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| 1 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 2 | The role of critical shear stress on acute coronary syndrome显示文摘 | F. Jung O.K. Baskurt Jongyoun Kim Hyemoon Chung Minhee Cho Byoung-Kwon Lee Ali Karimi Sehyun Shin | 2013 | Clinical Hemorheology and Microcirculation2013，，1： | 1 |
| 3 | What's so different about the mobile Intemet? 显示文摘 | Minhee Chae Jinwoo Kim | 2003 | Communications of the ACM2003，46，12： | 1 |
| 4 | Sleep disturbances after cerebral infarction: role of depression and fatigue显示文摘 | Suh Minhee Choi-Kwon Kim Jong S | 2014 | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2014，23，7： | 1 |
| 5 | , Remediation of heavy metal contaminated groundwater originated from abandoned mine using lime and calcium carbonate显示文摘 | Minhee Lee In Sung Paik Insu Kim | 2007 | Journal of Hazardous Materials2007，144，12： | 1 |
| 6 | A high‐fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity‐resistant BALB/c mice显示文摘 | Heesook Park Minhee Kim Gyoo Taik Kwon Do Young Lim Rina Yu Mi‐Kyung Sung Ki Won Lee James W. Daily Jung Han Yoon Park | 2011 | Mol Carcinog2011，，11： | 1 |
| 7 | Two Types of Diurnal Variations in Heavy Rainfall during July over Korea显示文摘This study examined the characteristics of the diurnal variations of heavy rainfall(≥110 mm in 12 hours)in Korea and the related atmospheric circulation for July from 1980−2020.During the analysis period,two dominant pattens of diurnal variation of the heavy rainfall emerged:all-day heavy rainfall(AD)and morning only heavy rainfall(MO)types.For the AD-type,the heavy rainfall is caused by abundant moisture content in conjunction with active convection in the morning(0000−1200,LST;LST=UTC+9)and the afternoon hours(1200−2400 LST).These systems are related to the enhanced moisture inflow and upward motion induced by the strengthening of the western North Pacific subtropical high and upper-tropospheric jet.For the MO-type,heavy rainfall occurs mostly in the morning hours;the associated atmospheric patterns are similar to the climatology.We find that the atmospheric pattern related to severe heavy rainfalls in 2020 corresponds to a typical AD-type and resembles the 1991 heavy-rainfall system in its overall synoptic/mesoscale circulations.The present results imply that extremely heavy rainfall episodes in Korea during the 2020 summer may occur again in the future associated with the recurring atmospheric phenomenon related to the heavy rainfall. | Chang-Kyun PARK Minhee CHANG Chang-Hoi HO Kyung-Ja HA Jinwon KIM Byung-Ju SOHN | 2021 | Advances in Atmospheric Sciences2021，38，12： | 1 |
| 8 | A comparison of some imidazoles in the curing of epoxy resin显示文摘 | YOUNG ROK HAMA SUN HEE KIM a YOUNG JAE SHIN b DONG HO LEE a MINHEE YANG a JI HYE MIN a JAE SUP SHIN a * | 2010 | Journal of Industrial and Engineering Chemistry2010，16，： | 1 |
| 9 | Bioethanol Ploduction from Ammonia Percolated Wheat Straw显示文摘 | MINHEE HAN SE-KWON MOON YULE KIM | 2009 | Biotechnology and Bioprocess Engineering2009，14，： | 1 |
| 10 | Microencapsulation of imidazole curing agent for epoxy resin显示文摘 | YOUNG ROK HAMA DONG HO LEE SUN HEE KIM YOUNG JAE SHIN MINHEE YANG JAE SUP SHIN | 2010 | Journal of Industrial and Engineering Chemistry2010，16，5： | 1 |
| 11 | Accumulation of poly(adenosine diphosphate-ribose)by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells显示文摘BACKGROUND The biochemical phenomenon defined as poly adenosine diphosphate(ADP)-ribosylation(PARylation)is essential for the progression of pancreatic cancer.However,the excessive accumulation of poly ADP-ribose(PAR)induces apoptosis-inducing factor(AIF)release from mitochondria and energy deprivation resulting in the caspase-independent death of cancer cells.AIM To investigate whether sustained calcium supply could induce an anticancer effect on pancreatic cancer by PAR accumulation.METHODS Two pancreatic cancer cell lines,AsPC-1 and CFPAC-1 were used for the study.Calcium influx and mitochondrial reactive oxygen species(ROS)were observed by fluorescence staining.Changes in enzyme levels,as well as PAR accumulation and energy metabolism,were measured using assay kits.AIF-dependent cell death was investigated followed by confirming in vivo anticancer effects by sustained calcium administration.RESULTS Mitochondrial ROS levels were elevated with increasing calcium influx into pancreatic cancer cells.Then,excess PAR accumulation,decreased PAR glycohydrolase and ADP-ribosyl hydrolase 3 levels,and energy deprivation were observed.In vitro and in vivo antitumor effects were confirmed to accompany elevated AIF levels.CONCLUSION This study visualized the potential anticancer effects of excessive PAR accumulation by sustained calcium supply on pancreatic cancer,however elucidating a clear mode of action remains a challenge,and it should be accompanied by further studies to assess its potential for clinical application. | Keun-Yeong Jeong Jae Jun Sim Minhee Park Hwan Mook Kim | 2022 | World Journal of Gastroenterology2022，28，27： | 0 |
| 12 | 不同肌肉组选择导出模块对组间肌电反复性的影响(英文)显示文摘目的评价组间肌电反复性对不同肌肉组选择导出模块的影响。方法记录12名参与实验者在自选速度下行走时16块肌肉的肌电图。用组内相关系数评价每个步行周期的肌肉兴奋度和肌肉模块。依据肌肉兴奋度的反复性,区分出3种类型的肌肉组。结果可靠肌肉组显示出较高的组内相关系数(>0.4),而全身肌肉组和混合肌肉组显示出较低的组内相关系数(<0.4)。3种类型肌肉组比较,可靠肌肉组分析得出的模块具有最好的反复性,全身肌肉组和混合肌肉组的反复性较低。结论具有较高可靠性的肌肉兴奋性能够得出较一致的模块。得出一致模块的方法非常重要,尤其是在依靠肌肉兴奋性反馈而改变的运动模式中。 | Yushin KIM Minhee KIM Bumchul YOON Sangheon LEE | 2019 | 医用生物力学2019，34，4： | 0 |
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