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| 1 | Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine显示文摘AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and VB.RESULTS: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB. | Ioannis S.Elefsiniotis Antonios Moulakakis Konstantinos D.Pantazis Irene Glynou Ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | HBeAg negative serological status and low viral replication levels characterize chronic hepatitis B virus-infected women at reproductive age in Greece: A one-year prospective single center study显示文摘AIM: To evaluate the seroprevalence of hepatitis B surface antigen (HBsAg) in 13 581 women at reproductive age and the hepatitis B e antigen (HBeAg)/anti-HBe status as well as serum hepatitis B virus (HBV)-DNA levels in a subgroup of HBsAg(+) pregnant women at labor in Greece.METHODS: Serological markers were detected using enzyme immunoassays. Serum HBV-DNA was determined by a sensitive quantitative PCR assay. Statistical analysis of data was based on parametric methodology.RESULTS: Overall, 1.156% of women were HBsAg(+)and the majority of them (71.3%) were Albanian. The prevalence of HBsAg was 5.1% in Albanian women, 4.2%in Asian women and 1.14% in women from Eastem European countries. The prevalence of HBsAg in African (0.36%) and Greek women (0.29%) was very low. Only 4.45% of HBsAg (+) women were also HBeAg(+) whereas the vast majority of them were HBeAg(-)/anti-HBe(+). Undetectable levels of viremia (<200 copies/mL) were observed in 32.26% of pregnant women at labor and 29.03% exhibited extremely low levels of viral replication (<400 copies/mL). Only two pregnant women exhibited extremely high serum HBVDNA levels (>10 000 000 copies/mL), whereas 32.26%exhibited HBV-DNA levels between 1 500 and 40 000copies/mL.CONCLUSION: The overall prevalence of HBsAg is relatively low among women at reproductive age in Greece but is higher enough among specific populations. The HBeAg(-)/anti-HBe(+) serological status and the extremely low or even undetectable viral replicative status in the majority of HBsAg(+) women of our study population, suggest that only a small proportion of HBsAg(+) women in Greece exhibit a high risk for vertical transmission of the infection. | Ioannis S. Elefsiniotis Irene Glynou Ioanna Magaziotou Konstantinos D. Pantazis Nikolaos V. Fotos Hero Brokalaki Helen Kada George Saroglou | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 3 | Serological and virological profile of chronic HBV infected women at reproductive age in Greece显示文摘 | Ioannis S. Elefsiniotis Irene Glynou Hero Brokalaki Ioanna Magaziotou Konstantinos D. Pantazis Aikaterini Fotiou George Liosis Helen Kada George Saroglou | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 2 |
| 4 | Detection of transgenes in soybean via a polymerase chain reaction and a simple bi oluminometric assay based on a universal aequorin labeled oligo nueleotide probe显示文摘 | Glynou K Ioannou P C Christopoulos T K | 2004 | Anal Bioanal Chem2004，378，7： | 1 |
| 5 | One-step purification and refolding of recombinant photoprotein aequorin by immobilized metal-ion affinity chromatography显示文摘 | Glynou K Ioannou P C Christopoulos T K | 2003 | Protein Expr Purif2003，27，2： | 1 |
| 6 | One-step purification and refolding of recombinant photoprotein aequorin by immol/Lobilized metalion aftinity chromatography 显示文摘 | Glynou K Ioannou PC Christopoulos TK | 2003 | Protein Expr Purif2003，27，2： | 1 |
| 7 | One - step purification andrefolding of recombinant photoprotein aequorin by immobilized metal - ion affinity chromatography 显示文摘 | Glynou K Ioannou PC Christopoulos TK | 2003 | Proteia Expression and Purification2003，27，2： | 1 |
| 8 | Oligonucleotide -functionalized gold nanoparticles as probes in a dry - reagent strip biosensor for DNA analysis by hybridization显示文摘 | GLYNOU K LOANNOU P C CHRISTOPOULOS T K | 2003 | Anal Chem2003，75，16： | 1 |
| 9 | Advances in molecular techniques for the detection and quantification of genetically modified organisms显示文摘 | Elenis D S Kalogianni D P Glynou K | 2008 | Anal Bioanal Chem2008，392，3： | 1 |
| 10 | Advances in molecular techniques for the detection and quantification of genetically modified organisms显示文摘 | Dimitrios S. Elenis Despina P. Kalogianni Kyriaki Glynou Penelope C. Ioannou Theodore K. Christopoulos | 2008 | Analytical and Bioanalytical Chemistry2008，，3： | 1 |
| 11 | Advances in molecular techniques for the detection and quantifica- tion of genetically modified organisms 显示文摘 | aElenis D S Kalogianni D P Glynou K | 2008 | Analytical and Bioanalytical Chemistry2008，392，3： | 1 |
| 12 | Advances in molecular techniques for the detection and quantification of genetically modified organisms 显示文摘 | Elenis D Kalogianni D Glynou K | 2008 | Analytical and Bioanalytieal Chemistry2008，，3： | 1 |
| 13 | Rapid genotyping of CYP2D6, CYP2C19 and TPMTpolymorphisms by primer extension reaction in a dipstickformat显示文摘 | Litos I K Emmanouilidou E Glynou K M | 2007 | Anal Bioanal Chem2007，389，6： | 1 |
| 14 | Oligonucleotide-functionalized gold nanoparticles as probes in a dry-reagent strip biosensor for DNA analysis by hybridization 显示文摘 | GLYNOU K IOANNOUP C CHRISTOPOULOS T K | 2003 | Anal Chem2003，75，16： | 1 |
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