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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | The formation of two layers in the internal oxidation of binary alloys by two oxidations in the absence of external scales 显示文摘 | Gesmundo F Niu Y | 1999 | Oxidation of Metals1999，51，12： | 1 |
| 5 | Arg-Gly-Asp (RGD) modified biomimetic polymeric materials显示文摘 | Niu X F Wang Y L Luo Y F | 2005 | J Mater Sci Techn2005，21，4： | 1 |
| 6 | Method for large-scale isolation and purification of R-phycoerythrin from red alga Polysiphonia urceolata Grev显示文摘 | NIU J F WANG G C TSENG C K | 2006 | Protein Expression and Purification2006，49，： | 1 |
| 7 | Activation of ERK1/2- CREB pathway during potentiating synaptic transmission of (-) clausenamide in rat dentate gyrus 显示文摘 | HU J F NIU F NING N | 2012 | J Asian Nat Prod Res2012，46，3： | 1 |
| 8 | Characterization of a novel piscidin- like antimicrobial peptide fl'om Pseudosciaena crocea and its immune response to Cryptocaryon irritar: 显示文摘 | Niu S F Jin Y Xu X | 2013 | Fish Shellfish Immun2013，，2： | 1 |
| 9 | 查看详情显示文摘 | Fan H Xu X F Niu X J | | 0，，： | 1 |
| 10 | Yin and Yang of PDGF-mediated signaling pathway in the context of HIV infection and drug abuse 显示文摘 | Yao H Bethel-Brown C Niu F | 2014 | J Neuroimmune Pharmacol2014，9，2： | 1 |
| 11 | Image resizing via non-homoge- neous warping 显示文摘 | Niu Y Z Liu F Li X Q | 2012 | Multimedia Tools and Applications2012，56，3： | 1 |
| 12 | Talanta显示文摘 | Li Y H Niu W F Lu J R | 2007 | 71:11242007，71，： | 1 |
| 13 | Electrical resistivity evolution in the annealed amorphous Fe78Si9B13 ribbons 显示文摘 | Wang W M Niu Y C Wang F | 2008 | Journal of Non-Crystalline Solids2008，354，30： | 1 |
| 14 | Reconstruction of old orbital wall fractures with mandibular outer cortex显示文摘 | LIU W NIU F ZHANG Z Y | 2010 | J Craniofac Surg2010，21，4： | 1 |
| 15 | Agonists at PPAR-gamma suppress angiotensin II induced production of plasminogen activator inhibitor 1 and extracellular matrix in rat cardiac fibroblasts 显示文摘 | HAO G H NIU X L GAO D F | 2008 | Br J Pharmacol2008，153，7： | 1 |
| 16 | Adsorption of phosphorus on sediments from the Three Gorges Reservoir (China) and the relation with sediment compositions 显示文摘 | Wang Y Z Shen Z Y Niu J F | 2009 | Journal of Hazardous Materials2009，162，1： | 1 |
| 17 | Graphene-based non-noble-metal Co/N/C catalyst for oxygen reduction reaction in alkaline solution显示文摘 | Niu K X Yang B P Cui J F | 2013 | J Power Sources2013，243，6： | 1 |
| 18 | Electrochemical deposition and characterization of diamond-like carbon films doped with sur- face-capped silica nanoparticles显示文摘 | Niu F Ma J Y Yu L G | 2013 | Surface ~ Coatings Tech nology2013，221，2： | 1 |
| 19 | Three-dimensional nonlinear analysis for temperature characteristic of ventilated embankment in permafrost regions显示文摘 | Lai Y M Wang Q S Niu F J | 2004 | Cold Regions Science and Technology2004，38，23： | 1 |
| 20 | An invasive aster (Ageratina adenophora )invades and dominates forest understo- ries in China: altered soil microbial communities facilitate the invader and inhibit natives 显示文摘 | NIU H LIU W WAN F | 2007 | Plant and soil2007，294，1： | 1 |
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