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| 1 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 2 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 3 | Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study显示文摘 | Gennaro Galizia Eva Lieto Ferdinando Vita Francesca Ferraraccio Anna Zamboli Andrea Mabilia Annamaria Auricchio Paolo Castellano Vincenzo Napolitano Michele Orditura | 2014 | International Journal of Colorectal Disease2014，，1： | 3 |
| 4 | Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary*显示文摘 | Robert G. Martindale Stephen A. McClave Vincent W. Vanek Mary McCarthy Pamela Roberts Beth Taylor Juan B. Ochoa Lena Napolitano Gail Cresci | 2009 | Critical Care Medicine2009，，5： | 3 |
| 5 | Nonalcoholic fatty liver disease, spleen and psoriasis:New aspects of low-grade chronic inflammation显示文摘AIM: To investigate spleen status in psoriasis and itsrelationship with hepatic steatosis, Psoriasis Area and Severity Index, and insulin resistance.METHODS: Seventy-nine psoriatic patients who were not suffering from any chronic inflammatory disease were retrospectively selected for inclusion in this study,and their complete medical records were accessed.An age- and sex-matched group of 80 non-psoriatic,obese patients was included as a control. The following relevant data were collected: age, sex, weight, height,body mass index, waist circumference, blood pressure,insulin resistance status, age at psoriasis onset, and severity of psoriasis. Abdominal ultrasonography was performed to determine spleen longitudinal diameter(SLD), and hepatic steatosis grade.RESULTS: The SLD of control obese patients was greater than that of psoriatic subjects(P = 0.013),but body mass index predicted the size of the spleen in psoriatic patients(P < 0.001). The SLD of psoriatic patients with normal weight was significantly reduced with respect to the overweight/obese psoriatic patients(P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size(P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects(P =0.038).CONCLUSION: This study shows a correlation between the SLD and the duration of psoriasis. | Nicola Balato Maddalena Napolitano Fabio Ayala Cataldo Patruno Matteo Megna Giovanni Tarantino | 2015 | World Journal of Gastroenterology2015，21，22： | 3 |
| 6 | HOW ARE PRODUCT-SERVICE COMBINED OFFERS PROVIDED IN GERMANY AND ITALY?ANALYSIS WITH COMPANY SIZES AND COUNTRIES显示文摘以传统的产品出售企业的一个不同方法提供产品和服务的一个新企业概念特别在生产工业正在得到更多的注意。这篇论文调查借助于产品和服务的集成的这家新企业怎么在德国和意大利被完成。另外,它根据公司尺寸分析差别。结果包括那这类企业在他们顾客的焦点激发的许多情况中并且经常由物理产品和他们的维护组成。与德国的对比,意大利的公司经常为这类提议明确地设计他们的物理产品。从分析基于尺寸差别,当拥有物理产品时,小公司被发现为这类提议完成特定的设计。在那里别似乎是开发支持如此的提议的发展的任何确定的方法或工具,在如此的方法 / 工具以内,将为更多的改编处于良好的竟技状态有空间物理产品设计。 | Tomohiko SAKAO Nicola NAPOLITANO Massimo TRONCI Erik SUNDIN Mattias LINDAHL | 2008 | Journal of Systems Science and Systems Engineering2008，17，3： | 3 |
| 7 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019，2，1： | 2 |
| 8 | Endoscopic right thyroid lobectomy显示文摘 | M. M. Lirici C. S. G. Hüscher S. Chiodini C. Napolitano A. Recher | 1997 | Surgical Endoscopy1997，，8： | 2 |
| 9 | Endoscopic right thyroid lobectomy显示文摘 | Huscher CS Chiodini S Napolitano C | 1997 | Surg Endoscop1997，11，8： | 2 |
| 10 | Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer显示文摘 | Jennifer Y. Wo Harvey J. Mamon Cristina R. Ferrone David P. Ryan Lawrence S. Blaszkowsky Eunice L. Kwak Yolanda D. Tseng Brian N. Napolitano Marek Ancukiewicz Richard S. Swanson Keith D. Lillemoe Carlos Fernandez-del Castillo Theodore S. Hong | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 11 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 12 | Zero Energy Building – A review of definitions and calculation methodologies显示文摘 | A.J. Marszal P. Heiselberg J.S. Bourrelle E. Musall K. Voss I. Sartori A. Napolitano | 2011 | Energy & Buildings2011，，4： | 2 |
| 13 | Identification of a long QT Syndrome molecular defect in drug induced torsade depointes显示文摘 | Napolitano C Priori SG Schwartz PJ | 1997 | Circulation1997，96，1： | 1 |
| 14 | Endoscopic fight thyroid lobectomy显示文摘 | HUSCHER CS CHOLIDINI S NAPOLITANO C | 1997 | Surg Endosc1997，11，8： | 1 |
| 15 | Back to basics:valida-tion of the admission systemic inflammatory response syndrome score inpredicting outcome in trauma显示文摘 | Malone DL Kuhls D Napolitano LM | 2001 | J Trauma2001，51，3： | 1 |
| 16 | Endoscopic right thyroid lobectomy显示文摘 | Huscher CS Chiodini S Napolitano C | 1997 | Surg Endosc1997，11，8： | 1 |
| 17 | Epidemiology of ARDS and ALl 显示文摘 | Blank R Napolitano LM | 2011 | Crit Care Clin2011，27，3： | 1 |
| 18 | Dynamics of the self-as- sembly of complex cellular aggregates on micromolded nonadhesive hydrogels显示文摘 | Napolitano AP Chai P Dean DM | 2007 | Tissue Eng2007，13，8： | 1 |
| 19 | Guinea pig model of mycobacterium tuberculosis dormant infection 显示文摘 | Kashino SS Napolitano DR Skobe Z | 2008 | Microbes Infect2008，10，1415： | 1 |
| 20 | Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia显示文摘 | Mario Lapecorella Alessandro Lucchesi Mauro Di Ianni Mariasanta Napolitano Gino Coletti Gabriella Di Leonardo Luigi Dell?Orso Remo Barnabei Guglielmo Mariani | 2010 | Blood Coagulation & Fibrinolysis2010，，1： | 1 |
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