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| 1 | Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer显示文摘AIM: To determine the incidence and risk factors for colorectal cancer(CRC) in patients with ulcerative colitis from a low prevalence region for CRC.METHODS: Our prospective database yielded a cohort of 430 patients [age: 44 ± 14.6 years; 248 men(57.7%)] with ulcerative colitis(median disease duration 6, range: 1-39 years) for analysis. Of these, 131(30.5%) had left-sided colitis and 159(37%) extensive colitis. Patients with histologically confirmed CRC within the segment with colitis were compared with those without CRC, to determine the risk factors for the development of CRC.RESULTS: Twelve patients(2.8%) developed CRC. The overall incidence density was 3.56/1000 patient-years of disease- 3/1000 in the first 10 years, 3.3/1000 at 10 to 20 years, and 7/1000 at > 20 years. Three of our 12 patients developed CRC within 8 years of disease onset. On univariate analysis, extensive colitis, longer duration of disease, and poor control of disease were associated with development of CRC. On multivariate analysis, duration of disease and extent of colitis remained significant.CONCLUSION: CRC occurred in 2.8% of patients with ulcerative colitis in our population- an incidence density similar to that in Western countries in spite of a low overall prevalence of colon cancer in our population.The risk increased with extent and duration of disease. | Devendra Desai Sudeep Shah Abhijit Deshmukh Philip Abraham Anand Joshi Tarun Gupta Ramesh Deshpande Varun Khandagale Siji George | 2015 | World Journal of Gastroenterology2015，21，12： | 7 |
| 2 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 3 | In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models显示文摘 | Rajesh Kumar Gupta Achyut Narayan Kesari Sandhya Diwakar Ameetabh Tyagi Vibha Tandon Ramesh Chandra Geeta Watal | 2008 | Journal of Ethnopharmacology2008，，1： | 2 |
| 4 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 5 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 6 | Recovery of large prean- tral follicles from buffalo ovary:effect of season and corpus luteum显示文摘 | Gupta P S Ramesh H S Nandi S | 2007 | Anita Reprod Sci2007，101，12： | 1 |
| 7 | Dental pulp stem cells immobilized in alginate microspheres for applications in bone tissue engineering显示文摘 | M. M. Kanafi A. Ramesh P. K. Gupta R. R. Bhonde | 2014 | Int Endod J2014，，7： | 1 |
| 8 | Controlled attenuation parameter for non‐invasive assessment of hepatic steatosis: Does etiology affect performance?显示文摘 | Manoj Kumar Archana Rastogi Tarandeep Singh Chhagan Behari Ekta Gupta Hitendra Garg Ramesh Kumar Vikram Bhatia Shiv K Sarin | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
| 9 | Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs显示文摘 | Amita Gupta Jyoti S. Mathad Wei-Teng Yang Harjot K. Singh Nikhil Gupte Vidya Mave Renu Bharadwaj K. Zaman Eliza Roy Robert C. Bollinger Ramesh Bhosale Mark C. Steinhoff | 2014 | Vaccine2014，，： | 1 |
| 10 | Properties and application of a partially purified alkaline xylanasefrom an alkalophilic fungus Aspergillus nidulans KK-99显示文摘 | Kavita Taneja Saurabh Gupta Ramesh Chander Kuhad | 2002 | Bioresource Technology2002，，85： | 1 |
| 11 | Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents显示文摘Objective:To evaluate nephroprotective potential of Solarium xanthocarpum(S.xanthocarpum) fruit extract(SXE) against gentamicin(GM) induced nephrotoxicity) and renal dysfunction. Methods:Twenty-four Wistar rats were divided into four groups(n=6).Control rats that received normal saline(i.p.) and 0.5%carboxymethyl cellulose(p.o.) per day lor 8 d.Nephrotoxicity was induced in rats by intraperitoneal administration of GM(100 mg/kg/d for 8 d) and were treated with SXE(200 and 400 mg/kg/d(p.o.) for 8 d).Plasma and urine urea and creatinine,kidney weight,urine output,blood urea nitrogen,renal enzymatic and non-enzymatic antioxidants and lipid peroxidation was evaluated along with histopathological investigation in various experimental groupsof rats.Results:It was observed that the GM treatment induced significant elevation(P<0.001) in plasma and urine urea,creatinine,kidney weight,blood urea nitrogen, renal lipid peroxidation along with significant decrement(P<0.001) in urine output,renal enzymatic and non-enzymatic antioxidants.SXE 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement(up to P<0.001) in plasma and mine urea and creatinine, renal lipid peroxidation along with significanl increment(up to P<0.001) in renal enzymatic and non-enzvmatic antioxidants.Histological obsenatioiis of kidney tissues too correlated with the biochemical obsenatioiis.Conclusions:These finding powerfully supports that S,xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its elhnomedicinal use. | Talib Hussain Ramesh K Gupta K Sweety Bavani Eswaran M Vijayakumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 1 |
| 12 | Recovery of large preantral follicles from buffalo ovary: 15 effect of season and corpus luteum显示文摘 | GUPTA P S P RAMESH H S NANDI S | 2007 | Anim Reprod Sci2007，101，： | 1 |
| 13 | Efficacy of picroliv in combination with miltefosine,an orally effective antileishmanial drug against experimental visceral leishmaniasis显示文摘 | Ramesh SC Srivastava VM | 2005 | Acta Trop2005，94，1： | 1 |
| 14 | A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes: The INFINITY Study显示文摘 | Mina Madan Tasnim Vira Emmanouil Rampakakis Anup Gupta Anil Khithani Lyn Balleza Julie Vaillancourt Stella Boukas John Sampalis Emidio de Carolis Ramesh Vemulapalli | 2012 | Advances in Preventive Medicine2012，，： | 1 |
| 15 | Accounting Based Valuation Models and Security Prices in India:An Empirical Assessment 显示文摘 | Ramesh Gupta IIM Ahmedabad | 2007 | The Business Review2007，，10： | 1 |
| 16 | Molecular markers and their applications in wheat breeding 显示文摘 | Varshney Sharma P C Ramesh B | 1999 | Plant Breeding1999，118，： | 1 |
| 17 | Sequence characterization and polymerase chain reaction–restriction fragment length polymorphism of the mitochondrial DNA 12S rRNA gene provides a method for species identification of Indian deer显示文摘 | Amit R. Gupta Ramesh C. Patra Dhanjit K. Das Praveen K. Gupta Devendra Swarup Mohini Saini | 2008 | Mitochondrial DNA2008，，4： | 1 |
| 18 | Polyethylenimine nanoparticles as efficient transfecting agents for mammalian cells显示文摘 | Surendra Nimesh Anita Goyal Vikas Pawar Sujatha Jayaraman Pradeep Kumar Ramesh Chandra Yogendra Singh Kailash C. Gupta | 2005 | Journal of Controlled Release2005，，2： | 1 |
| 19 | Use of Leishmania donovani field isolates expressing the luciferase reporter gene in in vitro drug screening显示文摘 | Ashutosh Gupta S Ramesh | 2005 | Antimicrob Agents Chemother2005，49，9： | 1 |
| 20 | flow in vacuum enhanced resin Fiber optic sensors for monitoring infusion technology (VERITy) process 显示文摘 | Nitesh Gupta Ramesh Sundaram | 2009 | Composites part A2009，40，8： | 1 |
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