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| 1 | Safety of immediate endoscopic sphincterotomy in acutesuppurative cholangitis caused by choledocholithiasis显示文摘AIM: To examine the safety of immediate endoscopic sphincterotomy(EST) in patients with acute suppurative cholangitis(ASC) caused by choledocholithiasis, as compared with elective EST.METHODS: Patients with ASC due to choledocholithiasis were allocated to two groups: Those who underwent EST immediately and those who underwent EBD followed by EST 1 wk later because they were under anticoagulant therapy, had a coagulopathy(international normalized ratio > 1.3, partial thromboplastin time greater than twice that of control), or had a platelet count < 50000 × 103/μL. One of four trainees [200-400 cases of endoscopic retrograde cholangiopancreatography(ERCP)] supervised by a specialist(> 10000 cases of ERCP) performed the procedures. The success and complication rates associated with EST in each group were examined.RESULTS: Of the 87 patients with ASC, 59 were in the immediate EST group and 28 in the elective EST group. EST was successful in all patients in both groups. There were no complications associated with EST in either group of patients, although white blood cell count, C-reactiveprotein, total bilirubin, and serum concentrations of liver enzymes just before EST were significantly higher in the immediate EST group than in the elective EST group.CONCLUSION: Immediate EST can be as safe as elective EST for patients with ASC associated with choledocholithiasis provided they are not under anticoagulant therapy, or do not have a coagulopathy or a platelet count < 50000 × 103/μL. Moreover, the procedure was safely performed by a trainee under the supervision of an experienced specialist. | Tomoyasu Ito Jin Kan Sai Hironao Okubo Hiroaki Saito Shigeto Ishii Ryo Kanazawa Ko Tomishima SumioWatanabe Shuichiro Shiina | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 10 |
| 2 | Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients显示文摘谷胱甘肽 S-transferases (GST ) , superoxide dismutase 2 (SOD2 ) 并且 NAD (P) H:quinone oxidoreductase (NQO1 ) 1 是抗氧化剂酶基因。GST, SOD2 和 NQO1 的多型性被报导了影响单个危险性到各种各样的疾病。在更早的研究,我们获得了有精索静脉曲张的谷胱甘肽 S-transferase T1 (GSTT1 )-wt 病人的一个子集可以展出的初步的调查结果对 varicocelectomy 的好反应。在这研究,我们扩大了更早的学习在不肥沃的人口决定每基因的遗传型的分发并且评估这些基因的多型性是否影响精索静脉曲张的外科的治疗的结果。我们分析了 72 个不肥沃的精索静脉曲张病人,没有精索静脉曲张的 202 个不肥沃的病人和 101 男控制。GST 的遗传型被聚合酶链反应(PCR ) 决定。SOD2 和 NQO1 的 Genotyping 用 PCR 限制碎片长度多型性(PCR-RFLP ) 被执行方法。对 varicocelectomy 的显著地更好的回答分别地与 GSTT1 空的遗传型(35.3%) 或 NQO1-Pro/Ser 遗传型(45.2%) 比在那些与 GSTT1-wt 遗传型(63.2%) 和 NQO1-Ser/Ser 遗传型(80.0%) 在病人被发现。谷胱甘肽 S-transferase M1/T1, SOD2 和 NQO1 遗传型的频率没在精索静脉曲张病人,自发的不肥沃的病人和男控制之中显著地不同。GSTT1 遗传型在 varicocelectomy 以后与精液参数的改进被联系。因为有 NQO1-Ser/Ser 遗传型的病人的数字不是足够的得出明确的结论,有 varicocelectomy 的 NQO1 遗传型的协会要求进一步的调查。 | Kentaro Ichioka Kanji Nagahama Kazutoshi Okubo Takeshi Soda Osamu Ogawa Hiroyuki Nishiyama | 2009 | Asian Journal of Andrology2009，11，3： | 7 |
| 3 | 回廊 laparoscopic 胆囊炎: 在在日本的一所社区医院的天大小写对一夜的外科的审计显示文摘 AIM: To evaluate the applicability and safety of ambulatory laparoscopic cholecystectomy (LC) and to compare day case and overnight stay LC. METHODS: Data were collected retrospectively and consecutively for day case and overnight stay LC patients from July 1, 2009 to April 30, 2011. Outcomes were analyzed for patient demographics, operation time, blood loss during operation and frequency and reasons for unexpected or prolonged hospitalization in each group. RESULTS: There was no hospital mortality and no patient was readmitted with serious morbidity after discharge. 50 patients received a day case LC and 19 had an overnight stay LC. There was a significant difference in age between both groups (P<0.02). There were no significant differences between the day case LC performed (n=41) and failed (n=9) groups and between the day case LC performed and the one night stay LC (n=12) groups. There was a significant difference in age between the one night stay and more nights stay LC groups (P<0.05). Thus, elderly patients showed a tendency to like to stay in hospital rather than being a day case. The proportion of unexpected or prolonged hospitalization was not significantly different between the day case and overnight stay LC groups, when the patient’s request was excluded. CONCLUSION: Day case LC can be performed with a low rate of complications. In overnight stay patients, there are many who could be performed safely as a day case. Moreover, we need to take special care to treat elderly patients. | Atsushi Sato Yukio Terashita Yoichiro Mori Tomotaka Okubo | 2012 | World Journal of Gastrointestinal Surgery2012，4，12： | 7 |
| 4 | Association between endotoxemia and histological features of nonalcoholic fatty liver disease显示文摘AIM To assess whether surrogate biomarkers of endotoxemia were correlated with the histological features ofnonalcoholic fatty liver disease(NAFLD).METHODS One hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide(LPS)-binding protein(LBP) and anti-endotoxin core immunoglobulin G(Endo Cab Ig G) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores. RESULTS Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis(NASH) patients as compared with nonalcoholic fatty liver(NAFL) subjects and was correlated with steatosis(r = 0.38, P < 0.0001) and ballooning scores(r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum Endo Cab Ig G concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between Endo Cab Ig G and histological findings. CONCLUSION LBP/Endo Cab Ig G were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. | Hiroyuki Kitabatake Naoki Tanaka Naoyuki Fujimori Michiharu Komatsu Ayaka Okubo Kyogo Kakegawa Takefumi Kimura Ayumi Sugiura Tomoo Yamazaki Soichiro Shibata Yuki Ichikawa Satoru Joshita Takeji Umemura Akihiro Matsumoto Masayoshi Koinuma Kenji Sano Toshifumi Aoyama Eiji Tanaka | 2017 | World Journal of Gastroenterology2017，23，4： | 5 |
| 5 | Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study显示文摘AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma(HCC) treated with radiofrequency ablation (RFA) andCyberKnife?.METHODS: Seventy three consecutive patients withinitial solitary HCC treated with RFA (38 patients;RFA group) and CyberKnife (35 patients; CK group)were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two groups.These were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was investigated.RESULTS: In background factors, age was significantlyhigher (P = 0.005) and the tumor diameter wassignificantly larger (P = 0.001) in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively (P= 0.71); the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively (P= 0.91); and the 1-year cumulative survival rates were100% and 95.2%, respectively (P = 0.075), showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group (P = 0.003) and significantly higher than thescore before treatment (P = 0.034).CONCLUSION: The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto Yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino | 2015 | World Journal of Gastroenterology2015，21，48： | 4 |
| 6 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 7 | Gangliocytic paraganglioma: An overview and future perspective显示文摘Gangliocytic paraganglioma(GP) is rare neuroendocrine tumor(NET) with a good prognosis that commonly arising from duodenum. Although the tumor is characterized by its unique triphasic cells(epithelioid, spindle, and ganglion-like cells), the proportions of these three tumor cells vary widely from case to case,and occasionally, morphological and immunohistochemical similarities are found between GP and NET G1(carcinoid tumors). Further, GP accounts for a substantial number of duodenal NETs. Therefore, GP continues to be misdiagnosed, most often as NET G1. However, GP has a better prognosis than NET G1, and it is important to differentiate GP from NET G1. In this article, I wish to provide up-to-date clinicopathological information to help oncologists gain better insight into the diagnosis and clinical management of this tumor. | Yoichiro Okubo | 2019 | World Journal of Clinical Oncology2019，10，9： | 4 |
| 8 | Fulminant gastrointestinal graft-versus-host disease concomitant with cytomegalovirus infection:Case report and literature review显示文摘Here,we report a case of fulminant gastrointestinal graft-versus-host disease(GI-GVHD) with cytomegalovirus(CMV) infection in 44-year-old woman.Despite the difficulties associated with the treatment of GIGVHD and GI-CMV disease,the mucosal findings and the clinical course showed marked improvements during long-term clinical observation.The endoscopic findings were remarkable,with diffuse sloughing mucosa in the stomach and highly active inflammation and deep discrete ulcers throughout the colon.Changes in the CMV quantitative polymerase chain reaction results were correlated with the endoscopic mucosal findings and were useful for assessing the efficacy of the treatment.Although a definite diagnosis of GI-GVHD is generally made by endoscopy with biopsy,the gross appearance of this disease can vary depending on the endoscopy.In this paper,we also conduct a literature review of patients with GI-GVHD. | Hidetaka Okubo Naoyoshi Nagata Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，4： | 3 |
| 9 | IN VIVO ENDOSCOPY OF THE SEMINAL VESICLE显示文摘 | KAZUTOSHI OKUBO SHINYA MAEKAWA YOSHITAKA AOKI TAKASHI OKADA HIROSHI MAEDA YOICHI ARAI | 1998 | The Journal of Urology1998，，6： | 2 |
| 10 | Endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of gastrointestinal stromal tumors in the stomach显示文摘 | Kenji Okubo Kenji Yamao Tsuneya Nakamura Masahiro Tajika Akira Sawaki Kazuo Hara Hiroki Kawai Yoshitaka Yamamura Yoshinari Mochizuki Takashi Koshikawa Ken-ichi Inada | 2004 | Journal of Gastroenterology2004，，8： | 2 |
| 11 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 12 | Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 13 | Development of bamboo-based polymer composites and their mechanical properties显示文摘 | Kazuya Okubo Toru Fujii Yuzo Yamamoto | 2003 | Composites Part A2003，，3： | 2 |
| 14 | Culture of endodermal stem/progenitor cells of the mouse tongue 显示文摘 | Luo X Okubo T Randell S | 2009 | In Vitro Cell Dev Biol Anim2009，45，12： | 1 |
| 15 | Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular ultrasound显示文摘 | Kawasaki M Sano K Okubo M | 2005 | J Am Coll Cardiol2005，45，12： | 1 |
| 16 | Estimation of morphology composite polymer emulsion particles by soap titration method 显示文摘 | OKUBO M YAMADA A MATSUMOTO T | 1980 | J Polym Chem Ed1980，，16： | 1 |
| 17 | Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites 显示文摘 | Bessho K Fujimura K | 2000 | Int J Oral Maxillofac Surg2000，29，： | 1 |
| 18 | Loading rate dependence of class II rock behaviour in uniaxial and triaxial compression tests-an application of a proposed new control method显示文摘 | OKUBO S NISHIMATSU Y HE C R | 1990 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1990，27，6： | 1 |
| 19 | The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix显示文摘 | Okubo T Nagai F Seto T | 2000 | Biol Pharm Bull2000，23，： | 1 |
| 20 | Primary retroperitoneal pure choriocarcinoma显示文摘 | Okubo Y Fukui I Sakano Y | 1995 | Nippon Hinyokika Gakkai Zasshi1995，86，12： | 1 |
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