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| 1 | Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA显示文摘Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.Much of the newly-discovered transcriptome appears to represent long non-coding RNA(lncRNA),a heterogeneous group of largely uncharacterised transcripts.Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date.One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA(miRNA) pathways.lnc RNA has been shown to act as both a source and an inhibitory regulator of mi RNA.At the transcriptional level,a model is emerging whereby lnc RNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes.Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping,as well as conferring specificity on histone modifying complexes by directing them to specific loci. | Iain M.Dykes Costanza Emanueli | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 71 |
| 2 | 全球生态系统服务与自然资本的价值估算显示文摘编者按:地球上的生态系统是一种复杂的生命支持系统,生态系统对人类的贡献,在生态学研究中经常用“社会效益和经济效益”来表述,是可以用经济价值来估算的。然而,由于其复杂性和不确定性,对这两个效益如何进行估价,一直是困扰生态学家和经济学家的重要问题。Cos... | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) | 1999 | 生态学杂志1999，18，2： | 38 |
| 3 | 海岸湿地在飓风防护中的价值显示文摘海岸湿地可以减少飓风对沿海群落的破坏作用。把1980年以来美国34次主要飓风在其袭击区所造成的单位国民生产总值损失的自然对数值作为因变量,风速和飓风袭击区湿地面积的自然对数值作为自变量,回归模型显示两者之间的差异极显著,说明了其相对损失的差别的60%。在上述模型中,每减少1 hm^2的湿地面积,来自特定风暴造成的风暴损害将平均增加33 000美元的损失(中值5000美元)。利用这个关系,把各年度不同强度飓风发生的概率考虑在内,我们以1km×1km为像素,以州为单元将湿地的年度价值绘制成图,湿地年度价值的变化范围为250~51 000美元/hm^2·a,平均价值为8240美元/hm^2·a(中值3230美元/hm^2·a),这显著高于以前估算的湿地价值。据估算,美国的海岸湿地目前能够提供的保护作用相当于232亿美元/a。在风暴防护中,海岸湿地是一种有价值的、能够自我维持的'水平堤防',并且能够提供垂直堤防所不能提供的许多其他的生态系统功能。对于人类社会来说,对沿海湿地的修复与维护是一种极其划算的战略性投资。 | Robert Costanza Octavio Pérez-Maqueo M. Luisa Martinez Paul Sutton Sharolyn J. Anderson Kenneth Mulder 唐晓宇(译) 王书磊(校) 张晓琴(校) | 2008 | AMBIO-人类环境杂志2008，37，4： | 8 |
| 4 | Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study显示文摘瞄准:评估兰伯氏贾第虫的流行(G。兰氏鞭毛虫属) 在有急躁的肠症候群(IBS ) 和消化不良并且到的病人的感染证实哪个是最精确的测试在这个背景诊断感染。方法:连续地由于 IBS 或消化不良的症状在 2002 年 1 月和 2003 年 12 月之间第一次出席了门诊病人肠胃病学诊所的 137 个病人被招募。所有病人经历了临床的评估,第一步的 haematology 和化学测试,为乳糜泻的血清学试金, lactose-H (2 ) 呼吸测试,腹的 ultrasonography,和 esophagogastroduodenoscopy。Helicobacter pylori 地位被评估。在有比 45 年旧的 IBS 的症状的病人,结肠镜检查也被执行。在所有病人,十二指肠的活体检视和凳子样品为 G 的 trophozoites 和包囊被检验。由几个方法的兰氏鞭毛虫属。结果:G。兰氏鞭毛虫属在 9 个病人被识别。下列诊断也被做:IBS (100/137, 73%) ,机能性消化不良(62/137, 45%) ,器官的消化不良(33/137, 24%) ,并且乳糖不耐(75/137, 55%) 。一个重要协会在贾第虫病和 H pylori 感染之间被发现(c2=6.632, OR=12.4, CI=1.5-68.1 ) 。没有症状,可靠地允许贾第虫病的识别。当十二指肠的活体检视的组织学的检查显示了低敏感时,在十二指肠的活体检视和凳子样品考试的寄生虫的直接搜索在所有情况中给了一致结果(例如, 22.2%) 。结论:在这个连续系列, G 的诊断。兰氏鞭毛虫属感染与 IBS 和消化不良说明了 6.5% 病人。如果凳子样品检查被执行,为贾第虫病的诊断的十二指肠的活体检视可能是不必要的。 | Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 5 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d’Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O’Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 4 |
| 6 | 程序升温汽化大体积进样气相色谱法同时测定空气中的甲醛及其他10种羰基污染物(英文)显示文摘Long-term indoor-air limit for formaldehyde stipulated by the European Commission is 1 μg/m3,while the World Health Organization has set a threshold of 100 μg/m3 that should not be exceeded for more than 30 min. To date,however,only a few analytical techniques have been developed that can be used to detect formaldehyde at these very restrictive limits. Thus,there is a need to develop for comprehensive methods for analyzing airborne formaldehyde and other carbonyl pollutants in the ambient environment. The aim of this study is to develop a highly sensitive online automated preconcentration gas chromatographic method using large-volume injection with a programmed temperature vaporization injector for the analysis of airborne formaldehyde and ten other carbonyl compounds. The influence of several parameters,such as the maximum volume injected,programmed temperature vaporization transfer time and temperature,carrier gas flow rate,and type of packing material was investigated. After optimization,highly satisfactory results in terms of the absolute and methodological detection limits were achieved,i. e. as low as the μg/m3 level for all the carbonyl pollutants studied. A commercially available sampler,originally designed for active sampling,was evaluated as a passive sampling device;this optimized technique was applied to monitor the concentrations of carbonyl pollutants in the indoor air of ten public buildings in Florence. The strength of this methodology lies both in the low detection limits reached in the simultaneous analysis of a wide group of 2,4-dinitrophenylhydrazine derivatives,and the potential adaptability of this method to other gas chromatographic applications to achieve lower sensitivity. | Stefano DUGHERI Nicola MUCCI Ilenia POMPILIO Giovanni CAPPELLI Costanza BOSSI AlessANDro BONARI Giulio ARCANGELI | 2018 | 色谱2018，36，12： | 3 |
| 7 | 高血压患者颈动脉粥样硬化和脉压及肾血流动力学的关系显示文摘动脉粥样硬化结构性损害、动脉硬化、脉压和肾血流动力学之间可能相互作用与相互影响。肾阻力指数(renal resistance index,RRI)被认为是可预测全身血管变化的一个很好的指标。 | Geraci G MulèG Costanza G Mogavero M Geraci C Cottone S 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 8 | Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats显示文摘 | Fabio Fiordaliso Roberto Bianchi Lidia Staszewsky Ivan Cuccovillo Mirko Doni Teresa Laragione Monica Salio Costanza Savino Silvia Melucci Francesco Santangelo Eugenio Scanziani Serge Masson Pietro Ghezzi Roberto Latini | 2004 | Journal of Molecular and Cellular Cardiology2004，，5： | 2 |
| 9 | 城市的生态系统占用显示文摘本文对欧洲波罗的海地区城市及世界城市生态环境占用面积进行了估算。为欧洲波罗的海地区29个大城市提供资源消耗和废物同化的森林、农业、海洋和湿地生态系统的总面积,至少应是这29个大城市本身面积的565~1130倍。全球20%的人口(11亿)居住在世界744个大城市中。目前全球有生产能力的海洋生态系统的25%为这些人提供海洋产品。这些城市占用未吸收CO_2排放的森林,超过世界森林总汇能力的10%以上。如果正如1996年联合国第二届生境大会所强调的:我们的目标是'可持续的人类住区'的话,那么,就必须在城市规划和发展的过程中明确地说明,生态系统维持城市规模的能力正日益变得有限。 | Carl Folke sa Jansson Jonas Larsson Robert Costanza 王燕 | 1997 | 人类环境杂志1997，26，3： | 2 |
| 10 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O'Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 2 |
| 11 | miRNAGE-34 induces cardiac damAGE显示文摘 | Costanza Emanueli Thomas Thum | 2013 | Cell Research2013，23，7： | 2 |
| 12 | MR differential diagnosis of acute deep grey matter pathology in paediatric patients显示文摘 | Carlo Cosimo Quattrocchi Daniela Longo Luciana Nogueira Delfino Yuri Errante Costanza Aiello Giuseppe Fariello Bruno Bernardi | 2013 | Pediatric Radiology2013，，： | 2 |
| 13 | Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy:A review of literature显示文摘BACKGROUND The standard treatment of locally advanced rectal cancers(LARC)consists on neoadjuvant chemoradiotherapy followed by total mesorectal excision.Different data in literature showed a benefit on tumor downstaging and pathological complete response(pCR)rate using radiotherapy dose escalation,however there is shortage of studies regarding dose escalation using the innovative techniques for LARC(T3-4 or N1-2).AIM To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy techniques.METHODS In December 2020,we conducted a comprehensive literature search of the following electronic databases:PubMed,Web of Science,Scopus and Cochrane library.The limit period of research included articles published from January 2009 to December 2020.Screening by title and abstract was carried out to identify only studies using radiation doses equivalent dose 2 Gy fraction(EQD2)≥54 Gy and Volumetric Modulated Arc Therapy(VMAT),intensity-modulated radiotherapy or image-guided radiotherapy(IGRT)techniques.The authors’searches generated a total of 2287 results and,according to PRISMA Group(2009)screening process,21 publications fulfil selection criteria and were included for the review.RESULTS The main radiotherapy technique used consisted in VMAT and IGRT modality.The mainly dose prescription was 55 Gy to high risk volume and 45 Gy as prophylactic volume in 25 fractions given with simultaneous integrated boosts technique(42.85%).The mean pCR was 28.2%with no correlation between dose prescribed and response rates(P value≥0.5).The R0 margins and sphincter preservation rates were 98.88%and 76.03%,respectively.After a mean follow-up of 35 months local control was 92.29%.G3 or higher toxicity was 11.06%with no correlation between dose prescription and toxicities.Patients receiving EQD2 dose>58.9 Gy and BED>70.7 Gy had higher surgical complications rates compared to other group(P value=0.047).CONCLUSION Dose escalation neoadjuvant radiotherapy using innovative techniques is safe for LARC achieving higher rates of pCR.EQD2 doses>58.9 Gy is associated with higher rate of surgical complications. | Durim Delishaj Ilaria Costanza Fumagalli Stefano Ursino Agostino Cristaudo Francesco Colangelo Antonio Stefanelli Alessandro Alghisi Giuseppe De Nobili Romerai D’Amico Alessandra Cocchi Antonio Ardizzoia Carlo Pietro | 2021 | World Journal of Clinical Cases2021，9，30： | 2 |
| 14 | The ecological, economic, and social importance of the oceans显示文摘 | Robert Costanza | 1999 | Ecological Economics1999，，2： | 2 |
| 15 | Changes in the global value of ecosystem services显示文摘 | Robert Costanza Rudolf de Groot Paul Sutton Sander van der Ploeg Sharolyn J. Anderson Ida Kubiszewski Stephen Farber R. Kerry Turner | 2014 | Global Environmental Change2014，，： | 2 |
| 16 | Economic and ecological concepts for valuing ecosystem services显示文摘 | Stephen C. Farber Robert Costanza Matthew A. Wilson | 2002 | Ecological Economics2002，，3： | 2 |
| 17 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 18 | The value of the world's ecosystem services and natural capital 显示文摘 | COSTANZA R DARGE R DE G R | 1997 | Nature1997，387，： | 1 |
| 19 | Social Goals and the Value of Ecosystem Service显示文摘 | | 2002 | Ecosystem2002，，3： | 1 |
| 20 | Assessing ecosystem health显示文摘 | Rapport DJ Costanza R and Mc Michael AJ | 1998 | Trend s in Ecology & Evolution1998，13，10： | 1 |
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