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| 1 | Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common and fatal cancer in the world. HCC frequently presents with advanced disease, has a high recurrence rate and limited treatment options, which leads to very poor prognosis. This warrants urgent improvement in the diagnosis and treatment. Liver biopsy plays very important role in the diagnosis and prognosis of HCC, but with technical advancements and progression in the field of imaging, clinical guidelines have restricted the role of biopsy to very limited situations. Biopsy also has its own problems of needle tract seeding of tumor, small risk of complications, technical and sampling errors along with interpretative errors. Despite this, tissue analysis is often required because imaging is not always specific, limited expertise and lack of advanced imaging in many centers and limitations of imaging in the diagnosis of small, mixed and other variant forms of HCC. In addition, biopsy confirmation is often required for clinical trials of new drugs and targeted therapies. Tissue biomarkers along with certain morphological features, phenotypes and immune-phenotypes that serve as important prognostic and outcome predictors and as decisive factors for therapy decisions, add to the continuing role of histopathology. Advancements in cancer biology and development of molecular classification of HCC with clinic pathological correlation, lead to discovery of HCC phenotypic surrogates of prognostic and therapeutically significant molecular signatures. Thus tissue characteristics and morphology based correlates of molecular subtypes provide invaluable information for management and prognosis. This review thus focuses on the importance of histopathology and resurgence of role of biopsy in the diagnosis, management and prognostication of HCC. | Archana Rastogi | 2018 | World Journal of Gastroenterology2018，24，35： | 17 |
| 2 | The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on real-time endoscopic assessment of the histology of diminutive colorectal polyps显示文摘 | Douglas K. Rex Charles Kahi Michael O’Brien T.R. Levin Heiko Pohl Amit Rastogi Larry Burgart Tom Imperiale Uri Ladabaum Jonathan Cohen David A. Lieberman | 2011 | Gastrointestinal Endoscopy2011，，3： | 7 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke显示文摘Nicotinamide adenine dinucleotide phosphate oxidase(NOX) is a multisubunit enzyme complex that utilizes nicotinamide adenine dinucleotide phosphate to produce superoxide anions and other reactive oxygen species. Under normal circumstances, reactive oxygen species mediate a number of important cellular functions, including the facilitation of adaptive immunity. In pathogenic circumstances, however,excess reactive oxygen species generated by NOX promotes apoptotic cell death. In ischemic stroke, in particular, it has been shown that both NOX activation and derangements in glucose metabolism result in increased apoptosis. Moreover, recent studies have established that glucose, as a NOX substrate, plays a vital role in the pathogenesis of reperfusion injury. Thus, NOX inhibition has the potential to mitigate the deleterious impact of hyperglycemia on stroke. In this paper, we provide an overview of this research,coupled with a discussion of its implications for the development of NOX inhibition as a strategy for the treatment of ischemic stroke. Both inhibition using apocynin, as well as the prospect of developing more specific inhibitors based on what is now understood of the biology of NOX assembly and activation, will be highlighted in the course of our discussion. | Jiamei Shen Radhika Rastogi Xiaokun Geng Yuchuan Ding | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 5 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 6 | Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells显示文摘Rheumatic heart disease(RHD)is a major cause of cardiovascular morbidity and mortality in developing nations like India.RHD commonly affects the mitral valve which is lined by a single layer of endothelial cells(ECs).The role of ECs in mitral valve damage during RHD is not well elucidated.In here,anti-endothelial cell antibody from RHD patients has been used to stimulate the ECs(HUVECs and HMVECs).ECs proinflammatory phenotype with increased expression of TNFa,IL-6,IL-8,IFNg,IL-1b,ICAM1,VCAM1,E-selectin,laminin B,and vimentin was documented in both ECs.The promoter hypomethylation of various key inflammatory cytokines(TNFa,IL-6,and IL-8),integrin(ICAM1)associated with leukocyte transendothelial migration,and extracellular matrix genes(vimentin,and laminin)were also observed.Further,the in-vitro data was in accordance with ex-vivo observations which correlated significantly with the etiological factors such as smoking,socioeconomic status,and housing.Thus,the study sheds light on the role of ECs in RHD which is a step forward in the elucidation of disease pathogenesis. | Mukul Rastogi Subendu Sarkar Ankita Makol Rana Sandip Singh Uma Nahar Saikia Dibyajyoti Banerjee Seema Chopra Anuradha Chakraborti | 2018 | Genes & Diseases2018，5，3： | 5 |
| 7 | Role of locking plates in treatment of difficult ununited fractures: a clinical study显示文摘我们在长骨头与锁在长骨头破裂的 10 困难的 nonunions 锁板固定的 plateMethodsRetrospective 评估折断的困难的 ununited 的处理的经验被做的在场的 ObjectiveTo。固定为大腿骨的柄骨折( 3 个病人)用完了锁住的板腿节的 supracondylar 骨折(差距不属于工会)两根前臂骨头(半径和尺骨)的锁骨骨折的骨折胫骨的骨干的肱骨骨折的柄的尺骨骨折的骨折和肱骨的 supracondylar 骨折(一耐心的各个)。五破裂有超过一以前的没有通过的内部固定。一个病人感染了不属于工会它被清创术管理,演员组固定与在六个星期锁板由固定列在后面。七破裂是衰退的二是寡营养的,一个人是 hypertrophic。腓骨的自体移植在 2 种情况和在所有 patientsResultsMinimum 后续使用的肠骨的冠 cancellous 骨头接枝中被使用是 6 月(范围, 6 月到 2.5 年) 。联合的平均时间是 3.4 月(范围 2.5 ~ 6 月) 。任何一个都没与与锁压缩板,过细的软织物解剖,可接受的减小,好固定技术和骨头 grafting 完成稳定性病人让板相关的复杂并发症或手术后的创伤 infections.ConclusionAlong 能帮助在困难的不属于工会的盒子中完成联合。尽管锁住的板不由自己做,保证多骨的联合,我们发现了它是我们为对待困难的破裂 nonunions 的一套设备的另一有用增加。 | Ashok Kumar Himanshu Gupta Chandra Shekhar Yadav Shah Alam Khan Shishir Rastogi | 2013 | Chinese Journal of Traumatology2013，16，1： | 5 |
| 8 | 脂肪族聚酯-酰胺的研究进展显示文摘脂肪族聚酯-酰胺(polyester_amides)综合了聚酯和聚酰胺的优点,如具有优良的物理力学性能和加工性能等等。因此,对脂肪族聚酯-酰胺的研究成为近年来的研究热点。本文从脂肪族聚酯-酰胺的模型化合物(以双酰胺-二醇单体为例)的研究进展入手,分析了模型化合物的结构特点,以及模型化合物与相应聚合物之间的联系,从而为进一步研究聚合物打下一定的基础。本文还综述了脂肪族聚酯-酰胺的分类,各类脂肪族聚酯-酰胺的合成方法,以及脂肪族聚酯-酰胺在可生物降解材料和热塑性弹性体等领域的应用。 | 崔宁 RASTOGI Sanjay | 2006 | 高分子通报2006，，11： | 4 |
| 9 | The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: a meta-analysis显示文摘 | M. Madhoun S. Wani A. Rastogi D. Early S. Gaddam W. Tierney J. Maple | 2013 | Endoscopy2013，，02： | 4 |
| 10 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 11 | Clinical practice of early extubation after liver transplantation显示文摘BACKGROUND: Anesthetic practices such as early tracheal extubation facilitate postoperative recovery. Early extubation after liver transplantation has been adopted by some centers in the recent two decades. No universal clinical guidelines are used and questions remain. This review aimed to address the current status of early extubation after liver transplantation. DATA SOURCES: A literature search of MEDLINE and ISI Web of Knowledge databases was performed using terms such as liver transplantation, early extubation, immediate tracheal extubation fast tracking or fast track anesthesia and postoperative tracheal extubation. Additional papers were identified by a manual search of the references in the key articles. RESULTS: Review of the available literature provided an insight into the definition, evolution, advantages and risks of early extubation, and anesthetic techniques that prompt early extubation in liver transplant patients. Early extubation has proved to be feasible and safe in these patients, but the outcomes are still uncertain. CONCLUSIONS: Early extubation after liver transplantation is feasible, safe and cost-effective in the majority of patients and has been increasingly accepted as an option for conventional postoperative ventilation. Comprehensive and individualized evaluation of the patient's condition before extubation by an experienced anesthesiologist is the cornerstone of success Understanding of its effect on the outcome remains incomplete In the future, additional trials are required to establish universal early extubation guidelines and to determine its benefits for patients and practitioners. | Vaibhav Rastogi | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 3 |
| 12 | Determination of flavonoids,polyphenols and antioxidant activity of Tephrosia purpurea:a seasonal study显示文摘OBJECTIVE:Tephrosia purpurea(Linn.) Pers.is widely used in traditional medicine to treat liver disorders,febrile attacks,enlargement and obstruction of liver,spleen,and kidney.In the present study,investigations were carried out to determine the seasonal impact on the content of flavonoid glycosides and on antioxidant activities so as to identify the optimal time of harvesting.METHODS:The plant materials were collected in different seasons during 2013-2014.Air-dried,powdered plant materials were extracted with 95%ethanol and ethanokwater(1:1) by ultrasound-assisted extraction process.Their chemical composition in terms of total polyphenol and flavonoid contents(TPCs and TFCs) was determined using modified colorimetric Folin-Ciocalteu method and aluminum chloride colorimetric assay respectively.To determine the in vitro antioxidant activity,diphenyl-picryl hydrazyl(DPPH) radical-scavenging assay and total antioxidant capacity by phosphomolybdate antioxidant assay were carried out.High-performance liquid chromatography(HPLC)/photo-diode array(PDA) analysis was used to quantify the flavonoid glycosides in the samples collected in different seasons.Correlation studies were also carried out between antioxidant activities and TPCs.RESULTS:The highest TPC and TFC were found to be in the 95%ethanolic extract of the August sample and the lowest in the 50%hydro-alcoholic extract of the plant sample collected in winter season.It was observed that in both the assays used to determine the antioxidant activity,the 95%ethanolic extracts in all the seasons showed a higher activity than their respective 50%hydroalcoholic extracts with an increase in activity as we go from cold to hot to rainy seasons.Based on correlation analysis,DPPH radical-scavenging activities as well as the spectrophotometrically measured phosphomolybdenum complex were also strongly correlated with TPC of the extracts.The most abundant flavonoid glycoside was quercetin-3-O-rhamnoglucoside in all the seasons.The content of all flavonoids was observed highest in the 95%ethanolic extract of the plant collected in August(TP-3).The 50%hydro-alcoholic extract of the plant collected in December(TP-6) showed the lowest amount of flavonoids and antioxidant activity.CONCLUSION:The findings of this study confirmed that the metabolism and production of flavonoids in T.purpurea are vigorously affected by seasonal factors.Significant differences were observed in the TPC,TFC and flavonoid glycoside composition in the 95%ethanolic as well as 50%hydro-alcoholic extracts of T.purpurea collected in different seasons.Since the 95%ethanolic extract of the August sample(TP-3),which also happens to be its flowering season,exhibited the highest TPC.TFC and antioxidant activities in both DPPH and phosphomolybdate assays as well as contained the highest content of all flavonoids,it could be recommended as the optimal season of harvesting T.purpurea with respect to its pharmaceutically important constituents,i.e.,flavonoids. | Madan Mohan Pandey Sayyada Khatoon Subha Rastogi Ajay Kumar Singh Rawat | 2016 | Journal of Integrative Medicine2016，14，6： | 3 |
| 13 | Bipolar radiofrequency ablation of tibialchondroblastomas: A report of three cases显示文摘Chondroblastoma is a rare benign cartilaginous neoplasm of bone. The recurrence rate is high and complications are frequent following open curettage with bone grafting which is the standard treatment forchondroblastomas. We performed radiofrequency ablation in three cases of tibialchondroblastoma using the bipolar system. One patient experienced residual pain for which repeat ablation was performed. No other complications were observed during follow-up. Radiofrequency ablation may offer an effective alternative for the treatment of selected cases of chondroblastoma. The lesion characteristics which are likely to influence treatment outcome and the advantages offered by the bipolar system are discussed. | Prathiba Rajalakshmi Deep N Srivastava Shivanand Gamanagatti Pramod Kumar Julka Sushma Bhatnagar Shishir Rastogi | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 14 | Recent advances in production,purification and applications of phycobiliproteins显示文摘An obligatory sunlight requirement for photosynthesis has exposed cyanobacteria to different quantity and quality of light. Cyanobacteria can exhibit efficient photosynthesis over broad region(450 to 650 nm) of solar spectrum with the help of brilliantly coloured pigment proteins called phycobiliproteins(PBPs). Besides light-harvesting, PBPs are found to involve in several life sustaining phenomena including photoprotection in cyanobacteria. The unique spectral features(like strong absorbance and fluorescence), proteineous nature and, some imperative properties like hepato-protective, antioxidants, anti-inflammatory and anti-aging activity of PBPs enable their use in food, cosmetics, pharmaceutical and biomedical industries. PBPs have been also noted to show beneficial effect in therapeutics of some disease like Alzheimer and cancer. Such large range of applications increases the demand of PBPs in commodity market. Therefore, the large-scale and coast effective production of PBPs is the real need of time. To fulfil this need, many researchers have been working to find the potential producer of PBPs for the production and purification of PBPs. Results of these efforts have caused the inventions of some novel techniques like mixotrophic and heterotrophic strategies for production and aqueous two phase separation for purification purpose. Overall, the present review summarises the recent findings and identifies gaps in the field of production, purification and applications of this biological and economically important proteins. | Ravi Raghav Sonani Rajesh Prasad Rastogi Rutvij Patel Datta Madamwar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 15 | Evaluation of functional outcome and stability of sutureless scleral tunnel fixated IOLs in children with ectopia lentis显示文摘AIM:To evaluate functional outcome of sutureless scleral tunnel intraocular lens(SSTIOL)in children with crystalline lens subluxation of more than 7 clock hours.METHODS:A prospective interventional study was conducted consisting of 45 eyes of 44 children in age group 6-18 y having>7 clock hours of lens subluxation who underwent lensectomy-vitrectomy followed by SSTIOL implantation.Primary outcome was improvement in best corrected visual acuity(BCVA)and secondary outcomes were assessment of intraocular lens(IOL)tilt using ultrasound biomicroscopy(UBM),mean change in astigmatism at last follow-up of 1 y and associated complications.RESULTS:The mean preoperative and postoperative BCVA was 1.05±0.28 and 0.64±0.45(log MAR)respectively(P=0.001)at last follow-up.The mean astigmatism preoperatively and postoperatively was-4.17±2.69 D and-1.86±1.25 D respectively(P=0.011).Significant IOL tilt(>5 degrees)was present in 5 cases.The mean percentage endothelial loss was 3.65%±1.92%.The most serious complication encountered was retinal detachment seen in 2 cases.CONCLUSION:SSTIOL implantation provides efficient visual rehabilitation in children provided there is stringent case selection.We recommend caution in children having white-to-white distance>12 mm and presence of peripheral retinal degenerations. | Anju Rastogi Prateek Kumar Shweta Dhiman Manisha Mishra Kamlesh AnAND Ankita Bhardwaj | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 16 | 基于胱抑素C和肌酐估算的肾小球滤过率差异及衰弱和不良结局的相关性显示文摘在之前的研究和实践中,尚未对基于胱抑素C水平估算的肾小球滤过率(estimated glomerular filtration rate,eGFR,eGFR胱抑素)和基于肌酐水平估算的eGFR(eGFR肌酐)之间差异的临床重要性和相关性进行评估。研究者旨在评估这些差异是否包含衰弱的重要信息。研究设计:一项收缩压干预试验(the systolic blood pressure intervention trial,SPRINT)的队列分析。设置与参与者:SPRINT(9 092例)高血压参与者在基线时检测血清肌酐、胱抑素C和衰弱水平。 | 袁源(摘译) 练桂丽(审校) Potok OA Ix JH Shlipak MG Katz R Hawfield AT Rocco MV Ambrosius WT Cho ME Pajewski NM Rastogi A Rifkin DE | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 17 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
| 18 | 强化与标准降压治疗对脑卒中亚型的影响显示文摘在收缩压干预试验(systolic blood pressure intervention trial, SPRINT)中,各治疗组的脑卒中发生比例差异无统计学意义,但脑卒中亚型的病因不同,可能对强化降压治疗的反应不同。SPRINT纳入患者(n=9 361)随机分为目标收缩压<120 mm Hg(1 mm Hg=0.133 kPa)的强化治疗与目标收缩压<140 mm Hg的标准治疗组。 | Wright CB Auchus AP Lerner A Ambrosius WT Ay H Bates JT Chen J Meschia JF Pancholi S Papademetriou V Rastogi A Sweeney M Willard JJ Yee J Oparil S 赵狄(摘译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，3： | 2 |
| 19 | Adequacy of esophageal squamous mucosa specimens obtained during endoscopy: are standard biopsies sufficient for postablation surveillance in Barrett’s esophagus?显示文摘 | Neil Gupta Sharad C. Mathur John A. Dumot Vikas Singh Srinivas Gaddam Sachin B. Wani Ajay Bansal Amit Rastogi John R. Goldblum Prateek Sharma | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 20 | Epidemiology of patients admitted to a major trauma centre in northern India显示文摘在印度的 ObjectiveTrauma 是一个逐渐地重要的问题,特别地考虑到快速的开发和增加的动力化。社会变化在损伤的传染病学正在导致改变。学习的目的是估计在同意到一个主要损伤中心进入随机的分类选择的 748 个病人的北 India.MethodsAn 观察学习的病人影响损害的原因的各种各样的流行病学的参数在 1 年(到 2009 年 7 月的 2008 年 8 月) 的一个时期上被执行。年龄,性别,损害类型和模式被注意。上面、更低的手足的损害模式也是 noted.ResultsInjuries 在 15-30 年的年龄组主要发生。男性们与男性一起招致了更多的损害到 6:1 的女比率。最脆弱的组是摩托车用户。在之中伤害,农民们是通常包含的大多数。钝损害(94.92%) 比渗透损害是更普通的。在有头损害的病人之中,二 wheelers 联系了事故最普通(40.3%) 。最针的绳索损害从高度(51.09%) 到下降被引起。大多数更低的手足破裂是简单类型。更低的手足的复合破裂比交通规则的上面的手足 fractures.ConclusionStrict 实施更普通,与改进基础结构和行为变化结合了能减少在印度和另外的发展中的国家的道路交通事故的负担。这研究能在作为需要被称为死亡和病态的一个可防止的原因的一个公共健康问题提起道路交通事故的侧面帮助,并且为这主要挑战计划适当干预。预防策略应该根据这些流行病学的趋势被做。 | Devarshi Rastogi Sanjay Meena Vineet Sharma Girish Kumar Singh | 2014 | Chinese Journal of Traumatology2014，17，2： | 2 |
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