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| 1 | Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AM PK显示文摘 | Feng ZOU Xian-qing MAO Nian WANG Jian LIU Jing-ping OU-YANG | 2009 | Acta Pharmacologica Sinica2009，30，12： | 38 |
| 2 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 3 | Pyroptosis: mechanisms and diseases显示文摘Currently,pyroptosis has received more and more attention because of its association with innate immunity and disease.The research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of tumors.The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds.In this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor treatment.In addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis.In brief,pyroptosis is a double-edged sword for tumors.The rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis. | Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 26 |
| 4 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 5 | Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases:An update显示文摘Long-chain acyl-Co A synthetase(ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-Co As, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or lossof-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Changes in the types and amounts of fatty acids, in turn, can alter the expression of intracellular ACSLs. ACSL family members affect not only the proliferation of normal cells, but the proliferation of malignant tumor cells. They also regulate cell apoptosis through different signaling pathways and molecular mechanisms. ACSL members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to liver diseases and metabolic diseases, such as fatty liver disease, obesity, atherosclerosis and diabetes. They are also linked to neurological disorders and other diseases. However, the mechanisms are unclear. This review addresses new findings in the classification and properties of ACSLs and the fatty acid metabolismassociated effects of ACSLs in diseases. | Sheng Yan Xue-Feng Yang Hao-Lei Liu Nian Fu Yan Ouyang Kai Qing | 2015 | World Journal of Gastroenterology2015，21，12： | 18 |
| 6 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
| 7 | Associations of blood pressure and arterial compliance with occupational noise exposure in female workers of textile mill显示文摘在那里的背景是噪音暴露的动脉的依从上的很少研究。学习是理解在听见损失,血压和在噪音在工作地点铺平的纺织品 mill.Methods 暴露了到职业噪音的女工人的动脉的依从之间的关系的这的目的与一 HS6288 健全水平米被测量。堆积噪音暴露(CNE ) 根据噪音紧张和暴露时期被计算。听说能力和动脉的依从在 618 噪音被测量暴露了工人。数据库与 EpiData 被建立,统计分析与噪音铺平的 SAS 软件 9.1.3 .Results 被执行是到 113.5dB (A) ,在监视地点的 92.5% 噪音的层次在国家标准上是的 80.1dB (A) 。高频率听觉损失(HFHL ) 的发生是 24.43% ,语言频率听觉缺陷(LFHI ) 是 0.81% 。高血压的发生是 7.93% 。收缩血压(SBP ) 和在高频率听觉损失组的心脏舒张的血压(DBP ) 比在正常听觉组(P0.05 ) 的那些显著地高,当 C1 (大动脉依从) 和 C2 (小动脉依从) 显著地更低时(P0.05 ) 。高血压组的高频率听觉阀值(HFHT ) 比在正常血压组(P0.05 ) 显著地高,当 C1 和 C2 显著地更低时(P0.05 ) 。 C1 和 C2 与 HFHT 有否定关联, SBP , DBP ,动脉的压力(地图)的平均数,脉搏压力( PP )和多重回归分析的 .The 显示出的脉搏率( PR )( P0.05 )血压和 PR 是 C1 和 C2.LFHT 上的主要影响因素,这是对 C2 的影响, C1.Conclusions 纺织品工厂噪音污染上的 HFHT 是很严肃的并且在工人的家上有明显的影响听觉的功能。有 Iow 动脉依从或与高血压的女工人可能正在受不了听觉损失;那些与噪音导致了听说如果她常常暴露于大声工业的噪音,损失可能正在患高血压。 | NI Chun-hui CHEN Zhi-yong ZHOU Yin ZHOU Jian-wei Pan Jing-jing LIU Nian WANG Jun LIANG Chen-ke ZHANG Zhi-zhong ZHANG Yu-jun | 2007 | Chinese Medical Journal2007，，15： | 12 |
| 8 | CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation显示文摘The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP. | Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU Yimin LIU Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，8： | 12 |
| 9 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 10 | Analysis of 2D Flow and Heat Transfer Modeling in Fracture of Porous Media显示文摘Heat and mass transfer between porous media and fluid is a complex coupling process, which is widely used in various fields of engineering applications, especially for natural and artificial fractures in oil and gas extraction. In this study, a new method is proposed to deal with the flow and heat transfer problem of steady flow in a fracture. The fluid flow in a fracture was described using the same method as Mohais, who considered a fracture as a channel with porous wall, and the perturbation method was used to solve the mathematical model. Unlike previous studies, the shear jump boundary condition proposed by Ochoa-Tapia and Whitaker was used at the interface between the fluid and porous media. The main methods were perturbation analysis and the application of shear jump boundary conditions. The influence of permeability, channel width, shear jump degree and effective dynamic viscosity on the flow and heat transfer in the channel was studied by analysing the analytical solution. The distribution of axial velocity in the channel with the change of the typical parameters and the sensitivity of the heat transfer was obtained. | GUO Chunsheng NIAN Xianbo LIU Yong QI Chao SONG Jinsheng YU Wenhe | 2017 | Journal of Thermal Science2017，26，4： | 9 |
| 11 | Multi-microgrid Energy Management Systems: Architecture, Communication, and Scheduling Strategies显示文摘The increasing penetration of various distributed and renewable energy resources at the consumption premises,along with the advanced metering,control and communication technologies,promotes a transition on the structure of traditional distribution systems towards cyber-physical multi-microgrids(MMGs).The networked MMG system is an interconnected cluster of distributed generators,energy storage as well as controllable loads in a distribution system.And its operation complexity can be decomposed to decrease the burdens of communi-cation and control with a decentralized framework.Consequently,the multi-microgrid energy management system(MIVIGEIV1S)plays a significant role in improving energy efficiency,power quality and reliability of distribution systems,especially in enhancing system resiliency during contingencies.A comprehensive overview on typical functionalities and architectures of MMGEMS is illustrated.Then,the emerging communication technologies for information monitoring and interaction among MMG clusters are surveyed.Furthermore,various energy scheduling and control strategies of MMGs for interactive energy trading,multi-energy management,and resilient operations are thoroughly analyzed and investigated.Lastly,some challenges with great importance in the future research are presented. | Bin Zhou Jianting Zou Chi Yung Chung Huaizhi Wang Nian Liu Nikolai Voropai Daosen Xu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，3： | 8 |
| 12 | Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis显示文摘AIM:To investigate the potential anti-Helicobacter pylori(H.pylori ) and anti-inflammation in vivo effects of two lactobacillus strains from human stomach.METHODS:Forty H.pylori infected Balb/c mice were randomly divided into 4 groups:proton pump inhibitor and antibiotics triple treated group,Lactobacillus fermenti(L.fermenti ) treated group,Lactobacillus acidophilus treated group and normal saline control group.Ten uninfected mice were also included as blank control group.The infection of H.pylori was detected by rapid urease tests,Giemsa staining and bacterial culture.The colonization of H.pylori was assessed in bacterial density score and gastric inflammation was assessed in histological score.The colonization of L.fermenti was performed by fluorescent probe.RESULTS:Histopathologic evaluation showed significant release of mucosal inflammation in gastric antrum and gastric body in lactobacillus treated groups and triple treated group.H.pylori eradication rate in both lactobacillus treated groups and triple treated group were higher than normal saline control group.Lactobacillus treated groups and triple treated group showed significant decrease of H.pylori bacterial density.CONCLUSION:Both lactobacillus strains have a significant anti-H.pylori activity;L.fermenti displays more efficient antagonistic activity in vivo against H.pylori infection. | Cui, Yi Wang, Chun-Lian Liu, Xiao-Wei Wang, Xue-Hong Chen, Lin-Lin Zhao, Xin Fu, Nian Lu, Fang-Gen | 2010 | World Journal of Gastroenterology2010，16，4： | 7 |
| 13 | Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells(MSCs)显示文摘Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the treatment of cartilage injuries.Bone morphogenetic protein 2(BMP2)induces effective chondrogenesis of mesenchymal stem cells(MSCs)and can thus be explored as a potential therapeutic agent for cartilage defect repair.However,BMP2 also induces robust endochondral ossification.Although the precise mechanisms through which BMP2 governs the divergence of chondrogenesis and osteogenesis remain to be fully understood,blocking endochondral ossification during BMP2-induced cartilage formation may have practical significance for cartilage tissue engineering.Here,we investigate the role of Sox9-donwregulated Smad7 in BMP2-induced chondrogenic differentiation of MSCs.We find that overexpression of Sox9 leads to a decrease in BMP2-induced Smad7 expression in MSCs.Sox9 inhibits BMP2-induced expression of osteopontin while enhancing the expression of chondrogenic marker Col2a1 in MSCs.Forced expression of Sox9 in MSCs promotes BMP2-induced chondrogenesis and suppresses BMP2-induced endochondral ossification.Constitutive Smad7 expression inhibits BMP2-induced chondrogenesis in stem cell implantation assay.Mouse limb explant assay reveals that Sox9 expands BMP2-stimulated chondrocyte proliferating zone while Smad7 promotes BMP2-intitated hypertrophic zone of the growth plate.Cell cycle analysis indicates that Smad7 induces significant early apoptosis in BMP2-stimulated MSCs.Taken together,our results strongly suggest that Sox9 may facilitate BMP2-induced chondrogenesis by downregulating Smad7,which can be exploited for effective cartilage tissue engineering. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L.Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M.Tsai Tong-Chuan He Wei Huang | 2017 | Genes & Diseases2017，4，4： | 7 |
| 14 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 15 | DNA cleavage mediated by water-soluble manganese corrole显示文摘水的 DNA 像核酸酶的活动可溶的锰 corrole 5, 10, 15-tris (N-methyl-4-pyridyl )- corrolatomanganese (III )(MnIIITMPyC ) 被调查了。MnIIITMPyC 可以经由由吸收系列,粘性大小和 CD 系列显示了的外面的沟绑定模式强烈绑在 DNA。MnIIITMPyC 面对 hydroperoxide 在 DNA 氧化劈开展出了优秀催化活动。 | Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang | 2011 | Chinese Chemical Letters2011，22，1： | 6 |
| 16 | Nanomaterials for electrochemical energy storage显示文摘 | Nian Liu Weiyang Li Mauro Pasta Yi Cui | 2014 | Frontiers of physics2014，9，3： | 6 |
| 17 | 认知语言学研究的“实证周期”显示文摘本文从'实证——定量——多元统计'的思路论证了认知语言学方法论的发展理据,指出认知语言学研究应遵循'实证周期'的指导思想,对语言现象进行客观、科学的描述。并分别从研究假设的提出、实证数据的收集以及数据的定量分析三个方面具体阐释了如何在'实证周期'思想的指导下进行认知语言学研究。 | 张炜炜 Nian Liu | 2015 | 外语研究2015，0，3： | 5 |
| 18 | Tribo-informatics:Concept,architecture,and case study显示文摘Friction plays a vital role in energy dissipation,device failure,and even energy supply in modern society.After years of research,data and information on tribology research are becoming increasingly available.Because of the strong systematic and multi-disciplinary coupling characteristics of tribology,tribology information is scattered in various disciplines with different patterns,e.g.,technical documents,databases,and papers,thereby increasing the information entropy of the system,which is inconducive to the preservation and circulation of research information.With the development of computer and information science and technology,many subjects have begun to be combined with information technology,and multi-disciplinary informatics has been born.This paper describes the combination of information technology with tribology research,presenting the connotation and architecture of tribo-informatics,and providing a case study on implementing the proposed concept and architecture.The proposal and development of tribo-informatics described herein will improve the research efficiency and optimize the research process of tribology,which is of considerable significance to the development of this field. | Zhinan ZHANG Nian YIN Shi CHEN Chengliang LIU | 2021 | Friction2021，9，3： | 5 |
| 19 | A new cerebroside and its anti-proliferation effect on VSMCs from the radix of Cyperus rotundus L.显示文摘A new cerebroside,1-O-(β-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2′R)-2’-hydroxylignoceranoylamino]-4,8-tetradecene-3- diol was isolated from the 60%EtOH extract of traditional Chinese medical plant Cyperus rotundus L.Its structure was determined on the basis of spectroscopic data.This new compound showed anti-proliferation effect on vascular smooth muscle cells(VSMCs). | Pei Liu Li Liu Yu Ping Tang Jin Ao Duan Nian Yun Yang | 2010 | Chinese Chemical Letters2010，21，5： | 5 |
| 20 | Multi-objective Optimal Generation Dispatch With Consideration of Operation Risk显示文摘 | QIU Wei ZHANG Jianhua LIU Nian ZHU Xingyang LIU Lihua | 2012 | 中国电机工程学报2012，32，22： | 4 |
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