|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Performance deterioration modeling and optimal preventive maintenance strategy under scheduled servicing subject to mission time显示文摘Servicing is applied periodically in practice with the aim of restoring the system state and prolonging the lifetime. It is generally seen as an imperfect maintenance action which has a chief influence on the maintenance strategy. In order to model the maintenance effect of servicing, this study analyzes the deterioration characteristics of system under scheduled servicing. And then the deterioration model is established from the failure mechanism by compound Poisson process. On the basis of the system damage value and failure mechanism, the failure rate refresh factor is proposed to describe the maintenance effect of servicing. A maintenance strategy is developed which combines the benefits of scheduled servicing and preventive maintenance. Then the optimization model is given to determine the optimal servicing period and preventive maintenance time, with an objective to minimize the system expected life-cycle cost per unit time and a constraint on system survival probability for the duration of mission time. Subject to mission time, it can control the ability of accomplishing the mission at any time so as to ensure the high dependability. An example of water pump rotor relating to scheduled servicing is introduced to illustrate the failure rate refresh factor and the proposed maintenance strategy. Compared with traditional methods, the numerical results show that the failure rate refresh factor can describe the maintenance effect of servicing more intuitively and objectively. It also demonstrates that this maintenance strategy can prolong the lifetime, reduce the total lifetime maintenance cost and guarantee the dependability of system. | Li Dawei Zhang Zhihua Zhong Qianghui Zhai Yali | 2014 | Chinese Journal of Aeronautics2014，27，4： | 14 |
| 3 | Leader-Following Consensus of Multi-Agent Systems via Adaptive Event-Based Control显示文摘In this paper, the adaptive event-based control approach is applied to study leader-following consensus of multi-agent systems with linear dynamic models. Adaptive event-based controller and triggering function for each agent are designed, where the adaptive function is only dependent on its own event time instants. A sufficient condition on consensus is proposed, which shows that the adaptive event-based method presented in this paper not only can reduce the communication among neighboring agents, but also can determine the event time instants for each agent without using the global information. Furthermore, the Zeno-behavior for the concerned closed-loop system is excluded. Finally, an example is presented to ilhistratc the effectiveness of the obtained theoretical results. | ZHU Wei WANG Dandan ZHOU Qianghui | 2019 | Journal of Systems Science & Complexity2019，32，3： | 6 |
| 4 | Fully distributed consensus of second-order multi-agent systems using adaptive event-based control显示文摘Dear editor, In recent years,the distributed consensus of multiagent systems (MASs)has attracted compelling attention because of its potential applications in many fields such as sensor networks,unmanned aerial vehicle (UAV)formation flying,and multiple signals tracking.The central task in the distributed consensus of MASs is to design distributed control protocols to achieve the consensus using only local information. | Wei ZHU Qianghui ZHOU DANDan WANG Gang FENG | 2018 | Science China(Information Sciences)2018，61，12： | 5 |
| 5 | Optimization of Wind Farm Collection Line Structure under Symmetrical Grid Fault显示文摘A power-transmission collection line is connected to each wind turbine of a wind farm and then connected to the incoming switchgear at the low-voltage side of the booster station at a certain distance.Therefore,the grouping of the wind turbines in the wind farm determines the layout of the lines and affects the line impedance.The line structure and composition of the wind farm are analyzed,and the relationship between the impedance of the collection line and reactive power generated by the wind turbine at low-voltage ride through is derived.We conclude that the smaller the equivalent impedance of the wind farm collection line structure is,the greater the reactive power at the wind farm collection line point is.In addition,the economic aspect of the collection line needs to be considered in the design.The economic aspect and impedance values have contrasting characteristics.Therefore,according to the condition of minimum impedance and optimized economic aspect,an optimization model of a wind-farm collector-circuit structure is proposed.The optimal structure of the wind farm collector circuit is calculated using the Monte Carlo method,and the theoretical analysis is verified by simulation. | Huan Jin Xueyi Zhang Yang Zhang Qianghui Xiao Juan Li Ya Liu | 2019 | Chinese Journal of Electrical Engineering2019，5，3： | 3 |
| 6 | Adaptive Event-Based Consensus of Multi-Agent Systems with General Linear Dynamics显示文摘在这份报纸,有一般线性动力学的多代理人系统的适应基于事件的一致被考虑。一个新奇适应基于事件的控制器和州依赖者的被触发功能为每个代理人被建议。没有假设,一致能被完成(一, B ) 是 stabilizable。而且,担心的靠近环的系统的 Zeno 行为也在某些条件下面被排除。最后,一个数字模拟例子被举显示出理论结果的有效性。 | WANG Dandan ZHOU Qianghui ZHU Wei | 2018 | Journal of Systems Science & Complexity2018，31，1： | 3 |
| 7 | IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation显示文摘 | Zhongming Tan Xiaofeng Qian Runqiu Jiang Qianghui Liu Youjing Wang Chen Chen Xuehao Wang Bernhard Ryffel Beicheng Sun | 2013 | The Journal of Immunology2013，，4： | 2 |
| 8 | Response surface optimization and identification of isothiocyanates produced from broccoli sprouts显示文摘 | Qianghui Guo Liping Guo Zhiying Wang Yan Zhuang Zhenxin Gu | 2013 | Food Chemistry2013，，3： | 1 |
| 9 | GABA shunt and polyamine degradation pathway on γ-aminobutyric acid accumulation in germinating fava bean ( Vicia faba L.) under hypoxia显示文摘 | Runqiang Yang Qianghui Guo Zhenxin Gu | 2013 | Food Chemistry2013，，1： | 1 |
| 10 | NaCl stress and supplemental CaCl 2 regulating GABA metabolism pathways in germinating soybean显示文摘 | Yongqi Yin Runqiang Yang Qianghui Guo Zhenxin Gu | 2014 | European Food Research and Technology2014，，5： | 1 |
| 11 | Effect of temperature on the effective thermal conductivity of n-tetradecane-based nanofluids containing copper nanoparticles显示文摘Nanofluids were prepared by dispersing Cu nanoparticles(~20nm) in n-tetradecane by a two-step method.The effective thermal conductivity was measured for various nanoparticle volume fractions(0.0001-0.02) and temperatures(306.22-452.66 K).The experimental data compares well with the Jang and Choi model.The thermal conductivity enhancement was lower above 391.06 K than for that between306.22 and 360.77 K.The interfacial thermal resistance increased with increasing temperature.The effective thermal conductivity enhancement was greater than that obtained with a more viscous fluid as the base media at 452.66 K because of nanoconvection induced by nanoparticle Brownian motion at high temperature. | Haifeng Jiang Qianghui Xu Chao Huang Lin Shi | 2015 | Particuology2015，13，5： | 1 |
| 12 | A novel oscillator based on heterogeneous carbon@ MoS2 nanotubes显示文摘新奇异构的振荡器的摆动的行为碳创作了,铝二硫化物 nanotubes (CNT@MST ) 第一次被调查,由使用古典分子的动力学的方法。在建议振荡器,铝二硫化物 nanotube (山区标准时间) 被放作为一个外部试管,导致与半导体工业标准的更好的相容性。有到达 20 GHz 的频率的一个光滑、稳定的振荡器为大量差距宽度基于双 walled CNT@MST hetero-nanotube 被获得,显示建议振荡器比从双 walled 碳 nanotubes (CNT ) 造的那些更好表现要求差距宽度的一个狭窄的范围。另外,包含不同内部、外部的试管 chirality 的 CNT@MST 振荡器的摆动特征比与一样的 chirality 包含二个试管的 CNT@MST 振荡器的那些显著地好。 | Wugui Jiang Yonghui Zeng Qinghua Qin Qianghui Luo | 2016 | Nano Research2016，9，6： | 1 |
| 13 | GABA shunt and polyamine degradation pathway on γ-aminobutyric acid accumulation in germinating fava bean ( Vicia faba L.) under hypoxia显示文摘 | Runqiang Yang Qianghui Guo Zhenxin Gu | 2013 | Food Chemistry2013，，1： | 1 |
| 14 | IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation显示文摘 | Zhongming Tan Xiaofeng Qian Runqiu Jiang Qianghui Liu Youjing Wang Chen Chen Xuehao Wang Bernhard Ryffel Beicheng Sun | 2013 | The Journal of Immunology2013，，4： | 1 |
| 15 | Quick assembly of 1-alkylidenyl-tetrahydroisoquinolines via a Catellani reaction/NBS-mediated cyclization sequence and synthetic applications显示文摘We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides,aziridines,and terminal alkynes followed by an N-bromosuccinimide(NBS)-mediated cyclization.This approach features mild reaction conditions,wide substrate scope,good step-economy and good scalability.Based on this new method,we have accomplished the concise total synthesis of(±)-cularine,formal synthesis of 8-oxopseudopalmatine as well as the first total synthesis of dactyllactone A,demonstrating the wide synthetic potential of this method. | Shihu Jia Miao Bai Siwei Zhou Ruiqing Sheng Hong-Gang Cheng Qianghui Zhou | 2023 | Science China Chemistry2023，66，11： | 0 |
| 16 | Study on the Changes of GPDA II in the Serum and Liver of Experimental Rats with Hepatoma显示文摘 | QiangHui HuangJie-fei MengXian-yong | 2000 | 胃肠病学2000，5，B08： | 0 |
| 17 | Haplotype-resolved Genome of Sika Deer Reveals Allele-specific Gene Expression and Chromosome Evolution显示文摘Despite the scientific and medicinal importance of diploid sika deer(Cervus nippon),its genome resources are limited and haplotype-resolved chromosome-scale assembly is urgently needed.To explore mechanisms underlying the expression patterns of the allele-specific genes in antlers and the chromosome evolution in Cervidae,we report,for the first time,a high-quality haplotype-resolved chromosome-scale genome of sika deer by integrating multiple sequencing strategies,which was anchored to 32 homologous groups with a pair of sex chromosomes(XY).Several expanded genes(RET,PPP2R1A,PPP2R1B,YWHAB,YWHAZ,and RPS6)and positively selected genes(eIF4E,Wnt8A,Wnt9B,BMP4,and TP53)were identified,which could contribute to rapid antler growth without carcinogenesis.A comprehensive and systematic genome-wide analysis of allele expression patterns revealed that most alleles were functionally equivalent in regulating rapid antler growth and inhibiting oncogenesis.Comparative genomic analysis revealed that chromosome fission might occur during the divergence of sika deer and red deer(Cervus elaphus),and the olfactory sensation of sika deer might be more powerful than that of red deer.Obvious inversion regions containing olfactory receptor genes were also identified,which arose since the divergence.In conclusion,the high-quality allele-aware reference genome provides valuable resources for further illustration of the unique biological characteristics of antler,chromosome evolution,and multi-omics research of cervid animals. | Ruobing Han Lei Han Xunwu Zhao Qianghui Wang Yanling Xia Heping Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 18 | A Lyapunov Approach to Consensus of Linear Multi-Agent Systems with Infinite Distributed Communication Delays显示文摘This paper considers the leaderless consensus problem of linear time-invariant multi-agent systems with infinite distributed communication delays.A novel distributed low gain controller is proposed based on the solution to a parametric algebraic Riccati equation.It is shown via the newly developed Lyapunov-like method that not only the consensus of linear time-invariant multi-agent systems can be achieved exponentially under some mild assumptions but also an estimate of the exponential convergence rate of consensus is given in this work.The Lyapunovlike method is also extended to handle a special case of linear time-varying multi-agent systems.In addition,the obtained results include the results on the leaderless consensus of linear multiagent systems with bounded distributed communication delays as special cases.To the best of our knowledge,this is thefirst work that develops the Lyapunov-like method for the leaderless consensus problems of both time-invariant and time-varying linear multi-agent systems with infinite distributed communication delays.Finally,a numerical example is presented to illustrate the effectiveness of the proposed controller. | Qianghui Zhou Gang Feng Xiang Xu | 2022 | Guidance, Navigation and Control2022，2，3： | 0 |
| 19 | Weighted spectral correlation angle target detection method for land‑based hyperspectral imaging显示文摘In land-based spectral imaging,the spectra of ground objects are inevitably afected by the imaging conditions(weather conditions,atmospheric conditions,light conditions,zenith and azimuth angle conditions)and spatial distribution of targets,leading to uncertainties featured by“same object diferent spectrum”.That is,the spectrum of a ground object may change within a certain range under diferent imaging conditions.Traditional target detection(TD)methods are mainly based on similarity measurements and do not fully account for the spectral uncertainties.These detection methods are prone to false detections or missed detections.Therefore,reducing the impact of spectral uncertainties on TD is an important research topic in hyperspectral imaging.In this paper,we frst review traditional TD methods and compare their principles and characteristics.It is found that the spectral correlation angle(SCA)method has good adaptability in land-based imaging.The shortcoming of the SCA method that it cannot refect the local spectrum characteristics,is also analyzed.As the efect of spectral uncertainties cannot be completely overcome by the SCA method,a new similarity measurement method,the weighted spectral correlation angle(WSCA)method,is proposed.It can reduce the infuence of spectral uncertainties on TD by increasing the weight of particular bands.Finally,we use two sets of experiments to analyze the efect of the WSCA method on TD.Its performance in overcoming spectral uncertainties caused by variations in imaging conditions or uneven spatial distributions of targets is tested.The results show that the WSCA method can efectively reduce the infuence of spectral uncertainties and obtain a good detection result. | Qianghui Wang Bing Zhou Wenshen Hua Jiaju Ying Xun Liu Yue Cheng | 2023 | Frontiers of Optoelectronics2023，16，4： | 0 |
| 20 | Diversity-Oriented Synthesis of Flavones and Isoflavones via Palladium/Norbornene Cooperative Catalysis显示文摘Flavones and isoflavones are recognized as privileged heterocyclic scaffolds for the preparation of bioactive compounds.Efficient methods to access these heterocycles are in urgent need.Herein,we report diversity-oriented synthesis of flavones and isoflavones from 3-iodochromones via palladium/norbornene cooperative catalysis.The success of this research relies on the use of a unique bridge-head ester modified norbornene derivative as the mediator.Salient features of this include readily available starting materi-als regarding 3-iodochromones,ortho-C-H arylating and alkylating reagents and ipso-terminating reagents,broad substrate scope,good chemoselectivity,good step-economy and scalability.A large number of structurally diversified flavones,isoflavones and 2,3-diarylated chromones can be quickly prepared in a predictable manner.As showcased by the efficient formal synthesis of um-bralisib,this chemistry can be treated as another valuable addition to the toolbox of medicinal chemists. | Yuanyuan Ma Qianwen Gao Lan Zhou Shanshan Liu Hong-Gang Cheng Qianghui Zhou | 2022 | Chinese Journal of Chemistry2022，40，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员