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| 1 | Multiple-Element Matching Reservoir Formation and Quantitative Prediction of Favorable Areas in Superimposed Basins显示文摘在韦斯特中国的附加的盆经历了多级式的构造事件和 multicycle 烃水库形成,并且复杂的烃水库在这种类型的盆广泛地被发现了。大多数复杂的烃水库被重定位,规模重建,部件变化和阶段国家转变描绘,并且他们的分布是很困难的预言。研究显示出那地区性的 caprock (C) ,高质量的沉积外形(存款, D ) , paleohighs (山, M ) 并且来源岩石(S) 是贡献复杂的烃水库形成和西方的附加的盆的分发的四个地质的元素。四个元素的纵的顺序的联合控制烃水库形成的阶层,并且平面重迭和联合控制烃水库的范围,他们在 geohistory 的同时的联合效果决定烃水库形成的时间。多重元素的匹配水库形成介绍水库形成的一个基本模式在里面附加的盆,和我们建议它被表示为 T-CDMS。基于多重元素的匹配水库形成模式,一个全面水库形成索引(Tcdms ) 在这篇论文被开发描绘水库形成条件,和一个方法被介绍在附加的盆预言水库形成范围和出现的概率。通过新理论,方法和技术的申请,在奥陶纪的出现的有利水库形成范围和概率在四个不同水库形成时期在 Tarim 盆指向地区被预言。结果证明中央 Tarim, Yinmaili 和 Lunnan 是奥陶纪油和煤气的地可能形成了的三个很有利的区域。有当前发现的烃水库的预言结果的巧合到达 97% 。这反映新理论,方法和技术的有效性和可靠性。 | WANG Huaijie PANG Xiongqi WANG Zhaoming YU Qiuhua HUO Zhipeng MENG Qingyang | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 8 |
| 2 | Arabidopsis calcium-dependent protein kinase CPK28 is potentially involved in the response to osmotic stress显示文摘As calcium sensors, plant calcium-dependent protein kinases(CDPKs) play important roles in plants' responses to various abiotic stresses. Here, we report the functional characterization of CPK28, a member of the CDPK family in Arabidopsis, in response to osmotic stress.The cpk28 mutant, a loss-of-function mutant, exhibited an NaCl- and mannitol-sensitive phenotype in green cotyledons, while CPK28-overexpressing plants displayed stronger tolerance to NaCl and mannitol stresses than wildtype plants. Reverse transcriptase-polymerase chain reaction and beta-glucuronidase staining assays showed that NaCl and mannitol stresses induced CPK28. CPK28-overexpressing lines accumulated significantly more proline relative to wild-type plants and mutant plants under NaCl and mannitol stresses. Transient expression of CPK28-GFP in mesophyll cell protoplasts, as well as stable transgenic lines expressing CPK28-GFP, showed that CPK28 was localized in the plasma membrane. Expression levels of known stress-responsive genes were not significantly altered in the null mutant and overexpression lines,suggesting that CPK28 possibly mediated the stress response via the regulation of target proteins rather than via regulation at the level of transcription. Meanwhile, CPK28could autophosphorylate. Taken together, these data demonstrated that CPK28, a potential positive regulator, is involved in the response to osmotic stress in Arabidopsis. | Anli Gao Qingyang Wu Yu Zhang Yuchen Miao Chunpeng Song | 2014 | Chinese Science Bulletin2014，59，11： | 5 |
| 3 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 4 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 5 | All-optical computing based on convolutional neural networks显示文摘The rapid development of information technology has fueled an ever-increasing demand for ultrafast and ultralow-en-ergy-consumption computing.Existing computing instruments are pre-dominantly electronic processors,which use elec-trons as information carriers and possess von Neumann architecture featured by physical separation of storage and pro-cessing.The scaling of computing speed is limited not only by data transfer between memory and processing units,but also by RC delay associated with integrated circuits.Moreover,excessive heating due to Ohmic losses is becoming a severe bottleneck for both speed and power consumption scaling.Using photons as information carriers is a promising alternative.Owing to the weak third-order optical nonlinearity of conventional materials,building integrated photonic com-puting chips under traditional von Neumann architecture has been a challenge.Here,we report a new all-optical comput-ing framework to realize ultrafast and ultralow-energy-consumption all-optical computing based on convolutional neural networks.The device is constructed from cascaded silicon Y-shaped waveguides with side-coupled silicon waveguide segments which we termed“weight modulators”to enable complete phase and amplitude control in each waveguide branch.The generic device concept can be used for equation solving,multifunctional logic operations as well as many other mathematical operations.Multiple computing functions including transcendental equation solvers,multifarious logic gate operators,and half-adders were experimentally demonstrated to validate the all-optical computing performances.The time-of-flight of light through the network structure corresponds to an ultrafast computing time of the order of several picoseconds with an ultralow energy consumption of dozens of femtojoules per bit.Our approach can be further expan-ded to fulfill other complex computing tasks based on non-von Neumann architectures and thus paves a new way for on-chip all-optical computing. | Kun Liao Ye Chen Zhongcheng Yu Xiaoyong Hu Xingyuan Wang Cuicui Lu Hongtao Lin Qingyang Du Juejun Hu Qihuang Gong | 2021 | Opto-Electronic Advances2021，4，11： | 3 |
| 6 | Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy显示文摘Cognitive impairment is the most common complication in patients with temporal lobe epilepsy with hippocampal scle rosis.There is no effective treatment for cognitive impairment.Medial septum cholinergic neurons have been reported to be a potential target for controlling epileptic seizures in tempo ral lobe epile psy.However,their role in the cognitive impairment of temporal lobe epilepsy remains unclear.In this study,we found that patients with temporal lobe epile psy with hippocampal sclerosis had a low memory quotient and severe impairment in verbal memory,but had no impairment in nonverbal memory.The cognitive impairment was slightly correlated with reduced medial septum volume and medial septum-hippocampus tra cts measured by diffusion tensor imaging.In a mouse model of chronic temporal lobe epilepsy induced by kainic acid,the number of medial septum choline rgic neurons was reduced and acetylcholine release was reduced in the hippocampus.Furthermore,selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice,and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid-and kindling-induced epile psy models.These res ults suggest that activation of medial septum cholinergic neurons reduces cognitive deficits in temporal lobe epilepsy by increasing acetylcholine release via projections to the hippocampus. | Junzi Chen Yu Wang Cong Chen Qingyang Zhang Shuang Wang Yi Wang Jiajia Fang Ying Wang | 2023 | Neural Regeneration Research2023，18，11： | 1 |
| 7 | Study on distribution rule of sliding pushing force and remnant resistant sliding force acting on anti-sliding pile显示文摘Anti-slide pile is one of the important methods to administer landslide geological disaster because of its advantages.It plays important role in administering landslide.It is a premise of reasonable economy and technological advance to know the distribution rule and feature of the force between anti-sliding pile and surrounding rock.To determine the sliding force and remnant resistant sliding force,according to need of study,this paper sets up the geological model and mechanics model in term of a typical landslide,and analyzes the effect rule of sliding body distortion,strength and gravity to the pushing force and remnant resistant sliding force by use of the numerical model.The distribution rule of pushing force and remnant resistant sliding force of the type of landslide is given. | Qingyang YU Lei NIE | 2006 | Global Geology2006，9，2： | 1 |
| 8 | High performance top-emitting and transparent white organic light-emitting diodes based on Al/Cu/TcTa transparent electrodes for active matrix displays and lighting applications显示文摘 | Zhensong Zhang Pingrui yan Shouzhen Yue Guohua Xie Yu Chen Qingyang Wu Dalong Qu Yi Zhao Shiyong Liu | 2013 | Organic Electronics2013，，6： | 1 |
| 9 | Numerical simulation for settlement urban tunnel construction显示文摘The excavation for the municipal tunnel will disturb the soil around the tunnel,and the deformation and subsidence of the earth surface always take place,which may lead to instability and even collapse for the building above the tunnel. At the same time the deformation and subsidence of the earth surface affect the normal use of underground municipal pipelines,and may cause the road sudden collapse,leading to significantly traffic accidents. The authors did a research by simulating for the excavation of municipal tunnel and designed the related supporting plan,and put forward some suggestions and measures for the design and construction of urban tunnel. | WANG Qingsong YU Qingyang | 2014 | Global Geology2014，17，3： | 1 |
| 10 | Real-time,in situ probing of gamma radiation damage with packaged integrated photonic chips显示文摘Integrated photonics is poised to become a mainstream solution for high-speed data communications and sensing in harsh radiation environments,such as outer space,high-energy physics facilities,nuclear power plants,and test fusion reactors.Understanding the impact of radiation damage in optical materials and devices is thus a prerequisite to building radiation-hard photonic systems for these applications.In this paper,we report real-time,in situ analysis of radiation damage in integrated photonic devices.The devices,integrated with an optical fiber array package and a baseline-correction temperature sensor,can be remotely interrogated while exposed to ionizing radiation over a long period without compromising their structural and optical integrity.We also introduce a method to deconvolve the radiation damage responses from different constituent materials in a device.The approach was implemented to quantify gamma radiation damage and post-radiation relaxation behavior of SiO2-cladded SiC photonic devices.Our findings suggest that densification induced by Compton scattering displacement defects is the primary mechanism for the observed index change in SiC.Additionally,post-radiation relaxation in amorphous SiC does not restore the original pre-irradiated structural state of the material.Our results further point to the potential of realizing radiation-hard photonic device designs taking advantage of the opposite signs of radiation-induced index changes in SiC and SiO2. | QINGYANG DU JEROME MICHON BINGZHAO LI DEREK KITA DANHAO MA HAIJIE ZUO SHAOLIANG YU TIAN GU ANURADHA AGARWAL MO LI JUEJUN HU | 2020 | Photonics Research2020，8，2： | 1 |
| 11 | A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue显示文摘Due to the abuse of antibiotics,antibiotic residues can be detected in both natural environment and various industrial products,posing threat to the environment and human health.Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline(Tc)-one of the commonly used antibiotics once on humans and now on poultry,cattle and fisheries.A Tcdegrading enzyme,TetX,from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E.coli and fully characterized,including its Km and kcat value.We quantitatively evaluated its activity both in vitro and in vivo by UVeVis spectrometer and LC-MS.Moreover,we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX,and studied the dose-response of TetX under different inducer concentrations.Since the deployment of genetically modified organisms(GMOs)outside laboratory brings about safety concerns,it is necessary to explore the possibility of integrating a kill-switch.Toxin-Antitoxin(TA)systems were used to construct a mutually dependent host-plasmid platform and biocontainment systems in various academic and industrious situations.We selected nine TA systems from various bacteria strains and measured the toxicity of toxins(T)and the detoxifying activity of cognate antitoxins(A)to validate their potential to be used to build a kill-switch.These results prove the possibility of using engineered microorganisms to tackle antibiotic residues in environment efficiently and safely. | Zepeng Mu Zhuoning Zou Ye Yang Wenbo Wang Yue Xu Jianyi Huang Ruiling Cai Ye Liu Yajin Mo Boyi Wang Yiqun Dang Yongming Li Yushan Liu Yueren Jiang Qingyang Tan Xiaohong Liu Cheng Hu Hua Li Sha Wei Chunbo Lou Yang Yu Jiangyun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 0 |
| 12 | Human-machine interactive streaming anomaly detection by online self-adaptive forest显示文摘At nomaly detectors are used to distinguish differences between normal and abnormal data,which are usually implemented by evaluating and ranking the anomaly scores of each instance.A static unsupervised streaming anomaly detector is difficult to dynamically adjust anomaly score calculation.In real scenarios,anomaly detection often needs to be regulated by human feedback,which benefits adjusting anomaly detectors.In this paper,we propose a human-machine interactive streaming anomaly detection method,named ISPForest,which can be adaptively updated online under the guidance of human feedback.In particular,the feedback will be used to adjust the anomaly score calculation and structure of the detector,ideally attaining more accurate anomaly scores in the future.Our main contribution is to improve the tree-based streaming anomaly detection model that can be updated online from perspectives of anomaly score calculation and model structure.Our approach is instantiated for the powerful class of tree-based streaming anomaly detectors,and we conduct experiments on a range of benchmark datasets.The results demonstrate that the utility of incorporating feedback can improve the performance of anomaly detectors with a few human efforts. | Qingyang LI Zhiwen YU Huang XU Bin GUO | 2023 | Frontiers of Computer Science2023，17，2： | 0 |
| 13 | A chromosome-level genome assembly provides insights into Cornus wilsoniana evolution, oil biosynthesis, and floral bud development显示文摘Cornus wilsoniana W.is a woody oil plant with high oil content and strong hypolipidemic effects,making it a valuable species for medicinal,landscaping,and ecological purposes in China.To advance genetic research on this species,we employed PacBio together with Hi-C data to create a draft genome assembly for C.wilsoniana.Based on an 11-chromosome anchored chromosome-level assembly,the estimated genome size was determined to be 843.51 Mb.The N50 contig size and N50 scaffold size were calculated to be 4.49 and 78.00 Mb,respectively.Furthermore,30474 protein-coding genes were annotated.Comparative genomics analysis revealed that C.wilsoniana diverged from its closest species∼12.46 million years ago(Mya).Furthermore,the divergence between Cornaceae and Nyssaceae occurred>62.22 Mya.We also found evidence of whole-genome duplication events and whole-genome triplicationγ,occurring at∼44.90 and 115.86 Mya.We further inferred the origins of chromosomes,which sheds light on the complex evolutionary history of the karyotype of C.wilsoniana.Through transcriptional and metabolic analysis,we identified two FAD2 homologous genes that may play a crucial role in controlling the oleic to linoleic acid ratio.We further investigated the correlation between metabolites and genes and identified 33 MADS-TF homologous genes that may affect f lower morphology in C.wilsoniana.Overall,this study lays the groundwork for future research aimed at identifying the genetic basis of crucial traits in C.wilsoniana. | Zhenxiang He Haoyu Chao Xinkai Zhou Qingyang Ni Yueming Hu Ranran Yu Minghuai Wang Changzhu Li Jingzhen Chen Yunzhu Chen Yong Chen Chunyi Cui Liangbo Zhang Ming Chen Dijun Chen | 2023 | Horticulture Research2023，10，11： | 0 |
| 14 | Finite element analysis for blasting law of jointed rock mass显示文摘On the basis of Mises strength theory,rock models are built including vertical,horizontal and diagonal joints to simulate jointed rock mass under blasting load by using FEM. The dynamic procedures of jointed rock mass under blasting are quantified and the effective stress-time curves of typical elements are compared to analyze the barrier of joints to the stress wave. The blasting law was studied according to the process of computer simulation and the effect of blasting,and some suggestions were given for solving the problems of overbreak and underbreak. | YU Qingyang NIE Lei ZHOU Nengjuan | 2009 | Global Geology2009，12，4： | 0 |
| 15 | Pancreatic head cancer with gastrointestinal bleeding as the initial manifestation:a case report and literature review显示文摘Gastrointestinal bleeding(GIB)as the initial symptom is rare in patients with pancreatic cancer,which is prone to misdiagnosis and should be paid attention to by clinicians.Here,we present a patient with pancreatic head cancer whose first symptom was only severe upper gastrointestinal bleeding,which initially led to misdiagnosis.However,subsequent imaging revealed a mass in the pancreatic head which was considered a malignant tumor.After surgical resection,the pathology confirmed that the mass in the pancreatic head was pancreatic ductal adenocarcinoma,and the duodenal bulb’s full thickness was infiltrated.A literature review found that pancreatic cancer can present gastrointestinal bleeding by invading the digestive tract and blood vessels,left-sided portal hypertension(LSPH),digestive tract metastasis,and canceration of ectopic pancreatic tissue in the digestive tract.For these cases,clinicians should utilize multidisciplinary diagnosis and treatment based on digestive endoscopy,imaging,interventional therapy,and surgery to control bleeding,identify etiology,and remove tumors. | Minghui Zheng Zhiping Fu Ting Niu Anan Liu Danlei Chen Junfeng Peng Judong Li Zhiyuan Hao Qingyang Yu Zechao Lyu Chenghao Shao | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 16 | MEIC-global-CO_(2):A new global CO_(2)emission inventory with highly-resolved source category and sub-country information显示文摘CO_(2)emission inventory provides fundamental data for climate research and emission mitigation.Currently,most global CO_(2)emission inventories were developed with energy statistics from International Energy Agency(IEA)and were available at country level with limited source categories.Here,as the first step toward a high-resolution and dynamic updated global CO_(2)emission database,we developed a data-driven approach to construct seamless and highly-resolved energy consumption data cubes for 208 countries/territories,797 sub-country administrative divisions in 29 countries,42 fuel types,and 52 sectors,with the fusion of activity data from 24 international statistics and 65 regional/local statistics.Global CO_(2)emissions from fossil fuel combustion and cement production in 1970–2021 were then estimated with highly-resolved source category(1,484 of total)and sub-country information(797 of total).Specifically,73%of global CO_(2)emissions in 2021 were estimated with sub-country information,providing considerably improved spatial resolution for global CO_(2)emission accounting.With the support of detailed information,the dynamics of global CO_(2)emissions across sectors and fuel types were presented,representing the evolution of global economy and progress of climate mitigation.Remarkable differences of sectoral contribution were found across sub-country administrative divisions within a given country,revealing the uneven distribution of energy and economic structure among different regions.Our estimates were generally consistent with existing databases at aggregated level for global total or large emitters,while large discrepancies were observed for middle and small emitters.Our database,named the Multiresolution Emission Inventory model for Climate and air pollution research(MEIC)is publicly available through http://gffzz6c575fb1d0a54d36hcuqfn09pfvpn65vw.ffgz.tsg.suse.edu.cn with highly-resolved information and timely update,which provides an independent carbon emission accounting data source for climate research. | Ruochong XU Dan TONG Qingyang XIAO Xinying QIN Cuihong CHEN Liu YAN Jing CHENG Can CUI Hanwen HU Wenyu LIU Xizhe YAN Huaxuan WANG Xiaodong LIU Guannan GENG Yu LEI Dabo GUAN Kebin HE Qiang ZHANG | 2024 | Science China Earth Sciences2024，67，2： | 0 |
| 17 | Rhodium catalyzed asymmetric synthesis of Chiraphos derivatives显示文摘Herein,we report a highly efficient versatile synthetic route to Chiraphos derivatives through Rh/Ph-bod catalyzed asymmetric addition of aryl boronic acids to phosphinyl dienes.Various substituted phosphinyl dienes,both on the parent skeleton and the phosphine atoms,were well tolerated with this method and provided chiral phosphine oxides in satisfied yield and up to 95%ee.The corresponding Chiraphos derivative displayed an advantage over Chiraphos in the representative Pd-catalyzed asymmetric 1,4-addition reaction. | Ying-Ying Sun Bin Zhang Liangbin Yu Ranran Cui Qingyang Zhao Qing-Wei Zhang | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 18 | Influence and characteristic of shading on photovoltaic performance of bifacial modules and method for estimating bifacial gain显示文摘Bifacial PV modules have unique advantages in low-carbon building applications such as BIPV systems but often suffer from the shading problem resulting from higher surrounding objects or building facades.Point-blank quantitative studies of PV performance of bifacial modules operating in actual environments as affected by shading on PV cells are lacking due to the difficulties of analysis caused by the existing multiple variable factors.By constructing an experimental comparison system on a flat roof of a building,we experimentally tested and analyzed the comparative variation characteristics of PV performance of bifacial and mono-facial modules under different shading area fractions.The results show that from the viewpoint of photoelectric efficiency,the PV performance of both bifacial and mono-facial PV modules clearly varied with the shading fraction of PV cell in some linear rules,though it is difficult to find regularity from the perspective of output power which was also affected by dynamic solar radiation intensity.An abnormal phenomenon emerged that the photoelectric efficiencies of the bifacial modules with small shading fraction were higher compared to the case without shading.Based on the findings of the experimental results,a regression approximation method based on shading test results(RAST Method)is further proposed to analyze and calculate the bifacial gain of bifacial modules.In the case of the existing roof installation,the mean bifacial gains of the two bifacial modules with different inclination angles were 8.86%and 11.30%,respectively. | Chenglong Luo Yuandan Wu Xiaoxiao Su Wu Zou Yanshun Yu Qingyang Jiang Lijie Xu | 2023 | Building Simulation2023，16，10： | 0 |
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