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| 1 | Alcohol,nutrition and liver cancer:Role of Toll-like receptor signaling显示文摘This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors, S-adenosylmethionine and betaine, prevent the upregulation of the TLR signaling pathways and abrogate the stem cell/progenitor proliferation response when fed with the carcinogenic drug. This observation supports a nutritional approach to liver cancer prevention and treatment. The observation that upregulation of the TLR signaling pathways leads to liver tumor formation gives evidence to the popular concept that the chronic pro-inflammatory response is an important mechanism of liver oncogenesis. It provides a nutritional approach, which could prevent HCC from developing in many chronic liver diseases. | Samuel W French Joan Oliva Barbara A French Fawzia Bardag-Gorce | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 2 | Effects of ethanol on the proteasome interacting proteins显示文摘Proteasome dysfunction has been repeatedly reported in alcoholic liver disease. Ethanol metabolism endproducts affect the structure of the proteasome, and, therefore, change the proteasome interaction with its regulatory complexes 19S and PA28, as well as its interacting proteins. Chronic ethanol feeding alters the ubiquitin-proteasome activity by altering the interaction between the 19S and the 20S proteasome interaction. The degradation of oxidized and damaged proteins is thus decreased and leads to accumulation of insoluble protein aggregates, such as Mallory-Denk bodies. Ethanol also affects the immunoproteasome formation. PA28a/b interactions with the 20S proteasome are decreased in the proteasome fraction isolated from the liver of rats fed ethanol chronically, thus affecting the cellular antigen presentation and defense against pathogenic agents. Recently, it has been shown that ethanol also affects the proteasome interacting proteins (PIPs). Interaction of the proteasome with Ecm29 and with deubiquitinating enzymes Rpn11, UCH37, and Usp14 has been found to decrease. However, the two UBL-ubiquitin-associated domain (UBA) PIPs p62 and valosin-containing protein are upregulated when the proteasome is inhibited. The increase of these UBL-UBA proteins, as well as the increase in Hsp70 and Hsp25 levels, compensated for the proteasome failure and helped in the unfolding/docking of misfolded proteins. Chronic alcohol feeding to rats causes a significant inhibition of the proteasome pathway and this inhibition results from a decreases of the interaction between the 20S proteasome and the regulatory complexes, PIPs, and the ubiquitin system components. | Fawzia Bardag-Gorce | 2010 | World Journal of Gastroenterology2010，16，11： | 4 |
| 3 | Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically显示文摘AIM:To examine the effects of ethanol-induced proteasome inhibition,and the effects of proteasome inhibition in the regulation of epigenetic mechanisms. METHODS:Rats were fed ethanol for 1 mo using the Tsukamoto-French model and were compared to rats given the proteasome inhibitor PS-341(Bortezomib, Velcade?)by intraperitoneal injection.Microarray analysis and real time PCR were performed and proteasome activity assays and Western blot analysis were performed using isolated nuclei. RESULTS:Chronic ethanol feeding caused a significant inhibition of the ubiquitin proteasome pathway in the nucleus,which led to changes in the turnover of transcriptional factors,histone-modifying enzymes, and,therefore,affected epigenetic mechanisms. Chronic ethanol feeding was related to an increase in histone acetylation,and it is hypothesized that the proteasome proteolytic activity regulated histone modifications by controlling the stability of histone modifying enzymes,and,therefore,regulated the chromatin structure,allowing easy access to chromatin by RNA polymerase,and,thus,proper gene expression.Proteasome inhibition by PS-341 increased histone acetylation similar to chronic ethanol feeding. In addition,proteasome inhibition caused dramatic changes in hepatic remethylation reactions as there was a significant decrease in the enzymes responsible for the regeneration of S-adenosylmethionine,and, in particular,a significant decrease in the betaine- homocysteine methyltransferase enzyme.This suggested that hypomethylation was associated with proteasome inhibition,as indicated by the decrease in histone methylation. CONCLUSION:The role of proteasome inhibition in regulating epigenetic mechanisms,and its link to liver injury in alcoholic liver disease,is thus a promising approach to study liver injury due to chronic ethanol consumption. | Joan Oliva Jennifer Dedes Samuel W French Fawzia Bardag-Gorce | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 4 | Proteasome inhibitor treatment in alcoholic liver disease显示文摘Oxidative stress, generated by chronic ethanol consumption, is a major cause of hepatotoxicity and liver injury. Increased production of oxygen-derived free radicals due to ethanol metabolism by CYP2E1 is principally located in the cytoplasm and in the mitochondria, which does not only injure liver cells, but also other vital organs, such as the heart and the brain. Therefore, there is a need for better treatment to enhance the antioxidant response elements. To date, there is no established treatment to attenuate high levels of oxidative stress in the liver of alcoholic patients. To block this oxidative stress, proteasome inhibitor treatment has been found to significantly enhance the antioxidant response elements of hepatocytes exposed to ethanol. Recent studies have shown in an experimental model of alcoholic liver disease that proteasome inhibitor treatment at low dose has cytoprotective effects against ethanol-induced oxidative stress and liver steatosis. The beneficial effects of proteasome inhibitor treatment against oxidative stress occurred because antioxidant response elements (glutathione peroxidase 2, superoxide dismutase 2, glutathione synthetase, glutathione reductase, and GCLC) were upregulated when rats fed alcohol were treated with a low dose of PS-341 (Bortezomib, Velcade ). This is animportant finding because proteasome inhibitor treatment up-regulated reactive oxygen species removal and glutathione recycling enzymes, while ethanol feeding alone down-regulated these antioxidant elements. For the first time, it was shown that proteasome inhibition by a highly specific and reversible inhibitor is different from the chronic ethanol feeding-induced proteasome inhibition. As previously shown by our group, chronic ethanol feeding causes a complex dysfunction in the ubiquitin proteasome pathway, which affects the proteasome system, as well as the ubiquitination system. The beneficial effects of proteasome inhibitor treatment in alcoholic liver disease are related to proteasome inhibitor reversibility and the rebound of proteasome activity 72 h post PS-341 administration. | Fawzia Bardag-Gorce | 2011 | World Journal of Gastroenterology2011，17，20： | 4 |
| 5 | Nuclear effects of ethanol-induced proteasome inhibition in liver cells显示文摘Alcohol ingestion causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunological response defects, and fibrosis. These phenomena are associated with significant changes in the epigenetic mechanisms, and subsequently, to liver cell memory. The ubiquitin-proteasome pathway is one of the vital pathways in the cell that becomes dysfunctionial as a result of chronic ethanol consumption. Inhibition of the proteasome activity in the nucleus causes changes in the turnover of transcriptional factors, histone modifying enzymes, and therefore, affects epigenetic mechanisms. Alcohol consumption has been associated with an increase in histone acetylation and a decrease in histone methylation, which leads to gene expression changes. DNA and histone modifications that result from ethanol-induced proteasome inhibition are key players in regulating gene expression, especially genes involved in the cell cycle, immunological responses, and metabolism of ethanol. The present review highlights the consequences of ethanol-induced proteasome inhibition in the nucleus of liver cells that are chronically exposed to ethanol. | Fawzia Bardag-Gorce | 2009 | World Journal of Gastroenterology2009，15，10： | 4 |
| 6 | Bortezomib enhances fatty liver preservation in I nstitut G eorge L opez‐1 solution through adenosine monophosphate activated protein kinase and Akt / mTOR pathways显示文摘 | Mohamed Bejaoui Mohamed Amine Zaouali Emma Folch‐Puy Eirini Pantazi Fawzia Bardag‐Gorce Teresa Carbonell Joan Oliva Antoni Rimola Hassen Ben Abdennebi Joan Roselló‐Catafau | 2014 | J Pharm Pharmacol2014，，1： | 3 |
| 7 | Screening of biological activities of Polygonum maritimum L.from A lgerian coast显示文摘Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(P.maritimum)and to find new actives biomolecules.Methods:The whole plant was collected from the Rechgoune coast(West of Algeria),and methanolic crude extract of aerial parts ofP.maritimum(PMCE)was prepared.The extract was tested against different bacterial strain and tested for his ability to neutralize free radical(DPPH)and to scavenge the H2O2.Results:PMCE had a very high content of total phenol,which was(352.49依18.03)mg/g dry weight,expressed as gallic acid equivalent.PMCE exhibited excellent antioxidant activity,as measured using DPPH and H2O2 scavenging assays.It also showed a high antibacterial activity against gram-positive bacterial strains:Bacillus cereus,Bacillus subtilisandStaphylococcus aureus with an highest MIC of 120μg/mL.Conclusions:The antioxidant and antibacterial activity of the PMCE is probably due to phenolic compounds present in the extract.The contemporary presence of antioxidant and antibacterialactivities in the PMCE suggests that this plant may be a source of bioactive substances with multifaceted activity. | Imad Abdelhamid El-Haci Fawzia Atik Bekkara Wissame Mazari Fay al Hassani Mohamed AmineDidi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 2 |
| 8 | Periodic behavior of groundwater level fluctuations in residential areas显示文摘 | Jaber Almedeij Fawzia Al-Ruwaih | 2006 | Journal of Hydrology2006，，3： | 1 |
| 9 | First and second derivative synchronous fluorescence and speetrophotometrie speetrosccopy , for the simultaneous determination of fexofenadine hydrochloride in presence of its degradation products, application to stability studies显示文摘 | MOHIEKSE FAWZIA A l MANALIE etal | 2011 | Acta Chim Slov2011，58，5： | 1 |
| 10 | Learning Styles of Medical Students at Taibah University:Trends and Implica- tions显示文摘 | Guraya S S Guraya S Y Fawzia A | 2014 | J Res Med Sci2014，19，12： | 1 |
| 11 | Long-term improvement in unsafe injection practices following community intervention显示文摘 | Stephen Luby Fawzia Hoodbhoy Aziz Jan Aly Shah Yvan Hutin | 2004 | International Journal of Infectious Diseases2004，，1： | 1 |
| 12 | Influence of boron concentrations on some metabolites of date palm and sorghum seedlings 显示文摘 | FAWZIA S A YOUSIF MOHAMMED H | 1994 | J Plant Nutr1994，17，： | 1 |
| 13 | Bond char- acteristics between CFRP and steel plates in double strap joints 显示文摘 | Fawzia S Zhao X L Al-Mahaidi R | 2005 | Advances in Steel Construction-An In- ternational Journal2005，1，2： | 1 |
| 14 | Insecticidal and Ovicidal Effects of the Seed Extract of Atriplex Canescens against Culex Quinquefasciatus显示文摘 | Nazar A. Ouda Badia&CloseCurlyQuote a M. Al-Chalabi Fawzia M.R. Al-Charchafchi Zohair H. Mohsen | 1998 | Pharmaceutical Biology1998，，1： | 1 |
| 15 | The p105/50 NF-κB pathway is essential for Mallory body formation显示文摘 | Li Nan Yong Wu Fawzia Bardag-Gorce Jun Li Barbaba A. French La Toyia Wilson Samuel W. French | 2004 | Experimental and Molecular Pathology2004，，3： | 1 |
| 16 | Influence of boron concentrations on some metabolites of date palm and sorghum seedlings显示文摘 | Fawzia S Al - Yousif Mohammed H | 1994 | Journal of Plant Nutrition1994，17，6： | 1 |
| 17 | Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral‐Mediated Diseases显示文摘 | Kusum K. Kharbanda Fawzia Bardag‐Gorce Shirish Barve Patricia E. Molina Natalia A. Osna | 2012 | Alcohol Clin Exp Res2012，，1： | 1 |
| 18 | Insecticidal and Ovicidal Effects of the Seed Extract of Atriplex Canescens against Culex Quinquefasciatus显示文摘 | Nazar A. Ouda Badia&CloseCurlyQuote a M. Al-Chalabi Fawzia M.R. Al-Charchafchi Zohair H. Mohsen | 1998 | Pharmaceutical Biology1998，，1： | 1 |
| 19 | Removal of benzene traces from contaminated water by vacuum membrane distillation显示文摘 | FAWZIA A BANAT JANA SIMANDL | 1996 | Chemical Engineering Science1996，51，8： | 1 |
| 20 | Designing a watershed scorecard as a performance evaluation tool for Ur River watershed,Tikamgarh District,Madhya Pradesh显示文摘The study is an attempt to design a watershed scorecard by identifying and evaluating selected set of indicators,such as surface water quality,ground water quality,soil condition,agriculture condition,and forest condition,which accurately reflect the health of the watershed.Ur River Watershed in Tikamgarh District,Madhya Pradesh was taken as a case study to assess the watershed health.Evaluation was done by calculating different indices for the selected set of indicators and comparing them with the National standards and guidelines.Based on the performance of each indicator,the grades were assigned to the indicators which helped in designing the watershed scorecard.The results revealed that within the watershed,the forest and soil conditions need a considerable plan for improvement in order to maintain the ecosystem whereas the surface water quality,groundwater quality and the agricultural conditions requires protection as well as enhancement in certain areas. | Meeta Gupta V.C.Goyal Fawzia Tarannum Jyoti P.Patil | 2017 | International Soil and Water Conservation Research2017，5，4： | 1 |
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