AP using the PubMed database.Some basic and pathological reports revealed expression of angiotensin-converting enzyme 2 and transmembrane protease serine 2,key proteins that aid in the entry of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)into the pancreas.The experimental and pathological evaluation suggested that SARS-CoV-2 infects human endocrine and exocrine pancreas cells,and thus,SARS-CoV-2 may have a direct involvement in pancreatic disorders.Additionally,systemic inflammation,especially in children,may cause AP.Levels of immune mediators associated with AP,including interleukin(IL)-1β,IL-10,interferon-γ,monocyte chemotactic protein 1,and tumor necrosis factor-αare higher in the plasma of patients with COVID-19,that suggests an indirect involvement of the pancreas.In real-world settings,some clinical features of AP complicate COVID-19,such as a high complication rate of pancreatic necrosis,severe AP,and high mortality.However,clinical features of COVID-19-attributed AP remain uncertain due to insufficient research on etiologies of AP.Therefore,high-quality clinical studies and case reports that specify methods for differential diagnoses of other etiologies of AP are needed. | Takumi Onoyama Hiroki Koda Wataru Hamamoto Shiho Kawahara Yuri Sakamoto Taro Yamashita Hiroki Kurumi Soichiro Kawata Yohei Takeda Kazuya Matsumoto Hajime Isomoto | 2022 | World Journal of Gastroenterology2022，28，19： | 1 |
| 10 | Effect of tumor size on prognosis in patients with non–small cell lung cancer: The role of segmentectomy as a type of lesser resection显示文摘 | Morihito Okada Wataru Nishio Toshihiko Sakamoto Kazuya Uchino Tsuyoshi Yuki Akio Nakagawa Noriaki Tsubota | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，1： | 1 |
| 11 | Safety and efficacy of faldaprevir with pegylated interferon alfa‐2a and ribavirin in Japanese patients with chronic genotype‐1 hepatitis C infection显示文摘 | Shuhei Nishiguchi Yoshiyuki Sakai Makoto Kuboki Satoshi Tsunematsu Yasuhisa Urano Wataru Sakamoto Yasuhiro Tsuda Gerhard Steinmann Masao Omata | 2014 | Liver Int2014，，1： | 1 |
| 12 | Synthesis and optical properties of ZrO 2 with incorporated Ti nanoparticle/polymer hybrid显示文摘 | Toshihiko Asai Wataru Sakamoto Toshinobu Yogo | 2012 | Journal of Nanoparticle Research2012，，： | 1 |
| 13 | Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells显示文摘 | Wataru Sakamoto Haruo Isomura Katsutoshi Fujie Yoshiaki Deyama Akihisa Kato Jun Nishihira Hiroshi Izumi | 2005 | BBA - Molecular Basis of Disease2005，，1： | 1 |
| 14 | Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation显示文摘 | Hayato Nakagawa Shin Maeda Yohko Hikiba Tomoya Ohmae Wataru Shibata Ayako Yanai Kei Sakamoto Keiji Ogura Takuya Noguchi Michael Karin Hidenori Ichijo Masao Omata | 2008 | Gastroenterology2008，，： | 1 |
| 15 | Reduction in amounts of mitochondrial DNA in the sperm cells as a mechanism for maternal inheritance in Hordeum vulgare显示文摘 | Sodmergen Quan Zhang Yingtao Zhang Wataru Sakamoto Tsuneyoshi Kuroiwa | 2002 | Planta2002，，2： | 1 |
| 16 | Effect of Brazilian Propolis on Exacerbation of Respiratory Syncytial Virus Infection in Mice Exposed to TetrabromobisphenolA, a Brominated Flame Retardant显示文摘 | Tomomi Takeshita Wataru Watanabe Satomi Toyama Yuya Hayashi Shiori Honda Shuichi Sakamoto Sayuri Matsuoka Hiroki Yoshida Shiro Takeda Muneaki Hidaka Shigetoshi Tsutsumi Ken Yasukawa Yong Kun Park Masahiko Kurokawa F. R. F. Nascimento | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 17 | Fabrication and characterization of BiFeO3-BaTiO3 ceramics by solid state reaction显示文摘 | Itoh Naoyuki Shimura Tetsuo Sakamoto Wataru | 2007 | Ferroelectries2007，356，1： | 1 |
| 18 | Processing and Piezoelectric Properties of Lead-Free ( K, Na) ( Nb, Ta) 03 Ceramics 显示文摘 | Masato Matsubara Toshiaki Yamaguchi Wataru Sakamoto | 2005 | Journal of the American Ceramic Society2005，88，5： | 1 |
| 19 | Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy显示文摘 | Naoki Ohmiya Tomonori Yano Hironori Yamamoto Daigo Arakawa Masanao Nakamura Wataru Honda Akihiro Itoh Yoshiki Hirooka Yasumasa Niwa Osamu Maeda Takafumi Ando Tsuneyoshi Yao Toshiyuki Matsui Mitsuo Iida Shinji Tanaka Tsutomu Chiba Choitsu Sakamoto Kentaro | 2007 | Gastrointestinal Endoscopy2007，，3： | 1 |
| 20 | Liver–intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer显示文摘 | Naoya Sakamoto Naohide Oue Kazuhiro Sentani Katsuhiro Anami Naohiro Uraoka Yutaka Naito Htoo Zarni Oo Takao Hinoi Hideki Ohdan Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Wataru Yasui | 2012 | Cancer Sci2012，，9： | 1 |
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