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| 1 | Role of sirtuins in ischemia-reperfusion injury显示文摘Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation.Several factors contribute to its complexity;the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury.Recently,the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers,due to their involvement in the modulation of a wide variety of cellular functions.There are seven mammalian sirtuins and,among them,the nuclear/cytoplasmic sirtuin 1(SIRT1)and the mitochondrial sirtuin 3(SIRT3)are ubiquitously expressed in many tissue types.Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways,which are key processes during IRI.In this review,we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress,apoptosis,microcirculatory stress and inflammation during reperfusion.We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action. | Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Joan Roselló-Catafau | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 2 | Polyethylene glycol rinse solution:An effective way to prevent ischemia-reperfusion injury显示文摘AIM:To test whether a new rinse solution containing polyethylene glycol 35(PEG-35)could prevent ischemia-reperfusion injury(IRI)in liver grafts.METHODS:Sprague-Dawley rat livers were stored in University of Wisconsin preservation solution and then washed with different rinse solutions(Ringer’s lactate solution and a new rinse solution enriched with PEG-35 at either 1 or 5 g/L)before ex vivo perfusion with Krebs-Heinseleit buffer solution.We assessed the following:liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity),liver function(bile output and vascular resistance),oxidative stress(malondialdehyde),nitric oxide,liver autophagy(Beclin-1 and LCB3)and cytoskeleton integrity(filament and globular actin fraction);as well as levels of metalloproteinases(MMP2 and MMP9),adenosine monophosphate-activated protein kinase(AMPK),heat shock protein 70(HSP70)and heme oxygenase 1(HO-1).RESULTS:When we used the PEG-35 rinse solution,reduced hepatic injury and improved liver function were noted after reperfusion.The PEG-35 rinse solution prevented oxidative stress,mitochondrial damage,and liver autophagy.Further,it increased the expression of cytoprotective heat shock proteins such as HO-1 and HSP70,activated AMPK,and contributed to the restoration of cytoskeleton integrity after IRI.CONCLUSION:Using the rinse solution containing PEG-35 was effective for decreasing liver graft vulnerability to IRI. | Mohamed Amine Zaouali Mohamed Bejaoui Maria Calvo Emma Folch-Puy Eirini Pantazi Gianfranco Pasut Antoni Rimola Hassen Ben Abdennebi René Adam Joan Roselló-Catafau | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 3 | Emerging concepts in liver graft preservation显示文摘The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion(MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures(hypothermia at 4 ℃, normothermia a t 3 7 ℃ and subnormothermia at 20 ℃- 2 5 ℃). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the 'state of the art' and future perspectives in static and dynamic liver graft preservation in order to improve graft viability. | Mohamed Bejaoui Eirini Pantazi Emma Folch-Puy Pedro M Baptista Agustín García-Gil René Adam Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，2： | 5 |
| 4 | Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach显示文摘AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trimetazidine(TMZ).METHODS:Male Sprague-Dawley rats were used as donors and recipients.Livers were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kamada’s cuff technique without arterialization.In another group,livers were stored in IGL-1 preservation solution supplemented with TMZ,at10-6 mol/L,for 8 h at 4℃and then underwent OLT.Rats were sacrificed 24 h after reperfusion,and liver and plasma samples were collected.Liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity)oxidative stress(malondialdehyde levels),and nicotinamide adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determined by biochemical methods.SIRT1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinamide phosphoribosyltransferase(NAMPT),as well as the phosphorylation of adenosine monophosphate activated protein kinase(AMPK),p-m TOR,p-p70S6K(direct substrate of m TOR),autophagy parameters(beclin-1,LC3B)and MAP kinases(p-p38 and p-ERK)were determined by Western blot.RESULTS:Liver grafts preserved in IGL-1 solution enriched with TMZ presented reduced liver injury and mitochondrial damage compared with those preservedin IGL-1 solution alone.In addition,livers preserved in IGL-1+TMZ presented reduced levels of oxidative stress.This was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox O1.The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD+/NADH levels.Up-regulation of SIRT1 was consistent with activation of AMPK and inhibition of phosphorylation of m TOR and its direct substrate(p-p70S6K).As a consequence,autophagy mediators(beclin-1 and LC3B)were overexpressed.Furthermore,MAP kinases were regulated in livers preserved with IGL-1+TMZ,as they were characterized by enhanced p-ERK and decreased p-p38protein expression.CONCLUSION:Our study shows that IGL-1 preservation solution enriched with TMZ protects liver grafts from the IRI associated with OLT,through SIRT1 up-regulation. | Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos Marques Palmeira Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，6： | 5 |
| 5 | Bortezomib enhances fatty liver preservation in I nstitut G eorge L opez‐1 solution through adenosine monophosphate activated protein kinase and Akt / mTOR pathways显示文摘 | Mohamed Bejaoui Mohamed Amine Zaouali Emma Folch‐Puy Eirini Pantazi Fawzia Bardag‐Gorce Teresa Carbonell Joan Oliva Antoni Rimola Hassen Ben Abdennebi Joan Roselló‐Catafau | 2014 | J Pharm Pharmacol2014，，1： | 3 |
| 6 | HBeAg negative serological status and low viral replication levels characterize chronic hepatitis B virus-infected women at reproductive age in Greece: A one-year prospective single center study显示文摘AIM: To evaluate the seroprevalence of hepatitis B surface antigen (HBsAg) in 13 581 women at reproductive age and the hepatitis B e antigen (HBeAg)/anti-HBe status as well as serum hepatitis B virus (HBV)-DNA levels in a subgroup of HBsAg(+) pregnant women at labor in Greece.METHODS: Serological markers were detected using enzyme immunoassays. Serum HBV-DNA was determined by a sensitive quantitative PCR assay. Statistical analysis of data was based on parametric methodology.RESULTS: Overall, 1.156% of women were HBsAg(+)and the majority of them (71.3%) were Albanian. The prevalence of HBsAg was 5.1% in Albanian women, 4.2%in Asian women and 1.14% in women from Eastem European countries. The prevalence of HBsAg in African (0.36%) and Greek women (0.29%) was very low. Only 4.45% of HBsAg (+) women were also HBeAg(+) whereas the vast majority of them were HBeAg(-)/anti-HBe(+). Undetectable levels of viremia (<200 copies/mL) were observed in 32.26% of pregnant women at labor and 29.03% exhibited extremely low levels of viral replication (<400 copies/mL). Only two pregnant women exhibited extremely high serum HBVDNA levels (>10 000 000 copies/mL), whereas 32.26%exhibited HBV-DNA levels between 1 500 and 40 000copies/mL.CONCLUSION: The overall prevalence of HBsAg is relatively low among women at reproductive age in Greece but is higher enough among specific populations. The HBeAg(-)/anti-HBe(+) serological status and the extremely low or even undetectable viral replicative status in the majority of HBsAg(+) women of our study population, suggest that only a small proportion of HBsAg(+) women in Greece exhibit a high risk for vertical transmission of the infection. | Ioannis S. Elefsiniotis Irene Glynou Ioanna Magaziotou Konstantinos D. Pantazis Nikolaos V. Fotos Hero Brokalaki Helen Kada George Saroglou | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 7 | Early surgical treatment vs conservative management for spontaneous supratentorial intracerebral hematomas: a prospective randomized study显示文摘 | Georgios Pantazis Parmenion Tsitsopoulos Constantinos Mihas Vasiliki Katsiva Vasilios Stavrianos Stylianos Zymaris | 2006 | Surgical Neurology2006，，5： | 2 |
| 8 | Serological and virological profile of chronic HBV infected women at reproductive age in Greece显示文摘 | Ioannis S. Elefsiniotis Irene Glynou Hero Brokalaki Ioanna Magaziotou Konstantinos D. Pantazis Aikaterini Fotiou George Liosis Helen Kada George Saroglou | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 2 |
| 9 | Changes in parameters of bone and mineral metabolism during therapy for hyperthyroidism 显示文摘 | Pantazi H Papapetrou PD | 2000 | J Clin Endocrinol Metab2000，85，3： | 1 |
| 10 | 9 Nitrocamptothecin显示文摘 | Pantazis P Han Z Y Chatterjee D | 1999 | Drug Fut1999，24，12： | 1 |
| 11 | Assessment of ventricular repolarization alterations in subjects with early repolarization显示文摘 | Dilaveris P Pantazis A Gialafos E | 2004 | Int J Cardiol2004，96，2： | 1 |
| 12 | l)issociation of the 7S-nerve growth tactor complex in solution显示文摘 | Pantazis N J Murphy R A Saide J D | 1977 | Bioehemis- try1977，16，7： | 1 |
| 13 | Aromatase inhibitor anastrozole for treating endometrial hyperplasia in obese postmenopausal women显示文摘 | Agorastos T Vaitsi V Pantazis K | 2005 | Eur J Obstet Gynecol Reprod Biol2005，118，2： | 1 |
| 14 | Diagnosis of leftventricular non-compaction in patients with left-ventricular systolic dysfunction:time for a reappraisal of diagnostic criteria? 显示文摘 | Kohli SK Pantazis AA Shah JS | 2008 | Eur Heart J2008，29，1： | 1 |
| 15 | Early surgical treatment vs conservative management for spontaneous supratentorial intracerebral hematomas:A prospective randomized study显示文摘 | Pantazis G Tsitsopoulos P Mihas C | 2006 | Surg Neurol2006，66，5： | 1 |
| 16 | Energy-Efficient Routing Protocols in Wireless Sensor Networks: A Survey 显示文摘 | Nikolaos A Pantazis Stefanos A Nikolidakis Dimitrios D Vergados | 2012 | IEEE Communications Surveys and Tutorials2012，，99： | 1 |
| 17 | Cytotoxic efficacy of 9 - nitrocamptothecin in treatment of human malignant melanoma cells in vitro 显示文摘 | Pantazis P Early JA MendozaJT | 1994 | Cancer Res1994，54，3： | 1 |
| 18 | Adaptive AM - FM signal decomposition with application to speech analysis 显示文摘 | Pantazis Y Rosec O Stylianou Y | 2011 | IEEE Transactions on Audio Speech and Language Processing2011，19，2： | 1 |
| 19 | The spatial QRS-T angle as a marker of ventricular repolarisation in hypertension显示文摘 | Dilaveris P Gialafos E Pantazis A | 2001 | JHum Hypertens2001，15，1： | 1 |
| 20 | Structure-activity relationship of alkyl camptothecin esters 显示文摘 | Pantazis P Mendoza J | 2000 | Ann NY Acad Sci2000，922，： | 1 |
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