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您的检索式：作者名="Jae Jun Sim"
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| 1 | Temperature-Responsive Tensile Actuator Based on Multi-walled Carbon Nanotube Yarn显示文摘Many temperature indicators or sensors show color changes for materials used in food and medical fields.However, they are not helpful for a color-blind person or children who lack judgment. In this paper, we introduce simply fabricated and more useful low-temperature indicator(~30 °C) for devices that actuates using paraffin-infiltrated multiwalled carbon nanotube(MWCNT) coiled yarn. The density difference of MWCNT yarn provides large strain(~330 %)when heat causes the melted polymer to move. Furthermore, the MWCNT yarn decreases the melting point of paraffin.These properties allow control of the actuating temperature. In addition, mechanical strength was enhanced by MWCNT than previously reported temperature-responsive actuators based on shape memory polymers. This simply fabricated temperature indicator can be applied in latching devices for medical and biological fields. | Hyunsoo Kim Jae Ah Lee Hyeon Jun Sim Márcio D.Lima Ray H.Baughman Seon Jeong Kim | 2016 | Nano-Micro Letters2016，8，3： | 0 |
| 2 | Accumulation of poly(adenosine diphosphate-ribose)by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells显示文摘BACKGROUND The biochemical phenomenon defined as poly adenosine diphosphate(ADP)-ribosylation(PARylation)is essential for the progression of pancreatic cancer.However,the excessive accumulation of poly ADP-ribose(PAR)induces apoptosis-inducing factor(AIF)release from mitochondria and energy deprivation resulting in the caspase-independent death of cancer cells.AIM To investigate whether sustained calcium supply could induce an anticancer effect on pancreatic cancer by PAR accumulation.METHODS Two pancreatic cancer cell lines,AsPC-1 and CFPAC-1 were used for the study.Calcium influx and mitochondrial reactive oxygen species(ROS)were observed by fluorescence staining.Changes in enzyme levels,as well as PAR accumulation and energy metabolism,were measured using assay kits.AIF-dependent cell death was investigated followed by confirming in vivo anticancer effects by sustained calcium administration.RESULTS Mitochondrial ROS levels were elevated with increasing calcium influx into pancreatic cancer cells.Then,excess PAR accumulation,decreased PAR glycohydrolase and ADP-ribosyl hydrolase 3 levels,and energy deprivation were observed.In vitro and in vivo antitumor effects were confirmed to accompany elevated AIF levels.CONCLUSION This study visualized the potential anticancer effects of excessive PAR accumulation by sustained calcium supply on pancreatic cancer,however elucidating a clear mode of action remains a challenge,and it should be accompanied by further studies to assess its potential for clinical application. | Keun-Yeong Jeong Jae Jun Sim Minhee Park Hwan Mook Kim | 2022 | World Journal of Gastroenterology2022，28，27： | 0 |
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