|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury显示文摘Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties.We hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve injury.In this study,rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1,7,and 14 days after cavernous nerve injury.Serum superoxide dismutase and glutathione peroxidase activities significantly increased at 1 and 2 weeks post-injury.Serum malondialdehyde levels decreased at 2 and 4 weeks.At 12 weeks,peak intracavernous pressure,the number of myelinated axons and nicotinamide adenine dinucleotide phosphate-diaphorase-positive nerve fibers,levels of phospho-endothelial nitric oxide synthase protein and 3-nitrotyrosine were higher in rats administered at 1 day post-injury compared with rats administered at 7 and 14 days post-injury.These findings suggest that application of Lycium barbarum polysaccharides following cavernous nerve crush injury effectively promotes nerve regeneration and erectile functional recovery.This neuroregenerative effect was most effective in rats orally administered Lycium barbarum polysaccharides at 1 day after cavernous nerve crush injury. | Zhan-kui Zhao Hong-lian Yu Bo Liu Hui Wang Qiong Luo Xie-gang Ding | 2016 | Neural Regeneration Research2016，11，8： | 25 |
| 2 | Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy显示文摘骨头癌症疼痛(BCP ) 是在有恶意的癌症的病人的最普通的疼痛之一。位于 BCP 下面的机制大部分是未知的。我们的以前的研究和增加的证据两个都显示出那个酸察觉到的离子隧道(ASIC3 ) 3 是处于在一些疼痛模型的病理学的疼痛状态的重要蛋白质。我们假设了 ASIC3 的表示变化可能是与 BCP 有关的因素之一。在这研究,我们通过 intrathecally 把老鼠乳腺癌房间(MRMT-1 ) 注入 Sprague-Dawley 雌老鼠的左胫骨建立了 BCP 模型,并且发现 BCP 老鼠在 L4-L6 背面的根中心显示出骨头破坏,增加的机械疼痛敏感和起来调整的 ASIC3 蛋白质表示层次。然后, resveratrol, intraperitoneally 在手术后的白天 21 上被注入 BCP 老鼠, dose-dependently 增加了 BCP 老鼠的爪退却阀值,颠倒了疼痛行为,并且有 BCP 老鼠上的 antinociceptive 效果。在 ASIC3-transfected SH-SY5Y 房间, ASIC3 蛋白质表示层次被 resveratrol 在一个剂量依赖者和时间依赖者举止调整。同时, resveratrol 也在调停 ASIC3 的疼痛老鼠模型有 antinociceptive 效果。而且, resveratrol 也在 ASIC3-transfected SH-SY5Y 房间提高了 AMPK, SIRT1,和 LC3-II 层次的 phosphorylation,显示 resveratrol 能激活在 ASIC3-transfected SH-SY5Y 房间的 AMPK-SIRT1-autophagy 信号小径。在 BCP 老鼠, SIRT1 和 LC3-II 也是下面调整的。这些调查结果在 BCP 状态期间作为一个治疗学的处理为 resveratrol 的使用提供新证据(?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Haili Zhu Jieqiong Ding Ji Wu Tingting Liu Jing Liang Qiong Tang Ming Jiao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 12 |
| 3 | Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling显示文摘Bone cancer pain(BCP)is induced by primary bone cancer and secondary bone metastasis.During BCP pathogenesis,activated spinal astrocytes release proinflammatory cytokines,which participate in pain information transmission.In this study,we found that BCP rats showed disruption of trabecular bone structure,mechanical allodynia,and spinal inflammation.Moreover,reduced adenosine monophosphate-activated protein kinase(AMPK)activity,increased mitochondrial fission-associated protein Drp1 GTPase activity accompanied by the dysfunction of mitochondrial function,and abnormal BAX and Bcl-2 expression were found in the spinal cord of BCP rats.Notably,these alterations are reversed by resveratrol(Res)administration.Cell experiment results demonstrated that Res promotes mitochondrial function by activating AMPK,decreasing Drp1 activity,and inhibiting tumor necrosis factor-cα-induced mitochondrial membrane potential reduction.Taken together,these results indicate that Res suppresses BCP in rats by attenuation of the inflammatory responses through the AMPK/Drp1 signaling pathway. | Miaomiao Hao Qiong Tang Banghua Wang Yisheng Li Jieqiong Ding Mingyue Li Min Xie Haili Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 8 |
| 4 | Compact plant type rice has higher lodging and N resistance under machine transplanting显示文摘To identify the major factors that contribute to the difference in lodging among different rice varieties under machine transplanting and their responses to nitrogen(N),field experiments were conducted at Danyang County(a representative eco-site of the Lower Yangtze River)in Jiangsu Province,China in 2017 and 2018,22 hybrid indica varieties(HIs),22 inbred japonica varieties(IJs)and two indica japonica hybrid varieties(IJHs)were transplanted by machine with three N rates(N0,N150 and N300,0,150 and 300 kg ha–1,respectively).Lodging-related physical parameters,morphological characteristics and apparent transport rates of dry matter were examined.Significant difference in yield was observed among different types of rice,and followed by IJs | DING Chao LUO Xi-kun WU Qiong LU Bo DING Yan-feng WANG Shao-hua LI Gang-hua | 2021 | Journal of Integrative Agriculture2021，20，1： | 7 |
| 5 | Characterization of mechanochemical treated fly ash from a medical waste incinerator显示文摘The mechanochemical treatment of fly ash generated from a medical waste incinerator was subjected to grinding for 2 hr at 400 r/min in a planetary ball mill.The treated fly ash was characterized by a suite of analytical methods including High Resolution Gas Chromatograph/High Resolution Mass Spectrometer,Mastersizer 2000 Particle Size Analyzer,QUADRASORBTM SI Surface Area Analyzer,Scanning Electron Microscopy and X-ray diffraction.Results showed that abatement effciency of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDDs/Fs) in terms of total concentration averagely amount to 76%which was relatively higher than that of I-TEQ concentration averagely amount to 56%;the most concentration of toxic congeners as well as isomers of PCDDs/Fs decreased after mechanochemical treatment.The treated fly ash was characterized by a more homogeneous distribution of concaves as well as the significant decreasing in overall particle size and great enlargement in surface area.The major crystallization phases or intensities were considerably changed by mechanochemical treatment,of which a new phase containing chlorine formed may be a possible factor suggesting chlorination reaction occurring on the crystalline surface. | Zheng Peng Qiong Ding Yangzhao Sun Chen Jiang Xinhua Gao Jianhua Yan | 2010 | Journal of Environmental Sciences2010，22，10： | 7 |
| 6 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 7 | The Herpes Simplex Virus Type 1 Multiple Function Protein ICP27显示文摘The herpes simplex virus type 1 (HSV-1) infected-cell protein 27 (ICP27) is an essential,highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. Recently,many novel functions performed by the HSV-1 ICP27 protein were shown,including leptomycin B resistance,inhibition of the type Ⅰ interferon signaling,regulation of the viral mRNA translation and determining the composition of HSV-1 virions. | Lei ZHAO Wen-bo ZHU Qiong DING Gui-qing PENG Chun-fu ZHENG | 2008 | Virologica Sinica2008，23，6： | 6 |
| 8 | Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation显示文摘Mitochondrial dysfunction is considered to be one of the important pathogenesis in Parkinson’s disease (PD). We previously showed that pyrroloquinoline quinone (PQQ) could protect SH-SY5Y cells and dopaminergic neurons from cytotoxicity and prevent mitochondrial dysfunction in rotenone-induced PD models. In the present study we investigated the mechanisms underlying the protective effects of PQQ in a mouse PD model, which was established by intraperitoneal injection of rotenone (3 mg·kg^(−1)·d^(−1), ip) for 3 weeks. Meanwhile the mice were treated with PQQ (0.8, 4, 20 mg·kg^(−1)·d^(−1), ip) right after rotenone injection for 3 weeks. We showed that PQQ treatment dose-dependently alleviated the locomotor deficits and nigral dopaminergic neuron loss in PD mice. Furthermore, PQQ treatment significantly diminished the reduction of mitochondria number and their pathological change in the midbrain. PQQ dose-dependently blocked rotenone-caused reduction in the expression of PGC-1α and TFAM, two key activators of mitochondrial gene transcription, in the midbrain. In rotenone-injured human neuroblastoma SH-SY5Y cells, PTMScan Direct analysis revealed that treatment with PQQ (100 μM) differentially regulated protein phosphorylation;the differentially expressed phosphorylated proteins included the signaling pathways related with adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) pathway. We conducted Western blot analysis and confirmed that AMPK was activated by PQQ both in PD mice and in rotenone-injured SH-SY5Y cells. Pretreatment with AMPK inhibitor dorsomorphin (4 μM) significantly attenuated the protective effect and mitochondrial biogenesis by PQQ treatment in rotenone-injured SH-SY5Y cells. Taken together, PQQ promotes mitochondrial biogenesis in rotenone-injured mice and SH-SY5Y cells via activation of AMPK signaling pathway. | Qiong Cheng Juan Chen Hui Guo Jin-li Lu Jing Zhou Xin-yu Guo Yue Shi Yu Zhang Shu Yu Qi Zhang Fei Ding | 2021 | Acta Pharmacologica Sinica2021，42，5： | 6 |
| 9 | The Role of OsMSH5 in Crossover Formation during Rice Meiosis显示文摘MSH5,傻瓜相当或相同的事物家庭的一个成熟分裂特定的成员,在开始发育的酵母,老鼠, Caenorhabditis elegans,和 Arabidopsis 为再结合的正常水平被要求。这里,我们报导它的米饭相当或相同的事物的鉴定和描述, OsMSH5,并且在米饭表明它的功能成熟分裂。五独立 Osmsh5 异种展出了正常植物的生长和严重绝育。当交叉频率极大地被归结为观察了在那中的约 10% 个时, synaptonemal 建筑群很好在 Osmsh5 被安装野类型,导致相应不分离和完全的无菌的显型。OsMSH5 主要在圆锥花序被表示。Immunofluorescence 研究显示 OsMSH5 chromosomal 本地化限于早 meiotic 前期我。OsMSH5 能在 Oszip4, Osmer3,和 hei10 被装载到 meiotic 染色体上。然而,那些 ZMM 蛋白质不能当 OsMSH5 不在时通常是局部性的。而且,剩余 chiasmata 被显示在 zmm 异种之中最不经常,包括 Osmer3, Oszip4, hei10,和 Osmsh5。一起拿,我们建议 OsMSH5 工作在一级转线路的 OsZIP4, OsMER3,和 HEI10 在上游形成。 | Qiong Luo Ding Tang MO Wang Weixiong Luo Lei Zhang Baoxiang Qin Yi Shen Kejian Wang Yafei Li Zhukuan Cheng | 2013 | Molecular Plant2013，6，3： | 5 |
| 10 | The Achyranthes bidentata polypeptide k fraction enhances neuronal growth in vitro and promotes peripheral nerve regeneration after crush injury in vivo显示文摘We have previously shown that Achyranthes bidentata polypeptides(ABPP), isolated from Achyranthes bidentata Blume(a medicinal herb), exhibit neurotrophic and neuroprotective effects on the nervous system. To identify the major active component of ABPP, and thus optimize the use of ABPP, we used reverse-phase high performance liquid chromatography to separate ABPP. We obtained 12 fractions, among which the fraction of ABPPk demonstrated the strongest neuroactivity. Immunocytochemistry and western blot analysis showed that ABPPk promoted neurite growth in cultured dorsal root ganglion explant and dorsal root ganglion neurons, which might be associated with activation of Erk1/2. A combination of behavioral tests, electrophysiological assessment, and histomorphometric analysis indicated that ABPPk enhanced nerve regeneration and function restoration in a mouse model of crushed sciatic nerve. All the results suggest that ABPPk, as the key component of ABPP, can be used for peripheral nerve repair to yield better outcomes than ABPP. | Qiong Cheng Chunyi Jiang Caiping Wang Shu Yu Qi Zhang Xiaosong Gu Fei Ding | 2014 | Neural Regeneration Research2014，9，24： | 5 |
| 11 | Mitochondrial localization of ORF346 causes pollen abortion in alloplasmic male sterility显示文摘The Nsa cytoplasmic male sterility(CMS) system confers stable male sterility and offers great potential for production of hybrid seeds in oilseed rape. However, genes responsible for male sterility in Nsa CMS have not been identified. By mitochondrial genome sequencing of Nsa CMS and its maintainer line,we identified in an Nsa CMS line several chimeric genes encoding hypothetical proteins harboring transmembrane domains. One novel chimeric gene orf346 showed high identity with cox1 at the 50 terminal region and was co-transcribed with nad3 and rps12 genes. Transgenic plants of orf346 fused with or without mitochondrial targeting peptide conferred complete male sterility in Arabidopsis. ORF346 was mitochondrion-localized. Expression of orf346 in Escherichia coli inhibited bacterial growth, with excessive accumulation of reactive oxygen species and decreased ATP content. These results reveal a link between the newly identified mitochondrial gene orf346 and the abortion of Nsa CMS. Inadequate energy supply and excessive accumulation of reactive oxygen species may account for pollen abortion in Nsa CMS plants. | Shifei Sang Hongtao Cheng Mengyu Hao Bingli Ding Desheng Mei Hui Wang Wenxiang Wang Jia Liu Li Fu Kede Liu Qiong Hu | 2021 | The Crop Journal2021，9，6： | 5 |
| 12 | Selective oxidation of biomass derived 5-hydroxymethylfurfural to 2,5-diformylfuran using sodium nitrite显示文摘A mild and simple process for the effective oxidation of 5-hydroxymethylfurfural(HMF) into 2,5-diformylfuran(DFF) has been developed using Na NO_2 as the oxidant. Some important reaction parameters were investigated to optimize the oxidation of HMF into DFF. It was found that the reaction solvent was very crucial for this reaction. Trifluoroacetic acid was the best solvent for the oxidation of HMF into DFF by Na NO_2.Under the optimal reaction condition, almost quantitative HMF conversion and high DFF yield of 90.4% were obtained after 1 h at room temperature. | Xianxiang Liu Hui Ding Qiong Xu Wenzhou Zhong Dulin Yin Shengpei Su | 2016 | Journal of Energy Chemistry2016，25，1： | 4 |
| 13 | Catalysis-based specific detection and inhibition of tyrosinase and their application显示文摘Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome,and plays a key role in the pigmentation of hair and skin.The abnormal expression or activation of tyrosinase is associated with several diseases such as albinism,vitiligo,melanoma and Parkinson disease.Excessive deposition of melanin could cause diseases such as freckles and brown spots in the human body,and it is also closely related to browning of fruits and vegetables and insect molting.Detecting and inhibiting the activity of tyrosinase is of extraordinary value in the progress of diagnosis and treatment of these diseases.Therefore,many selective optical detection probes and small molecular inhibitors have been developed,and have made significant contributions to the basic and clinical research on these diseases.In this paper,the detection and inhibition of tyrosinase and their application in whitening products are reviewed,with special emphasis on development of fluorescent probes and inhibitors.Hopefully,this review will help design more efficient and sensitive tyrosinase probes and inhibitors,as well as shed light on novel treatment of diseases such as melanoma. | Yunwei Qu Qing Zhan Shubo Du Yang Ding Bin Fang Wei Du Qiong Wu Haidong Yu Lin Li Wei Huang | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 2 |
| 14 | Clinical features of dementia with lewy bodies in 35 Chinese patients显示文摘Objective:To investigate the clinical features of dementia with Lewy bodies(DLB)in a Chinese population.Methods:Computer-based online searches through China Biology Medicine disc and China National Knowledge Infrastructure were performed to collect case reports of DLB published between 1980 and 2012.Clinical characteristics were analyzed.Results:A total of 18 studies comprising 35 patients(26 males and 9 females)were included.The mean age at onset was 67.2±9.8 years.Onset was characterized by memory impairment and accounted for 58.8%of all cases,followed by parkinsonism(11.8%),visual hallucinations(8.8%),and compulsive personality disorder(2.9%).The other patients(17.6%)presented two of the three core features of DLB at onset.With disease progression,parkinsonism was reported in 100%of cases,followed by visual hallucinations(97.1%),psychiatric symptoms(85.7%),severe neuroleptic sensitivity(81.8%),fluctuating cognition(68.6%),repeated falls(40.0%),sleep disorders(22.9%),and transient loss of consciousness(17.1%).26 patients who were subjected to Mini-Mental State Examination scored≤24.10 patients presented relative preservation of hippocampus and medial temporal lobe structures on CT/MRI scan.Occipital hypometabolism occurred in 2 of 3 patients who underwent SPECT/PET perfusion scan.12 patients showed an increasing of slow frequency activity on EEG,prominently in frontal and temporal lobes.Conclusions:DLB often strikes elderly individuals.Its clinical core features are dementia,fluctuating cognition,recurrent visual hallucinations and spontaneous features of parkinsonism.Neuropsychological,neuroimaging and EEG examinations may improve the diagnostic accuracy and discriminate DLB from other dementias. | Ding Han Qiong Wang Zhongbao Gao Tong Chen Zhenfu Wang | 2014 | Translational Neurodegeneration2014，3，1： | 2 |
| 15 | Two novel terpyridine-based chromophores with donor-acceptor structural model containing modified triphenylamine moiety: Synthesis, crystal structures and two-photon absorption properties显示文摘Two novel terpyridine-based chromophores with D-A (D = donor, A = acceptor) structural model containing modified triphenylamine moiety (L1 and L2 ) have been conveniently synthesized via formylation and reduction in satisfactory yields, and fully characterized. The single crystals of them were obtained and determined by X-ray diffraction analysis. The relationships between structure and photophysical properties of the two chromophores were investigated both experimentally and theoretically. The measured maximum TPA cross-sections per molecular weight (δmax /MW) of the chromophores are 0.63 GM/(g mol) (L1) and 0.72 GM/(g mol) (L2), respectively, in DMF as a high polar solvent. The results indicate that the value of δmax/MW could be well tuned by the intramolecular charge transfer (ICT), which could be realized by introducing additional elecron-donor/acceptor groups. | LIU Jie ZHANG Qiong DING HongJuan ZHANG Jun TAN JingYun WANG ChuanKui WU JieYing LI ShengLi ZHOU HongPing YANG JiaXiang TIAN YuPeng | 2013 | Science China Chemistry2013，56，9： | 2 |
| 16 | Highly aligned lithiophilic electrospun nanofiber membrane for the multiscale suppression of Li dendrite growth显示文摘Using inorganic fibrous membranes as protective layers has yielded success in suppressing dendrite growth.However,conventional fibrous membranes usually have large voids and low affinity for Li,promoting inhomogeneous charge distribution and allowing some dendrites to grow.Herein,we introduce a highly aligned TiO_(2)/SiO_(2)(A-TS)electrospun nanofiber membrane as a protective layer for the Li metal anode.The A-TS membrane is fabricated by a custom-made electrospinning system with an automatic fiber alignment collector that allows control of the fibers’orientation.At the scale of the individual fibers,their high binding energies with Li can attract more“dead”Li by reacting with the SiO_(2) component of the composite,avoiding uncontrollable deposition on the metal anode.At the membrane scale,these highly ordered structures achieve homogeneous contact and charge distribution on the Li metal surface,leaving no vulnerable areas to nucleate dendrite formation.Additionally,the excellent mechanical and thermal stability properties of the A-TS membrane prevent any potential puncturing by dendrites or thermal runaway in a battery.Hence,an A-TS@Li anode exhibits stable cycling performance when used in both Li-S and Li-NCM811 batteries,highlighting significant reference values for the future design and development of high-energy-density metal-based battery systems. | Jianan Wang Qianyue Ma Shiyi Sun Kai Yang Qiong Cai Emilia Olsson Xin Chen Ze Wang Amr MAbdelkader Yinshi Li Wei Yan Shujiang Ding Kai Xi | 2022 | eScience2022，2，6： | 2 |
| 17 | Laser light-scattering studies of pachyman显示文摘 | Qiong Ding Suhong Jiang Lina Zhang | 1998 | Carbohydrate Research1998，308，： | 1 |
| 18 | Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons显示文摘 | Xia Chen Qi Zhang Qiong Cheng Fei Ding | 2009 | Molecular and Cellular Biochemistry . 2009 (1-2)2009，，1： | 1 |
| 19 | Construction of covalent organic framework for catalysis: Pd/COF-LZU1 in Suzuki Miyaura coupling reaction显示文摘 | Ding Sanyuan Gao Jia Wang Qiong etal | 2011 | Journal of American Chemistry Society2011，133，19： | 1 |
| 20 | Rut-induced changes in the activity budgets of male tropical ungulates: Eld's deer on Hainan Island显示文摘 | Jianhua DING Zhitao LIU Yanling SONG Zhigao ZENG Qiong ZHANG Benjamin D.BRAVERY | 2012 | Current Zoology2012，58，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员