|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platinum drugs:from Pt(Ⅱ)compounds,Pt(Ⅳ)prodrugs,to Pt nanocrystals/nanoclusters显示文摘Platinum(Pt) based drugs, such as cisplatin, are widely used as anti-cancer agents, but their severe adverse reactions and resistance of cancer patients have limited their board clinical use. For the last few decades, Pt(Ⅱ) compounds, Pt(Ⅳ) prodrugs as well as smart drug delivery systems have been developed to overcome these problems. However, most conventional strategies rely on the similar anti-cancer mechanism with cisplatin and consequently only achieve limited success. Recently, Pt nanocrystals/nanoclusters(Pt NCs), with a brand new anti-cancer mechanism, have shown a promising potential in targeted cancer therapy, especially in Pt resistance circumvention. This review is helpful to understand the research strategies of Pt drugs, particularly, the recent developments and medical applications of Pt NCs. | Xi Hu Fangyuan Li Nabila Noor Daishun Ling | 2017 | Science Bulletin2017，62，8： | 4 |
| 2 | Degradation of direct azo dye by Cucurbita pepo free and immobilized peroxidase显示文摘Enzymatic decolourization of the azo dye,Direct Yellow(DY106) by Cucurbita pepo(courgette) peroxidase(CP) is a complex process,which is greatly affected by pH,temperature,enzyme activity and the concentrations of H2O2 and dye.Courgette peroxidase was extracted and its performance was evaluated by using the free-CP(FCP) and immobilized-CP(ICP) forms in the decolourization of DY106.Immobilization of peroxidase in calcium alginate beads was performed according to a strategy aiming to minimize enzyme leakage and keep its activity at a maximum value by optimizing sodium alginate content,enzyme loading and calcium chloride concentration.The initial conditions at which the highest DY106 decolourization yield was obtained were found at pH 2,temperature 20℃,H2O2 dose 1 mmol/L(FCP) and 100 mmol/L(ICP).The highest decolourization rates were obtained for dye concentrations 50 mg/L(FCP) and 80 mg/L(ICP).Under optimal conditions,the FCP was able to decolorize more than 87% of the dye within 2 min.While with ICP,the decolourization yield was 75% within 15 min.The decolourization and removal of DY106 was proved by UV-Vis analysis.Fourier transform infrared(FT-IR) spectroscopy analysis was also performed on DY106 and enzymatic treatment precipitated byproduct. | Nabila Boucherit Mahmoud Abouseoud Lydia Adour | 2013 | Journal of Environmental Sciences2013，25，6： | 3 |
| 3 | Phytochemical screening and free radical scavenging activity of Citrullus colocynthis seeds extracts显示文摘Objective:To study the phytochemical screening of different extracts from Citrullus colocynthis(C.colocynthis)seeds extracts and to assess their antioxidant activity on the DPPH free radical scavenging.Methods:Phytochemical screening,total content of polyphenols and flavonoids of C.colocynthis seeds extracts,including a crude aqueous extract(E1),a defatted aqueous extract(E2),a hydromethanolic extract(HM),an ethyl acetate extract(EA)and a n-butanol extract(n-B)was carried out according to the standard methods and to assess their corresponding effect on the antioxidant activity of this plant.Results:None of these extracts contained detectable amount of alkaloid,quinone,antraquinone,or reducing sugar.Catechic tannins and flavonoids were abundant in E1,MM and EA,whilst terpenoids were abundantly present in E1 and n-B but only weekly in HM.Coumarins were found in E2,EA and n-B.Polyphenols,expressed as gallic acid equivalent,amounted,per 100 g plant matter,to 329,1002 and 150 mg in EA,HM an E1 respectively.Flavonoids,expressed as catechin equivalent,amounted.per 100 g plant matter to 620,241 and 94 mg in EA,HM and E1 respectively.Comparable values were found in n-B and E1,with lower values in E2.Quercetin,myricetin and gallic acid were found in the EA and HM extracts by thin layer chromatography,The antioxidative effect of these extracts yielded,when tested at a concentration of 2000μg/mL in a 1,1-diphenyl-2-picrylhydrazyl assay,a reducing percentage of 88.8%with EA,74.5%with HM and 66.2%with E1,and corresponding IC_(50)of 350,580and 500μg/mL as compared to 1.1μg/mL for ascorbic acid.Conclusions:These qualitative and quantitative analytical data document the presence in C.colocynthis extracts of such chemical compounds as flavonoids responsible for the antioxidant activity,as well as other biological activities of this plant. | Nabila Benariba Rabeh Djaziri Wafaa Bellakhdar Nacera Belkacem Marcel Kadiata Willy J.Malaisse Abdullah Sener | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 3 |
| 4 | Predictors of thirty-day readmission in nonagenarians presenting with acute heart failure with preserved ejection fraction: a nationwide analysis显示文摘BACKGROUD Acute heart failure with preserved ejection fraction(HFpEF)is a common but poorly studied cause of hospital admissions among nonagenarians.This study aimed to evaluate predictors of thirty-day readmission,in-hospital mortality,length of stay,and hospital charges in nonagenarians hospitalized with acute HFpEF.METHODS Patients hospitalized between January 2016 and December 2018 with a primary diagnosis of diastolic heart failure were identified using ICD-10 within the Nationwide Readmission Database.We excluded patients who died in index admission,and discharged in December each year to allow thirty-day follow-up.Univariate regression was performed on each variable.Vari-ables with P-value<0.2 were included in the multivariate regression model.RESULTS From a total of 45,393 index admissions,43,646 patients(96.2%)survived to discharge.A total of 7,437 patients(15.6%)had a thirty-day readmission.Mean cost of readmission was 43,265 United States dollars(USD)per patient.Significant predictors of thirty-day readmission were chronic kidney disease stage III or higher[adjusted odds ratio(aOR)=1.20,95%CI:1.07−1.34,P=0.002]and diabetes mellitus(aOR=1.18,95%CI:1.07−1.29,P=0.001).Meanwhile,female(aOR=0.90,95%CI:0.82−0.99,P=0.028)and palliative care encounter(aOR=0.27,95%CI:0.21−0.34,P<0.001)were associated with lower odds of readmission.Cardiac arrhythmia(aOR=1.46,95%CI:1.11−1.93,P=0.007)and aortic stenosis(aOR=1.36,95%CI:1.05−1.76,P=0.020)were amongst predictors of in-hospital mortality.CONCLUSIONS In nonagenarians hospitalized with acute HFpEF,thirty-day readmission is common and costly.Chronic co-morbidities predict poor outcomes.Further strategies need to be developed to improve the quality of care and prevent the poor outcome in nonagenarians. | Ahmed Maraey Mahmoud Salem Nabila Dawoud Mahmoud Khalil Ahmed Elzanaty Hadeer Elsharnoby Ahmed Younes Ahmed Hashim Amit Alam | 2021 | Journal of Geriatric Cardiology2021，18，12： | 3 |
| 5 | Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release显示文摘Photoresponsive hydrogels have been attractive because they can provide precise spatial and temporal control for molecule release, whereas the conventional preparation of photoresponsive hydrogels generally involves complex chemical synthesis steps or specific conditions which limits their practical applications. Herein, a new photoresponsive hydrogel is facilely prepared via co-assembly of two simple molecules, Fmoc-Phe-OH and Azp, without chemical synthesis. The co-assembly mechanism, morphology, and photoresponsiveness of(Fmoc-Phe-OH)-Azp hydrogel are investigated by circular dichroism(CD), ultraviolet-visible(UV-Vis), fluorescence, ~1 H nuclear magnetic resonance(~1 H-NMR), attenuated total internal reflection Fourier transform Infrared(ATR-FTIR) spectroscopy, and scanning electron microscopy(SEM). Furthermore, the enhanced release of encapsulated sulforhodamine B(SRB) dye molecules can be achieved via UV light irradiation. The enhanced dye release amount can be controlled by manipulating photoirradiation time. This study provides a facile way to prepare photoresponsive hydrogel which holds great potential for controllable drug release. | Xiao-Qiu Dou Chang-Li Zhao Nabila Mehwish Ping Li Chuan-Liang Feng Holger Sch?nherr | 2019 | Chinese Journal of Polymer Science2019，37，5： | 3 |
| 6 | Cytoprotective Effect of Silymarin against Diabetes-Induced Cardiomyocyte Apoptosis in Diabetic Rats显示文摘Objective The beneficial effects of silymarin have been extensively studied in the context of inflammation and cancer treatment, yet much less is known about its therapeutic effect on diabetes. The present study was aimed to investigate the cytoprotective activity of silymarin against diabetes-induced cardiomyocyte apoptosis. Methods Rats were randomly divided into: control group, untreated diabetes group and diabetes group treated with silymarin(120 mg/kg·d) for 10 d. Rats were sacrificed, and the cardiac muscle specimens and blood samples were collected. The immunoreactivity of caspase-3 and Bcl-2 in the cardiomyocytes was measured. Total proteins, glucose, insulin, creatinine, AST, ALT, cholesterol, and triglycerides levels were estimated. Results Unlike the treated diabetes group, cardiomyocyte apoptosis increased in the untreated rats, as evidenced by enhanced caspase-3 and declined Bcl-2 activities. The levels of glucose, creatinine, AST, ALT, cholesterol, and triglycerides declined in the treated rats. The declined levels of insulin were enhanced again after treatment of diabetic rats with silymarin, reflecting a restoration of the pancreatic β-cells activity. Conclusion The findings of this study are of great importance, which confirmed for the first time that treatment of diabetic subjects with silymarin may protect cardiomyocytes against apoptosis and promote survival-restoration of the pancreatic β-cells. | Muobarak J.Tuorkey Nabila I.El-Desouki Rabab A.Kamel | 2015 | Biomedical and Environmental Sciences2015，28，1： | 2 |
| 7 | Red ginseng extract protects against aflatoxin B 1 and fumonisins- induced hepatic pre-cancerous lesions in rats 显示文摘 | Mosaad A Nabila S Hassan A A | 2010 | Food Chem Toxicol2010，48，2： | 1 |
| 8 | Radiation synthesis of poly bydrogels and its application as a carrier for anticancer delivery显示文摘 | Nabila A Mazied Sahar A Ismail Manal F | 2009 | Radiation Physics and Chemistry2009，78，11： | 1 |
| 9 | Prevalence, Antibiogram, and cdt Genes of Toxigenic Campylobacter jejuni in Salad Style Vegetables (Ulam) at Farms and Retail Outlets in Terengganu显示文摘 | Khalid Mohd Ikhsan Tang John YewHuat Baharuddin Nabila Huda Rahman Nasiha Shakina Rahimi Nurul Faizzah Radu Son | 2015 | Journal of Food Protection2015，，1： | 1 |
| 10 | Adsorption/desorption of Cd(11),Cu(11) and Pb (11) using chemically modifedorange peel:Equilibrium and kinetic studies显示文摘 | Mohamed R L Nabila S A Hanan S I | 2012 | Solid State Sciences2012，14，2： | 1 |
| 11 | COVID-19 and liver diseases,what we know so far显示文摘Coronavirus disease 2019(COVID-19)pneumonia outbreak started in December 2019.On March 12,2020,the World Health Organization(WHO)declared that the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)constitutes a pandemic,and as of May 2021,SARS-CoV-2 has infected over 167.3 million patients,including 3.4 million deaths,reported to WHO.In this review,we will focus on the relationship between SARS-CoV-2 infection and the liver.We will discuss how chronic liver diseases affect the COVID-19 disease course and outcomes.We will also discuss the SARS-CoV-2 effects on the liver,mechanisms of acute liver injury,and potential management plans. | Mohamed Elnaggar Ahmed Abomhya Ismail Elkhattib Nabila Dawoud Rajkumar Doshi | 2022 | World Journal of Clinical Cases2022，10，13： | 1 |
| 12 | Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase显示文摘 | Erika Salvi Zoltán Kutalik Nicola Glorioso Paola Benaglio Francesca Frau Tatiana Kuznetsova Hisatomi Arima Clive Hoggart Jean Tichet Yury P. Nikitin Costanza Conti Jitka Seidlerova Valérie Tikhonoff Katarzyna Stolarz-Skrzypek Toby Johnson Nabila Devos Lau | 2012 | Hypertension2012，，2： | 1 |
| 13 | De- Misty- fying the mesentery: an algorithmic approach to neoplastic and non-neoplastic mesenteric abnormalities显示文摘 | Myles T. Taffel Nadia J. Khati Nabila Hai Vahid Yaghmai Paul Nikolaidis | 2014 | Abdominal Imaging2014，，4： | 1 |
| 14 | Linear programming with interval right hand sides 显示文摘 | Virginie Gabrel Cecile Murat Nabila Remli | 2010 | International Transactions in Operational Research2010，17，3： | 1 |
| 15 | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11 β -Hydroxylase Deficiency显示文摘 | Nadia Charfi Mahdi Kamoun Mouna Feki Mnif Neila Mseddi Fatma Mnif Nozha Kallel Basma Ben Naceur Nabila Rekik Hela Fourati Emna Daoud Zainab Mnif Mourad Hadj Sliman Tahia Sellami-Boudawara Mohamed Abid S. K. Hong S. Srinivas | 2012 | Case Reports in Urology2012，，： | 1 |
| 16 | Heat and flow properties of a temperature dependent visco- plastic fluid including viscous dissipation显示文摘 | Nabila Labsi Youb Khaled Benkahla Abdelkader Boutra | 2013 | Journal of Food Process Engineering2013，36，4： | 1 |
| 17 | Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats显示文摘 | Ahmed S. Gad Yasser A. Khadrawy Aziza A. El-Nekeety Sherif R. Mohamed Nabila S. Hassan Mosaad A. Abdel-Wahhab | 2011 | Nutrition2011，，5： | 1 |
| 18 | Detection of Learning Styles from Learner's Browsing Behavior During e-Learning Activities显示文摘 | Nabila Bousbia Jean-Marc Labat Amar Balla | 2008 | Computer Science2008，，5091： | 1 |
| 19 | Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé显示文摘 | Nabila Zaabat Anne-Emmanuelle Hay Serge Michalet Nicole Darbour Christine Bayet Inès Skandrani Leila Chekir-Ghedira Salah Akkal Marie-Geneviève Dijoux-Franca | 2011 | Food and Chemical Toxicology2011，，12： | 1 |
| 20 | Modified starch as a retention aid in papermaking显示文摘 | El-Shinawy Nabila E1-Mehbad N Y | | 0，，09： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员