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| 1 | Utility of co-transplanting mesenchymal stem cells in islet transplantation显示文摘Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function. | Naoaki Sakata Masafumi Goto Gumpei Yoshimatsu Shinichi Egawa Michiaki Unno | 2011 | World Journal of Gastroenterology2011，17，47： | 5 |
| 2 | 包含的小岛移植: 过去,现在和未来显示文摘 Islet transplantation could become an ideal treatment for severe diabetes to prevent hypoglycemia shock and irreversible diabetic complications, once some of the major and unresolved obstacles are overcome, including limited donor supplies and side effects caused by permanent immunosuppressant use. Approximately 30 years ago, some groups succeeded in improving the blood glucose of diabetic animals by transplanting encapsulated islets with semi-permeable membranes consisting of polymer. A semi-permeable membrane protects both the inner islets from mechanical stress and the recipient’s immune system (both cellular and humoral immunities), while allowing bidirectional diffusion of nutrients, oxygen, glucose, hormones and wastes, i.e., immune-isolation. This device, which enables immune-isolation, is called encapsulated islets or bio-artificial pancreas. Encapsulation with a semipermeable membrane can provide some advantages: (1) this device protects transplanted cells from the recipient’s immunity even if the xenogeneic islets (from large animals such as pig) or insulin-producing cells are derived from cells that have the potential for differentiation (some kinds of stem cells). In other words, the encapsulation technique can resolve the problem of limited donor supplies; and (2) encapsulation can reduce or prevent chronic administration of immunosuppressants and, therefore, important side effects otherwise induced by immunosuppressants. And now, many novel encapsulated islet systems have been developed and are being prepared for testing in a clinical setting. | Naoaki Sakata Shoichiro Sumi Gumpei Yoshimatsu Masafumi Goto Shinichi Egawa Michiaki Unno | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，1： | 4 |
| 3 | Chronic pancreatitis caused by an autoimmune abnormality显示文摘 | Kenji Yoshida Fumitake Toki Tadashi Takeuchi Shin-Ichiro Watanabe Keiko Shiratori Naoaki Hayashi | 1995 | Digestive Diseases and Sciences1995，，7： | 4 |
| 4 | Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis显示文摘 | Chikako Namikawa Zhang Shu-Ping John Raynor Vyselaar Yasuko Nozaki Yoshihisa Nemoto Masafumi Ono Naoaki Akisawa Toshiji Saibara Makoto Hiroi Hideaki Enzan Saburo Onishi | 2004 | Journal of Hepatology2004，，5： | 3 |
| 5 | Successful endovascular treatment of endoscopically unmanageable hemorrhage from a duodenal ulcer fed by a renal artery: A case report显示文摘A 52-year-old woman was admitted with hypovolemic shock. Emergency endoscopy revealed three hemorrhagic duodenal ulcers(all stage A1) with exposed vessels. Two ulcers were successfully treated by endoscopic clipping; however, the remaining ulcer on the posterior wall of the horizontal portion of the duodenum could not be clipped. Because her vital signs were rapidly worsening, we performed transcatheter arterial embolization(TAE) as it is less invasive than surgery. Computed tomography aortography showed that the duodenal hemorrhage was sourced from the lower branch of the right renal artery. In general, the duodenum is fed by branches from the gastroduodenal artery or superior mesenteric artery. However, this patient had three right renal arteries. The lower branch of the right renal artery at the L3 vertebral level was at the same level as the horizontal portion of the duodenum. Complete hemostasis was achieved by TAE using metallic coils and n-butyl-2-cyanoacrylate. After TAE, she recovered from the hypovolemic shock and was discharged from hospital. She has had no recurrence of the hemorrhagic duodenal ulcer for over 1 yr, and followup endoscopy showed no necrosis or stricture of the duodenum. Although she developed a small infarct of her right kidney, her renal function was satisfactory. In summary, the present case is the first reported case of hemorrhagic duodenal ulcer in which the culprit vessel was a renal artery that was successfully treated by TAE. Computed tomography aortography before TAE provides valuable information regarding the source of a duodenal hemorrhage. | Shimpei Anami Hiroki Minamiguchi Naoaki Shibata Takao Koyama Hirotatsu Sato Akira Ikoma Motoki Nakai Takuji Yamagami Tetsuo Sonomura | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 6 | Chronic pancreatitis caused by an autoimmune abnormality显示文摘 | Kenji Yoshida MD Fumitake Toki MD Tadashi Takeuchi MD Shin-Ichiro Watanabe MD Keiko Shiratori MD Naoaki Hayashi MD | 1995 | Digestive Diseases and Sciences1995，，7： | 2 |
| 7 | Chronic pancreatitis caused by an autoimmune abnormality显示文摘 | Kenji Yoshida MD Fumitake Toki MD Tadashi Takeuchi MD Shin-Ichiro Watanabe MD Keiko Shiratori MD Naoaki Hayashi MD | 1995 | Digestive Diseases and Sciences1995，，7： | 2 |
| 8 | Descending Branch of the Perforating Branch of the Peroneal Artery Perforator–Based Island Flap for Reconstruction of the Lateral Malleolus with Minimal Invasion显示文摘 | Shinsuke Akita Nobuyuki Mitsukawa Naoaki Rikihisa Juni Himeta Yoshitaka Kubota Natsuko Shimada Hideki Tokumoto Takane Suzuki Kaneshige Satoh | 2013 | Plastic and Reconstructive Surgery2013，，2： | 2 |
| 9 | Bone marrow cells produce nerve growth factor and promote angiogenesis around transplanted islets显示文摘AIM:To clarify the mechanism by which bone marrow cells promote angiogenesis around transplanted islets.METHODS: Streptozotocin induced diabetic BALB/ c mice were transplanted syngeneically under the kidney capsule with the following: (1) 200 islets (islet group: n=12), (2) 1-5×106 bone marrow cells (bone marrow group: n=11), (3) 200 islets and 1-5×106 bone marrow cells (islet + bone marrow group: n= 13), or (4) no cells (sham group:n=5). All mice were evaluated for blood glucose, serum insulin, serum nervegrowth factor (NGF) and glucose tolerance (GTT) up to postoperative day (POD) 14. Histological assessment for insulin, von Willebrand factor (vWF) and NGF was performed at POD 3, 7 and 14.RESULTS: Blood glucose level was lowest and serum insulin was highest in the islet + bone marrow group. Serum NGF increased in islet, bone marrow, and islet + bone marrow groups after transplantation, and there was a significant difference (P=0.0496, ANOVA) between the bone marrow and sham groups. The number of vessels within the graft area was signif icantly increased in both the bone marrow and islet + bone marrow groups at POD 14 as compared to the islet alone group (21.2 ± 3.6 in bone marrow, P=0.01, vs islet group, 22.6 ± 1.9 in islet + bone marrow, P = 0.0003, vs islet group, 5.3 ± 1.6 in islet-alone transplants). NGF was more strongly expressed in bone marrow cells compared with islets. CONCLUSION: Bone marrow cells produce NGF and promote angiogenesis. Islet co-transplantation with bone marrow is associated with improvement of islet graft function. | Naoaki Sakata Nathaniel K Chan John Chrisler Andre Obenaus Eba Hathout | 2010 | World Journal of Gastroenterology2010，16，10： | 2 |
| 10 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 11 | Serological survey of Babesia bovis and Babesia bigemina in cattle in South Africa显示文摘 | Mohamad Alaa Terkawi Oriel M.M. Thekisoe Charles Katsande Abdalla A. Latif Ben J. Mans Olivier Matthee Nozipho Mkize Nomsa Mabogoane Frances Marais Naoaki Yokoyama Xuenan Xuan Ikuo Igarashi | 2011 | Veterinary Parasitology2011，，2： | 1 |
| 12 | Seroprevalence of Babesia infections of dairy cows in northern Thailand显示文摘 | Hiroshi Iseki Lijia Zhou Chulmin Kim Tawin Inpankaew Chainirun Sununta Naoaki Yokoyama Xuenan Xuan Sathaporn Jittapalapong Ikuo Igarashi | 2010 | Veterinary Parasitology2010，，3： | 1 |
| 13 | Chronic pancreatitis caused by an autoimmune abnormality显示文摘 | Kenji Yoshida MD Fumitake Toki MD Tadashi Takeuchi MD Shin-Ichiro Watanabe MD Keiko Shiratori MD Naoaki Hayashi MD | 1995 | Digestive Diseases and Sciences1995，，7： | 1 |
| 14 | 显示文摘 | Naoaki Y Tsutomu O | 2003 | J Power Sources2003，，： | 1 |
| 15 | Thymosin α1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts显示文摘 | Chun-Lin Li Ting Zhang Toshiji Saibara Yoshihisa Nemoto Masafumi Ono Naoaki Akisawa Shinji Iwasaki Takashi Maeda Saburo Onishi | 2002 | International Immunopharmacology2002，，1： | 1 |
| 16 | Effect of topical application of raspberry ketone on dermal production of insulin - like growth factor - I in mice and on hair growth and skin elasticity in humans 显示文摘 | Harada Naoaki Okajima Kenji Narimatsu Noriko | 2008 | Growth Hormone & IGF Research2008，18，： | 1 |
| 17 | Comparative evaluation of the sensitivity of LAMP, PCR and in vitro culture methods for the diagnosis of equine piroplasmosis显示文摘 | Andy Alhassan Yadav Govind Nguyen Thanh Tam Oriel M. M. Thekisoe Naoaki Yokoyama Noboru Inoue Ikuo Igarashi | 2007 | Parasitology Research2007，，5： | 1 |
| 18 | Novel Lithium Insertion Material of LiNi1/3Co1/3Mn1/3O2 for Advanced Lithium-ion Batteries显示文摘 | Naoaki Y Tsutomu O | 2003 | J Power Sources2003，，119121： | 1 |
| 19 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 20 | Thin film lithium-ion battery with amorphous solid e- lectrolyte fabricated by pulsed laser deposition显示文摘 | Naoaki Kuwata J unichi Kawamura Keisuke Toribami | 2004 | J Elec- trochemistry Communications2004，6，： | 1 |
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